The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Controllable versus uncontrollable stressors bi-directionally modulate conditioned but not innate fear
Open accessAbstract
Fear conditioning and fear extinction play key roles in the development and treatment of anxiety-related disorders, yet there is little information concerning experiential variables that modulate these processes. Here we examined the impact of exposure to a stressor in a different environment on subsequent fear conditioning and extinction, and whether the degree of behavioral control that the subject has over the stressor is of importance. Rats received a session of either escapable (controllable) tail shock (ES), yoked inescapable (uncontrollable) tail shock (IS), or control treatment (home cage, HC) 7 days before fear conditioning in which a tone and foot shock were paired. Conditioning was measured 24 h later. In a second experiment rats received ES, IS or HC 24 h after contextual fear conditioning. Extinction then occurred every day beginning 7 days later until a criterion was reached. Spontaneous recovery of fear was assessed 14 days after extinction. IS potentiated fear conditioning when given before fear conditioning, and potentiated fear responding during extinction when given after conditioning. Importantly, ES potently interfered with later fear conditioning, decreased fear responding during fear extinction, and prevented spontaneous recovery of fear. Additionally, we examined if the activation of the ventral medial prefrontal cortex (mPFCv) by ES is critical for the protective effects of ES on later fear conditioning. Inactivation of the mPFCv with muscimol at the time of the initial experience with control prevented ES-induced reductions in later contextual and auditory fear conditioning. Finally, we explored if the protective effects of ES extended to an unconditioned fear stimulus, ferret odor. Unlike conditioned fear, prior ES increased the fear response to ferret odor to the same degree as did IS.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Prior rodent research has demonstrated that behavioral control over an aversive stimulus reduces Pavlovian threat responses, even when control is no longer possible, and involves the vmPFC and striatum (Baratta et al., 2007; Cain and LeDoux, 2007; Moscarello and LeDoux, 2013; Ramirez et al., 2015).”
From Active avoidance: Neural mechanisms and attenuation of pavlovian conditioned responding (2017) · cites this paper as Baratta et al., 2007
In the citing paper
“Our finding of a between-group difference in vmPFC BOLD signal during cue presentation in late Avoidance/Extinction and Retrieval (at an uncorrected threshold) is also consistent with the rodent literature suggesting a key role for the vmPFC in avoidance learning and its subsequent behavioral consequences (Baratta et al., 2007; Moscarello and LeDoux, 2013).”
From Active avoidance: Neural mechanisms and attenuation of pavlovian conditioned responding (2017) · cites this paper as Baratta et al., 2007
In the citing paper
“Research in rats has suggested that vmPFC activity may mediate the persistent effects of behavioral control on reduction of Pavlovian responses (Baratta et al., 2007; Moscarello and LeDoux, 2013).”
From Active avoidance: Neural mechanisms and attenuation of pavlovian conditioned responding (2017) · cites this paper as Baratta et al., 2007
Citations
Cites
Context and Behavioral Processes in Extinction: Table 1.
