Astrocyte–neuron interplay in maladaptive plasticity.

Papa, Michele; De Luca, Ciro; Petta, Federica; Alberghina, Lilia; Cirillo, Giovanni

doi:10.1016/j.neubiorev.2014.01.010

Cited by 104Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchPain Mechanisms and Treatments

Astrocyte–neuron interplay in maladaptive plasticity.

Papa, Michele, De Luca, Ciro, Petta, Federica, Alberghina, Lilia, Cirillo, Giovanni·2014·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2014.01.010

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Abstract

The complexity of neuronal networks cannot only be explained by neuronal activity so neurobiological research in the last decade has focused on different components of the central nervous system: the glia. Glial cells are fundamental elements for development and maintenance of physiological brain work. New data confirm that glia significantly influences neuronal communication through specific molecules, named "gliotransmitters", and their related receptors. This new approach to the traditional model of the way synapses work is also supported by changes occurring in pathological conditions, such as neurodegenerative diseases or toxic/traumatic injury to nervous system. Experimental models have revealed that glial cells are the starting point of damage progression that subsequently involves neurons. The "bedside to bench" approach has demonstrated that clinical phenotypes are strictly related to neuronal death, however it is conceivable that the disease begins earlier, years before clinical onset. This temporal gap is necessary to determine complex changes in the neuro-glial network organization and produce a "maladaptive plasticity". We review the function of glial cells in health and disease, pointing the putative mechanisms of maladaptive plasticity, suggesting that glial cells may represent a fascinating therapeutic target to prevent irreversible neuronal cell death.

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366 · see citing works
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244 · see citing works
The Classical Complement Cascade Mediates CNS Synapse Elimination
Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313 · see citing works
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
Mangiarini, L., Sathasivam, K., Seller, M., Cozens, B., Harper, A., Hetherington, C., Lawton, M., Trottier, Y., Lehrach, H., Davies, S. W., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81369-0 · Cited by 3,073 · see citing works
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.
Shah, M. A., Datson, N. A., Srinidhi, L., Stanton, V. P., MacDonald, M. E., Allard, M. W., Youngman, S., Am, F., Mott, R., Draths, K., et al. (1993) · Cell · Cited by 3,055 · see citing works
Transcriptional regulation by the phosphorylation-dependent factor CREB
Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587 · see citing works
Genomic analysis of reactive astrogliosis
Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6221-11.2012 · Cited by 2,404 · see citing works
Tripartite synapses: astrocytes process and control synaptic information
Perea, G., Navarrete, M., & Araque, A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.05.001 · Cited by 1,820 · see citing works
Astrocytes, from brain glue to communication elements: the revolution continues
Volterra, A., & Meldolesi, J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1722 · Cited by 1,763 · see citing works
Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1
Tanaka, K., Watase, K., Manabe, T., Yamada, K., Watanabe, M., Takahashi, K., Iwama, H., Nishikawa, T., Ichihara, N., Kikuchi, T., et al. (1997) · Science · doi:10.1126/science.276.5319.1699 · Cited by 1,755 · see citing works
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688 · see citing works
Resting Microglia Directly Monitor the Functional State of Synapses <i>In Vivo</i> and Determine the Fate of Ischemic Terminals
Wake, H., Moorhouse, A. J., Jinno, S., Kohsaka, S., & Nabekura, J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4363-08.2009 · Cited by 1,619 · see citing works
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
Rothstein, J. D., Patel, S., Regan, M. R., Haenggeli, C., Huang, Y. H., Bergles, D. E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D. S., et al. (2005) · Nature · doi:10.1038/nature03180 · Cited by 1,518 · see citing works
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495 · see citing works
Uniquely Hominid Features of Adult Human Astrocytes
