Cited by 97Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesGambling Behavior and Treatments

Increased impulsive behavior and risk proneness following lentivirus-mediated dopamine transporter over-expression in rats' nucleus accumbens

Adriani, W., Boyer, F., Gioiosa, L., Macrì, S., Dreyer, J.-L., Laviola, G.·2009·Neuroscience

Abstract

Multiple theories have been proposed for sensation seeking and vulnerability to impulse-control disorders [Zuckerman M, Kuhlman DM (2000) Personality and risk-taking: Common biosocial factors. J Pers 68:999-1029], and many of these rely on a dopamine system deficit. Available animal models reproduce only some behavioral symptoms and seem devoid of construct validity. We used lentivirus tools for over-expressing or silencing the dopamine transporter (DAT) and we evaluated the resulting behavioral profiles in terms of motivation and self-control. Wistar adult rats received stereotaxic inoculation of a lentivirus that allowed localized intra-accumbens delivery of a DAT gene enhancer/silencer, or the green fluorescent protein, GFP. These animals were studied for intolerance to delay, risk proneness and novelty seeking. As expected, controls shifted their demanding from a large reward toward a small one when the delivery of the former was increasingly delayed (or uncertain). Interestingly, in the absence of general locomotor effects, DAT over-expressing rats showed increased impulsivity (i.e. a more marked shift of demanding from the large/delayed toward the small/soon reward), and increased risk proneness (i.e. a less marked shift from the large/uncertain toward the small/sure reward), compared with controls. Rats with enhanced or silenced DAT expression did not show any significant preference for a novel environment. In summary, consistent with literature on comorbidity between attention-deficit/hyperactivity disorder and pathological gambling, we demonstrate that DAT over-expression in rats' nucleus accumbens leads to impulsive and risk prone phenotype. Thus, a reduced dopaminergic tone following altered accumbal DAT function may subserve a sensation-seeker phenotype and the vulnerability to impulse-control disorders.

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Crossref · 10.1016/j.neuroscience.2008.11.042

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Authors
Adriani, W., Boyer, F., Gioiosa, L., Macrì, S., Dreyer, J.-L., & Laviola, G.
Affiliations
  • Istituto Superiore di Sanità (IT)
  • University of Fribourg (CH)
Venue
Neuroscience
Publisher
Elsevier BV
Published
2009-03
Volume
159
Issue
1
Pages
47-58
ISSN
0306-4522 (ISSN-L)
OpenAlex
W1994298252
Cited by
97
References
76
Citations by year
2026: 2 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 8 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 10
FWCI
3.17
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • reroDoc Digital Library (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Keywords
dopamine transporter, nucleus accumbens, impulsivity, sensation seeking, novelty seeking, delay discounting, risk-taking, self-control, attention deficit hyperactivity disorder, gambling addiction, dopaminergic tone, gene silencing
MeSH terms
Analysis of Variance, Animals, Choice Behavior, Conditioning, Operant, Exploratory Behavior, Gene Expression Regulation, Impulsive Behavior, Male, Mutation, Nucleus Accumbens, Probability, Reward, Risk-Taking, RNA, Messenger, Statistics as Topic, Lentivirus, Rats, Wistar, RNA, Small Interfering, Green Fluorescent Proteins, Dopamine Plasma Membrane Transport Proteins, Rats

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