Bouton, M. E. (2004) · Learning & Memory · doi:10.1101/lm.78804 · Cited by 1,808
Charney, D. S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.195 · Cited by 1,605
Sesack, S. R., Deutch, A. Y., Roth, R. H., & Bunney, B. S. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902900205 · Cited by 1,568
Differential projections of the infralimbic and prelimbic cortex in the rat
Vertes, R. P. (2004) · Synapse · doi:10.1002/syn.10279 · Cited by 1,550
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428
Rauch, S. L., Shin, L. M., & Phelps, E. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.004 · Cited by 1,397
Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
SHIN, L. M., RAUCH, S. L., & PITMAN, R. K. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.007 · Cited by 1,203
The neuroanatomical and neurochemical basis of conditioned fear
Fendt, M., & Fanselow, M. S. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00016-0 · Cited by 1,092
Urry, H. L., van Reekum, C. M., Johnstone, T., Kalin, N. H., Thurow, M. E., Schaefer, H. S., Jackson, C. A., Frye, C. J., Greischar, L. L., Alexander, A. L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3215-05.2006 · Cited by 1,056
Amat, J., Baratta, M. V., Paul, E., Bland, S. T., Watkins, L. R., & Maier, S. F. (2005) · Nature Neuroscience · doi:10.1038/nn1399 · Cited by 931
Self-citationMineka, S., & Zinbarg, R. (2006) · American Psychologist · doi:10.1037/0003-066x.61.1.10 · Cited by 929
Quirk, G. J., Likhtik, E., Pelletier, J. G., & Paré, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08800.2003 · Cited by 927
Vertes, R. P. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.06.027 · Cited by 855
Bremner, J. D., Staib, L. H., Kaloupek, D. G., Southwick, S. M., Soufer, R., & Charney, D. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00297-2 · Cited by 727
Vidal-Gonzalez, I., Vidal-Gonzalez, B., Rauch, S. L., & Quirk, G. J. (2006) · Learning & Memory · doi:10.1101/lm.306106 · Cited by 705
Prefrontal involvement in the regulation of emotion: convergence of rat and human studies
Quirk, G. J., & Beer, J. S. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.07.004 · Cited by 701
McDonald, A. J., Mascagni, F., & Guo, L. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00417-3 · Cited by 689
Activity in Prelimbic Cortex Is Necessary for the Expression of Learned, But Not Innate, Fears
Corcoran, K. A., & Quirk, G. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5327-06.2007 · Cited by 639
Neural circuits and mechanisms involved in Pavlovian fear conditioning: A critical review
Kim, J. J., & Jung, M. W. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.06.005 · Cited by 636
Wilensky, A. E., Schafe, G. E., Kristensen, M. P., & LeDoux, J. E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4316-06.2006 · Cited by 533
Applying Learning Principles to the Treatment of Post‐Trauma Reactions
ROTHBAUM, B. O., & DAVIS, M. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1301.012 · Cited by 454
Stress-induced enhancement of fear learning: An animal model of posttraumatic stress disorder
Rau, V., DeCola, J. P., & Fanselow, M. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.010 · Cited by 452
Emotional Perseveration: An Update on Prefrontal-Amygdala Interactions in Fear ExtinctionPreprint
Sotres-Bayón, F., Bush, D. E. A., & LeDoux, J. E. (2004) · Learning & Memory · doi:10.1101/lm.79504 · Cited by 419
Inverse amygdala and medial prefrontal cortex responses to surprised faces
Kim, H., Somerville, L. H., Johnstone, T., Alexander, A. L., & Whalen, P. J. (2003) · NeuroReport · doi:10.1097/00001756-200312190-00006 · Cited by 359
Milad, M. R., Vidal-Gonzalez, I., & Quirk, G. J. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.2.389 · Cited by 354
An Inhibitory Interface Gates Impulse Traffic between the Input and Output Stations of the Amygdala
Royer, S., Martina, M., & Paré, D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-23-10575.1999 · Cited by 350
Rosenkranz, J. A., Moore, H., & Grace, A. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11054.2003 · Cited by 344
Synaptic Mechanisms of Associative Memory in the Amygdala
Maren, S. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.009 · Cited by 341
Fendt, M., Endres, T., & Apfelbach, R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00023.2003 · Cited by 278
Amat, J., Paul, E., Zarza, C., Watkins, L. R., & Maier, S. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3630-06.2006 · Cited by 249
Self-citationControllability and predictability in acquired motivation
Mineka, S., & Hendersen, R. W. (1985) · Annual Review of Psychology · doi:10.1146/annurev.ps.36.020185.002431 · Cited by 234
The role of the human amygdala in the production of conditioned fear responses
Knight, D. C., Nguyen, H. T., & Bandettini, P. A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.03.020 · Cited by 223
Infralimbic cortex activation increases c-fos expression in intercalated neurons of the amygdala
Berretta, S., Pantazopoulos, H., Caldera, M., Pantazopoulos, P., & Paré, D. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.020 · Cited by 223
Sümer, N., Karanci, A. N., Berument, S. K., & Güneş, H. (2005) · Journal of Traumatic Stress · doi:10.1002/jts.20032 · Cited by 214
Psychosocial treatment of posttraumatic stress disorder.