Oberheim, N. A., Takano, T., Han, X., He, W., Lin, J. H. C., Wang, F., Xu, Q., Wyatt, J. D., Pilcher, W., Ojemann, J. G., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4707-08.2009 · Cited by 1,488 · see citing works
Pathological and protective roles of glia in chronic pain
Milligan, E. D., & Watkins, L. R. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2533 · Cited by 1,404 · see citing works
Control of Synapse Number by Glia
Ullian, E. M., Sapperstein, S. K., Christopherson, K. S., & Barres, B. A. (2001) · Science · doi:10.1126/science.291.5504.657 · Cited by 1,380 · see citing works
Control of Synaptic Strength by Glial TNFα
Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344 · see citing works
Astrocyte Control of Synaptic Transmission and Neurovascular Coupling
Haydon, P. G., & Carmignoto, G. (2006) · Physiological Reviews · doi:10.1152/physrev.00049.2005 · Cited by 1,326 · see citing works
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
Tuszynski, M. H., Thal, L., Pay, M., Salmon, D. P., U, H. S., Bakay, R., Patel, P., Blesch, A., Vahlsing, H. L., Ho, G., et al. (2005) · Nature Medicine · doi:10.1038/nm1239 · Cited by 1,050 · see citing works
Microglia and neuroinflammation: a pathological perspective
Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039 · see citing works
Emerging roles of astrocytes in neural circuit development
Clarke, L. E., & Barres, B. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3484 · Cited by 975 · see citing works
CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity
Bezzi, P., Domercq, M., Brambilla, L., Galli, R., Schols, D., De Clercq, E., Vescovi, A., Bagetta, G., Kollias, G., Meldolesi, J., et al. (2001) · Nature Neuroscience · doi:10.1038/89490 · Cited by 964 · see citing works
Multicolor and Electron Microscopic Imaging of Connexin Trafficking
Gaietta, G. M., Deerinck, T. J., Adams, S., Bouwer, J. C., Tour, O., Laird, D. W., Sosinsky, G. E., Tsien, R. Y., & Ellisman, M. H. (2002) · Science · doi:10.1126/science.1068793 · Cited by 909 · see citing works
Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies
Lee, H.-J., Suk, J.-E., Patrick, C., Bae, E.-J., Cho, J.-H., Rho, S., Hwang, D., Masliah, E., & Lee, S.-J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081125 · Cited by 877 · see citing works
A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death
Saijo, K., Winner, B., Carson, C. T., Collier, J. G., Boyer, L., Rosenfeld, M. G., Gage, F. H., & Glass, C. K. (2009) · Cell · doi:10.1016/j.cell.2009.01.038 · Cited by 859 · see citing works
Purinergic signalling in neuron–glia interactions
Fields, R. D., & Burnstock, G. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1928 · Cited by 852 · see citing works
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1
Herrero-Mendez, A., Almeida, A., Fernández, E., Maestre, C., Moncada, S., & Bolaños, J. P. (2009) · Nature Cell Biology · doi:10.1038/ncb1881 · Cited by 844 · see citing works
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
Howland, D., Liu, J., She, Y., Goad, B., Maragakis, N. J., Kim, B. B., Erickson, J., Kulik, J., DeVito, L., Psaltis, G. C., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032539299 · Cited by 841 · see citing works
Mechanisms of Disease: astrocytes in neurodegenerative disease
Maragakis, N., & Rothstein, J. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0355 · Cited by 834 · see citing works
Supply and demand in cerebral energy metabolism: the role of nutrient transporters
Simpson, I. A., Carruthers, A., & Vannucci, S. J. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600521 · Cited by 812 · see citing works
An astrocytic basis of epilepsy
Tian, G.-F., Azmi, H., Takano, T., Xu, Q., Peng, W., Lin, J., Oberheim, N., Lou, N., Wang, X., Zielke, H. R., et al. (2005) · Nature Medicine · doi:10.1038/nm1277 · Cited by 806 · see citing works
Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation
Ramírez, B. G., Blázquez, C., del Pulgar, T. G., Guzmán, M., & CEBALLOS, M. L. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4540-04.2005 · Cited by 785 · see citing works
Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis
Lee, J., Calkins, M. J., Chan, K., Kan, Y. W., & Johnson, J. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211558200 · Cited by 783 · see citing works
Connexins regulate calcium signaling by controlling ATP release
