Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894 · see citing works

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996 · see citing works

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882 · see citing works

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500 · see citing works

Cell death during development of the nervous system

Oppenheim, R. W. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002321 · Cited by 3,084 · see citing works

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082 · see citing works

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Narendra, D. P., Jin, S. M., Tanaka, A., Suen, D.-F., Gautier, C. A., Shen, J., Cookson, M. R., & Youle, R. J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000298 · Cited by 2,944 · see citing works

Functional neurogenesis in the adult hippocampus

van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853 · see citing works

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835 · see citing works

Brain development in rodents and humans: identifying benchmarks of maturation and vulnerability to injury across species

Semple, B. D., Blomgren, K., Gimlin, K., Ferriero, D. M., & Noble-Haeusslein, L. J. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.04.001 · Cited by 2,132 · see citing works

ER Tubules Mark Sites of Mitochondrial Division

Friedman, J. R., Lackner, L. L., West, M., DiBenedetto, J. R., Nunnari, J., & Voeltz, G. K. (2011) · Science · doi:10.1126/science.1207385 · Cited by 2,072 · see citing works

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, C. A., Sou, Y.-S., Saiki, S., Kawajiri, S., Sato, F., et al. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200910140 · Cited by 1,969 · see citing works

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

Ravikumar, B., Sarkar, S., Davies, J. E., Futter, M., Garcı́a-Arencibia, M., Green-Thompson, Z. W., Jiménez-Sánchez, M., Korolchuk, V. I., Lichtenberg, M., Luo, S., et al. (2010) · Physiological Reviews · doi:10.1152/physrev.00030.2009 · Cited by 1,726 · see citing works

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

Jin, S. M., Lazarou, M., Wang, C., Kane, L. A., Narendra, D. P., & Youle, R. J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201008084 · Cited by 1,375 · see citing works

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

Tanaka, A., Cleland, M. M., Xu, S., Narendra, D. P., Suen, D.-F., Karbowski, M., & Youle, R. J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201007013 · Cited by 1,369 · see citing works

Selective Mitochondrial Autophagy, or Mitophagy, as a Targeted Defense Against Oxidative Stress, Mitochondrial Dysfunction, and Aging

Lemasters, J. J. (2005) · Rejuvenation Research · doi:10.1089/rej.2005.8.3 · Cited by 1,342 · see citing works

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

Zhong, Z., Umemura, A., Sanchez-Lopez, E., Liang, S., Shalapour, S., Wong, J., He, F., Boassa, D., Perkins, G., Ali, S. R., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.057 · Cited by 1,197 · see citing works

Essential role for Nix in autophagic maturation of erythroid cells

Sandoval, H., Thiagarajan, P., Dasgupta, S. K., Schumacher, A., Prchal, J. T., Chen, M., & Wang, J. (2008) · Nature · doi:10.1038/nature07006 · Cited by 1,185 · see citing works

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

Wang, X., Winter, D., Ashrafi, G., Schlehe, J. S., Wong, Y. L., Selkoe, D. J., Rice, S. E., Steen, J. A. J., LaVoie, M. J., & Schwarz, T. L. (2011) · Cell · doi:10.1016/j.cell.2011.10.018 · Cited by 1,161 · see citing works

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

Menzies, F. M., Fleming, A., Caricasole, A., Bento, C. F., Andrews, S. P., Ashkenazi, A., Füllgrabe, J., Jackson, A., Jimenez Sanchez, M., Karabiyik, C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.022 · Cited by 1,134 · cited 2× · see citing works

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

Nargund, A. M., Pellegrino, M., Fiorese, C. J., Baker, B. M., & Haynes, C. M. (2012) · Science · doi:10.1126/science.1223560 · Cited by 1,027 · see citing works

Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome

Yan, Y., Jiang, W., Liu, L., Wang, X., Ding, C., Tian, Z., & Zhou, R. (2015) · Cell · doi:10.1016/j.cell.2014.11.047 · Cited by 1,014 · see citing works

Potential therapeutic applications of autophagy

Rubinsztein, D. C., Gestwicki, J. E., Murphy, L. O., & Klionsky, D. J. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2272 · Cited by 1,004 · see citing works

Lithium induces autophagy by inhibiting inositol monophosphatase

Sarkar, S., Floto, R. A., Berger, Z., Imarisio, S., Cordenier, A., Pasco, M., Cook, L. J., & Rubinsztein, D. C. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200504035 · Cited by 985 · see citing works

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

Shin, J.-H., Ko, H. S., Kang, H., Lee, Y., Lee, Y.-I., Pletinkova, O., Troconso, J. C., Dawson, V. L., & Dawson, T. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.010 · Cited by 953 · see citing works

NIX is required for programmed mitochondrial clearance during reticulocyte maturation

Schweers, R. L., Zhang, J., Randall, M. S., Loyd, M. R., Li, W., Dorsey, F. C., Kundu, M., Opferman, J. T., Cleveland, J. L., Miller, J. L., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708818104 · Cited by 939 · see citing works

A new pathway for mitochondrial quality control: Mitochondrial-derived vesicles

Sugiura, A., McLelland, G., Fon, E. A., & McBride, H. M. (2014) · The EMBO Journal · doi:10.15252/embj.201488104 · Cited by 862 · see citing works

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

Bingol, B., Tea, J. S., Phu, L., Reichelt, M., Bakalarski, C. E., Song, Q., Foreman, O., Kirkpatrick, D. S., & Sheng, M. (2014) · Nature · doi:10.1038/nature13418 · Cited by 855 · see citing works

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

Wong, Y. C., & Holzbaur, E. L. F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405752111 · Cited by 812 · see citing works

Parkin Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity

Imai, Y., Soda, M., & Takahashi, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000447200 · Cited by 766 · see citing works

Identification of a candidate therapeutic autophagy-inducing peptide

Shoji-Kawata, S., Sumpter, R., Leveno, M., Campbell, G. R., Zou, Z., Kinch, L., Wilkins, A. D., Sun, Q., Pallauf, K., MacDuff, D., et al. (2013) · Nature · doi:10.1038/nature11866 · Cited by 760 · see citing works

Autosis and autophagic cell death: the dark side of autophagy

Liu, Y., & Levine, B. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.143 · Cited by 746 · see citing works