Foa, E. B. (2000) · PubMed · Cited by 210
Role of the Amygdala in Fear Extinction Measured with Potentiated Startle
DAVIS, M., WALKER, D. L., & MYERS, K. M. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07084.x · Cited by 152
Stressor controllability and the pituitary-adrenal system.
Maier, S. F., Ryan, S. M., Barksdale, C. M., & Kalin, N. H. (1986) · Behavioral Neuroscience · doi:10.1037//0735-7044.100.5.669 · Cited by 150
Self-citationFerret Odor as a Processive Stress Model in Rats: Neurochemical, Behavioral, and Endocrine Evidence.
Masini, C. V., Sauer, S., & Campeau, S. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.1.280 · Cited by 125
Self-citationPalyo, S. A., & Beck, G. J. (2005) · Pain · doi:10.1016/j.pain.2005.05.028 · Cited by 92
Helmreich, Watkins, Deak, Maier, Akil, & Watson (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00300.x · Cited by 73
Doerfler, L. A., Paraskos, J. A., & Piniarski, L. (2005) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200505000-00008 · Cited by 72
Non-associative defensive responses of rats to ferret odor
Masini, C. V., SAUER, S., WHITE, J., Day, H. E. W., & Campeau, S. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.044 · Cited by 57
Self-citationNeuroimaging and neurocircuitry in post-traumatic stress disorder: What is currently known?
Tanev, K. S. (2003) · Current Psychiatry Reports · doi:10.1007/s11920-003-0072-7 · Cited by 14
Cited by
Sorted by citations
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645
Learned helplessness at fifty: Insights from neuroscience.
Maier, S. F., & Seligman, M. E. P. (2016) · Psychological Review · doi:10.1037/rev0000033 · Cited by 1,031
“…medial striatum circuit DETECTS control, and because the prelimbic communicates with the infralimbic region of the ventromedial prefrontal cortex, Baratta et al. (2007) wondered whether the experience of control over an aversive event might reduce later fear in a different situation.”
BackgroundSelf-citationSex differences in anxiety and depression: circuits and mechanisms
Bangasser, D. A., & Cuarenta, A. (2021) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00513-0 · Cited by 479
Mineka, S., & Oehlberg, K. A. (2008) · Acta Psychologica · doi:10.1016/j.actpsy.2007.11.007 · Cited by 428
George, M. S., & Aston‐Jones, G. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.87 · Cited by 407
Metadata
- Authors
- Baratta, M. V., Christianson, J. P., Gomez, D. M., Zarza, C. M., Amat, J., Masini, C. V., Watkins, L. R., & Maier, S. F.
- Affiliations
- University of Colorado Boulder (US)
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 146
- Issue
- 4
- Pages
- 1495-1503
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC1978104
- OpenAlex
- W2078066808
- Cited by
- 156
- References
- 43
- Citations by year
- 2025: 4 · 2024: 9 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 10 · 2019: 11 · 2018: 8 · 2017: 14 · 2016: 7 · 2015: 9 · 2014: 10 · 2013: 9 · 2012: 7
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH050479, R37MH050479, MH 075213, F31MH075213, R01MH050479)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- fear conditioning, fear extinction, ventromedial prefrontal cortex, muscimol inactivation, contextual fear, auditory fear, innate fear, anxiety disorders
- MeSH terms
- Acoustic Stimulation, Analysis of Variance, Animals, Association Learning, Behavior, Animal, Conditioning, Classical, Electroshock, Escape Reaction, Extinction, Psychological, Fear, Helplessness, Learned, Male, Muscimol, Stress, Physiological, Rats, Sprague-Dawley, Prefrontal Cortex, GABA Agonists, Freezing Reaction, Cataleptic, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