Cotrina, M. L., Lin, J. H.-C., Alves‐Rodrigues, A., Liu, S., Li, J., Azmi, H., Kang, J., Naus, C. C. G., & Nedergaard, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15735 · Cited by 773 · see citing works
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors
Allen, N. J., Bennett, M. L., Foo, L. C., Wang, G. X., Chakraborty, C., Smith, S. J., & Barres, B. A. (2012) · Nature · doi:10.1038/nature11059 · Cited by 764 · see citing works
Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression
Griffin, W., Sheng, J. G., Royston, M., Gentleman, S., McKenzie, J., Graham, D. I., Roberts, G., & Mrak, R. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00136.x · Cited by 751 · see citing works
GLIA: A novel drug discovery target for clinical pain
Watkins, L. R., & Maier, S. F. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1251 · Cited by 674 · see citing works
Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus
Seri, B., García‐Verdugo, J. M., Collado-Morente, L., McEwen, B. S., & Álvarez-Buylla, A. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20288 · Cited by 628 · see citing works
Conditional Knock-Out of K ir 4.1 Leads to Glial Membrane Depolarization, Inhibition of Potassium and Glutamate Uptake, and Enhanced Short-Term Synaptic Potentiation
Djukic, B., Casper, K. B., Philpot, B. D., Chin, L., & McCarthy, K. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0723-07.2007 · Cited by 623 · see citing works
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
Talantova, M., Sanz-Blasco, S., Zhang, X., Xia, P., Akhtar, M. W., Okamoto, S.-I., Dziewczapolski, G., Nakamura, T., Cao, G., Pratt, A. E., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306832110 · Cited by 600 · see citing works
Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll‐like receptor‐mediated neuronal injury
Lehnardt, S. (2009) · Glia · doi:10.1002/glia.20928 · Cited by 596 · see citing works
SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat
Burright, E. N., Clark, H. B., Servadio, A., Matilla‐Dueñas, A., Feddersen, R. M., Yunis, W. S., Duvick, L. A., Zoghbi, H. Y., & Orr, H. T. (1995) · Cell · doi:10.1016/0092-8674(95)90273-2 · Cited by 596 · see citing works
The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention
Sheldon, A. L., & Robinson, M. B. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.03.012 · Cited by 593 · see citing works
Synthesis of the Antioxidant Glutathione in Neurons: Supply by Astrocytes of CysGly as Precursor for Neuronal Glutathione
Dringen, R., Pfeiffer, B., & Hamprecht, B. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00562.1999 · Cited by 589 · see citing works
Glial cells in (patho)physiology
Parpura, V., Heneka, M. T., Montana, V., Oliet, S. H. R., Schousboe, A., Haydon, P. G., Stout, R. F., Spray, D. C., Reichenbach, A., Pannicke, T., et al. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07664.x · Cited by 561 · see citing works
Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity
Frischknecht, R., Heine, M., Perrais, D., Seidenbecher, C. I., Choquet, D., & Gundelfinger, E. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2338 · Cited by 554 · see citing works
Aquaporin-4 in the central nervous system: Cellular and subcellular distribution and coexpression with KIR4.1
Nagelhus, E. A., Mathiisen, T. M., & Ottersen, O. P. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.053 · Cited by 513 · see citing works
cAMP Response Element-Mediated Gene Transcription Is Upregulated by Chronic Antidepressant Treatment
Thome, J., Sakai, N., Shin, K.-H., Steffen, C., Zhang, Y.-J., Impey, S., Storm, D. R., & Duman, R. S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04030.2000 · Cited by 507 · see citing works
Neurotrophic factors in Alzheimer’s and Parkinson’s disease brain
Siegel, G. J., & Chauhan, N. B. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00030-8 · Cited by 492 · see citing works
Storage and Release of ATP from Astrocytes in Culture
Coco, S., Calegari, F., Pravettoni, E., Pozzi, D., Taverna, E., Rosa, P., Matteoli, M., & Verderio, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209454200 · Cited by 492 · see citing works
Neuron-Specific Expression of Mutant Superoxide Dismutase 1 in Transgenic Mice Does Not Lead to Motor Impairment
Pramatarova, A., Laganière, J., Roussel, J., Brisebois, K., & Rouleau, G. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03369.2001 · Cited by 482 · see citing works
Astrocytes in Alzheimer's Disease
Verkhratsky, A., Olabarria, M., Noristani, H. N., Yeh, C., & Rodriguez, J. J. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.017 · Cited by 453 · see citing works
