The interaction between the dopaminergic forebrain projections and the medial prefrontal cortex is critical for memory of objects: implications for Parkinson’s disease
Abstract
Neuropsychological and neuroimaging studies have implicated the dopaminergic nigrostriatal pathway and the prefrontal cortex in learning and memory deficits in patients with Parkinson's disease. However, little is known about how these two brain regions interact in the processing of learning and memory. We employed a disconnection procedure to test whether interaction of these regions contributes to performance in various memory tasks. Male rats received either a unilateral injection of 6-hydroxydopamine into the nigro-striatal tract or a unilateral NMDA lesion in the medial prefrontal cortex, or both these lesions combined in either the same or opposite hemispheres. Spontaneous object exploration, spatial working memory, locomotor, emotional and sensorimotor tests were administered. Only the group with both lesions placed in opposite hemispheres failed to show object recognition memory. None of the groups treated with 6-hydroxydopamine showed intact temporal order memory, whereas only the groups that received combined lesions failed to show object-in-place and spatial recognition memory. No differences between groups were found in the spatial working memory test. Our data indicate that locomotor, emotional and sensorimotor factors are not likely to confound the results of the memory tests. Thus, the interaction between the dopaminergic forebrain projections, particularly the nigrostriatal dopamine, and the medial prefrontal cortex is critical for object recognition memory but not for spatial working memory in rats.
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A unilateral PFC lesion combined with midbrain DAergic deficiency in the unilateral hemisphere impairs NOP (90 min interval) if lesions are in different hemispheres, but not when in the same hemisphere.
“A unilateral PFC lesion combined with a midbrain DAergic systems deficiency in the unilateral hemisphere, impaired NOP (90 min interval) if the lesions were in different hemispheres, but not when they were in the same hemisphere.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Chao et al., 2013
The same disconnected lesions do not influence spatial working memory tested by a T-maze non-matching to place task.
“The same disconnected lesions did not influence spatial working memory tested by a T-maze non-matching to place task (Chao et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Chao et al., 2013
Rats with unilateral DA deficiency also show deficits in the TOM test.
“Interestingly, the rat with the unilateral DA deficiency also showed deficits in the TOM test, suggestive of a relationship between “time”, DA systems and PFC/hippocampus functions (Chao et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Chao et al., 2013
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- Authors
- Chao, O. Y.-H., Pum, M. E., & Huston, J. P.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Corresponding author
- Huston, Joseph P.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 247
- Pages
- 373-382
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W1996475191
- Cited by
- 39
- References
- 92
- Citations by year
- 2024: 2 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 7 · 2013: 2
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Forschungskommission of the Medical Faculty of the University of Duesseldorf
- ERA-Net NEURON
- German Academic Exchange Service (DAAD)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- Parkinson's disease, medial prefrontal cortex, nigrostriatal pathway, 6-hydroxydopamine lesion, NMDA lesions, object recognition memory, spatial working memory, temporal order memory, learning and memory impairment
- MeSH terms
- Animals, Body Weight, Dark Adaptation, Dopamine, Exploratory Behavior, Functional Laterality, Male, Medial Forebrain Bundle, Memory, Neural Pathways, Psychomotor Performance, Serotonin, Space Perception, Sympatholytics, N-Methylaspartate, Oxidopamine, Rats, Wistar, Prefrontal Cortex, Excitatory Amino Acid Agonists, Hand Strength, Maze Learning, Recognition, Psychology, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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