Cited by 204Gut microbiota and healthMaternal Mental Health During Pregnancy and PostpartumChild Abuse and Trauma

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Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

O’Mahony, S.M., Clarke, G., Dinan, T.G., Cryan, J.F.·2017·Neuroscience

DOI 10.1016/j.neuroscience.2015.09.068

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Abstract

The prenatal and postnatal early-life periods are both dynamic and vulnerable windows for brain development. During these important neurodevelopmental phases, essential processes and structures are established. Exposure to adverse events that interfere with this critical sequence of events confers a high risk for the subsequent emergence of mental illness later in life. It is increasingly accepted that the gastrointestinal microbiota contributes substantially to shaping the development of the central nervous system. Conversely, several studies have shown that early-life events can also impact on this gut community. Due to the bidirectional communication between the gut and the brain, it is possible that aberrant situations affecting either organ in early life can impact on the other. Studies have now shown that deviations from the gold standard trajectory of gut microbiota establishment and development in early life can lead not only to disorders of the gastrointestinal tract but also complex metabolic and immune disorders. These are being extended to disorders of the central nervous system and understanding how the gut microbiome shapes brain and behavior during early life is an important new frontier in neuroscience.

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Items 201–296 of 296

Review article: modulation of the brain–gut axis as a therapeutic approach in gastrointestinal disease
Mayer, E. A., Tillisch, K., & Bradesi, S. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03078.x · Cited by 139
Friends with social benefits: host-microbe interactions as a driver of brain evolution and development?
Stilling, R. M., Bordenstein, S. R., Dinan, T. G., & Cryan, J. F. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00147 · Cited by 139
Self-citation
Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1Preprint
Koçak, H., Ballew, B. J., Bisht, K. K., Eggebeen, R., Hicks, B. D., Suman, S., O’Neil, A., Giri, N., NCI DCEG Cancer Sequencing Working Group, Maillard, I. P., et al. (2014) · Genes & Development · doi:10.1101/gad.248567.114 · Cited by 138
Neurobiological Bases of Behavioral Development in the First Year
HERSCHKOWITZ, N. N., Kagan, J., & Zilles, K. (1997) · Neuropediatrics · doi:10.1055/s-2007-973720 · Cited by 138
Parental Obesity and Risk of Autism Spectrum Disorder
Surén, P., Gunnes, N., Roth, C., Bresnahan, M. A., Hornig, M., Hirtz, D., Lie, K. K., Lipkin, W. I., Magnus, P. M., Reichborn-Kjennerud, T., et al. (2014) · PEDIATRICS · doi:10.1542/peds.2013-3664 · Cited by 137
Early adrenalectomy stimulates subsequent growth and development of the rat brain
Meyer, J. S. (1983) · Experimental Neurology · doi:10.1016/0014-4886(83)90415-6 · Cited by 136
The gut microbiota and mucosal homeostasis: Colonized at birth or at adulthood, does it matter?
El Aidy, S., Hooiveld, G., Tremaroli, V., Bäckhed, F., & Kleerebezem, M. (2013) · Gut Microbes · doi:10.4161/gmic.23362 · Cited by 131
Early experience and cross‐generational continuity of mother‐infant contact in vervet monkeys
Fairbanks, L. A. (1989) · Developmental Psychobiology · doi:10.1002/dev.420220703 · Cited by 131
Enriched environment treatment restores impaired hippocampal synaptic plasticity and cognitive deficits induced by prenatal chronic stress
Yang, J., Hou, C., Ma, N., Liu, J., Zhang, Y., Zhou, J., Xu, L., & Li, L. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.09.001 · Cited by 127
Impaired Executive Function Mediates the Association between Maternal Pre-Pregnancy Body Mass Index and Child ADHD Symptoms
Buß, C., Entringer, S., Davis, E. P., Hobel, C. J., Swanson, J. M., Wadhwa, P. D., & Sandman, C. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037758 · Cited by 126
Use of Probiotics in Pediatrics: Rationale, Mechanisms of Action, and Practical Aspects