The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects
Kanai, Y., & Hediger, M. A. (2004) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-003-1146-4 · Cited by 450 · see citing works
Astrocytes and the regulation of cerebral blood flow
Koehler, R. C., Roman, R. J., & Harder, D. R. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.11.005 · Cited by 439 · see citing works
Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease
Lobsiger, C. S., & Cleveland, D. W. (2007) · Nature Neuroscience · doi:10.1038/nn1988 · Cited by 438 · see citing works
Targeting adenosine A2A receptors in Parkinson's disease
Schwarzschild, M. A., Agnati, L. F., Fuxé, K., Chen, J., & Morelli, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.09.004 · Cited by 433 · see citing works
Increased glutathione S -transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease
Whitworth, A. J., Theodore, D. A., Greene, J. C., Beneš, H., Wes, P. D., & Pallanck, L. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501078102 · Cited by 421 · see citing works
The neuropoietic cytokine family in development, plasticity, disease and injury
Bauer, Š., Kerr, B. J., & Patterson, P. H. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2054 · Cited by 412 · see citing works
Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease
Wang, X., Zhu, S., Drozda, M., Zhang, W., Stavrovskaya, I. G., Cattaneo, E. F., Ferrante, R. J., Kristal, B. S., & Friedlander, R. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1832501100 · Cited by 407 · see citing works
Altered Expression and Uptake Activity of Spinal Glutamate Transporters after Nerve Injury Contribute to the Pathogenesis of Neuropathic Pain in Rats
Sung, B., Lim, G., & Mao, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02899.2003 · Cited by 398 · see citing works
Role of Excitatory Amino Acid Transporter‐2 (EAAT2) and glutamate in neurodegeneration: Opportunities for developing novel therapeutics
Kim, K., Lee, S., Kegelman, T. P., Su, Z.-Z., Das, S. K., Dash, R., Dasgupta, S., Barral, P. M., Hedvat, M., Diaz, P. W., et al. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22609 · Cited by 396 · see citing works
Age-associated increases of α-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
Chu, Y., & Kordower, J. H. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.08.021 · Cited by 396 · see citing works
Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons
Kadkhodaei, B., Ito, T., Joodmardi, E., Mattsson, B., Rouillard, C., Carta, M., Muramatsu, S.-I., Sumi-Ichinose, C., Nomura, T., Metzger, D., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3910-09.2009 · Cited by 382 · see citing works
Identification and characterization of the gene causing type 1 spinocerebellar ataxia
Banfi, S., Servadio, A., Chung, M., Kwiatkowski, T. J., McCall, A. E., Duvick, L. A., Shen, Y. H., Dahle, E. J., Orr, H. T., & Zoghbi, H. Y. (1994) · Nature Genetics · doi:10.1038/ng0894-513 · Cited by 373 · see citing works
Cell Signaling and the Genesis of Neuropathic Pain
Ji, R., & Strichartz, G. R. (2004) · Science s STKE · doi:10.1126/stke.2522004re14 · Cited by 371 · see citing works
Gliotransmission: Exocytotic release from astrocytes
Parpura, V., & Zorec, R. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.11.008 · Cited by 367 · see citing works
Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms
Bradford, J. W., Shin, J., Redd, M. A., Wang, C.-E., Li, X.-J., & Li, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911503106 · Cited by 362 · see citing works
BDNF as a pain modulator
Merighi, A., Salio, C., Ghirri, A., Lossi, L., Ferrini, F., Betelli, C., & Bardoni, R. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.04.004 · Cited by 356 · see citing works
Interleukin-1, neuroinflammation, and Alzheimer's disease
Mrak, R. E. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00287-1 · Cited by 356 · see citing works
MANF: A New Mesencephalic, Astrocyte-Derived Neurotrophic Factor with Selectivity for Dopaminergic Neurons
Petrova, P. S., Raibekas, A. A., Pevsner, J., Vigo, N. T., Anafi, M., Moore, M. K., Peaire, A. E., Shridhar, V., Smith, D. I., Kelly, J., et al. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:20:2:173 · Cited by 353 · see citing works
Inflammation and neurodegenerative diseases
Griffin, W. S. T. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.470s · Cited by 351 · see citing works
Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade
