Activity-dependent regulation of inhibitory synapse development by Npas4
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Neuronal activity regulates the development and maturation of excitatory and inhibitory synapses in the mammalian brain. Several recent studies have identified signalling networks within neurons that control excitatory synapse development. However, less is known about the molecular mechanisms that regulate the activity-dependent development of GABA (gamma-aminobutyric acid)-releasing inhibitory synapses. Here we report the identification of a transcription factor, Npas4, that plays a role in the development of inhibitory synapses by regulating the expression of activity-dependent genes, which in turn control the number of GABA-releasing synapses that form on excitatory neurons. These findings demonstrate that the activity-dependent gene program regulates inhibitory synapse development, and suggest a new role for this program in controlling the homeostatic balance between synaptic excitation and inhibition.
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Restoring Npas4 expression ameliorates social and cognitive deficits, GABAergic synaptic impairment, and neuronal hyperexcitability in 16p11dp/+ mice.
“Restoring the expression of Npas4, a key regulator of GABA synapses 135,136, ameliorates the social and cognitive deficits, as well as GABAergic synaptic impairment and neuronal hyperexcitability in 16p11dp/+ mice 134.”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [136]
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Cites
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571 · see citing works
Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection.
Li, C., & Wong, W. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.31 · Cited by 3,133 · see citing works
A simple method for organotypic cultures of nervous tissue
Stoppini, L., Buchs, P., & Muller, D. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90128-m · Cited by 3,097 · see citing works
Synaptic Activity and the Construction of Cortical Circuits
Katz, L. C., & Shatz, C. J. (1996) · Science · doi:10.1126/science.274.5290.1133 · Cited by 3,048 · see citing works
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768 · see citing works
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588 · see citing works
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485 · see citing works
Excitatory actions of gaba during development: the nature of the nurture
Ben-Ari, Y. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn920 · Cited by 2,448 · see citing works
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323 · see citing works
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226 · see citing works
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561 · see citing works
Self-citationHuang, Z. J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M. F., Maffei, L., & Tonegawa, S. (1999) · Cell · doi:10.1016/s0092-8674(00)81509-3 · Cited by 1,198 · see citing works
Mouse and rat <i>BDNF</i> gene structure and expression revisited
Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., & Timmusk, T. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21139 · Cited by 943 · see citing works
Xia, Z., Dudek, H., Miranti, C. K., & Greenberg, M. E. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05425.1996 · Cited by 794 · see citing works
Self-citationElectrical activity in early neuronal development
Spitzer, N. C. (2006) · Nature · doi:10.1038/nature05300 · Cited by 779 · see citing works
Activity-dependent regulation of dendritic growth and patterning
Wong, R. O. L., & Ghosh, A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn941 · Cited by 635 · see citing works
Chattopadhyaya, B., Di Cristo, G., Higashiyama, H., Knott, G. W., Kuhlman, S. J., Welker, E., & Huang, Z. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1851-04.2004 · Cited by 596 · see citing works
Chubykin, A. A., Atasoy, D., Etherton, M. R., Brose, N., Kavalali, E. T., Gibson, J. R., & Südhof, T. C. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.029 · Cited by 594 · see citing works
Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number
Flavell, S. W., Cowan, C. W., Kim, T.-K., Greer, P. L., Lin, Y., Paradis, S., Griffith, E. C., Hu, L. S., Chen, C., & Greenberg, M. E. (2006) · Science · doi:10.1126/science.1122511 · Cited by 573 · see citing works
Self-citationNumerous candidate plasticity-related genes revealed by differential cDNA cloning
Nedivi, E., Hevroni, D., Naot, D., Israeli, D., & Citri, Y. (1993) · Nature · doi:10.1038/363718a0 · Cited by 542 · see citing works