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

McLelland, G., Soubannier, V., Chen, C. X., McBride, H. M., & Fon, E. A. (2014) · The EMBO Journal · doi:10.1002/embj.201385902 · Cited by 743 · see citing works

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

Greene, A. W., Grenier, K., Aguileta, M. A., Muise, S., Farazifard, R., Haque, M. E., McBride, H. M., Park, D. S., & Fon, E. A. (2012) · The EMBO Reports · doi:10.1038/embor.2012.14 · Cited by 711 · cited 1× · see citing works

Measuring In Vivo Mitophagy

Sun, N., Yun, J., Liu, J., Malide, D. A., Liu, C., Rovira, I. I., Holmström, K. M., Fergusson, M. M., Yoo, Y. H., Combs, C. A., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.009 · Cited by 696 · see citing works

Neuronal differentiation in the adult hippocampus recapitulates embryonic development

Espósito, M. S., Piatti, V. C., Laplagne, D. A., Morgenstern, N. A., Ferrari, C. C., Pitossi, F. J., & Schinder, A. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3114-05.2005 · Cited by 679 · see citing works

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

Fiorese, C. J., Schulz, A. M., Lin, Y., Rosin, N., Pellegrino, M. W., & Haynes, C. M. (2016) · Current Biology · doi:10.1016/j.cub.2016.06.002 · Cited by 672 · see citing works

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

Lazarou, M., Jin, S. M., Kane, L. A., & Youle, R. J. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.014 · Cited by 670 · see citing works

Pathogenic mechanisms following ischemic stroke

Khoshnam, S. E., Winlow, W., Farzaneh, M., Farbood, Y., & Moghaddam, H. F. (2017) · Neurological Sciences · doi:10.1007/s10072-017-2938-1 · Cited by 618 · see citing works

The mitochondrial permeability transition initiates autophagy in rat hepatocytes

Elmore, S. P., Qian, T., Grissom, S. F., & Lemasters, J. J. (2001) · The FASEB Journal · doi:10.1096/fj.01-0206fje · Cited by 607 · see citing works

Autosis is a Na ⁺ ,K ⁺ -ATPase–regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia–ischemia

Liu, Y., Shoji-Kawata, S., Sumpter, R. M., Wei, Y., Ginet, V., Zhang, L., Posner, B., Tran, K. A., Green, D. R., Xavier, R. J., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319661110 · Cited by 607 · cited 1× · see citing works

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

McWilliams, T. G., Prescott, A. R., Montava-Garriga, L., Ball, G., Singh, F., Barini, E., Muqit, M. M. K., Brooks, S. P., & Ganley, I. G. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.12.008 · Cited by 591 · see citing works

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

Manzanillo, P. S., Ayres, J. S., Watson, R. O., Collins, A. C., Souza, G., Rae, C. S., Schneider, D. S., Nakamura, K., Shiloh, M. U., & Cox, J. S. (2013) · Nature · doi:10.1038/nature12566 · Cited by 588 · see citing works

Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

Matheoud, D., Sugiura, A., Bellemare-Pelletier, A., Laplante, A., Rondeau, C., Chemali, M., Fazel, A., Bergeron, J. J., Trudeau, L.-E., Burelle, Y., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.039 · Cited by 582 · see citing works

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

Arndt, V., Dick, N., Tawo, R., Dreiseidler, M., Wenzel, D., Hesse, M., Fürst, D. O., Säftig, P., Saint, R. B., Fleischmann, B. K., et al. (2010) · Current Biology · doi:10.1016/j.cub.2009.11.022 · Cited by 572 · see citing works

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

Boland, B., Yu, W. H., Corti, O., Mollereau, B., Henriques, A., Bézard, E., Pastores, G., Rubinsztein, D. C., Nixon, R. A., Duchen, M. R., et al. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.109 · Cited by 552 · see citing works

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

McWilliams, T. G., Prescott, A. R., Allen, G. F. G., Tamjar, J., Munson, M. J., Thomson, C., Muqit, M. M. K., & Ganley, I. G. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201603039 · Cited by 541 · see citing works

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

Ashrafi, G., Schlehe, J. S., LaVoie, M. J., & Schwarz, T. L. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201401070 · Cited by 502 · see citing works

Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice

Brandt, M., Jessberger, S., Steiner, B., Kronenberg, G., Reuter, K., Bick‐Sander, A., von der Behrens, W., & Kempermann, G. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00207-0 · Cited by 498 · see citing works

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

Koike, M., Shibata, M., Tadakoshi, M., Gotoh, K., Komatsu, M., Waguri, S., Kawahara, N., Kuida, K., Nagata, S., Kominami, E., et al. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070876 · Cited by 486 · see citing works

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

Hsieh, C.-H., Shaltouki, A., Gonzalez, A. E., da Cruz, A. B., Burbulla, L. F., Lawrence, E. S., Schüle, B., Krainc, D., Palmer, T. D., & Wang, X. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.08.002 · Cited by 459 · see citing works

Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice

Gong, G., Song, M., Csordás, G., Kelly, D. P., Matkovich, S. J., & Dorn, G. W. (2015) · Science · doi:10.1126/science.aad2459 · Cited by 441 · see citing works

Synergistic Activation of Caspase-3 by m-Calpain after Neonatal Hypoxia-Ischemia

Blomgren, K., Zhu, C., Wang, X., Karlsson, J., Leverin, A., Bahr, B. A., Mallard, C. E., & Hagberg, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007807200 · Cited by 440 · see citing works

Uth1p Is Involved in the Autophagic Degradation of Mitochondria

Bhatia‐Kiššová, I., Deffieu, M. S., Manon, S., & Camougrand, N. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406960200 · Cited by 418 · see citing works

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

Jin, S. M., & Youle, R. J. (2013) · Autophagy · doi:10.4161/auto.26122 · Cited by 411 · see citing works

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death

Darios, F. D. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg044 · Cited by 401 · see citing works

The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia–ischemia

Zhu, C., Wang, X., Xu, F., Bahr, B. A., Shibata, M., Uchiyama, Y., Hagberg, H., & Blomgren, K. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401545 · Cited by 400 · see citing works

Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways

Wen, Y.-D., Sheng, R., Zhang, L.-S., Han, R., Zhang, X., Zhang, X., Han, F., Fukunaga, K., & Qin, Z.-H. (2008) · Autophagy · doi:10.4161/auto.6412 · Cited by 390 · see citing works