Saavedra, J. M. (2007) · Nutrition in Clinical Practice · doi:10.1177/0115426507022003351 · Cited by 125
Correction for Prematurity and Its Consequences for the Assessment of the Very Low Birth Weight Infant
Siegel, L. S. (1983) · Child Development · doi:10.2307/1129673 · Cited by 124
The individual-specific and diverse nature of the preterm infant microbiota
Barrett, E., Kerr, C., Murphy, K., O'Sullivan, O., Ryan, C. A., Dempsey, E. M., Murphy, B. P., O'Toole, P. W., Cotter, P. D., Fitzgerald, G. F., et al. (2013) · Archives of Disease in Childhood - Fetal and Neonatal Edition · doi:10.1136/archdischild-2012-303035 · Cited by 120
More than just a gut instinct–the potential interplay between a baby's nutrition, its gut microbiome, and the epigenome
Mischke, M., & Plösch, T. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00551.2012 · Cited by 120
A sustained hypothalamic–pituitary–adrenal axis response to acute psychosocial stress in irritable bowel syndrome
Kennedy, P. J., Cryan, J. F., Quigley, E. M. M., Dinan, T. G., & Clarke, G. (2014) · Psychological Medicine · doi:10.1017/s003329171400052x · Cited by 120
Self-citation
Neuroimmune and neuroendocrine abnormalities in depression: two sides of the same coin
Horowitz, M. A., & Zunszain, P. A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12781 · Cited by 119
Maternal Prepregnancy Body Mass Index and Child Psychosocial Development at 6 Years of Age
Jo, H., Schieve, L. A., Sharma, A. J., Hinkle, S. N., Li, R., & Lind, J. N. (2015) · PEDIATRICS · doi:10.1542/peds.2014-3058 · Cited by 115
The microbiota link to irritable bowel syndrome
Jeffery, I. B., Quigley, E. M. M., Öhman, L., Simrén, M., & O’Toole, P. W. (2012) · Gut Microbes · doi:10.4161/gmic.21772 · Cited by 114
Correction for prematurity and its consequences for the assessment of the very low birth weight infant.
Siegel, L. S. (1983) · PubMed · Cited by 113
Prenatal maternal stress from a natural disaster predicts dermatoglyphic asymmetry in humans
King, S., Mancini-Marı̈e, A., Brunet, A., Walker, E. F., Meaney, M. J., & Laplante, D. P. (2009) · Development and Psychopathology · doi:10.1017/s0954579409000364 · Cited by 112
Newborns of mothers with depressive symptoms are less expressive
Lundy, B. L., Field, T. M., & Pickens, J. N. (1996) · Infant Behavior and Development · doi:10.1016/s0163-6383(96)90003-x · Cited by 111
A Nationwide Study on the Risk of Autism After Prenatal Stress Exposure to Maternal Bereavement
Li, J., Vestergaard, M., Obel, C., Christensen, J., Precht, D. H., Lu, M., & Olsen, J. (2009) · PEDIATRICS · doi:10.1542/peds.2008-1734 · Cited by 111
Maternal obesity and increased risk for autism and developmental delay among very preterm infants
Reynolds, L. C., Inder, T. E., Neil, J. J., Pineda, R. G., & Rogers, C. E. (2014) · Journal of Perinatology · doi:10.1038/jp.2014.80 · Cited by 110
Relations between recurrent trauma exposure and recent life stress and salivary cortisol among children
Bevans, K., Cerbone, A., & Overstreet, S. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000126 · Cited by 110
The effects of prenatal stress on learning in adult offspring is dependent on the timing of the stressor
Kapoor, A., Kostaki, A., Janus, C., & Matthews, S. G. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.08.018 · Cited by 109
Prenatal exposure to noise stress: Anxiety, impaired spatial memory, and deteriorated hippocampal plasticity in postnatal life
Barzegar, M., Sajjadi, F. S., Talaei, S. A., Hamidi, G. A., & Salami, M. (2014) · Hippocampus · doi:10.1002/hipo.22363 · Cited by 108
The autonomic nervous system in functional bowel disorders
Tougas, G. H. (2000) · Gut · doi:10.1136/gut.47.suppl_4.iv78 · Cited by 107
Maternal Prenatal Weight Gain and Autism Spectrum Disorders
Bilder, D. A., Bakian, A. V., Viskochil, J., Clark, E., Botts, E. L., Smith, K. R., Pimentel, R., McMahon, W. M., & Coon, H. H. (2013) · PEDIATRICS · doi:10.1542/peds.2013-1188 · Cited by 107
Epigenetics of Autism-related Impairment: Copy Number Variation and Maternal Infection
Mazina, V., Gerdts, J., Trinh, S., Ankenman, K., Ward, T., Dennis, M. Y., Girirajan, S., Eichler, E. E., & Bernier, R. (2015) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000126 · Cited by 101