Burrone, J., O'Byrne, M., & Murthy, V. N. (2002) · Nature · doi:10.1038/nature01242 · Cited by 487 · see citing works
The distribution of synapsin I and synaptophysin in hippocampal neurons developing in culture
Fletcher, T., Cameron, P. L., Camilli, P. V. D., & Banker, G. A. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-06-01617.1991 · Cited by 454 · see citing works
Selective reconfiguration of layer 4 visual cortical circuitry by visual deprivation
Maffei, A., Nelson, S. B., & Turrigiano, G. G. (2004) · Nature Neuroscience · doi:10.1038/nn1351 · Cited by 415 · see citing works
Rutherford, L. C., DeWan, A., Lauer, H. M., & Turrigiano, G. G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04527.1997 · Cited by 381 · see citing works
Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase
Kash, S. F., Johnson, R. S., Tecott, L. H., Noebels, J. L., Mayfield, R. D., Hanahan, D., & Bækkeskov, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14060 · Cited by 316 · see citing works
Gomeza, J., Ohno, K., Hülsmann, S., Armsen, W., Eulenburg, V., Richter, D. W., Laube, B., & Betz, H. (2003) · Neuron · doi:10.1016/s0896-6273(03)00673-1 · Cited by 298 · see citing works
Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine
Liu, Q., Lü, L., Zhu, X.-G., Gong, J.-P., Shaham, Y., & Uhl, G. R. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.004 · Cited by 297 · see citing works
Development of GABA innervation in the cerebral and cerebellar cortices
Huang, Z. J., Cristo, G. D., & Ango, F. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2188 · Cited by 281 · see citing works
GABA and Schizophrenia: A Review of Basic Science and Clinical Studies
Wassef, A. A., Baker, J. D., & Kochan, L. D. (2003) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000095349.32154.a5 · Cited by 243 · see citing works
Marty, S., Wehrlé, R., & Sotelo, C. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08087.2000 · Cited by 237 · see citing works
Paradis, S., Harrar, D. B., Lin, Y., Koon, A. C., Chatterjee, J. H., Griffith, E. C., Zhu, L., Brass, L. F., Chen, C., & Greenberg, M. E. (2007) · Neuron · doi:10.1016/j.neuron.2006.12.012 · Cited by 231 · see citing works
Self-citationKash, S. F., Tecott, L. H., Hodge, C. W., & Bækkeskov, S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1698 · Cited by 216 · see citing works
GABAAReceptors in Central Nervous System Disease: Anxiety, Epilepsy, and Insomnia
Möhler, H. (2006) · Journal of Receptors and Signal Transduction · doi:10.1080/10799890600920035 · Cited by 196 · see citing works
Polarized Signaling Endosomes Coordinate BDNF-Induced Chemotaxis of Cerebellar Precursors
Zhou, P., Porcionatto, M. A., Pilapil, M., Chen, Y., Choi, Y., Tolias, K. F., Bikoff, J. B., Hong, E. J., Greenberg, M. E., & Segal, R. A. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.030 · Cited by 169 · see citing works
Self-citationTrkB Receptor Ligands Promote Activity-Dependent Inhibitory Synaptogenesis
Seil, F. J., & Drake‐Baumann, R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05367.2000 · Cited by 144 · see citing works
Synaptogenesis: A Balancing Act between Excitation and Inhibition
Cline, H. T. (2005) · Current Biology · doi:10.1016/j.cub.2005.03.010 · Cited by 143 · see citing works
Synaptic basis for developmental plasticity in somatosensory cortex
Foeller, E., & Feldman, D. E. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.01.011 · Cited by 136 · see citing works
Brown, P., Ridding, M. C., Werhahn, K. J., et al. (1996) · Brain · doi:10.1093/brain/119.1.309 · Cited by 136 · see citing works
Activity-dependent synaptogenesis in the adult Mammalian cortex
Zito, K., & Svoboda, K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00903-0 · Cited by 134 · see citing works
Kohara, K., Yasuda, H., Huang, Y. Y., Adachi, N., Sohya, K., & Tsumoto, T. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1943-07.2007 · Cited by 124 · see citing works
Sensory pathways and their modulation in the control of locomotion
Büschges, A., & Manira, A. E. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80115-3 · Cited by 121 · see citing works
Ooe, N., Saito, K., Mikami, N., Nakatuka, I., & Kaneko, H. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.608-616.2004 · Cited by 120 · see citing works
Benevento, L. A., Bakkum, B. W., & Cohen, R. S. (1995) · Brain Research · doi:10.1016/0006-8993(95)00553-3 · Cited by 116 · see citing works
Kenet, T., Froemke, R. C., Schreiner, C. E., Pessah, I. N., & Merzenich, M. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701944104 · Cited by 97 · see citing works
