Understanding memory through hippocampal remapping
Abstract
Memory interference is a common cause of forgetting. Interference is a byproduct of the need to balance the formation of well-differentiated representations against the ability to retrieve memories from cues that are not identical to the original experience. How the brain accomplishes this has remained elusive. Here we review how insights can be gained from studies of an apparently unrelated phenomenon in the rodent brain--remapping in hippocampal place cells. Remapping refers to the formation of distinct representations in populations of place cells after minor changes in inputs to the hippocampus. Remapping might reflect processes involved generally in decorrelation of overlapping signals. These processes might be crucial for storing large numbers of similar experiences with only minimal interference.
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Theoretical models propose that remapping occurs because these cells respond to global contextual cues in order to decorrelate related experiences with distinct contextual relevance.
“Theoretical models of this phenomenon propose that remapping occurs because these cells are responding to global contextual cues (like arousal or attention) in order to decorrelate related experiences with distinct contextual relevance (Colgin et al., 2008; Sanders et al., 2020).”
From Remapping in a recurrent neural network model of navigation and context inference (2023) · cites this paper as Colgin et al., 2008
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BackgroundRemapping in a recurrent neural network model of navigation and context inference
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BackgroundRemapping in a recurrent neural network model of navigation and context inference
Low, I. I. C., Giocomo, L. M., & Williams, A. H. (2023) · doi:10.1101/2023.01.25.525596 · Cited by 3 · see citing works
Remapping in a recurrent neural network model of navigation and context inference
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- Authors
- Colgin, L. L., Moser, E. I., & Moser, M.-B.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Corresponding author
- Colgin, Laura Lee
- Moser, May-Britt
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 31
- Issue
- 9
- Pages
- 469-477
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2149615516
- Cited by
- 450
- References
- 9
- Citations by year
- 2026: 20 · 2025: 47 · 2024: 36 · 2023: 42 · 2022: 33 · 2021: 30 · 2020: 26 · 2019: 20 · 2018: 29 · 2017: 16 · 2016: 22 · 2015: 28 · 2014: 23 · 2013: 15 · 2012: 21
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- place cells, memory interference, forgetting, memory retrieval, hippocampal representations, rodent hippocampus, spatial memory
- MeSH terms
- Animals, Association Learning, Brain Mapping, Evoked Potentials, Hippocampus, Humans, Memory, Neuronal Plasticity, Space Perception, Spatial Behavior
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