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

McLelland, G., Goiran, T., Yi, W., Dorval, G., Chen, C. X., Lauinger, N. D., Krahn, A. I., Valimehr, S., Raković, A., Rouiller, I., et al. (2018) · eLife · doi:10.7554/elife.32866 · Cited by 386 · see citing works

Neuronal cell death in neonatal hypoxia‐ischemia

Northington, F. J., Chavez‐Valdez, R., & Martin, L. J. (2011) · Annals of Neurology · doi:10.1002/ana.22419 · Cited by 378 · see citing works

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

Wang, I.-F., Guo, B.-S., Liu, Y.-C., Wu, C.-C., Yang, C.-H., Tsai, K.-J., & Shen, C.-K. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206362109 · Cited by 377 · see citing works

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Hasson, S. A., Kane, L. A., Yamano, K., Huang, C.-H., Sliter, D. A., Buehler, E., Wang, C., Heman-Ackah, S. M., Hessa, T., Guha, R., et al. (2013) · Nature · doi:10.1038/nature12748 · Cited by 365 · see citing works

Mutation in <i>BAG3</i> causes severe dominant childhood muscular dystrophy

Selcen, D., Muntoni, F., Burton, B. K., Pegoraro, E., Sewry, C., Bite, A. V., & Engel, A. G. (2009) · Annals of Neurology · doi:10.1002/ana.21553 · Cited by 357 · see citing works

PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation

Gelmetti, V., Rosa, P. D., Torosantucci, L., Marini, E. S., Romagnoli, A., Rienzo, M. D., Arena, G., Vignone, D., Fimia, G. M., & Valente, E. M. (2017) · Autophagy · doi:10.1080/15548627.2016.1277309 · Cited by 355 · see citing works

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

Bouman, L., Schlierf, A., Lutz, A. K., Shan, J., Deinlein, A., Kast, J., Galehdar, Z., Palmisano, V., Patenge, N., Berg, D., et al. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.142 · Cited by 347 · see citing works

HspB8 Chaperone Activity toward Poly(Q)-containing Proteins Depends on Its Association with Bag3, a Stimulator of Macroautophagy

Carra, S., Seguin, S. J., Lambert, H., & Landry, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706304200 · Cited by 347 · see citing works

Involvement of Caspase-3 in Cell Death after Hypoxia–Ischemia Declines during Brain Maturation

Hu, B. R., Liu, C. L., Ouyang, Y., Blomgren, K., & Siesjö, B. K. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200009000-00003 · Cited by 345 · see citing works

Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin

Lee, J. J., Sánchez-Martínez, Á., Martinez, A., Benincá, C., Mayor, U., Clague, M. J., & Whitworth, A. J. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201801044 · Cited by 343 · see citing works

Type‐2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis

Steiner, B., Klempin, F., Wang, L., Kott, M., Kettenmann, H., & Kempermann, G. (2006) · Glia · doi:10.1002/glia.20407 · Cited by 342 · see citing works

Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons

Cai, Q., Zakaria, H. M., Simone, A., & Sheng, Z. (2012) · Current Biology · doi:10.1016/j.cub.2012.02.005 · Cited by 332 · see citing works

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

Crippa, V., Sau, D., Rusmini, P., Boncoraglio, A., Onesto, E., Bolzoni, E., Galbiati, M., Fontana, E., Marino, M., Carra, S., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq257 · Cited by 330 · see citing works

Innate Immunity and Neurodegeneration

Labzin, L. I., Heneka, M. T., & Latz, E. (2018) · Annual Review of Medicine · doi:10.1146/annurev-med-050715-104343 · Cited by 319 · see citing works

PINK1 and Parkin: emerging themes in mitochondrial homeostasis.

McWilliams, T. G., & Muqit, M. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.03.013 · Cited by 315 · see citing works

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

Nezich, C. L., Wang, C., Fogel, A. I., & Youle, R. J. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201501002 · Cited by 309 · see citing works

PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol

Sekine, S., & Youle, R. J. (2018) · BMC Biology · doi:10.1186/s12915-017-0470-7 · Cited by 308 · see citing works

Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence

Kim, S., Syed, G. H., Khan, M. A., Chiu, W.-W., Sohail, M. A., Gish, R. G., & Siddiqui, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321114111 · Cited by 293 · see citing works

Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease

Sarkar, S., Malovic, E., Harischandra, D. S., Ghaisas, S., Panicker, N., Charli, A., Palanisamy, B. N., Rokad, D., Jin, H., Anantharam, V., et al. (2017) · npj Parkinson s Disease · doi:10.1038/s41531-017-0032-2 · Cited by 283 · see citing works

Aging and Parkinson's disease: Different sides of the same coin?

Collier, T. J., Kanaan, N. M., & Kordower, J. H. (2017) · Movement Disorders · doi:10.1002/mds.27037 · Cited by 271 · see citing works

Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia

Carloni, S., Girelli, S., Scopa, C., Buonocore, G., Longini, M., & Balduini, W. (2010) · Autophagy · doi:10.4161/auto.6.3.11261 · Cited by 269 · see citing works

Excessive Autophagy Contributes to Neuron Death in Cerebral Ischemia

Shi, R., Weng, J., Zhao, L., Li, X., Gao, T., & Kong, J. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2012.00295.x · Cited by 264 · see citing works

Breaking BAG: The Co-Chaperone BAG3 in Health and Disease

Behl, C. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.04.007 · Cited by 264 · see citing works

Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases

Cai, Q., & Jeong, Y. Y. (2020) · Cells · doi:10.3390/cells9010150 · Cited by 263 · see citing works

TDP-43 Mediates Degeneration in a Novel Drosophila Model of Disease Caused by Mutations in VCP/p97

Ritson, G. P., Custer, S. K., Freibaum, B. D., Guinto, J. B., Geffel, D., Moore, J., Tang, W., Winton, M. J., Neumann, M., Trojanowski, J. Q., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5894-09.2010 · Cited by 256 · see citing works

Fanconi Anemia Proteins Function in Mitophagy and Immunity

Sumpter, R., Sirasanagandla, S., Fernández, Á. F., Wei, Y., Dong, X., Franco, L., Zou, Z., Marchal, C., Lee, M. Y., Clapp, D. W., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.006 · Cited by 250 · see citing works

