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Stressor controllability modulates fear extinction in humans
Open accessAbstract
Traumatic events are proposed to play a role in the development of anxiety disorders, however not all individuals exposed to extreme stress experience a pathological increase in fear. Recent studies in animal models suggest that the degree to which one is able to control an aversive experience is a critical factor determining its behavioral consequences. In this study, we examined whether stressor controllability modulates subsequent conditioned fear expression in humans. Participants were randomly assigned to an escapable stressor condition, a yoked inescapable stressor condition, or a control condition involving no stress exposure. One week later, all participants underwent fear conditioning, fear extinction, and a test of extinction retrieval the following day. Participants exposed to inescapable stress showed impaired fear extinction learning and increased fear expression the following day. In contrast, escapable stress improved fear extinction and prevented the spontaneous recovery of fear. Consistent with the bidirectional controllability effects previously reported in animal models, these results suggest that one's degree of control over aversive experiences may be an important factor influencing the development of psychological resilience or vulnerability in humans.
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“However, in order to persistently diminish threat conditioned responses in humans, avoidance actions need to be learned through trial and error and there needs to be a subjective sense of control over the unconditioned stimulus during learning [115].”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [115]
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“A small experimental literature on avoidance in humans and a large clinical literature have yielded conflicting findings regarding whether avoidance attenuates threat responses or patients' fear.”
From Active avoidance: Neural mechanisms and attenuation of pavlovian conditioned responding (2017) · cites this paper as Hartley et al., 2014
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“In humans, there is evidence that both avoidance learning and history with escapable shock can persistently reduce conditioned threat actions as measured with SCR, even when no avoidance action is available [114, 115].”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [115]
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“Consistent with the results of experiments in rodents discussed above, some studies in humans (Hartley et al., 2014; C. A. Hartley, C. A. Coelho, E. A. Boeke, F. Ramirez, and E. A. Phelps, unpublished observations) have found that learning to prevent shocks eliminated spontaneous recovery.”
From Active avoidance: Neural mechanisms and attenuation of pavlovian conditioned responding (2017) · cites this paper as Hartley et al., 2014
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“Translation of this research to humans has been limited (Collins et al., 2014; Hartley et al., 2014).”
From Active avoidance: Neural mechanisms and attenuation of pavlovian conditioned responding (2017) · cites this paper as Hartley et al., 2014
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“However, a previous study observed similar behavioral effects without any differential instruction between groups (Hartley et al., 2014).”
From Active avoidance: Neural mechanisms and attenuation of pavlovian conditioned responding (2017) · cites this paper as Hartley et al., 2014
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Citations
Cites
Generalized expectancies for internal versus external control of reinforcement.
Rotter, J. B. (1966) · Psychological Monographs: General and Applied · doi:10.1037/h0092976 · Cited by 21,937
Failure to escape traumatic shock.
Seligman, M. E., & Maier, S. F. (1967) · Journal of Experimental Psychology · doi:10.1037/h0024514 · Cited by 1,981 · cited 4×
“…over an aversive experience, or the ability to influence its intensity, duration, onset, or termination, has long been recognized as a critical factor determining its behavioral and physiological impact on an organism (Brady, 1958; Mineka & Hendersen, 1985; Rotter, 1966; Seligman & Maier, 1967).”