Bruno, M. A., & Cuello, A. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510645103 · Cited by 344 · see citing works
IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype
Masuda, T., Tsuda, M., Yoshinaga, R., Tozaki-Saitoh, H., Ozato, K., Tamura, T., & Inoue, K. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.02.014 · Cited by 338 · see citing works
A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis
Barbeito, L., Pehar, M., Cassina, P., Vargas, M. R., Peluffo, H., Viera, L., Estévez, Á. G., & Beckman, J. S. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.05.003 · Cited by 331 · see citing works
Research in motion: the enigma of Parkinson's disease pathology spread
Brundin, P., Li, J., Holton, J. L., Lindvall, O., & Révész, T. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2477 · Cited by 328 · see citing works
Vesicular transmitter release from astrocytes
Montana, V., Malarkey, E. B., Verderio, C., Matteoli, M., & Parpura, V. (2006) · Glia · doi:10.1002/glia.20367 · Cited by 325 · see citing works
Functional implications for Kir4.1 channels in glial biology: from K <sup>+</sup> buffering to cell differentiation
Olsen, M. L., & Sontheimer, H. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05615.x · Cited by 323 · see citing works
Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis
Vercelli, A., Mereuta, O., Garbossa, D., Muraca, G., Mareschi, K., Rustichelli, D., Ferrero, I., Mazzini, L., Madon, E., & Fagioli, F. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.016 · Cited by 310 · see citing works
Identification of Astrocyte-expressed Factors That Modulate Neural Stem/Progenitor Cell Differentiation
Barkho, B. Z., Song, H., Aimone, J. B., Smrt, R. D., Kuwabara, T., Nakashima, K., Gage, F. H., & Zhao, X. (2006) · Stem Cells and Development · doi:10.1089/scd.2006.15.407 · Cited by 303 · see citing works
Glial Glutamate Transporters Mediate a Functional Metabolic Crosstalk between Neurons and Astrocytes in the Mouse Developing Cortex
Voutsinos‐Porche, B., Bonvento, G., Tanaka, K., Steiner, P., Welker, E., Chatton, J., Magistretti, P. J., & Pellerin, L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01170-4 · Cited by 293 · see citing works
Extracellular metabolites in the cortex and hippocampus of epileptic patients
Çavuş, I., Kasoff, W. S., Cassaday, M. P., Jacob, R. J., Gueorguieva, R. V., Sherwin, R. S., Krystal, J. H., Spencer, D. D., & Abi‐Saab, W. (2005) · Annals of Neurology · doi:10.1002/ana.20380 · Cited by 292 · see citing works
The Nrf2–ARE cytoprotective pathway in astrocytes
Vargas, M. R., & Johnson, J. A. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409001094 · Cited by 289 · see citing works
Extracellular mutant SOD1 induces microglial‐mediated motoneuron injury
Zhao, W., Beers, D. R., Henkel, J. S., Zhang, W., Urushitani, M., Julien, J., & Appel, S. H. (2010) · Glia · doi:10.1002/glia.20919 · Cited by 288 · see citing works
MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology
Mallajosyula, J. K., Kaur, D., Chinta, S. J., Rajagopalan, S., Rane, A., Nicholls, D. G., Monte, D. A. D., Macarthur, H., & Andersen, J. K. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001616 · Cited by 287 · see citing works
Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: a reappraisal using a new HPLC method with coulometric detection in a large cohort of patients
Spreux‐Varoquaux, O., Bensimon, G., Lacomblez, L., et al. (2002) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(01)00661-x · Cited by 284 · see citing works
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport
Filosa, A., Paixão, S., Honsek, S. D., Carmona, M. A., Becker, L., Feddersen, B., Gaitanos, L., Rudhard, Y., Schoepfer, R., Klopstock, T., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2394 · Cited by 283 · see citing works
Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse
Miller, B. R., Dorner, J. L., Shou, M., Sari, Y., Barton, S. J., Sengelaub, D. R., Kennedy, R. T., & Rebec, G. V. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.004 · Cited by 280 · see citing works
Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors
Lavialle, M., Aumann, G., Anlauf, E., Pröls, F., Arpin, M., & Derouiche, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100957108 · Cited by 267 · see citing works
Reactive astrogliosis of the spinal cord in amyotrophic lateral sclerosis
Schiffer, D., Cordera, S., Cavalla, P., & Migheli, A. (1996) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(96)00073-1 · Cited by 255 · see citing works
