Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males
Abstract
The mammalian neuropeptide oxytocin has well-characterized effects in facilitating prosocial and affiliative behavior. Additionally, oxytocin decreases physiological and behavioral responses to social stress. In the present study we investigated the effects of oxytocin on cognitive appraisals after a naturalistic social stress task in healthy male students. In a randomized, double-blind, placebo-controlled trial, 48 participants self-administered either an oxytocin or placebo nasal spray and, following a wait period, completed an impromptu speech task. Eye gaze to a pre-recorded video of an audience displayed during the task was simultaneously collected. After the speech, participants completed questionnaires assessing negative cognitive beliefs about speech performance. Whilst there was no overall effect of oxytocin compared to placebo on either eye gaze or questionnaire measures, there were significant positive correlations between trait levels of anxiety and negative self-appraisals following the speech. Exploratory analyses revealed that whilst higher trait anxiety was associated with increasingly poorer perceptions of speech performance in the placebo group, this relationship was not found in participants administered oxytocin. These results provide preliminary evidence to suggest that oxytocin may reduce negative cognitive self-appraisals in high trait anxious males. It adds to a growing body of evidence that oxytocin seems to attenuate negative cognitive responses to stress in anxious individuals.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The studies showing stronger OT effects in less socially adapted individuals mainly used self-centered measures, such as anxiety traits measured by STAI-T, sociocognitive skills, or emotional sensitivity/regulation.
“However, the studies showing stronger OT effects in less socially adapted individuals mainly used self-centered measures, such as anxiety traits measured by State-Trait Anxiety Inventory (STAI-T) (34), sociocognitive skills (9), or emotional sensitivity/regulation (35, 36).”
From Distinct oxytocin effects on belief updating in response to desirable and undesirable feedback (2016) · cites this paper as [34]
Cites
(1970) · Cited by 24,983 · see citing works
Kirschbaum, C., Pirke, K.-M., & Hellhammer, D. H. (2008) · Neuropsychobiology · doi:10.1159/000119004 · Cited by 6,093 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
A cognitive-behavioral model of anxiety in social phobia
Rapee, R. M., & Heimberg, R. G. (1997) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(97)00022-3 · Cited by 2,987 · see citing works
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091 · see citing works
Mechanisms of attentional biases towards threat in anxiety disorders: An integrative review
Cisler, J. M., & Koster, E. H. W. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.11.003 · Cited by 1,753 · see citing works
Response and Habituation of the Human Amygdala during Visual Processing of Facial Expression
Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., Strauss, M. M., Hyman, S. E., & Rosen, B. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80219-6 · Cited by 1,711 · see citing works
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · see citing works
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,572 · cited 1× · see citing works
“These studies argue that oxytocin is of most benefit to individuals with difficulties processing social information or regulating emotion, acting selectively, depending on context or individual factors (Bartz et al., 2011).”
BackgroundAn information processing model of anxiety: Automatic and strategic processes
Beck, A. T., & Clark, D. A. (1997) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(96)00069-1 · Cited by 1,317 · see citing works
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · see citing works
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258 · see citing works
Schneier (1992) · doi:10.1001/archpsyc.1992.01820040034004 · Cited by 1,142 · see citing works
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059 · see citing works
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043 · see citing works
Neurocognitive mechanisms of anxiety: An integrative account
Bishop, S. J. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.05.008 · Cited by 976 · see citing works
Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.
Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962 · see citing works
Self-citationOxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856 · cited 1× · see citing works
“, 2005) as it engages a wide range of neural systems that underpin social behavior, including dopamine-modulated reward networks (McGregor et al., 2009; Ross and Young, 2009).”
BackgroundOxytocin increases gaze to the eye region of human faces
Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.026 · Cited by 798 · see citing works
Self-citationOxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · see citing works
Discrepancy between self- and observer ratings of performance in social phobics.
Rapee, R. M., & Lim, L. (1992) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.101.4.728 · Cited by 549 · see citing works
Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder
Labuschagne, I., Phan, K. L., Wood, A., Angstadt, M., Chua, P., Heinrichs, M., Stout, J. C., & Nathan, P. J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.123 · Cited by 549 · cited 2× · see citing works
“Previous research suggests that oxytocin attenuates amygdala activation during the processing of an initially threatening social stimulus (Kirsch et al., 2005; Labuschagne et al., 2010), whilst the results from the present study highlight a potential secondary mechanism in which oxytocin may act to increase recruitmen…”
BackgroundResultDiscrepancy between self- and observer ratings of performance in social phobics.