InfluentialDawson, M. E., Schell, A. M., Filion, D. L., & Berntson, G. G. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546396.007 · Cited by 1,776
Locus of control: Current trends in theory and research
Lefcourt, H. M. (1976) · Medical Entomology and Zoology · Cited by 1,750
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645
Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress
Milad, M. R., & Quirk, G. J. (2012) · Annual Review of Psychology · doi:10.1146/annurev.psych.121208.131631 · Cited by 1,466
Sierra-Mercado, D., Padilla-Coreano, N., & Quirk, G. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.184 · Cited by 1,190
Classical fear-conditioning in the anxiety disorders: a meta-analysis
Lissek, S., Powers, A. S., McClure, E. B., Phelps, E. A., Woldehawariat, G., Grillon, C., & Pine, D. S. (2005) · Behaviour Research and Therapy · doi:10.1016/j.brat.2004.10.007 · Cited by 1,034
Self-citationAmat, J., Baratta, M. V., Paul, E., Bland, S. T., Watkins, L. R., & Maier, S. F. (2005) · Nature Neuroscience · doi:10.1038/nn1399 · Cited by 931
Mineka, S., & Zinbarg, R. (2006) · American Psychologist · doi:10.1037/0003-066x.61.1.10 · Cited by 929
Maier, S. F., & Watkins, L. R. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.021 · Cited by 737
Clinical Implications of Neuroscience Research in PTSD
van der Kolk, B. A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.022 · Cited by 525
Peyron, C., Petit, J.-M., Rampon, C., Jouvet, M., & Luppi, P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00268-6 · Cited by 509
Stress-induced enhancement of fear learning: An animal model of posttraumatic stress disorder
Rau, V., DeCola, J. P., & Fanselow, M. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.010 · Cited by 452
Amorapanth, P., LeDoux, J. E., & Nader, K. (2000) · Nature Neuroscience · doi:10.1038/71145 · Cited by 374
Role of the medial prefrontal cortex in coping and resilience
Maier, S. F., & Watkins, L. R. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.039 · Cited by 292
Active Avoidance Learning Requires Prefrontal Suppression of Amygdala-Mediated Defensive Reactions
Moscarello, J. M., & LeDoux, J. E. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2596-12.2013 · Cited by 277
The Internal Control Index: A Newly Developed Measure of Locus of Control
Duttweiler, P. C. (1984) · Educational and Psychological Measurement · doi:10.1177/0013164484442004 · Cited by 269
Amat, J., Paul, E., Zarza, C., Watkins, L. R., & Maier, S. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3630-06.2006 · Cited by 249
A call to action: overcoming anxiety through active coping.
LeDoux, J. E., & Gorman, J. M. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.12.1953 · Cited by 238
Controllability and predictability in acquired motivation
Mineka, S., & Hendersen, R. W. (1985) · Annual Review of Psychology · doi:10.1146/annurev.ps.36.020185.002431 · Cited by 234 · cited 1×
“…over an aversive experience, or the ability to influence its intensity, duration, onset, or termination, has long been recognized as a critical factor determining its behavioral and physiological impact on an organism (Brady, 1958; Mineka & Hendersen, 1985; Rotter, 1966; Seligman & Maier, 1967).”
Amat, J., Matus-Amat, P., Watkins, L. R., & Maier, S. F. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00960-3 · Cited by 222
Brady, J. V. (1958) · Scientific American · doi:10.1038/scientificamerican1058-95 · Cited by 190
Maier, S. F., Grahn, R. E., Kalman, B. A., Sutton, L. C., Wiertelak, E. P., & Watkins, L. R. (1993) · Behavioral Neuroscience · doi:10.1037//0735-7044.107.2.377 · Cited by 177
Early life experience alters behavior during social defeat: Focus on serotonergic systems
Gardner, K. L., Thrivikraman, K. V., Lightman, S. L., Plotsky, P. M., & Lowry, C. A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.042 · Cited by 169
Maier, S. F., Grahn, R. E., & Watkins, L. R. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.3.404 · Cited by 167
Baratta, M. V., Christianson, J. P., Gomez, D. M., Zarza, C. M., Amat, J., Masini, C. V., Watkins, L. R., & Maier, S. F. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.042 · Cited by 156
Amat, J., Paul, E., Watkins, L. R., & Maier, S. F. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.005 · Cited by 153
Mineka, S., Gunnar, M. R., & Champoux, M. (1986) · Child Development · doi:10.2307/1130447 · Cited by 152
A Bayesian formulation of behavioral control
Huys, Q. J. M., & Dayan, P. (2009) · Cognition · doi:10.1016/j.cognition.2009.01.008 · Cited by 150
Baratta, M. V., Zarza, C. M., Gomez, D. M., Campeau, S., Watkins, L. R., & Maier, S. F. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06867.x · Cited by 106
Behavioral control over shock blocks behavioral and neurochemical effects of later social defeat
Amat, J., Aleksejev, R. M., Paul, E., Watkins, L. R., & Maier, S. F. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.005 · Cited by 101
Transituational immunization and therapy of learned helplessness in the rat.