Benson, D. L., & Cohen, P. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-20-06424.1996 · Cited by 73 · see citing works
Micheva, K. D., & Beaulieu, C. (1997) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y97-032 · Cited by 73 · see citing works
Npas4, a novel helix–loop–helix PAS domain protein, is regulated in response to cerebral ischemia
Shamloo, M., Soriano, L., von Schack, D., Rickhag, M., Chin, D. J., Gonzalez‐Zulueta, M., Gidö, G., Urfer, R., Wieloch, T. W., & Nikolich, K. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05172.x · Cited by 70 · see citing works
NxfandFbxo33: novel seizure‐responsive genes in mice
Flood, W. D., Moyer, R. W., Tsykin, A., Sutherland, G. R., & Koblar, S. A. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03646.x · Cited by 49 · see citing works
Chapter 23 Regulation of immediate early genes in brain: role of NMDA receptor activation
Worley, P. F., Cole, A. J., Saffen, D. W., et al. (1990) · Progress in brain research · doi:10.1016/s0079-6123(08)63184-2 · Cited by 33 · see citing works
Hester, I., McKee, S., Pelletier, P., Thompson, C., Storbeck, C. J., Mears, A. J., Schulz, J. B., Hakim, A. A., & Sabourin, L. A. (2007) · Brain Research · doi:10.1016/j.brainres.2006.11.083 · Cited by 28 · see citing works
Activity-Dependent Changes in “Transplanted” Cerebellar Cultures
Seil, F. J., & Drake‐Baumann, R. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0071 · Cited by 5 · see citing works
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Widespread transcription at neuronal activity-regulated enhancers
Kim, T.-K., Hemberg, M., Gray, J. M., Costa, A. M., Bear, D. M., Wu, J., Harmin, D. A., Laptewicz, M., Barbara-Haley, K., Kuersten, S., et al. (2010) · Nature · doi:10.1038/nature09033 · Cited by 2,450 · see citing works
Self-citationExercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440 · see citing works
Self-citationEditing DNA Methylation in the Mammalian Genome
Liu, X. S., Wu, H., Ji, X., Stelzer, Y., Wu, X., Czauderna, S., Shu, J., Dadon, D., Young, R. A., & Jaenisch, R. (2016) · Cell · doi:10.1016/j.cell.2016.08.056 · Cited by 1,224 · see citing works
Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes
Renier, N., Adams, E. L., Kirst, C., Wu, Z., Azevedo, R., Kohl, J., Autry, A. E., Kadiri, L., Umadevi Venkataraju, K., Zhou, Y., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.007 · Cited by 918 · see citing works
Activity-dependent neuronal signalling and autism spectrum disorder
Ebert, D. H., & Greenberg, M. E. (2013) · Nature · doi:10.1038/nature11860 · Cited by 666 · see citing works
Self-citationGreer, P. L., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.002 · Cited by 661 · see citing works
Self-citationThe Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc
Greer, P. L., Hanayama, R., Bloodgood, B. L., Mardinly, A. R., Lipton, D. M., Flavell, S. W., Kim, T.-K., Griffith, E. C., Waldon, Z., Maehr, R., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.026 · Cited by 30 · see citing works
Self-citationREM sleep and dreaming: towards a theory of protoconsciousness
Hobson, J. A. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2716 · Cited by 625 · see citing works
Immune proteins in brain development and synaptic plasticity
Boulanger, L. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.001 · Cited by 555 · see citing works
Neuronal Activity-Regulated Gene Transcription in Synapse Development and Cognitive Function
West, A. E., & Greenberg, M. E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005744 · Cited by 532 · see citing works
Self-citationSingle-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex
Hrvatin, S., Hochbaum, D. R., Nagy, M. A., Cicconet, M., Robertson, K., Cheadle, L., Zilionis, R., Ratner, A., Borges-Monroy, R., Klein, A. M., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0029-5 · Cited by 497 · see citing works
Self-citationStructural plasticity upon learning: regulation and functions
Caroni, P., Donato, F., & Muller, D. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3258 · Cited by 491 · see citing works
Spiegel, I., Mardinly, A. R., Gabel, H. W., Bazinet, J. E., Couch, C. H., Tzeng, C. P., Harmin, D. A., & Greenberg, M. E. (2014) · Cell · doi:10.1016/j.cell.2014.03.058 · Cited by 416 · see citing works
“This function is different from Npas4’s previously described function in excitatory neurons (Bloodgood et al., 2013; Lin et al., 2008) and suggests that Npas4 functions in a cell-type-specific manner to control excitatory-inhibitory balance.”