Stress, Depression and Hippocampal Apoptosis
Lucassen, P. J., Heine, V. M., Müller, M. B., van der Beek, E. M., Wiegant, V. M., de Kloet, E. R., Joëls, M., Fuchs, E., Swaab, D. F., & Czéh, B. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706778559273 · Cited by 253 · see citing works
Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1
Fumagalli, E. R., Funicello, M., Rauen, T., Gobbi, M., & Mennini, T. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.10.023 · Cited by 248 · see citing works
Neurological Diseases as Primary Gliopathies: A Reassessment of Neurocentrism
Verkhratsky, A., Sofroniew, M. V., Messing, A., deLanerolle, N. C., Rempe, D. A., Rodriguez, J. J., & Nedergaard, M. (2012) · ASN NEURO · doi:10.1042/an20120010 · Cited by 247 · see citing works
Synthetic cannabinoid WIN55,212‐2 inhibits generation of inflammatory mediators by IL‐1β‐stimulated human astrocytes
Sheng, W. S., Hu, S., Min, X. M., Cabral, G. A., Lokensgard, J. R., & Peterson, P. K. (2004) · Glia · doi:10.1002/glia.20108 · Cited by 246 · see citing works
Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport
Custer, S. K., Garden, G. A., Gill, N., Rueb, U., Libby, R. T., Schultz, C., Guyenet, S. J., Deller, T., Westrum, L. E., Sopher, B. L., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1750 · Cited by 240 · see citing works
A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease
Hsiao, H., Chen, Y., Chen, H., Tu, P., & Chern, Y. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt036 · Cited by 238 · see citing works
Early‐onset Parkinson's disease caused by a compound heterozygous DJ‐1 mutation
Hague, S., Rogaeva, E. A., Hernandez, D. G., Gulick, C., Singleton, A., Hanson, M., Johnson, J. O., Weiser, R., Gallardo, M., Ravina, B. M., et al. (2003) · Annals of Neurology · doi:10.1002/ana.10663 · Cited by 237 · see citing works
Microglial activation with atypical proinflammatory cytokine expression in a rat model of Parkinson's disease
Depino, A. M., Earl, C. D., Kaczmarczyk, E., Ferrari, C. C., Besedovsky, H. O., del Rey, A., Pitossi, F. J., & Oertel, W. H. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03014.x · Cited by 237 · see citing works
Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research
Morris, G. P., Clark, I. A., Zinn, R., & Vissel, B. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.002 · Cited by 236 · see citing works
Nervenkitt: Notes on the history of the concept of neuroglia
Somjen, G. G. (1988) · Glia · doi:10.1002/glia.440010103 · Cited by 230 · see citing works
Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis
Pehar, M., Cassina, P., Vargas, M. R., Castellanos, R., Viera, L., Beckman, J. S., Estévez, Á. G., & Barbeito, L. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02357.x · Cited by 228 · see citing works
Like cops on the beat: the active role of resting microglia
Raivich, G. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.09.001 · Cited by 225 · see citing works
Astrocyte-Mediated Distributed Plasticity at Hypothalamic Glutamate Synapses
Gordon, G. R., Iremonger, K. J., Kantevari, S., Ellis‐Davies, G. C. R., MacVicar, B. A., & Bains, J. S. (2009) · Neuron · doi:10.1016/j.neuron.2009.10.021 · Cited by 225 · see citing works
Overexpression of Adenosine Kinase in Epileptic Hippocampus Contributes to Epileptogenesis
Gouder, N., Scheurer, L., Fritschy, J., & Boison, D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4781-03.2004 · Cited by 224 · see citing works
Adenosine and Epilepsy: From Therapeutic Rationale to New Therapeutic Strategies
Boison, D. (2005) · The Neuroscientist · doi:10.1177/1073858404269112 · Cited by 217 · see citing works
Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
Damme, P. V., Bogaert, E., Dewil, M., Hersmus, N., Kiraly, D., Scheveneels, W., Bockx, I., Braeken, D., Verpoorten, N., Verhoeven, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705046104 · Cited by 216 · see citing works
Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease
Peskind, E. R., Griffin, W. S. T., Akama, K. T., Raskind, M. A., & Eldik, L. J. V. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00048-1 · Cited by 215 · see citing works
The genetics of Parkinson's syndromes: a critical review
Hardy, J., Lewis, P. A., Révész, T., Lees, A. J., & Paisán‐Ruiz, C. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.03.008 · Cited by 210 · see citing works
Glutathione and Parkinson's disease: Is this the elephant in the room?