A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment

Okatsu, K., Uno, M., Koyano, F., Go, E., Kimura, M., Oka, T., Tanaka, K., & Matsuda, N. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.509653 · Cited by 248 · see citing works

Walking the tightrope: proteostasis and neurodegenerative disease

Yerbury, J. J., Ooi, L., Dillin, A. G., Saunders, D. N., Hatters, D. M., Beart, P. M., Cashman, N. R., Wilson, M. R., & Ecroyd, H. W. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13575 · Cited by 243 · see citing works

HspB8 and Bag3: A new chaperone complex targeting misfolded proteins to macroautophagy

Carra, S., Seguin, S. J., & Landry, J. (2008) · Autophagy · doi:10.4161/auto.5407 · Cited by 240 · see citing works

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

Cornelissen, T., Vilain, S., Vints, K., Gounko, N., Verstreken, P., & Vandenberghe, W. (2018) · eLife · doi:10.7554/elife.35878 · Cited by 239 · see citing works

PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson’s Disease Pathobiology?

Truban, D., Hou, X., Caulfield, T. R., Fiesel, F. C., & Springer, W. (2016) · Journal of Parkinson’s Disease · doi:10.3233/jpd-160989 · Cited by 237 · see citing works

Autophagy in acute brain injury

Galluzzi, L., Bravo-San Pedro, J. M., Blomgren, K., & Kroemer, G. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.51 · Cited by 234 · see citing works

Function and Mechanisms of Autophagy in Brain and Spinal Cord Trauma

Lipinski, M. M., Wu, J., Faden, A. I., & Sarkar, C. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6306 · Cited by 221 · see citing works

Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization

Laar, V. S. V., Arnold, B. A., Cassady, S. J., Chu, C. T., Burton, E. A., & Berman, S. B. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq531 · Cited by 221 · see citing works

Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: A challenge for neuroprotection

Puyal, J., Ginet, V., & Clarke, P. G. H. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.03.002 · Cited by 218 · see citing works

PINK1 and Parkin Control Localized Translation of Respiratory Chain Component mRNAs on Mitochondria Outer Membrane

Gehrke, S., Wu, Z., Klinkenberg, M., Sun, Y., Auburger, G. W. J., Guo, S., & Lu, B. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.007 · Cited by 213 · see citing works

Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease

da Costa, C. A., Sunyach, C., Giaime, E., West, A. B., Corti, O., Brice, A., Safe, S. H., Abou‐Sleiman, P. M., Wood, N. W., Takahashi, H., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1981 · Cited by 211 · see citing works

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

Lee, Y., Stevens, D. A., Kang, S.-U., Jiang, H., Lee, Y.-I., Ko, H. S., Scarffe, L. A., Umanah, G. K. E., Kang, H., Ham, S., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.090 · Cited by 207 · see citing works

Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain

Naylor, A. S., Bull, C., Nilsson, M. K. L., Zhu, C., Björk‐Eriksson, T., Eriksson, P. S., Blomgren, K., & Kuhn, H. G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711128105 · Cited by 205 · see citing works

Mitochondrial disappearance from cells: a clue to the role of autophagy in programmed cell death and disease?

Tolkovsky, A. M., Xue, L., Fletcher, G. C., & Borutaite, V. (2002) · Biochimie · doi:10.1016/s0300-9084(02)01371-8 · Cited by 203 · see citing works

Therapeutic targeting of autophagy in neurodegenerative and infectious diseases

Rubinsztein, D. C., Bento, C. F., & Deretic, V. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20150956 · Cited by 202 · see citing works

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

Rose, C., Menzies, F. M., Renna, M., Acevedo‐Arozena, A., Corrochano, S., Sadiq, O., Brown, S. D. M., & Rubinsztein, D. C. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq093 · Cited by 200 · see citing works

Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis

Greene, J. C., Whitworth, A. J., Andrews, L. A., Parker, T. J., & Pallanck, L. J. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi074 · Cited by 194 · see citing works

The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

Johnson, B. N., Berger, A. K., Cortese, G. P., & LaVoie, M. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113248109 · Cited by 189 · see citing works

(Patho‐)physiological relevance of PINK1‐dependent ubiquitin phosphorylation

Fiesel, F. C., Ando, M., Hudec, R., Hill, A. R., Castanedes‐Casey, M., Caulfield, T. R., Moussaud‐Lamodière, E. L., Stankowski, J. N., Bauer, P. O., Lorenzo‐Betancor, O., et al. (2015) · The EMBO Reports · doi:10.15252/embr.201540514 · Cited by 185 · cited 1× · see citing works

Comparing Intelligence Quotient Change After Treatment With Proton Versus Photon Radiation Therapy for Pediatric Brain Tumors

Kahalley, L. S., Ris, M. D., Grosshans, D. R., Okcu, M. F., Paulino, A. C., Chintagumpala, M., Moore, B. D., Guffey, D., Minard, C. G., Stancel, H. H., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.62.1383 · Cited by 185 · see citing works

Neuronal macroautophagy: from development to degeneration.

Boland, B., & Nixon, R. (2006) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2006.08.009 · Cited by 181 · see citing works

Pathological apoptosis in the developing brain

Blomgren, K., Leist, M., & Groc, L. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0754-4 · Cited by 181 · see citing works

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders.

Maiese, K. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12804 · Cited by 173 · see citing works

Functional interplay between Parkin and Drp1 in mitochondrial fission and clearance

Buhlman, L. M., Damiano, M. G., Bertolin, G., Ferrando-Miguel, R., Lombès, A., Brice, A., & Corti, O. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.05.012 · Cited by 165 · see citing works

HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells

Carra, S., Sivilotti, M., Chávez-Zobel, A. T., Lambert, H., & Landry, J. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi174 · Cited by 163 · see citing works

LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson’s disease

Bonello, F., Hassoun, S.-M., Mouton-Liger, F., Shin, Y. S., Muscat, A., Tesson, C., Lesage, S., Beart, P. M., Brice, A., Krupp, J., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz004 · Cited by 163 · see citing works

Risk factors for cognitive decline in children treated for brain tumors

Duffner, P. K. (2009) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2009.10.005 · Cited by 161 · see citing works

Neuroprotection by selective neuronal deletion of <i>Atg7</i> in neonatal brain injury

Xie, C., Ginet, V., Sun, Y., Koike, M., Zhou, K., Li, T., Li, H., Li, Q., Wang, X., Uchiyama, Y., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1132134 · Cited by 160 · see citing works