Rapee, R. M., & Lim, L. (1992) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.101.4.728 · Cited by 549 · see citing works
Effects of intranasal oxytocin on emotional face processing in women
Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.016 · Cited by 521 · cited 2× · see citing works
“As sexually dimorphic effects of oxytocin have previously been described (Domes et al., 2010), and possible interactions between fluctuating levels of estrogen”
BackgroundDifferent amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
Gamer, M., Zurowski, B., & Büchel, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000985107 · Cited by 487 · cited 1× · see citing works
“, 2010), and attention to socially relevant information of human faces (Guastella et al., 2008a; Gamer et al., 2010).”
BackgroundOxytocin selectively improves empathic accuracy
Bartz, J. A., Zaki, J., Bolger, N., Hollander, E., Ludwig, N. N., Kolevzon, A., & Ochsner, K. N. (2010) · Psychological Science · doi:10.1177/0956797610383439 · Cited by 442 · see citing works
Oxytocin Attenuates Affective Evaluations of Conditioned Faces and Amygdala Activity
Petrovic, P., Kalisch, R., Singer, T., & Dolan, R. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4572-07.2008 · Cited by 424 · see citing works
Lukas, M., Toth, I., Reber, S. O., Slattery, D. A., Veenema, A. H., & Neumann, I. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.95 · Cited by 403 · see citing works
Neumann, I. D. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39014-9 · Cited by 387 · see citing works
Graustella, A. J., & MacLeod, C. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.002 · Cited by 379 · see citing works
Guastella, A. J., Howard, A. L., Dadds, M. R., Mitchell, P., & Carson, D. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.005 · Cited by 366 · see citing works
Self-citationOxytocin enhances the encoding of positive social memories in humans.
Guastella, A. J., Mitchell, P. B., & Mathews, F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.008 · Cited by 352 · see citing works
Self-citationInformation processing in social phobia: A critical review
Heinrichs, N., & Hofmann, S. G. (2001) · Clinical Psychology Review · doi:10.1016/s0272-7358(00)00067-2 · Cited by 351 · see citing works
Oxytocin improves specific recognition of positive facial expressions
Marsh, A. A., Yu, H. H., Pine, D. S., & Blair, R. J. R. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1780-4 · Cited by 321 · see citing works
Theodoridou, A., Rowe, A. C., Penton-Voak, I. S., & Rogers, P. J. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.019 · Cited by 318 · see citing works
Neural mechanisms of cognitive reappraisal of negative self-beliefs in social anxiety disorder.
Goldin, P. R., Manber-Ball, T., Werner, K., Heimberg, R., & Gross, J. J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.07.014 · Cited by 305 · see citing works
Prenatal stress generates deficits in rat social behavior: Reversal by oxytocin
Lee, P. R., Brady, D. L., Shapiro, R. A., Dorsa, D. M., & Koenig, J. I. (2007) · Brain Research · doi:10.1016/j.brainres.2007.04.042 · Cited by 270 · see citing works
Effects of oxytocin on recollections of maternal care and closeness
Bartz, J. A., Zaki, J., Ochsner, K. N., Bolger, N., Kolevzon, A., Ludwig, N., & Lydon, J. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012669107 · Cited by 235 · see citing works
Salonia, A., Nappi, R. E., Pontillo, M., Daverio, R., Smeraldi, A., Briganti, A., Fabbri, F., Zanni, G. E., Rigatti, P., & Montorsi, F. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.10.002 · Cited by 229 · see citing works
Lischke, A., Berger, C., Prehn, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.015 · Cited by 221 · see citing works
Quirin, M., Kuhl, J., & Düsing, R. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.12.005 · Cited by 204 · see citing works
Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats
Slattery, D. A., & Neumann, I. D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.038 · Cited by 195 · see citing works
Oxytocin increases recognition of masked emotional faces
Schulze, L., Lischke, A., Greif, J., Herpertz, S. C., Heinrichs, M., & Domes, G. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.011 · Cited by 180 · see citing works