Cesarean delivery is associated with an increased risk of obesity in adulthood in a Brazilian birth cohort study
Goldani, H. A., Bettiol, H., Barbieri, M. A., da Sílva, A. A. M., Agranonik, M., de Morais, M. B., & Goldani, M. Z. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.010033 · Cited by 101
The origins of health and disease: the influence of maternal diseases and lifestyle during gestation
Capra, L., Tezza, G., Mazzei, F., & Boner, A. L. (2013) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/1824-7288-39-7 · Cited by 100
Corticotropin-releasing hormone and the hypothalamic–pituitary–adrenal axis in psychiatric disease
Naughton, M., Dinan, T. G., & Scott, L. V. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-59602-4.00005-8 · Cited by 97
Self-citation
Integrating Neuroscience and Psychological Approaches in the Study of Early Experiences
Gunnar, M. R. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1301.024 · Cited by 97
Desipramine treatment reduces the long-term behavioural and neurochemical sequelae of early-life maternal separation
MacQueen, G. M., Ramakrishnan, K., Ratnasingan, R., Chen, B., & Young, L. T. (2003) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145703003729 · Cited by 96
Fermented foods, neuroticism, and social anxiety: An interaction model
Hilimire, M. R., DeVylder, J., & Forestell, C. A. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.04.023 · Cited by 96
Infantile experience and the maturation of the pituitary adrenal axis
Levine, S., Alpert, M., & Lewis, G. W. (1957) · Science · doi:10.1126/science.126.3287.1347 · Cited by 95
The pathways from mother's love to baby's future
Kőrösi, A. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.027.2009 · Cited by 95
Latent Effects of Prenatal Malnutrition on Adult Health
Susser, E., Clair, D. S., & He, L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1425.024 · Cited by 93
The Ups and Downs of Modelling Mood Disorders in Rodents
Slattery, D. A., & Cryan, J. F. (2014) · ILAR Journal · doi:10.1093/ilar/ilu026 · Cited by 92
Self-citation
Spatial and temporal variability of the human microbiota
Parfrey, L. W., & Knight, R. D. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2012.03861.x · Cited by 89
Fetal programming of schizophrenia: Select mechanisms
Debnath, M., Venkatasubramanian, G., & Berk, M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.003 · Cited by 89
A population-based study of the risk of schizophrenia and bipolar disorder associated with parent–child separation during development
Paksarian, D., Eaton, W. W., Mortensen, P. B., Merikangas, K. R., & Pedersen, C. B. (2015) · Psychological Medicine · doi:10.1017/s0033291715000781 · Cited by 88
Gene–Environment Interactions and Intermediate Phenotypes: Early Trauma and Depression
Hornung, O. P., & Heim, C. C. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00014 · Cited by 85
Gestational Stress Leads to Depressive-Like Behavioural and Immunological Changes in the Rat
O’Mahony, S. M., Myint, A.-M., van den Hove, D., Desbonnet, L., Steinbusch, H. W. M., & Leonard, B. E. (2006) · NeuroImmunoModulation · doi:10.1159/000096090 · Cited by 83
Self-citation
Neonatal maternal separation in the rat impacts on the stress responsivity of central corticotropin-releasing factor receptors in adulthood
O’Malley, D., Dinan, T. G., & Cryan, J. F. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1885-9 · Cited by 82
Self-citation
Mode of Delivery and Early Nutrition Modulate Microbial Colonization and Fermentation Products in Neonatal Piglets
Wang, M., Radlowski, E. C., Monaco, M. H., Fahey, G. C., Jr., Gaskins, H. R., & Donovan, S. M. (2013) · Journal of Nutrition · doi:10.3945/jn.112.173096 · Cited by 80
Long-term neuroendocrine effects of childhood maltreatment
Sjöberg, R. L. (2000) · JAMA · doi:10.1001/jama.284.18.2317 · Cited by 79
n-3 PUFAs have beneficial effects on anxiety and cognition in female rats: Effects of early life stress
Pusceddu, M. M., Kelly, P. M., Ariffin, N., Cryan, J. F., Clarke, G. A., & Dinan, T. G. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.04.015 · Cited by 79
Self-citation
The infant intestinal microbiome: Friend or foe?