<scp>P</scp>arkin deficiency modulates <scp>NLRP</scp>3 inflammasome activation by attenuating an <scp>A</scp>20‐dependent negative feedback loop

Mouton‐Liger, F., Rosazza, T., Sepulveda‐Diaz, J., Ieang, A., Hassoun, S., Claire, E., Mangone, G., Brice, A., Michel, P. P., Corvol, J., et al. (2018) · Glia · doi:10.1002/glia.23337 · Cited by 160 · see citing works

Involvement of autophagy in hypoxic-excitotoxic neuronal death

Ginet, V., Spiehlmann, A., Rummel, C., Rudinskiy, N., Grishchuk, Y., Luthi‐Carter, R., Clarke, P. G., Truttmann, A. C., & Puyal, J. (2014) · Autophagy · doi:10.4161/auto.28264 · Cited by 159 · see citing works

The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance

Bertolin, G., Ferrando-Miguel, R., Jacoupy, M., Traver, S., Grenier, K., Greene, A. W., Dauphin, A., Waharte, F., Bayot, A., Salamero, J., et al. (2013) · Autophagy · doi:10.4161/auto.25884 · Cited by 154 · see citing works

Distinct chaperone mechanisms can delay the formation of aggresomes by the myopathy-causing R120G B-crystallin mutant

Chávez-Zobel, A. T. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg173 · Cited by 141 · see citing works

The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations

Gautier, C., Erpapazoglou, Z., Mouton‐Liger, F., Mp, M., Cormier‐Dequaire, F., Bigou, S., Duffaure, S., Girard, M., Forêt, B., Iannielli, A., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw148 · Cited by 141 · see citing works

Bit-by-bit autophagic removal of parkin-labelled mitochondria

Yang, J., & Yang, W. Y. (2013) · Nature Communications · doi:10.1038/ncomms3428 · Cited by 140 · see citing works

Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord

Anagnostou, G., Akbar, M. T., Paul, P., Angelinetta, C., Steiner, T. J., & de Belleroche, J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.07.005 · Cited by 138 · see citing works

Lithium reduces apoptosis and autophagy after neonatal hypoxia–ischemia

Li, Q., Li, H., Roughton, K., et al. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.33 · Cited by 137 · see citing works

Changes in Autophagy after Traumatic Brain Injury

Liu, C. L., Chen, S., Dietrich, D., & Hu, B.-R. (2008) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/sj.jcbfm.9600587 · Cited by 137 · see citing works

Mutations in HSPB8 causing a new phenotype of distal myopathy and motor neuropathy

Ghaoui, R., Palmio, J., Brewer, J. M., Lek, M., Needham, M., Evilä, A., Hackman, P., Jonson, P. H., Penttilä, S., Vihola, A., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000002324 · Cited by 135 · see citing works

The interplay of neuronal mitochondrial dynamics and bioenergetics: Implications for Parkinson's disease

Laar, V. S. V., & Berman, S. B. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.05.015 · Cited by 133 · see citing works

Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy

Fang, X., Bogomolovas, J., Wu, T., Zhang, W., Liu, C., Veevers, J., Stroud, M. J., Zhang, Z., Ma, X., Mu, Y., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci94310 · Cited by 132 · see citing works

Age‐dependent sensitivity of the developing brain to irradiation is correlated with the number and vulnerability of progenitor cells

Fukuda, A., Fukuda, H., Swanpalmer, J., Hertzman, S., Lannering, B., Márky, I., Björk‐Eriksson, T., & Blomgren, K. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02894.x · Cited by 130 · see citing works

Subcellular distribution of calcium and ultrastructural changes after cerebral hypoxia-ischemia in immature rats

Puka‐Sundvall, M., Gajkowska, B., Cholewiński, M., Blomgren, K., Łazarewicz, J. W., & Hagberg, H. (2000) · Developmental Brain Research · doi:10.1016/s0165-3806(00)00110-3 · Cited by 127 · see citing works

Small heat shock protein HspB8: its distribution in Alzheimer’s disease brains and its inhibition of amyloid-β protein aggregation and cerebrovascular amyloid-β toxicity

Wilhelmus, M. M. M., Boelens, W. C., Otte‐Höller, I., Kamps, B., Küsters, B., Maat–Schieman, M. L. C., de Waal, R. M. W., & Verbeek, M. M. (2006) · Acta Neuropathologica · doi:10.1007/s00401-005-0030-z · Cited by 126 · see citing works

Developmental Shift of Cyclophilin D Contribution to Hypoxic-Ischemic Brain Injury

Wang, X., Carlsson, Y., Basso, E., Zhu, C., Rousset, C. I., Rasola, A., Johansson, B. R., Blomgren, K., Mallard, C. E., Bernardi, P., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5832-08.2009 · Cited by 125 · see citing works

Irradiation-induced progenitor cell death in the developing brain is resistant to erythropoietin treatment and caspase inhibition

Fukuda, H., Fukuda, A., Zhu, C., Korhonen, L., Swanpalmer, J., Hertzman, S., Leist, M., Lannering, B., Lindholm, D., Björk‐Eriksson, T., et al. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401472 · Cited by 123 · see citing works

HspB8 Participates in Protein Quality Control by a Non-chaperone-like Mechanism That Requires eIF2α Phosphorylation

Carra, S., Brunsting, J. F., Lambert, H., Landry, J., & Kampinga, H. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807440200 · Cited by 123 · see citing works

Inhibition of α‐synuclein aggregation by small heat shock proteins

Bruinsma, I. B., Bruggink, K. A., Kinast, K., Versleijen, A., Segers-Nolten, I., Subramaniam, V., Kuiperij, H., Boelens, W., de Waal, R., & Verbeek, M. (2011) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.23152 · Cited by 121 · see citing works

Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up?