McGregor, I. S., Callaghan, P. D., & Hunt, G. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.132 · Cited by 171 · see citing works
Windle, R. J., Shanks, N., Lightman, S. L., & Ingram, C. D. (1997) · Endocrinology · doi:10.1210/en.138.7.2829 · Cited by 170 · see citing works
Hypervigilance–avoidance pattern in spider phobia
Pflugshaupt, T., Mosimann, U. P., von Wartburg, R., Schmitt, W. J., Nyffeler, T., & Müri, R. M. (2004) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2003.12.002 · Cited by 166 · see citing works
Anxiolytic-like effect of oxytocin in the simulated public speaking test
de Oliveira, D. C., Zuardi, A. W., Graeff, F. G., Queiroz, R. H., & Crippa, J. A. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111400642 · Cited by 154 · see citing works
McNair, D. M., Lorr, M., & Droppleman, L. F. (1989) · Cited by 141 · see citing works
Detection of negative and positive audience behaviours by socially anxious subjects
Veljaca, K.-A., & Rapee, R. M. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(98)00016-3 · Cited by 137 · see citing works
Time course of attentional bias to emotional scenes in anxiety: Gaze direction and duration
Calvo, M. G., & Avero, P. (2005) · Cognition & Emotion · doi:10.1080/02699930441000157 · Cited by 130 · see citing works
Personality and anxiety disorders
Brandes, M., & Bienvenu, O. J. (2006) · Current Psychiatry Reports · doi:10.1007/s11920-006-0061-8 · Cited by 118 · see citing works
Rapee, R., & Abbott, M. J. (2007) · Behaviour Research and Therapy · doi:10.1016/j.brat.2007.08.008 · Cited by 108 · see citing works
Opposite effects of oxytocin and vasopressin on the emotional expression of the fear response
VIVIANI, D., & STOOP, R. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00418-4 · Cited by 96 · see citing works
Selective influences of oxytocin on the evaluative processing of social stimuli
Norman, G. J., Cacioppo, J. T., Morris, J. S., Karelina, K., Malarkey, W. B., DeVries, A. C., & Berntson, G. G. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110367452 · Cited by 92 · cited 1× · see citing works
“, 2009), increase positive evaluative ratings of social images (Norman et al., 2011), and facilitate subsequent recall of positive social memories (Guastella et al.”
BackgroundEllenbogen, M. A., Linnen, A., Grumet, R., Cardoso, C., & Joober, R. (2012) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01278.x · Cited by 82 · see citing works
Plasma oxytocin concentrations during the menstrual cycle
Mitchell, M. D., Haynes, P. J., Anderson, A. B. M., & Turnbull, A. C. (1981) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(81)90077-0 · Cited by 43 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Oxytocin in general anxiety and social fear: a translational approach
Neumann, I. D., & Slattery, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.004 · Cited by 468 · see citing works
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393 · see citing works
Cochran, D. M., Fallon, D., Hill, M., & Frazier, J. A. (2013) · Harvard Review of Psychiatry · doi:10.1097/hrp.0b013e3182a75b7d · Cited by 267 · see citing works
Quintana, D. S., Lischke, A., Grace, S., Scheele, D., Ma, Y., & Becker, B. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00864-7 · Cited by 263 · see citing works
Oxytocin facilitates protective responses to aversive social stimuli in males
Striepens, N., Scheele, D., Kendrick, K. M., Becker, B., Schäfer, L., Schwalba, K., Reul, J., Maier, W., & Hurlemann, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208852109 · Cited by 242 · see citing works
Guastella, A. J., & Hickie, I. B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.028 · Cited by 223 · see citing works
Self-citationCarson, D. S., Berquist, S. W., Trujillo, T. H., Garner, J. P., Hannah, S. L., Hyde, S. A., Sumiyoshi, R. D., Jackson, L. P., Moss, J. K., Strehlow, M. C., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.132 · Cited by 196 · see citing works
Quintana, D. S., Alvares, G. A., Hickie, I. B., & Guastella, A. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.011 · Cited by 149 · see citing works
Self-citationYamasue, H., Yee, J. R., Hurlemann, R., Rilling, J. K., Chen, F. S., Meyer-Lindenberg, A., & Tost, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-12.2012 · Cited by 149 · see citing works