Mshvildadze, M., & Neu, J. (2010) · Early Human Development · doi:10.1016/j.earlhumdev.2010.01.018 · Cited by 77
Maternal Recall of Pregnancy History: Accuracy and Bias in Schizophrenia Research
Buka, S. L., Goldstein, J. M., Seidman, L. J., & Tsuang, M. T. (2000) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033457 · Cited by 77
Early-life stress induces visceral hypersensitivity in mice
Moloney, R. D., O’Leary, O. F., Felice, D., Bettler, B., Dinan, T. G., & Cryan, J. F. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.01.066 · Cited by 75
Self-citation
Antibiotic exposure in the first year of life and later treated asthma, a population based birth cohort study of 143,000 children
Pitter, G., Ludvigsson, J. F., Romor, P., Zanier, L., Zanotti, R., Simonato, L., & Canova, C. (2015) · European Journal of Epidemiology · doi:10.1007/s10654-015-0038-1 · Cited by 74
Neonatal handling permanently alters hypothalamic-pituitary- adrenal axis function, behaviour, and body weight in boars
Weaver, S., AHERNE, F. X., Meaney, M., Schaefer, A. L., & Dixon, W. T. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1640349 · Cited by 71
Obesity in pregnancy
Sirimi, N., & Goulis, D. G. (2010) · HORMONES · doi:10.14310/horm.2002.1280 · Cited by 68
ADRENOCORTICAL FUNCTION AND THE MEASUREMENT OF “EMOTIONALITY”*
Ader, R. (1969) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1969.tb12979.x · Cited by 67
Stress and the healthy adolescent brain: Evidence for the neural embedding of life events
Ganzel, B. L., Kim, P., Gilmore, H. M., Tottenham, N., & Temple, E. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000242 · Cited by 66
Prenatal Infection and Autism Spectrum Disorders in Childhood: A Population‐Based Case–Control Study in T aiwan
Fang, S., Wang, S. Z., Huang, N., Yeh, H.-H. H., & Chen, C. (2015) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12194 · Cited by 64
The Autonomic Nervous System in Functional Bowel Disorders
Tougas, G. H. (1999) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/1999/707105 · Cited by 64
Primate Early Life Stress Leads to Long-Term Mild Hippocampal Decreases in Corticosteroid Receptor Expression
Arabadzisz, D., Heijtz, R. D., Knuesel, I., Weber, E., Pilloud, S., Dettling, A. C., Feldon, J., Law, A. J., Harrison, P. J., & Pryce, C. R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.016 · Cited by 61
Towards translational rodent models of depression
O’Leary, O. F., & Cryan, J. F. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1587-9 · Cited by 60
Self-citation
The duration and timing of maternal depression as a moderator of the relationship between dependent interpersonal stress, contextual risk and early child dysregulation
Barker, E. D. (2012) · Psychological Medicine · doi:10.1017/s0033291712002450 · Cited by 59
Impact of Genetic Vulnerability and Hypoxia on Overall Intelligence by Age 7 in Offspring at High Risk for Schizophrenia Compared With Affective Psychoses
Goldstein, J. M., Seidman, L. J., Buka, S. L., Horton, N. J., Donatelli, J.-A. L., Rieder, R. O., & Tsuang, M. T. (2000) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033456 · Cited by 59
It's a gut feeling: How the gut microbiota affects the state of mind
Farmer, A. D., Randall, H. A., & Aziz, Q. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.270389 · Cited by 58
Cesarean Section Is Associated with Increased Peripheral and Central Adiposity in Young Adulthood: Cohort Study
Mesquita, D. N., Barbieri, M. A., Goldani, H. A. S., Cardoso, V. C., Goldani, M. Z., Kac, G., da Sílva, A. A. M., & Bettiol, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066827 · Cited by 58
Parenteral Antibiotics Reduce Bifidobacteria Colonization and Diversity in Neonates
Hussey, S., Wall, R., Gruffman, E., O’Sullivan, L., Ryan, C. A., Murphy, B. P., Fitzgerald, G., Stanton, C., & Ross, R. P. (2010) · International Journal of Microbiology · doi:10.1155/2011/130574 · Cited by 54
Gender differences in the association between body mass index and psychopathology
Desai, R. A., Manley, M. J., Desai, M. M., & Potenza, M. (2009) · CNS Spectrums · doi:10.1017/s1092852900023026 · Cited by 52
Gnotobiotics
Williams, S. C. P. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1324049111 · Cited by 52
Preventing mental health problems in offspring by targeting dietary intake of pregnant women
O'Neil, A., Itsiopoulos, C., Skouteris, H., Opie, R. S., McPhie, S., Hill, B., & Jacka, F. N. (2014) · BMC Medicine · doi:10.1186/s12916-014-0208-0 · Cited by 51
Intestinal dysbiosis: An emerging cause of pregnancy complications?