Grenier, K., McLelland, G., & Fon, E. A. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00100 · Cited by 120 · see citing works

Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS

Mitchell, J. C., Constable, R., So, E., Vance, C. A., Scotter, E. L., Glover, L., Hortobágyi, T., Arnold, E. S., Ling, S., McAlonis‐Downes, M., et al. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0212-4 · Cited by 118 · see citing works

Emerging roles of molecular chaperones and co-chaperones in selective autophagy: focus on BAG proteins

Gamerdinger, M., Carra, S., & Behl, C. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0795-6 · Cited by 113 · see citing works

Autophagic cell death exists

Clarke, P. G. H., & Puyal, J. (2012) · Autophagy · doi:10.4161/auto.20380 · Cited by 112 · see citing works

A novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis

Kang, R., Zeng, L., Xie, Y., Yan, Z., Zhou, B., Cao, L., Klionsky, D. J., Tracey, K. J., Li, J., Wang, H., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1239678 · Cited by 110 · see citing works

Lithium-Mediated Long-Term Neuroprotection in Neonatal Rat Hypoxia–Ischemia is Associated with Antiinflammatory Effects and Enhanced Proliferation and Survival of Neural Stem/Progenitor Cells

Li, H., Li, Q., Du, X., Sun, Y., Wang, X., Kroemer, G., Blomgren, K., & Zhu, C. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.75 · Cited by 109 · see citing works

Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy

Marrone, L., Poser, I., Casci, I., Japtok, J., Reinhardt, P., Janosch, A., Andree, C., Lee, H. O., Moebius, C., Koerner, E., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.12.018 · Cited by 104 · see citing works

A role of small heat shock protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases

Crippa, V., Carra, S., Rusmini, P., Sau, D., Bolzoni, E., Bendotti, C., De Biasi, S., & Poletti, A. (2010) · Autophagy · doi:10.4161/auto.6.7.13042 · Cited by 101 · see citing works

Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases

Crippa, V., D’Agostino, V. G., Cristofani, R., Rusmini, P., Cicardi, M. E., Messi, E., Loffredo, R., Pancher, M., Piccolella, M., Galbiati, M., et al. (2016) · Scientific Reports · doi:10.1038/srep22827 · Cited by 101 · see citing works

Sex‐dependent differences in behavior and hippocampal neurogenesis after irradiation to the young mouse brain

Roughton, K., Kalm, M., & Blomgren, K. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08197.x · Cited by 100 · see citing works

The HSPB8‐BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases

Seidel, K., Vinet, J., den Dunnen, W. F. A., Brunt, E. R. P., Meister, M., Boncoraglio, A., Zijlstra, M. P., Boddeke, H. W. G. M., Rüb, U., Kampinga, H. H., et al. (2011) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2011.01198.x · Cited by 98 · see citing works

PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease

Mouton‐Liger, F., Jacoupy, M., Corvol, J., & Corti, O. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00120 · Cited by 97 · see citing works

Therapeutic implication of autophagy in neurodegenerative diseases

Rahman, M. A., & Rhim, H. (2017) · BMB Reports · doi:10.5483/bmbrep.2017.50.7.069 · Cited by 96 · see citing works

The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity

Crippa, V., Cicardi, M. E., Ramesh, N., Seguin, S. J., Ganassi, M., Bigi, I., Diacci, C., Zelotti, E., Baratashvili, M., Gregory, J. M., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw232 · Cited by 95 · see citing works

Mutant HSPB8 causes motor neuron-specific neurite degeneration

Irobi, J., Almeida-Souza, L., Asselbergh, B., Winter, V. D., Goethals, S., Dierick, I., Krishnan, J., Timmermans, J., Robberecht, W., Jonghe, P. D., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq234 · Cited by 92 · see citing works

Rilmenidine promotes MTOR-independent autophagy in the mutant SOD1 mouse model of amyotrophic lateral sclerosis without slowing disease progression

Perera, N. D., Sheean, R. K., Lau, C. L., Shin, Y. S., Beart, P. M., Horne, M. K., & Turner, B. J. (2017) · Autophagy · doi:10.1080/15548627.2017.1385674 · Cited by 88 · see citing works

Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death

Sun, L., Shen, R., Agnihotri, S. K., Chen, Y., Huang, Z., & Büeler, H. (2018) · Scientific Reports · doi:10.1038/s41598-017-18786-w · Cited by 87 · see citing works

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

Torres-Odio, S., Key, J., Hoepken, H.-H., Canet-Pons, J., Valek, L., Roller, B., Walter, M. J., Morales-Gordo, B., Meierhofer, D., Harter, P. N., et al. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0928-0 · Cited by 85 · see citing works

Targeting autophagy to prevent neonatal stroke damage

Puyal, J., & Clarke, P. G. H. (2009) · Autophagy · doi:10.4161/auto.5.7.9728 · Cited by 83 · see citing works

Abnormal small heat shock protein interactions involving neuropathy‐associated HSP22 (HSPB8) mutants

Fontaine, J., Sun, X., Hoppe, A. D., Simon, S., Vicart, P., Michael J. Welsh, *., & Benndorf, R. (2006) · The FASEB Journal · doi:10.1096/fj.06-5911fje · Cited by 80 · see citing works

Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity

Cuervo, A. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3150 · Cited by 78 · see citing works

A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8

Bouhy, D., Juneja, M., Katona, I., Holmgren, A., Asselbergh, B., Winter, V. D., Hochepied, T., Goosens, S., Haigh, J. J., Libert, C., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1756-0 · Cited by 77 · see citing works

BAG3 myofibrillar myopathy presenting with cardiomyopathy

Konersman, C. G., Bordini, B. J., Scharer, G. H., Lawlor, M. W., Zangwill, S. D., Southern, J. F., Amos, L. B., Geddes, G. C., Kliegman, R. M., & Collins, M. P. (2015) · Neuromuscular Disorders · doi:10.1016/j.nmd.2015.01.009 · Cited by 75 · see citing works

Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases

Cristofani, R., Crippa, V., Rusmini, P., Cicardi, M. E., Meroni, M., Licata, N. V., Sala, G., Giorgetti, E., Grunseich, C., Galbiati, M., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1308985 · Cited by 75 · see citing works

Loss of hippocampal neurogenesis, increased novelty-induced activity, decreased home cage activity, and impaired reversal learning one year after irradiation of the young mouse brain

Kalm, M., Karlsson, N., Nilsson, M. K. L., & Blomgren, K. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.01.006 · Cited by 70 · see citing works

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies.

