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TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays
Open accessAbstract
Axon formation, the initial step in establishing neuronal polarity, critically depends on local microtubule reorganization and is characterized by the formation of parallel microtubule bundles. How uniform microtubule polarity is achieved during axonal development remains an outstanding question. Here, we show that the tripartite motif containing (TRIM) protein TRIM46 plays an instructive role in the initial polarization of neuronal cells. TRIM46 is specifically localized to the newly specified axon and, at later stages, partly overlaps with the axon initial segment (AIS). TRIM46 specifically forms closely spaced parallel microtubule bundles oriented with their plus-end out. Without TRIM46, all neurites have a dendrite-like mixed microtubule organization resulting in Tau missorting and altered cargo trafficking. By forming uniform microtubule bundles in the axon, TRIM46 is required for neuronal polarity and axon specification in vitro and in vivo. Thus, TRIM46 defines a unique axonal cytoskeletal compartment for regulating microtubule organization during neuronal development.
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“Among these proteins, TOGARAM1 and TRIM46 are associated with proper microtubule functions, 55 , 56 and MTFR1L is associated with mitochondrial fusion processes. 57”
From Unraveling sex differences in Alzheimer's disease and related endophenotypes with brain proteomes (2025) · cites this paper as [56]
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“Among these proteins, TOGARAM1 and TRIM46 are associated with proper microtubule functions, 55 , 56 and MTFR1L is associated with mitochondrial fusion processes. 57”
From Unraveling sex differences in Alzheimer's disease and related endophenotypes with brain proteomes (2025) · cites this paper as [56]
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Cites
RING Domain E3 Ubiquitin Ligases
Deshaies, R. J., & Joazeiro, C. A. P. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.101807.093809 · Cited by 2,679
Microtubule assembly, organization and dynamics in axons and dendrites
Conde, C., & Cáceres, A. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2631 · Cited by 1,086
GSK-3β Regulates Phosphorylation of CRMP-2 and Neuronal Polarity
Yoshimura, T., Kawano, Y., Arimura, N., Kawabata, S., Kikuchi, A., & Kaibuchi, K. (2005) · Cell · doi:10.1016/j.cell.2004.11.012 · Cited by 903
Axonal transport deficits and neurodegenerative diseases
Millecamps, S., & Julien, J.-P. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3380 · Cited by 755
Baas, P. W., Deitch, J. S., Black, M. M., & Banker, G. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.8335 · Cited by 742
Stepanova, T., Slemmer, J., Hoogenraad, C. C., Lansbergen, G. W. A., Dortland, B. R., Zeeuw, C. I. D., Grosveld, F. G., van Cappellen, G. W. A., Akhmanova, A. S., & Galjart, N. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02655.2003 · Cited by 702
Self-citationAxonal transport: cargo-specific mechanisms of motility and regulation
Maday, S., Twelvetrees, A. E., Moughamian, A. J., & Holzbaur, E. L. F. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.019 · Cited by 683
Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity
Jaworski, J., Kapitein, L. C., Gouveia, S. M., Dortland, B. R., Wulf, P. S., Grigoriev, I., Camera, P., Spangler, S. A., Di Stefano, P., Demmers, J., et al. (2009) · Neuron · doi:10.1016/j.neuron.2008.11.013 · Cited by 643
Self-citationMicrotubule stabilization specifies initial neuronal polarization
Witte, H., Neukirchen, D., & Bradke, F. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200707042 · Cited by 564
Establishment of axon-dendrite polarity in developing neurons.
