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Response inhibition is associated with white matter microstructure in children.
Open accessAbstract
Cognitive control of thoughts, actions and emotions is important for normal behaviour and the development of such control continues throughout childhood and adolescence. Several lines of evidence suggest that response inhibition is primarily mediated by a right-lateralized network involving inferior frontal gyrus (IFG), presupplementary motor cortex (preSMA), and subthalamic nucleus. Though the brain's fibre tracts are known to develop during childhood, little is known about how fibre tract development within this network relates to developing behavioural control. Here we examined the relationship between response inhibition, as measured with the stop-signal task, and indices of regional white matter microstructure in typically-developing children. We hypothesized that better response inhibition performance would be associated with higher fractional anisotropy (FA) in fibre tracts within right IFG and preSMA after controlling for age. Mean FA and diffusivity values were extracted from right and left IFG and preSMA. As hypothesized, faster response inhibition was significantly associated with higher FA and lower perpendicular diffusivity in both the right IFG and the right preSMA, possibly reflecting faster speed of neural conduction within more densely packed or better myelinated fibre tracts. Moreover, both of these effects remained significant after controlling for age and whole brain estimates of these DTI parameters. Interestingly, right IFG and preSMA FA contributed additively to the prediction of performance variability. Observed associations may be related to variation in phase of maturation, to activity-dependent alterations in the network subserving response inhibition, or to stable individual differences in underlying neural system connectivity.
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“In other studies of school-aged children, clear evidence has emerged for relationships between white matter FA and behavioral differences (e.g., on reading, verbal working memory, and inhibitory tasks) that remained after controlling for the age of the children (Madsen et al., 2010;Niogi & McCandliss, 2006).”
From White Matter Microstructure in Superior Longitudinal Fasciculus Associated with Spatial Working Memory Performance in Children (2011) · cites this paper as Madsen et al., 2010
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“The relationship between age-related changes in the microstructural properties of white matter and the concurrent development of cognitive functions in children is still poorly understood, although a few studies suggest associations between FA values in white matter and per-formance on cognitive tasks (Madsen et al., 2010;Niogi & McCandliss, 2006;Nagy, Westerberg, & Klingberg, 2004).”
From White Matter Microstructure in Superior Longitudinal Fasciculus Associated with Spatial Working Memory Performance in Children (2011) · cites this paper as Madsen et al., 2010
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Metadata
- Authors
- Madsen, K. S., Baaré, W. F. C., Vestergaard, M., Skimminge, A., Ejersbo, L. R., Ramsøy, T. Z., Gerlach, C., Åkeson, P., Paulson, O. B., & Jernigan, T. L.
- Affiliations
- University of Copenhagen (DK)
- Hvidovre Hospital (DK)
- Aarhus University (DK)
- Corresponding author
- Madsen, Kathrine Skak
- ORCID
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 48
- Issue
- 4
- Pages
- 854-862
- ISSN
- 0028-3932 (ISSN-L)
- OpenAlex
- W2102236305
- Cited by
- 104
- References
- 60
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 8 · 2013: 15 · 2012: 11
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.escholarship.org
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- CBS Research Portal (Copenhagen Business School) (submittedVersion)
- Funders
- Sundhed og Sygdom, Det Frie Forskningsråd
- Lundbeckfonden
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- response inhibition, white matter microstructure, cognitive control, children, inferior frontal gyrus, pre-supplementary motor area, fractional anisotropy, stop-signal task, brain maturation, individual differences
- MeSH terms
- Adolescent, Age Factors, Brain, Child, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Inhibition, Psychological, Functional Laterality, Magnetic Resonance Imaging, Male, Motor Cortex, Neural Pathways, Neuropsychological Tests, Psychomotor Performance, Reaction Time, Linear Models
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