InfluentialFlavell, S. W., Kim, T.-K., Gray, J. M., Harmin, D. A., Hemberg, M., Hong, E. J., Markenscoff-Papadimitriou, E., Bear, D. M., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.029 · Cited by 440 · see citing works
Self-citationHong, E. J., McCord, A. E., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.024 · Cited by 366 · see citing works
Self-citationThe Regulation of Transcription in Memory Consolidation
Alberini, C. M., & Kandel, E. R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021741 · Cited by 362 · see citing works
Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories
Gräff, J., Joseph, N. F., Horn, M. E., Samiei, A., Meng, J., Seo, J., Rei, D., Bero, A. W., Phan, T. X., Wagner, F., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.020 · Cited by 357 · see citing works
Mammalian Per-Arnt-Sim Proteins in Environmental Adaptation
McIntosh, B. E., Hogenesch, J. B., & Bradfield, C. A. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135922 · Cited by 352 · see citing works
The Requirement for Cyclin D Function in Tumor Maintenance
Choi, Y. J., Li, X., Hydbring, P., Sanda, T., Stefano, J., Christie, A. L., Signoretti, S., Look, A. T., Kung, A. L., von Boehmer, H., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.09.015 · Cited by 342 · see citing works
Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons
Chang, M. C., Park, J. M., Pelkey, K. A., Grabenstatter, H. L., Xu, D., Linden, D. J., Sutula, T. P., McBain, C. J., & Worley, P. F. (2010) · Nature Neuroscience · doi:10.1038/nn.2621 · Cited by 316 · see citing works
The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition
Bloodgood, B. L., Sharma, N., Browne, H. A., Trepman, A. Z., & Greenberg, M. E. (2013) · Nature · doi:10.1038/nature12743 · Cited by 310 · see citing works
Self-citationYan, Z., & Rein, B. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01092-3 · Cited by 300 · see citing works
“Restoring the expression of Npas4, a key regulator of GABA synapses [135, 136], ameliorates the social and cognitive de fi cits, as well as GABAergic synaptic impairment and neuronal hyperexcitability in 16p11 dp/ + mice [134].”
BackgroundCohen, S., Gabel, H. W., Hemberg, M., Hutchinson, A. N., Sadacca, L. A., Ebert, D. H., Harmin, D. A., Greenberg, R. S., Verdine, V. K., Zhou, Z., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.022 · Cited by 298 · see citing works
Self-citationDevelopmental sensory experience balances cortical excitation and inhibition
Dorrn, A. L., Yuan, K., Barker, A. J., Schreiner, C. E., & Froemke, R. C. (2010) · Nature · doi:10.1038/nature09119 · Cited by 296 · see citing works
Stimulus-specific combinatorial functionality of neuronal c-fos enhancers
Joo, J.-Y., Schaukowitch, K., Farbiak, L., Kilaru, G., & Kim, T.-K. (2016) · Nature Neuroscience · doi:10.1038/nn.4170 · Cited by 271 · see citing works
Self-citationJeanneteau, F. D., Lambert, W. M., Ismaili, N., Bath, K. G., Lee, F. S., Garabedian, M. J., & Chao, M. V. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114122109 · Cited by 252 · see citing works
Margolis, S. S., Salogiannis, J., Lipton, D. M., Mandel-Brehm, C., Wills, Z. P., Mardinly, A. R., Hu, L., Greer, P. L., Bikoff, J. B., Ho, H.-Y. H., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.038 · Cited by 256 · see citing works
Self-citationActivity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR
Ebert, D. H., Gabel, H. W., Robinson, N. D., Kastan, N. R., Hu, L. S., Cohen, S., Navarro, A. J., Lyst, M. J., Ekiert, R., Bird, A. P., et al. (2013) · Nature · doi:10.1038/nature12348 · Cited by 227 · see citing works
Self-citationGaray, P. (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00136 · Cited by 217 · see citing works
A common neuroendocrine substrate for diverse general anesthetics and sleep
Jiang-Xie, L.-F., Yin, L., Zhao, S., Prevosto, V., Han, B.-X., Dzirasa, K., & Wang, F. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.033 · Cited by 173 · see citing works
Arbogast, T., Ouagazzal, A.-M., Chevalier, C., Kopanitsa, M., Afinowi, N., Migliavacca, E., Cowling, B. S., Birling, M.-C., Champy, M.-F., Reymond, A., et al. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1005709 · Cited by 151 · see citing works
The serotonin-BDNF duo: developmental implications for the vulnerability to psychopathology
Homberg, J. R., Molteni, R., Calabrese, F., & Riva, M. A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.012 · Cited by 177 · see citing works
16p11.2 Copy Number Variations and Neurodevelopmental Disorders
