Dopaminergic and GABA‐ergic markers of impulsivity in rats: evidence for anatomical localisation in ventral striatum and prefrontal cortex
Abstract
Accumulating evidence indicates that impulsivity, in its multiple forms, involves cortical and subcortical mechanisms and abnormal dopamine (DA) transmission. Although decreased DA D2/D3 receptor availability in the nucleus accumbens (NA cb) predicts trait‐like impulsivity in rats it is unclear whether this neurochemical marker extends to both the NA cb core (NA cbC) and shell (NA cbS) and whether markers for other neurotransmitter systems implicated in impulsivity such as serotonin (5‐HT), endogenous opioids and γ‐amino‐butyric acid (GABA) are likewise altered in impulsive rats. We therefore used autoradiography to investigate DA transporter (DAT), 5‐HT transporter (5‐HTT) and D 1, D 2/D 3, μ‐opioid and GABA(A) receptor binding in selected regions of the prefrontal cortex and striatum in rats expressing low and high impulsive behaviour on the five‐choice serial reaction‐time task. High‐impulsive (HI) rats exhibited significantly lower binding for DAT and D 2/D 3 receptors in the NA cbS and for D 1 receptors in the NA cbC compared with low‐impulsive (LI) rats. HI rats also showed significantly lower GABA(A) receptor binding in the anterior cingulate cortex. For all regions where receptor binding was altered in HI rats, binding was inversely correlated with impulsive responding on task. There were no significant differences in binding for 5‐HTT or μ‐opioid receptors in any of the regions investigated. These results indicate that altered D 2/D 3 receptor binding is localised to the NA cbS of trait‐like impulsive rats and is accompanied by reduced binding for DAT. Alterations in binding for D 1 receptors in the NA cbC and GABA(A) receptors in the anterior cingulate cortex demonstrate additional markers and putative mechanisms underlying the expression of behavioural impulsivity.
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D2 receptor availability is reduced in the nucleus accumbens of impulsive rats.
“Using PET and autoradiography, previous studies have shown that D2 receptor availability is reduced in the nucleus accumbens of impulsive rats (Dalley et al., 2007; Jupp et al., 2013; Caprioli et al., 2013).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Jupp et al., 2013
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- Authors
- Jupp, B., Caprioli, D., Saigal, N., Reverte, I., Shrestha, S., Cumming, P., Everitt, B. J., Robbins, T. W., & Dalley, J. W.
- Affiliations
- The University of Melbourne (AU)
- University of Cambridge (GB)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- National Institutes of Health (US)
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Dalley, Jeffrey W.
- ORCID
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2013-02
- Volume
- 37
- Issue
- 9
- Pages
- 1519-1528
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2139885605
- Semantic Scholar
- f432e7bc51a7d93798107a38cb389ea60487a2bd
- Cited by
- 109
- References
- 75
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 9 · 2018: 11 · 2017: 6 · 2016: 11 · 2015: 13 · 2014: 12 · 2013: 10
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- impulsivity, dopamine D2/D3 receptors, dopamine transporter, nucleus accumbens shell, nucleus accumbens core, ventral striatum, prefrontal cortex, anterior cingulate cortex, GABAA receptor, serotonin transporter, mu-opioid receptor, 5-choice serial reaction time task, trait impulsivity, receptor binding
- MeSH terms
- Animals, Corpus Striatum, Impulsive Behavior, Ligands, Male, Protein Binding, Radionuclide Imaging, Reaction Time, Receptors, Dopamine, Receptors, GABA-A, Prefrontal Cortex, Dopamine Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins, Rats
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