MacDonald, K., MacDonald, T. M., Brüne, M., Lamb, K., Wilson, M. P., Golshan, S., & Feifel, D. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.05.014 · Cited by 140 · see citing works
A double-blind randomized controlled trial of oxytocin nasal spray in Prader Willi syndrome
Einfeld, S. L., Smith, E., McGregor, I. S., Steinbeck, K., Taffe, J., Rice, L. J., Horstead, S. K., Rogers, N., Hodge, M. A., & Guastella, A. J. (2014) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36653 · Cited by 131 · see citing works
Sex-specific effects of stress on oxytocin neurons correspond with responses to intranasal oxytocin
Steinman, M. Q., Duque-Wilckens, N., Greenberg, G. D., Hao, R., Campi, K. L., Laredo, S. A., Laman-Maharg, A., Manning, C. E., Doig, I. E., Lopez, E. M., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.007 · Cited by 131 · see citing works
Intranasal oxytocin increases covert attention to positive social cues
Domes, G., Sibold, M., Schulze, L., Lischke, A., Herpertz, S. C., & Heinrichs, M. (2013) · Psychological Medicine · doi:10.1017/s0033291712002565 · Cited by 130 · see citing works
Oxytocin and social functioning
Jones, C., Barrera, I., Brothers, S., Ring, R., & Wahlestedt, C. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.2/cjones · Cited by 132 · see citing works
Brewer, R., Happé, F., Cook, R., & Bird, G. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.006 · Cited by 117 · see citing works
Quintana, D. S., Westlye, L. T., Rustan, Ø. G., Tesli, N., Poppy, C. L., Smevik, H., Tesli, M., Røine, M., Mahmoud, R. A., Smerud, K. T., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.93 · Cited by 103 · see citing works
From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders
Romano, A., Tempesta, B., Bonaventura, M. V. M. D., & Gaetani, S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00497 · Cited by 102 · see citing works
Radke (2013) · doi:10.1177/0956797612472682 · Cited by 88 · see citing works
Oxytocin makes females, but not males, less forgiving following betrayal of trust
Yao, S., Zhao, W., Cheng, R., Geng, Y., Luo, L., & Kendrick, K. M. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571400090x · Cited by 74 · see citing works
Eckstein, M., Markett, S. A., Kendrick, K. M., Ditzen, B., Liu, F., Hurlemann, R., & Becker, B. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.01.078 · Cited by 69 · see citing works
Hyperscanning and avoidance in social anxiety disorder: The visual scanpath during public speaking
Chen, N. T. M., Thomas, L. M., Clarke, P., Hickie, I. B., & Guastella, A. J. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.11.025 · Cited by 63 · see citing works
Self-citationOxytocin Mediates a Calming Effect on Postpartum Mood in Primiparous Mothers
Niwayama, R., Nishitani, S., Takamura, T., Shinohara, K., Honda, S., Miyamura, T., Nakao, Y., Oishi, K., & 永橋, 美. (2017) · Breastfeeding Medicine · doi:10.1089/bfm.2016.0052 · Cited by 59 · see citing works
Oxytocin and anxiety disorders
Gottschalk, M. G., & Domschke, K. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_25 · Cited by 61 · see citing works
Distinct oxytocin effects on belief updating in response to desirable and undesirable feedback
Ma, Y., Li, S., Wang, C., Liu, Y., Li, W., Yan, X., Chen, Q., & Han, S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604285113 · Cited by 54 · see citing works
Kou, J., Zhang, Y., Zhou, F., Gao, Z., Yao, S., Zhao, W., Li, H., Lei, Y., Gao, S., Kendrick, K. M., et al. (2022) · Psychotherapy and Psychosomatics · doi:10.1159/000521348 · Cited by 54 · see citing works
Thielke, L. E., & Udell, M. A. R. (2015) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12235 · Cited by 55 · see citing works
Xin, F., Zhou, X., Dong, D., Zhao, Z., Yang, X., Wang, Q., Gu, Y., Kendrick, K. M., Chen, A., & Becker, B. (2020) · Advanced Science · doi:10.1002/advs.202001077 · Cited by 46 · see citing works
Oxytocin and cancer: An emerging link
Lerman, B., Harricharran, T., & Ogunwobi, O. O. (2018) · World Journal of Clinical Oncology · doi:10.5306/wjco.v9.i5.74 · Cited by 45 · see citing works
Effects of Oxytocin on Women's Aggression Depend on State Anxiety
Campbell, A. C., & Hausmann, M. (2013) · Aggressive Behavior · doi:10.1002/ab.21478 · Cited by 42 · see citing works