Rein, B., & Yan, Z. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.09.001 · Cited by 160 · see citing works
Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory
Sun, W., Liu, Z., Jiang, X., Chen, M. B., Dong, H., Liu, J., Südhof, T. C., & Quake, S. R. (2024) · Nature · doi:10.1038/s41586-023-07011-6 · Cited by 165 · see citing works
Miyoshi, G., Young, A., Petros, T., Karayannis, T., McKenzie Chang, M., Lavado, A., Iwano, T., Nakajima, M., Taniguchi, H., Huang, Z. J., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1164-15.2015 · Cited by 135 · see citing works
A NPAS4–NuA4 complex couples synaptic activity to DNA repair
Pollina, E. A., Gilliam, D. T., Landau, A. T., Lin, C., Pajarillo, N., Davis, C. P., Harmin, D. A., Yap, E.-L., Vogel, I. R., Griffith, E. C., et al. (2023) · Nature · doi:10.1038/s41586-023-05711-7 · Cited by 125 · see citing works
Self-citationAllene, C., & Cossart, R. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.178798 · Cited by 102 · see citing works
Michod, D., Bartesaghi, S., Khelifi, A., Bellodi, C., Berliocchi, L., Nicotera, P., & Salomoni, P. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.021 · Cited by 93 · see citing works
Synapse rearrangements upon learning: from divergent–sparse connectivity to dedicated sub-circuits
Caroni, P., Chowdhury, A., & Lahr, M. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.08.011 · Cited by 85 · see citing works
Bayesian sparse regression analysis documents the diversity of spinal inhibitory interneurons
Gabitto, M. I., Pakman, A., Bikoff, J. B., Abbott, L. F., Jessell, T. M., & Paninski, L. (2016) · Cell · doi:10.1016/j.cell.2016.01.026 · Cited by 73 · see citing works
Synapse development organized by neuronal activity-regulated immediate-early genes
Kim, S., Kim, H., & Um, J. W. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0025-1 · Cited by 77 · see citing works
Rein, B., Tan, T., Yang, F., Wang, W., Williams, J., Zhang, F., Mills, A., & Yan, Z. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-0693-9 · Cited by 58 · see citing works
Furness, S. G. B., & Whelan, F. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.09.004 · Cited by 63 · see citing works
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Stott, R. T., Kritsky, O., & Tsai, L.-H. (2021) · PLOS ONE · doi:10.1371/journal.pone.0249691 · Cited by 62 · see citing works
Nelson, P. A., Sage, J. R., Wood, S. C., Davenport, C. M., Anagnostaras, S. G., & Boulanger, L. M. (2013) · Learning & Memory · doi:10.1101/lm.031351.113 · Cited by 49 · see citing works
Sun, X., Jing, L., Li, F., Zhang, M., Diao, X., Zhuang, J., Rastinejad, F., & Wu, D. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2208804119 · Cited by 32 · see citing works
Rossi, J. J., Rosenfeld, J. A., Chan, K. M., Streff, H., Nankivell, V., Peet, D. J., Whitelaw, M. L., & Bersten, D. C. (2021) · Scientific Reports · doi:10.1038/s41598-021-86041-4 · Cited by 17 · see citing works
- Authors
- Lin, Y., Bloodgood, B. L., Hauser, J. L., Lapan, A. D., Koon, A. C., Kim, T.-K., Hu, L. S., Malik, A. N., & Greenberg, M. E.
- Affiliations
- Harvard University (US)
- Corresponding author
- Greenberg, Michael E.
- Venue
- Nature
- Published
- 2008-09-24
- Volume
- 455
- Issue
- 7217
- Pages
- 1198-1204
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2637532
- OpenAlex
- W2096123613
- Cited by
- 639
- References
- 52
- Citations by year
- 2026: 30 · 2025: 45 · 2024: 42 · 2023: 39 · 2022: 40 · 2021: 48 · 2020: 36 · 2019: 33 · 2018: 37 · 2017: 33 · 2016: 44 · 2015: 32 · 2014: 39 · 2013: 35 · 2012: 28
- FWCI
- 11.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Open Access System for Information Sharing (Pohang University of Science and Technology) (submittedVersion)
- Funders
- National Institutes of Health (5r01ns048276-15)
- National Institute of Mental Health (R01MH091220)
- National Institute of General Medical Sciences (T32GM007753)
- National Institute of Neurological Disorders and Stroke (NS48276, R01-NS-048276, P01NS047572, NS27572)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD18655, P30HD018655)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- Npas4, activity-dependent gene expression, GABAergic synapses, transcription factors, excitatory neurons, autism spectrum disorder, epilepsy, schizophrenia, synaptic homeostasis
- MeSH terms
- Animals, Cells, Cultured, Electrophysiology, gamma-Aminobutyric Acid, Gene Expression Regulation, Hippocampus, Neurons, Synapses, Transcription Factors, Transfection, Brain-Derived Neurotrophic Factor, Mice, Rats, Basic Helix-Loop-Helix Proteins
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