Episodic future thinking in amnesic mild cognitive impairment
Open accessAbstract
Results from behavioral studies of amnesic patients and neuroimaging studies of individuals with intact memory suggest that a brain system involving direct contributions from the medial temporal lobes supports both remembering the past and imagining the future (Episodic Future Thinking). In the present study, we investigated whether amnesic Mild Cognitive Impairment (aMCI) affects EFT. Amnesic MCI is a high-risk factor for Alzheimer's disease and is characterized by a selective impairment of episodic memory, likely reflecting hippocampal malfunctioning. The present study assessed, for the first time, whether the reduction of episodic specificity for past events, evident in aMCI patients, extends also to future events. We present data on 14 aMCI patients and 14 healthy controls, who mentally re-experienced and pre-experienced autobiographical episodes. Transcriptions were segmented into distinct details that were classified as either internal (episodic) or external (semantic). Results revealed that aMCI patients produced fewer episodic, event-specific details, and an increased number of semantic details for both past and future events, as compared to controls. These results are discussed with respect to the constructive episodic simulation hypothesis, which suggests that reminiscence and future thinking are the expression of the same neurocognitive system.
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The hypothesis that damage to episodic memory impairs future imagination has been confirmed in clinical cohorts including mild cognitive impairment, mild Alzheimer's disease, amnesic patients with medial temporal lobe damage, and developmental amnesia.
“This hypothesis has been confirmed in a number of clinical cohorts in which the capacity to remember the past is compromised, such as mild cognitive impairment (Gamboz et al., 2010), mild Alzheimer's disease (Addis et al., 2009b), amnesic patients with medial temporal lobe damage (Tulving, 1985;Hassabis et al., 2007b;Race et al., 2011) and developmental amnesia (Kwan et al., 2010).”
From Considering the role of semantic memory in episodic future thinking: evidence from semantic dementia (2012) · cites this paper as Gamboz et al., 2010
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- Authors
- Gamboz, N., De Vito, S., Brandimonte, M. A., Pappalardo, S., Galeone, F., Iavarone, A., & Sala, S. D.
- Affiliations
- Università degli Studi Suor Orsola Benincasa (IT)
- University of Naples Federico II (IT)
- University of Edinburgh (GB)
- Corresponding author
- Gamboz, Nadia
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 48
- Issue
- 7
- Pages
- 2091-2097
- ISSN
- 0028-3932 (ISSN-L)
- OpenAlex
- W2153109734
- Cited by
- 95
- References
- 52
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 11 · 2014: 8 · 2013: 7 · 2012: 11
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Developmental and Educational Psychology › Identity, Memory, and Therapy
- Keywords
- episodic future thinking, amnestic mild cognitive impairment, episodic memory, autobiographical memory, mental simulation, semantic memory, hippocampal dysfunction, Alzheimer's disease risk, medial temporal lobe
- MeSH terms
- Aged, Aged, 80 and over, Amnesia, Analysis of Variance, Cognition Disorders, Female, Humans, Male, Mental Status Schedule, Neuropsychological Tests, Mental Recall, Statistics as Topic, Temporal Lobe, Thinking
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