Geng, Y., Zhao, W., Zhou, F., Ma, X., Yao, S., Becker, B., & Kendrick, K. M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00572 · Cited by 40 · see citing works
Oxytocin increases eye-gaze towards novel social and non-social stimuli
Eckstein, M., Bamert, V., Stephens, S. B. Z., Wallen, K., Young, L. J., Ehlert, U., & Ditzen, B. (2018) · Social Neuroscience · doi:10.1080/17470919.2018.1542341 · Cited by 36 · see citing works
Donadon, M. F., Martín‐Santos, R., & Osório, F. D. L. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110098 · Cited by 32 · see citing works
Oxytozin: Evidenz für ein therapeutisches Potenzial des sozialen Neuromodulators
Eckstein, M., & Hurlemann, R. (2013) · Der Nervenarzt · doi:10.1007/s00115-013-3832-6 · Cited by 28 · see citing works
The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease
Aulinas, A., & Lawson, E. A. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf008 · Cited by 30 · see citing works
The Role of Oxytocin in Early-Life-Stress-Related Neuropsychiatric Disorders
Jin, Y., Song, D. F., Yan, Y., Quan, Z., & Qing, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310430 · Cited by 30 · see citing works
Aberrant Gaze Patterns in Social Anxiety Disorder: An Eye Movement Assessment during Public Speaking
Chen, N. T. M., Clarke, P., MacLeod, C., Hickie, I. B., & Guastella, A. J. (2015) · Journal of Experimental Psychopathology · doi:10.5127/jep.040313 · Cited by 28 · see citing works
Self-citationDemertzis, K. H., & Craske, M. G. (2006) · Springer eBooks · doi:10.1007/978-0-387-28370-8_30 · Cited by 27 · see citing works
Effects of intranasal oxytocin prior to encoding and retrieval on recognition memory
Weigand, A., Feeser, M., Gärtner, M., Brandt, E. S. L., Fan, Y., Fuge, P., Böker, H., Bajbouj, M., & Grimm, S. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2962-z · Cited by 23 · see citing works
Oxytocin increases eye gaze in schizophrenia
Bradley, E. R., Seitz, A., Niles, A. N., Rankin, K. P., Mathalon, D. H., O'Donovan, A., & Woolley, J. D. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.07.039 · Cited by 22 · see citing works
Burnley, A., Clair, M. S., Dack, C., Thompson, H., & Wren, Y. E. (2023) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-023-05946-3 · Cited by 22 · see citing works
Sex differences in stress reactivity after intranasal oxytocin in recreational cannabis users
Reed, S. C., Haney, M., Manubay, J. M., Campagna, B. R., Reed, B., Foltin, R. W., & Evans, S. M. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.11.008 · Cited by 20 · see citing works
Oxytocin strengthens the link between provocation and aggression among low anxiety people
Pfundmair, M., Reinelt, A., DeWall, C. N., & Feldmann, L. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.04.025 · Cited by 19 · see citing works
Oxytocin facilitates valence-dependent valuation of social evaluation of the self
Wang, D., & Ma, Y. (2020) · Communications Biology · doi:10.1038/s42003-020-01168-w · Cited by 19 · see citing works
Exposure to synthetic oxytocin during delivery and its effect on psychomotor development
Valenzuela, M. J. G., López‐Montiel, D., & González‐Mesa, E. (2015) · Developmental Psychobiology · doi:10.1002/dev.21321 · Cited by 16 · see citing works
Vasudeva, S. B., & Hollander, E. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16050559 · Cited by 16 · see citing works
Marazziti, D., Diep, P.-T., Carter, C. S., & Carbone, M. G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220727120646 · Cited by 16 · see citing works
Attention allocation in social anxiety during a speech
Lin, M., Hofmann, S. G., Qian, M., Kind, S., & Yu, H. (2015) · Cognition & Emotion · doi:10.1080/02699931.2015.1050359 · Cited by 15 · see citing works
Sabino, A. D. V., Chagas, M. H. N., & Osório, F. L. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05493-0 · Cited by 13 · see citing works
Advances in Psychopharmacology for Anxiety Disorders
Garakani, A., Murrough, J. W., & Iosifescu, D. V. (2014) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.12.2.152 · Cited by 13 · see citing works
Intranasal oxytocin as a treatment for anxiety and autism: From subclinical to clinical applications