Tramutola, A., Lanzillotta, C., & Di Domenico, F. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1244482 · Cited by 69 · see citing works

The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases

Rusmini, P., Cristofani, R., Galbiati, M., Cicardi, M. E., Meroni, M., Ferrari, V., Vezzoli, G., Tedesco, B., Messi, E., Piccolella, M., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00176 · Cited by 69 · see citing works

Quantitative autoradiographic localization in rat brain of α2-adrenergic and non-adrenergic I-receptor binding sites labelled by [3H]rilmenidine

King, P. R., Gundlach, A. L., & Louis, W. J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00083-3 · Cited by 68 · see citing works

Radiation induces progenitor cell death, microglia activation, and blood-brain barrier damage in the juvenile rat cerebellum

Zhou, K., Boström, M., Ek, C. J., Li, T., Xie, C., Xu, Y., Sun, Y., Blomgren, K., & Zhu, C. (2017) · Scientific Reports · doi:10.1038/srep46181 · Cited by 68 · see citing works

Up-regulation of autophagy-related gene 5 (ATG5) protects dopaminergic neurons in a zebrafish model of Parkinson's disease

Hu, Z., Chen, B., Zhang, J., & Ma, Y. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.764795 · Cited by 68 · see citing works

Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy

Fiesel, F. C., James, E. D., Hudec, R., & Springer, W. (2017) · Oncotarget · doi:10.18632/oncotarget.22287 · Cited by 67 · see citing works

Differences in protein quality control correlate with phenotype variability in 2 mouse models of familial amyotrophic lateral sclerosis

Marino, M., Papa, S., Crippa, V., Nardo, G., Peviani, M., Cheroni, C., Trolese, M. C., Lauranzano, E., Bonetto, V., Poletti, A., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.06.026 · Cited by 65 · see citing works

Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy

Rusmini, P., Crippa, V., Giorgetti, E., Boncoraglio, A., Cristofani, R., Carra, S., & Poletti, A. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.05.026 · Cited by 64 · see citing works

Differential autophagy power in the spinal cord and muscle of transgenic ALS mice

Crippa, V., Boncoraglio, A., Galbiati, M., Aggarwal, T., Rusmini, P., Giorgetti, E., Cristofani, R., Carra, S., Pennuto, M., & Poletti, A. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00234 · Cited by 63 · see citing works

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

Barini, E., Miccoli, A., Tinarelli, F., et al. (2017) · ChemBioChem · doi:10.1002/cbic.201700500 · Cited by 63 · see citing works

Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?

Deng, Z., Sheehan, P., Chen, S., & Yue, Z. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0232-6 · Cited by 61 · see citing works

Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression

Apolloni, S., Fabbrizio, P., Amadio, S., & Volonté, C. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0658-8 · Cited by 59 · see citing works

Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy

Piras, A., Schiaffino, L., Boido, M., Valsecchi, V., Guglielmotto, M., Amicis, E. D., Puyal, J., Garcerá, A., Tamagno, E., Soler, R. M., et al. (2017) · Cell Death and Disease · doi:10.1038/s41419-017-0086-4 · Cited by 58 · see citing works

The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells

Jacoupy, M., Hamon-Keromen, E., Ordureau, A., Erpapazoglou, Z., Cogé, F., Corvol, J., Nosjean, O., la Cour, C. M., Millan, M. J., Boutin, J. A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-47352-9 · Cited by 57 · see citing works

Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy

Rusmini, P., Polanco, M. J., Cristofani, R., Cicardi, M. E., Meroni, M., Galbiati, M., Piccolella, M., Messi, E., Giorgetti, E., Lieberman, A. P., et al. (2015) · Scientific Reports · doi:10.1038/srep15174 · Cited by 56 · see citing works

From dysfunctional endoplasmic reticulum-mitochondria coupling to neurodegeneration

Erpapazoglou, Z., Mouton‐Liger, F., & Corti, O. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.03.021 · Cited by 56 · see citing works

HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency

Guilbert, S. M., Lambert, H., Rodrigue, M., Fuchs, M., Landry, J., & Lavoie, J. N. (2018) · The FASEB Journal · doi:10.1096/fj.201700558rr · Cited by 56 · see citing works

Irradiation to the Young Mouse Brain Caused Long-Term, Progressive Depletion of Neurogenesis but did not Disrupt the Neurovascular Niche

Boström, M., Kalm, M., Karlsson, N., Erkenstam, N. H., & Blomgren, K. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.34 · Cited by 55 · see citing works

L ‐3‐hydroxyacyl‐CoA dehydrogenase II protects in a model of Parkinson's disease

Tieu, K., Perier, C., Vila, M., Caspersen, C. S., Zhang, H., Teismann, P., Jackson-Lewis, V. R., Stern, D. M., Yan, S. D., & Przedborski, S. (2004) · Annals of Neurology · doi:10.1002/ana.20133 · Cited by 55 · see citing works

Induction of Hsp22 (HspB8) by estrogen and the metalloestrogen cadmium in estrogen receptor– positive breast cancer cells

Sun, X., Fontaine, J., Bartl, I., Behnam, B., Welsh, M. J., & Benndorf, R. (2007) · Cell Stress and Chaperones · doi:10.1379/csc-276.1 · Cited by 55 · see citing works

The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells

Piccolella, M., Crippa, V., Cristofani, R., Rusmini, P., Galbiati, M., Cicardi, M. E., Meroni, M., Ferri, N., Morelli, F. F., Carra, S., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14422 · Cited by 53 · see citing works

Dying neurons in thalamus of asphyxiated term newborns and rats are autophagic

Ginet, V., Pittet, M. P., Rummel, C., Osterheld, M. C., Meuli, R. A., Clarke, P. G. H., Puyal, J., & Truttmann, A. C. (2014) · Annals of Neurology · doi:10.1002/ana.24257 · Cited by 52 · see citing works

Synergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy

Giorgetti, E., Rusmini, P., Crippa, V., Cristofani, R., Boncoraglio, A., Cicardi, M. E., Galbiati, M., & Poletti, A. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu419 · Cited by 47 · see citing works

Inhibition of autophagy prevents irradiation-induced neural stem and progenitor cell death in the juvenile mouse brain

Wang, Y., Zhou, K., Li, T., Xu, Y., Xie, C., Sun, Y., Zhang, Y., Rodríguez, J., Blomgren, K., & Zhu, C. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.120 · Cited by 45 · see citing works

Parkin maintains mitochondrial levels of the protective Parkinson’s disease-related enzyme 17-β hydroxysteroid dehydrogenase type 10

