Distinct roles for the amygdala and orbitofrontal cortex in representing the relative amount of expected reward
Open accessAbstract
The same reward can possess different motivational meaning depending upon its magnitude relative to other rewards. To study the neurophysiological mechanisms mediating assignment of motivational meaning, we recorded the activity of neurons in the amygdala and orbitofrontal cortex (OFC) of monkeys during a Pavlovian task in which the relative amount of liquid reward associated with one conditioned stimulus (CS) was manipulated by changing the reward amount associated with a second CS. Anticipatory licking tracked relative reward magnitude, implying that monkeys integrated information about recent rewards to adjust the motivational meaning of a CS. Upon changes in relative reward magnitude, neural responses to reward-predictive cues updated more rapidly in OFC than amygdala, and activity in OFC but not the amygdala was modulated by recent reward history. These results highlight a distinction between the amygdala and OFC in assessing reward history to support the flexible assignment of motivational meaning to sensory cues.
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Neuronal responses to reinforcement predictive cues in classical conditioning update more rapidly in the macaque OFC than in the amygdala.
“Furthermore, consistent with the poor rapid reversal learning found by amygdala neurons (Sanghera et al., 1979; Rolls, 2014) compared to OFC neurons, it has been found that neuronal responses to reinforcement predictive cues in classical conditioning update more rapidly in the macaque OFC than amygdala, and activity in the OFC but not the amygdala was modulated by recent reward history (Saez et al”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Saez et al., 2017
Activity in the OFC but not the amygdala was modulated by recent reward history.
“Furthermore, consistent with the poor rapid reversal learning found by amygdala neurons (Sanghera et al., 1979; Rolls, 2014) compared to OFC neurons, it has been found that neuronal responses to reinforcement predictive cues in classical conditioning update more rapidly in the macaque OFC than amygdala, and activity in the OFC but not the amygdala was modulated by recent reward history (Saez et al”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Saez et al., 2017
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- Authors
- Saez, R. A., Saez, A., Paton, J. J., Lau, B., & Salzman, C. D.
- Affiliations
- Columbia University (US)
- New York State Psychiatric Institute (US)
- Corresponding author
- Salzman, C. Daniel
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 95
- Issue
- 1
- Pages
- 70-77.e3
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC5710843
- OpenAlex
- W2730752446
- Cited by
- 75
- References
- 54
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 13 · 2020: 12 · 2019: 14 · 2018: 8 · 2017: 2
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- National Institutes of Health (R01 MH082017)
- James S. McDonnell Foundation
- Brain and Behavior Research Foundation
- Kavli Institute for Brain Science
- NICHD (T32 HD007430)
- NEI (EY013933)
- NIMH (T32-MH015144)
- Helen Hay Whitney Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- amygdala, orbitofrontal cortex, motivational value, classical conditioning, reward history, reward-predictive cues
- MeSH terms
- Amygdala, Animals, Behavior, Animal, Conditioning, Classical, Cues, Macaca mulatta, Motivation, Neurons, Reward, Linear Models, Prefrontal Cortex
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