Zhang, D., Huang, Y., & Ye, D. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2014.12.029 · Cited by 50
Early‐life stress increases the survival of midbrain neurons during postnatal development and enhances reward‐related and anxiolytic‐like behaviors in a sex‐dependent fashion
Chocyk, A., Majcher‐Maślanka, I., Przyborowska, A., Maćkowiak, M., & Wędzony, K. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.05.002 · Cited by 45
Early‐life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain–gut axis dysfunction
Hyland, N. P., O’Mahony, S. M., O’Malley, D., O'Mahony, C. M., Dinan, T. G., & Cryan, J. F. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12486 · Cited by 45
Self-citation
CSF Corticotropin-Releasing Factor in Personality Disorder: Relationship with Self-Reported Parental Care
Lee, R. J., Gollan, J., Kasckow, J., Geracioti, T., & Coccaro, E. F. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301104 · Cited by 44
The brain’s Geppetto—microbes as puppeteers of neural function and behaviour?
Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2015) · Journal of NeuroVirology · doi:10.1007/s13365-015-0355-x · Cited by 41
Self-citation
A Longitudinal Study of the Intelligence and Behavior of Preterm and Small for Gestational Age Children
Silva, P. A., McGee, R. O., & Williams, S. (1984) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-198402000-00001 · Cited by 38
Adolescent Brain Vulnerability and Psychopathology Through the Generations: Role of Diet and Dopamine
O’Connor, R. M., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.022 · Cited by 38
Self-citation
Impact of early-life stress, on group III mGlu receptor levels in the rat hippocampus: Effects of ketamine, electroconvulsive shock therapy and fluoxetine treatment
Connor, R. M. O., Pusceddu, M. M., Dinan, T. G., & Cryan, J. F. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.006 · Cited by 38
Self-citation
Differential activation of the prefrontal cortex and amygdala following psychological stress and colorectal distension in the maternally separated rat
Felice, V. D., Gibney, S. M., Gosselin, R., Dinan, T. G., O’Mahony, S. M., & Cryan, J. F. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.064 · Cited by 37
Self-citation
Host Demise as a Beneficial Function of Indigenous Microbiota in Human Hosts
Blaser, M. J., & Webb, G. F. (2014) · mBio · doi:10.1128/mbio.02262-14 · Cited by 37
Depression in Pregnancy and the Postpartum Period: Balancing Adverse Effects of Untreated Illness with Treatment Risks
Mian, A. I. (2005) · Journal of Psychiatric Practice · doi:10.1097/00131746-200511000-00005 · Cited by 35
Behavioral adjustment in children of diabetic mothers
Rizzo, T., Silverman, B., Metzger, B., & Cho, N. (1997) · Acta Paediatrica · doi:10.1111/j.1651-2227.1997.tb15181.x · Cited by 33
Do alcohol use disorders impact on long term outcomes from intensive care?
