Increased Attention to Spatial Context Increases Both Place Field Stability and Spatial Memory
Open accessAbstract
The hippocampal formation is critical for the acquisition and consolidation of memories. When recorded in freely moving animals, hippocampal pyramidal neurons fire in a location-specific manner: they are "place" cells, comprising a hippocampal representation of the animal's environment. To explore the relationship between place cells and spatial memory, we recorded from mice in several behavioral contexts. We found that long-term stability of place cell firing fields correlates with the degree of attentional demands and that successful spatial task performance was associated with stable place fields. Furthermore, conditions that maximize place field stability greatly increase orientation to novel cues. This suggests that storage and retrieval of place cells is modulated by a top-down cognitive process resembling attention and that place cells are neural correlates of spatial memory. We propose a model whereby attention provides the requisite neuromodulatation to switch short-term homosynaptic plasticity to long-term heterosynaptic plasticity, and we implicate dopamine in this process.
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Intermediate fixed points are unstable along a small number of dimensions (saddle fixed points) which funnel neural activity to the appropriate location during a remapping event.
“In line with observations by Susillo & Barak 31 on a discrete flip-flop task, these intermediate fixed points are unstable along a small number of dimensions (i.e.saddle fixed points; Figure 3D, gold points) which “funnel” neural activity to the appropriate location during a remapping event.”
From Remapping in a recurrent neural network model of navigation and context inference (2023) · cites this paper as [31]
Pharmacological studies have implicated the neurotransmitter dopamine in the stability of hippocampus-dependent memory.
“Pharmacological studies have implicated the neurotransmitter dopamine in the stability of hippocampus-dependent memory.”
From Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence (2014) · cites this paper as [8]
Blockade of D1/D5 dopaminergic receptors during exploration of novel environments curtails the stability of new spatial maps.
“while blockade during exploration of novel environments curtails the stability of new spatial maps8”
From Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence (2014) · cites this paper as [8]
D1 antagonists prevent the stabilization of place fields in CA1 after the animal enters a new environment.
“It was found that D1 antagonists prevent this stabilization [20].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [20]
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- Authors
- Kentros, C. G., Agnihotri, N. T., Streater, S., Hawkins, R. D., & Kandel, E. R.
- Affiliations
- New York State Psychiatric Institute (US)
- Columbia University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Kandel, Eric R
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 42
- Issue
- 2
- Pages
- 283-295
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2016985810
- Cited by
- 537
- References
- 41
- Citations by year
- 2026: 29 · 2025: 28 · 2024: 41 · 2023: 32 · 2022: 30 · 2021: 35 · 2020: 25 · 2019: 19 · 2018: 30 · 2017: 28 · 2016: 17 · 2015: 19 · 2014: 22 · 2013: 20 · 2012: 18
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3394 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Harvard University
- National Institutes of Health (NH50733)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Keywords
- place cells, spatial memory, attention, hippocampus, top-down attention, homosynaptic plasticity, heterosynaptic plasticity, dopamine, neuromodulation, mice
- MeSH terms
- Animals, Attention, Male, Mice, Inbred C57BL, Psychomotor Performance, Spatial Behavior, Pyramidal Cells, Mice
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