Barnes, A. P., & Polleux, F. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125536 · Cited by 523
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Bodakuntla, S., Jijumon, A. S., Villablanca, C., González-Billault, C. E., & Janke, C. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.07.004 · Cited by 377
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Leterrier, C. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1922-17.2018 · Cited by 317
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Akhmanova, A., & Kapitein, L. C. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00473-y · Cited by 233
Self-citationAxon initial segments: structure, function, and disease
Huang, C. Y., & Rasband, M. N. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13718 · Cited by 204
Gumy, L. F., Katrukha, E. A., Grigoriev, I., Jaarsma, D., Kapitein, L. C., Akhmanova, A., & Hoogenraad, C. C. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.046 · Cited by 186
Self-citationFang, L., Cai, W., Liu, S., Canela‐Xandri, O., Gao, Y., Jiang, J., Rawlik, K., Li, B., Schroeder, S., Rosen, B. D., et al. (2020) · Genome Research · doi:10.1101/gr.250704.119 · Cited by 185
Axon Initial Segment Cytoskeleton: Architecture, Development, and Role in Neuron Polarity
Jones, S. L., & Svitkina, T. (2016) · Neural Plasticity · doi:10.1155/2016/6808293 · Cited by 191
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Leterrier, C., Dubey, P., & Roy, S. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.129 · Cited by 175
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Bentley, M., & Banker, G. A. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.100 · Cited by 161
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Zhang, J., Qiu, Q., Wang, H., Chen, C., & Luo, D. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112800 · Cited by 141
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Matamoros, A. J., & Baas, P. W. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.06.016 · Cited by 137
Tortosa, E., Adolfs, Y., Fukata, M., Pasterkamp, R. J., Kapitein, L. C., & Hoogenraad, C. C. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.042 · Cited by 125
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Cunha‐Ferreira, I., Chazeau, A., Buijs, R. R., Stucchi, R., Will, L., Pan, X., Adolfs, Y., van der Meer, C., Wolthuis, J. C., Kahn, O. I., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.093 · Cited by 107
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Vukušić, K., Buđa, R., Bosilj, A., Milas, A., Pavin, N., & Tolić, I. M. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.09.010 · Cited by 101
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Tedeschi, A., Dupraz, S., Curcio, M., Laskowski, C. J., Schaffran, B., Flynn, K. C., Santos, T. E., Stern, S., Hilton, B. J., Larson, M. J. E., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.007 · Cited by 102
Farı́as, G. G., Freal, A., Tortosa, E., Stucchi, R., Pan, X., Portegies, S., Will, L., Altelaar, M. A. F., & Hoogenraad, C. C. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.030 · Cited by 96
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Nirschl, J., Ghiretti, A. E., & Holzbaur, E. L. F. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.100 · Cited by 102
Bell, M. J., & Zempel, H. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0152 · Cited by 92
Zhang, M., Ergin, V., Lin, L., Stork, C., Chen, L., & Zheng, S. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.022 · Cited by 92
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Self-citationKarasmanis, E. P., Phan, C.-T., Angelis, D., Kesisova, I. A., Hoogenraad, C. C., McKenney, R. J., & Spiliotis, E. T. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.013 · Cited by 81
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Self-citationA pair of E3 ubiquitin ligases compete to regulate filopodial dynamics and axon guidance
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Pan, X., Cao, Y., Stucchi, R., Hooikaas, P. J., Portegies, S., Will, L., Martin, M., Akhmanova, A. S., Harterink, M., & Hoogenraad, C. C. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.084 · Cited by 55
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Self-citation
Metadata
- Authors
- van Beuningen, S. F. B., Will, L., Harterink, M., Chazeau, A., van Battum, E. Y., Frias, C. P., Franker, M. A. M., Katrukha, E. A., Stucchi, R., Vocking, K., Antunes, A. T., Slenders, L., Doulkeridou, S., Sillevis Smitt, P., Altelaar, A. F. M., Post, J. A., Akhmanova, A., Pasterkamp, R. J., Kapitein, L. C., de Graaff, E., & Hoogenraad, C. C.
- Affiliations
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Corresponding author
- de Graaff, Esther
- Hoogenraad, Casper C.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 88
- Issue
- 6
- Pages
- 1208-1226
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2182809622
- Cited by
- 225
- References
- 53
- Citations by year
- 2026: 13 · 2025: 25 · 2024: 23 · 2023: 16 · 2022: 23 · 2021: 30 · 2020: 19 · 2019: 22 · 2018: 21 · 2017: 21 · 2016: 11 · 2015: 1
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- TRIM46, neuronal polarity, axon specification, microtubule polarity, axon initial segment, microtubule reorganization, axonal cytoskeleton, neuronal development
- MeSH terms
- Amino Acid Sequence, Animals, Axons, Cells, Cultured, Chlorocebus aethiops, Cerebral Cortex, Female, HeLa Cells, Humans, Mice, Inbred C57BL, Microtubules, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Pregnancy, Repressor Proteins, Cell Polarity, COS Cells, Mice, Rats, HEK293 Cells
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