Bertolin, G., Jacoupy, M., Traver, S., Ferrando-Miguel, R., Georges, T. S., Grenier, K., Ardila-Osorio, H., Mp, M., Takahashi, H., Lees, A. J., et al. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2014.224 · Cited by 44 · see citing works

Autophagic activity in cortical neurons under acute oxidative stress directly contributes to cell death

Higgins, G. C., Devenish, R. J., Beart, P. M., & Nagley, P. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0667-9 · Cited by 44 · see citing works

Reactive nitrogen species as therapeutic targets for autophagy: implication for ischemic stroke

Feng, J., Chen, X., & Shen, J. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1281250 · Cited by 44 · see citing works

Therapeutic Benefits of Delayed Lithium Administration in the Neonatal Rat after Cerebral Hypoxia-Ischemia

Xie, C., Zhou, K., Wang, X., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107192 · Cited by 43 · see citing works

The Role of the Protein Quality Control System in SBMA

Rusmini, P., Crippa, V., Cristofani, R., Rinaldi, C., Cicardi, M. E., Galbiati, M., Carra, S., Malik, B. A., Greensmith, L., & Poletti, A. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0675-6 · Cited by 41 · see citing works

Motoneuronal and muscle-selective removal of ALS-related misfolded proteins

Crippa, V., Galbiati, M., Boncoraglio, A., Rusmini, P., Onesto, E., Giorgetti, E., Cristofani, R., Zito, A., & Poletti, A. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130118 · Cited by 39 · see citing works

Dysregulation of axonal transport and motorneuron diseases

Sau, D., Rusmini, P., Crippa, V., Onesto, E., Bolzoni, E., Ratti, A., & Poletti, A. (2011) · Biology of the Cell · doi:10.1042/bc20100093 · Cited by 36 · see citing works

MDMA-induced neurotoxicity of serotonin neurons involves autophagy and rilmenidine is protective against its pathobiology

Mercer, L. D., Higgins, G. C., Lau, C. L., Lawrence, A. J., & Beart, P. M. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.01.010 · Cited by 33 · see citing works

Novel insights in the disease biology of mutant small heat shock proteins in neuromuscular diseases

Adriaenssens, E., Geuens, T., Baets, J., Echaniz‐Laguna, A., & Timmerman, V. (2017) · Brain · doi:10.1093/brain/awx187 · Cited by 33 · see citing works

An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington’s disease

Underwood, B. R., Green-Thompson, Z. W., Pugh, P. J., Lazic, S. E., Mason, S., Griffin, J., Jones, P. S., Rowe, J. B., Rubinsztein, D. C., & Barker, R. A. (2017) · Journal of Neurology · doi:10.1007/s00415-017-8647-0 · Cited by 29 · see citing works

Excitotoxicity‐induced endocytosis confers drug targeting in cerebral ischemia

Vaslin, A., Puyal, J., & Clarke, P. G. H. (2009) · Annals of Neurology · doi:10.1002/ana.21584 · Cited by 28 · see citing works

Transitory phases of autophagic death and programmed necrosis during superoxide-induced neuronal cell death

Higgins, G. C., Devenish, R. J., Beart, P. M., & Nagley, P. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.586 · Cited by 25 · see citing works

Localization of nuclear-encoded mRNAs to mitochondria outer surface

Golani‐Armon, A., & Arava, Y. (2016) · Biochemistry (Moscow) · doi:10.1134/s0006297916100023 · Cited by 22 · see citing works

The endoplasmic reticulum/mitochondria interface: a subcellular platform for the orchestration of the functions of the PINK1–Parkin pathway?

Erpapazoglou, Z., & Corti, O. (2015) · Biochemical Society Transactions · doi:10.1042/bst20150008 · Cited by 18 · see citing works

Evidence for the recruitment of autophagic vesicles in human brain after stroke

Frugier, T., Taylor, J. M., McLean, C., Bye, N., Beart, P. M., Devenish, R. J., & Crack, P. J. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.02.016 · Cited by 18 · see citing works

Comparative Microarray Analysis Identifies Commonalities in Neuronal Injury: Evidence for Oxidative Stress, Dysfunction of Calcium Signalling, and Inhibition of Autophagy–Lysosomal Pathway

Yap, Y. W., Llanos, R. M., Fontaine, S. L., Cater, M. A., Beart, P. M., & Cheung, N. S. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1666-2 · Cited by 16 · see citing works

Inhibition of bioenergetics provides novel insights into recruitment of <scp>PINK</scp>1‐dependent neuronal mitophagy

Shin, Y. S., Ryall, J. G., Britto, J. M., Lau, C. L., Devenish, R. J., Nagley, P., & Beart, P. M. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14667 · Cited by 13 · see citing works

Selective Neural Deletion of the Atg7 Gene Reduces Irradiation-Induced Cerebellar White Matter Injury in the Juvenile Mouse Brain by Ameliorating Oligodendrocyte Progenitor Cell Loss

Wang, Y., Zhou, K., Li, T., Xu, Y., Xie, C., Sun, Y., Rodríguez, J., Zhang, S., Song, J., Wang, X., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00241 · Cited by 13 · see citing works

Autophagy and ALS: mechanistic insights and therapeutic implications

Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189 · see citing works

Enhancing autophagy in Alzheimer's disease through drug repositioning

Eshraghi, M., Ahmadi, M., Afshar, S., Lorzadeh, S., Adlimoghaddam, A., Rezvani Jalal, N., West, R., Dastghaib, S., Igder, S., Torshizi, S. R. N., et al. (2022) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2022.108171 · Cited by 89 · see citing works

Induction of PINK1/Parkin-Mediated Mitophagy

Sato, S., & Furuya, N. (2017) · Methods in molecular biology · doi:10.1007/7651_2017_7 · Cited by 37 · see citing works

Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

Nguyen, T. N., Padman, B. S., & Lazarou, M. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.05.008 · Cited by 732 · see citing works

PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes

Kubli, D. A., Cortez, M. Q., Moyzis, A. G., Najor, R. H., Lee, Y., & Gustafsson, Å. B. (2015) · PLOS ONE · doi:10.1371/journal.pone.0130707 · Cited by 102 · see citing works

Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology

Jian, F., Chen, D., Chen, L., Yan, C., Lü, B., Zhu, Y., Chen, S., Shi, A., Chan, D. C., & Song, Z. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.015 · Cited by 108 · see citing works