Yin, H., Jiang, M., Han, T., & Xu, X. (2024) · Peptides · doi:10.1016/j.peptides.2024.171211 · Cited by 11 · see citing works
Thompson, R. R. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104742 · Cited by 10 · see citing works
Shin, K. E., LaFreniere, L. S., & Newman, M. G. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108140416.019 · Cited by 9 · see citing works
Osório, F. D. L., Rojas, G. V. E., & AGUIAR-RICZ, L. N. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.943578 · Cited by 9 · see citing works
Does oxytocin shield against negative effects of ostracism? A replication and extension
Pfundmair, M., & Echterhoff, G. (2021) · Biological Psychology · doi:10.1016/j.biopsycho.2021.108128 · Cited by 9 · see citing works
Short Review on the Aggressive Behaviour: Genetical, Biological Aspects and Oxytocin Relevance
Pădurariu, M., Prepelita, R., Ciobica, A. S., Dobrin, R., Timofte, D. V., Ștefănescu, C., & Chiriță, R. (2016) · International Letters of Natural Sciences · doi:10.18052/www.scipress.com/ilns.52.43 · Cited by 8 · see citing works
Schumacher, S., Oe, M., Wilhelm, F. H., Rufer, M., Heinrichs, M., Weidt, S., Moergeli, H., & Martin-Söelch, C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190809 · Cited by 8 · see citing works
Mohiyeddini, C., & Opacka‐Juffry, J. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.08.002 · Cited by 6 · see citing works
Gender-specific effects of vasopressin on human social communication: An ERP study
Wu, X., Feng, C., He, Z., Gong, X., Luo, Y., & Luo, Y. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.04.014 · Cited by 6 · see citing works
Defending the self: The role of oxytocin in responses to psychological threat
Feng, C., Luo, W., & Zhu, R. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106406 · Cited by 3 · see citing works
The Differential Effect of Oxytocin on Mindfulness in People with Different Resilience Level
Lau, W. K., Sánchez-Vidaña, D. I., Tai, A. P.-L., Chan, J. N.-M., Ngan, L. H.-M., Leung, M.-K., & Lau, B. W.-M. (2023) · Mindfulness · doi:10.1007/s12671-023-02186-5 · Cited by 2 · see citing works
Oxytocin Modulation of Explicit Pandemic Stigma in Men with Varying Social Anxiety Levels.
Wang, Y.-W., Zhu, J., Wang, J., & Mu, Y. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110140 · Cited by 1 · see citing works
Pay to know me in your eyes: A computational account and oxytocin modulation of social evaluationPreprint
Wang, D., & Ma, Y. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/864330 · Cited by 1 · see citing works
Intranasal oxytocin modulates very early visual processing of emotional facesPreprint
Hugrass, L., Labuschagne, I., Mu, E., Price, A., & Crewther, D. P. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.15.440078 · Cited by 1 · see citing works
The Neuroendocrinology of Social Anxiety Disorder
Alvares, G. A., & Guastella, A. J. (2014) · Wiley eBooks · doi:10.1002/9781118653920.ch21
Self-citationWeigand, A. (2013) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-5014
Masson, S., Bleuer‐Elsner, S., Muller, G., Médam, T., Chevallier, J., & Gaultier, E. (2024) · Springer eBooks · doi:10.1007/978-3-031-53012-8_27
Tomalika, N. (2025) · IMC Journal of Medical Science · doi:10.55010/imcjms.19.011
Bleuer‐Elsner, S., Masson, S., Lacoste, M., & Muller, G. (2026) · Springer eBooks · doi:10.1007/978-3-032-06260-4_26
- Authors
- Alvares, G. A., Chen, N. T. M., Balleine, B. W., Hickie, I. B., & Guastella, A. J.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Guastella, Adam J.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 37
- Issue
- 12
- Pages
- 2022-2031
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2149212681
- Cited by
- 71
- References
- 56
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 9 · 2017: 5 · 2016: 3 · 2015: 10 · 2014: 8 · 2013: 7 · 2012: 3
- FWCI
- 13.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, trait anxiety, speech performance, social stress, gaze, self-assessment, males, neuropeptides, stress response
- MeSH terms
- Administration, Intranasal, Adult, Affect, Anxiety, Cognition, Double-Blind Method, Eye Movements, Humans, Male, Oxytocin, Personality Inventory, Photic Stimulation, Psychomotor Performance, Visual Perception, Diagnostic Self Evaluation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