McPeake, J. M., Shaw, M., O’Neill, A., Forrest, E. H., Puxty, A., Quasim, T., & Kinsella, J. (2015) · Critical Care · doi:10.1186/s13054-015-0909-6 · Cited by 30
Persistent systemic monocyte and neutrophil activation in neonatal encephalopathy
O'Hare, F. M., Watson, R. W. G., O’Neill, A., Blanco, A., Donoghue, V. B., & Molloy, E. J. (2015) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2015.1012060 · Cited by 29
Influence of Glucocorticoids on Prenatal Development of the Gut and Pancreas in Rats
Majumdar, A. P. N., & Nielsen, H. S. (1985) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528509089634 · Cited by 27
Anticipation of public speaking and sleep and the hypothalamic‐pituitary‐adrenal axis in women with irritable bowel syndrome
Heitkemper, M. M., Cain, K. C., Deechakawan, W., Poppe, A., Jun, S., Burr, R. L., & Jarrett, M. E. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01915.x · Cited by 26
The effects of pre-natal-, early-life- and indirectly-initiated exposures to maximum adversities on the course of schizophrenia
Levine, S. Z., Levav, I., Yoffe, R., & Pugachova, I. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.07.003 · Cited by 26
Prenatal Stress Enhances Excitatory Synaptic Transmission and Impairs Long-Term Potentiation in the Frontal Cortex of Adult Offspring Rats
Sowa, J. E., Bobula, B., Głombik, K., Ślusarczyk, J., Basta‐Kaim, A., & Hess, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119407 · Cited by 25
Regulation of body fat mass by the gut microbiota: Possible mediation by the brain
Schéle, E., Grahnemo, L., Anesten, F., Hallén, A., Bäckhed, F., & Jansson, J. (2015) · Peptides · doi:10.1016/j.peptides.2015.03.027 · Cited by 25
Longitudinal symptom course in adults with recurrent depression: Impact on impairment and risk of psychopathology in offspring
Mars, B., Collishaw, S., Hammerton, G., Rice, F. J., Harold, G. T., Smıth, D. J., Jones, R. B., Sellers, R., Potter, R., Craddock, N., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.04.018 · Cited by 25
Diurnal cortisol rhythm: Associated with anxiety and depression, or just an indication of lack of energy?
Harris, A., Rème, S. E., Tangen, T., Hansen, Å. M., Garde, A. H., & Eriksen, H. R. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.04.006 · Cited by 22
Gut microbes and health
Lupp, C., Skipper, M., & Weiss, U. K. (2012) · Nature · doi:10.1038/489219a · Cited by 22
Maternal exposure to sexually transmitted infections and schizophrenia among offspring
Cheslack‐Postava, K., Brown, A. S., Chudal, R., Suominen, A., Huttunen, J., Surcel, H., & Sourander, A. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.05.012 · Cited by 20
The changing hypothesis of the gut
Hunter, P. (2012) · EMBO Reports · doi:10.1038/embor.2012.68 · Cited by 15
Complete Genome Sequence of Bifidobacterium breve CECT 7263, a Strain Isolated from Human Milk
Jiménez, E., Villar-Tajadura, M. A., Marín, M., Fontecha, J., Requena, T., Arroyo, R., Fernández, L., & Rodríguez, J. M. (2012) · Journal of Bacteriology · doi:10.1128/jb.00691-12 · Cited by 13
Persistent systemic monocyte and neutrophil activation in neonatal encephalopathy
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Authors: O’Mahony, S. M., Clarke, G., Dinan, T. G., & Cryan, J. F.
Affiliations: University College Cork (IE)
Corresponding author: O’Mahony, S.M.
Cryan, J.F.
ORCID: O’Mahony, S.M.
Clarke, G.
Dinan, T.G.
Cryan, J.F.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2017-02
Volume: 342
Pages: 37-54
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2015.09.068
OpenAlex: W2218048576
Cited by: 203
References: 298
Citations by year: 2026: 13 · 2025: 10 · 2024: 20 · 2023: 17 · 2022: 20 · 2021: 30 · 2020: 20 · 2019: 18 · 2018: 16 · 2017: 18
FWCI: 1.78
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: childhood adversity, brain development, gut microbiota, gut-brain axis, prenatal exposure, postnatal development, mental illness risk, central nervous system development, behavior
MeSH terms: Gastrointestinal Microbiome, Animals, Brain, Female, Humans, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological

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Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

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