Williams, J. L., & Maier, S. F. (1977) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.3.3.240 · Cited by 101
Goodkin, F. (1976) · Learning and Motivation · doi:10.1016/0023-9690(76)90044-8 · Cited by 92
Cain, C. K., & LeDoux, J. E. (2007) · Journal of Experimental Psychology: Animal Behavior Processes · doi:10.1037/0097-7403.33.4.451 · Cited by 72
Control of Their Environment Reduces Emotionality in Rats
Joffe, J. M., Rawson, R. A., & Mulick, J. A. (1973) · Science · doi:10.1126/science.180.4093.1383 · Cited by 66
Environmental Contingencies as Sources of Stress in Animals
Overmier, J. B., Patterson, J., & Wielkiewicz, R. M. (1980) · Springer eBooks · doi:10.1007/978-1-4684-1042-6_1 · Cited by 60
Baratta, M. V., Lucero, T. R., Amat, J., Watkins, L. R., & Maier, S. F. (2008) · Learning & Memory · doi:10.1101/lm.800308 · Cited by 58
Depression in an Animal Model: Focus on the Locus Ceruleus
Weiss, J. M., & Simson, P. G. (2007) · Novartis Foundation symposium · doi:10.1002/9780470513361.ch11 · Cited by 50
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Cited by
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Phelps, E. A., Lempert, K. M., & Sokol‐Hessner, P. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014119 · Cited by 482
Self-citationMaren, S., & Holmes, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.180 · Cited by 412
Prefrontal cortex, amygdala, and threat processing: implications for PTSD
Alexandra Kredlow, M., Fenster, R. J., Laurent, E. S., Ressler, K. J., & Phelps, E. A. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01155-7 · Cited by 346
“In humans, there is evidence that both avoidance learning and history with escapable shock can persistently reduce conditioned threat actions as measured with SCR, even when no avoidance action is available [114, 115].”
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Grahek, I., Shenhav, A., Musslick, S., Krebs, R. M., & Koster, E. H. W. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.011 · Cited by 389
Dunsmoor, J. E., Niv, Y., Daw, N., & Phelps, E. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.028 · Cited by 329
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Metadata
- Authors
- Hartley, C. A., Gorun, A., Reddan, M. C., Ramirez, F., & Phelps, E. A.
- Affiliations
- Weill Cornell Medicine (US)
- New York University (US)
- Icahn School of Medicine at Mount Sinai (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Phelps, Elizabeth A.
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 113
- Pages
- 149-156
- ISSN
- 1074-7427 (ISSN-L)
- PMC
- PMC4053478
- OpenAlex
- W2004180496
- Cited by
- 110
- References
- 39
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 12 · 2023: 10 · 2022: 9 · 2021: 15 · 2020: 9 · 2019: 9 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 4
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Science Foundation
- National Institute of Mental Health (R01MH080756, R01MH097085, MH 080756, MH062104, R01MH062104)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- stressor controllability, fear extinction, inescapable stress, fear conditioning, anxiety disorders, psychological resilience, trauma exposure, extinction retrieval
- MeSH terms
- Adolescent, Adult, Avoidance Learning, Conditioning, Classical, Extinction, Psychological, Fear, Female, Humans, Male, Middle Aged, Random Allocation, Stress, Psychological, Young Adult
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