Zeevalk, G. D., Razmpour, R., & Bernard, L. P. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.01.017 · Cited by 209 · see citing works
Nitric oxide induces rapid, calcium‐dependent release of vesicular glutamate and ATP from cultured rat astrocytes
Bal‐Price, A., Moneer, Z., & Brown, G. C. (2002) · Glia · doi:10.1002/glia.10124 · Cited by 204 · see citing works
Astroglia in Medullary Dorsal Horn (Trigeminal Spinal Subnucleus Caudalis) Are Involved in Trigeminal Neuropathic Pain Mechanisms
Okada‐Ogawa, A., Suzuki, I., Sessle, B. J., Chiang, C., Salter, M. W., Dostrovsky, J. O., Tsuboi, Y., Kondo, M., Kitagawa, J., Kobayashi, A., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3365-09.2009 · Cited by 203 · see citing works
Loss of GABAergic Interneurons in Laminae I–III of the Spinal Cord Dorsal Horn Contributes to Reduced GABAergic Tone and Neuropathic Pain after Spinal Cord Injury
Meisner, J. G., Marsh, A. D., & Marsh, D. R. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2009.1166 · Cited by 198 · see citing works
Circulating levels of tumour necrosis factor-α and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis
Poloni, M., Facchetti, D., Mai, R., Micheli, A., Agnoletti, L., Francolini, G., Mora, G., Camana, C., Mazzini, L., & Bachetti, T. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01177-0 · Cited by 197 · see citing works
Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes
Basak, J. M., Verghese, P. B., Yoon, H., Kim, J., & Holtzman, D. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.288746 · Cited by 192 · see citing works
Lack of the Kir4.1 Channel Subunit Abolishes K + Buffering Properties of Astrocytes in the Ventral Respiratory Group: Impact on Extracellular K + Regulation
Neusch, C., Papadopoulos, N., Müller, M., Maletzki, I., Winter, S. M., Hirrlinger, J., Handschuh, M., Bähr, M., Richter, D. W., Kirchhoff, F., et al. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00996.2005 · Cited by 192 · see citing works
Thalidomide and Lenalidomide Extend Survival in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Kiaei, M., Petri, S., Kipiani, K., Gardian, G., Choi, D., Chen, J., Calingasan, N. Y., Schafer, P. H., Muller, G. W., Stewart, C. A., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5253-05.2006 · Cited by 183 · see citing works
Astrocytes and human cognition: Modeling information integration and modulation of neuronal activity.
Pereira, A., & Furlan, F. A. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.07.001 · Cited by 177 · see citing works
Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes
Bergami, M., Santi, S., Formaggio, E., Cagnoli, C. M., Verderio, C., Blum, R., Berninger, B., Matteoli, M., & Canossa, M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200806137 · Cited by 173 · see citing works
Mechanisms of Oxidative Glutamate Toxicity: The Glutamate/Cystine Antiporter System xc¯ as a Neuroprotective Drug Target
Albrecht, P., Lewerenz, J., Dittmer, S., Noack, R., Maher, P. A., & Methner, A. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791292567 · Cited by 172 · see citing works
Ca2+ entry through TRPC1 channels contributes to intracellular Ca2+ dynamics and consequent glutamate release from rat astrocytes
Malarkey, E. B., Ni, Y., & Parpura, V. (2008) · Glia · doi:10.1002/glia.20656 · Cited by 171 · see citing works
Distribution of the Cystine/Glutamate Antiporter System x− c in the Brain, Kidney, and Duodenum
Burdo, J., Dargusch, R., & Schubert, D. (2006) · Journal of Histochemistry and Cytochemistry · doi:10.1369/jhc.5a6840.2006 · Cited by 169 · see citing works
Cooperative action of glutamate transporters and cystine/glutamate antiporter system Xc– protects from oxidative glutamate toxicity
Lewerenz, J., Klein, M., & Methner, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03921.x · Cited by 164 · see citing works
Intraoperative hippocampal electrocorticography to predict the extent of hippocampal resection in temporal lobe epilepsy surgery
McKhann, G. M., Schoenfeld-McNeill, J., Born, D. E., et al. (2000) · Journal of neurosurgery · doi:10.3171/jns.2000.93.1.0044 · Cited by 163 · see citing works
Glutamate‐mediated neuronal–glial transmission
Verkhratsky, A., & Kirchhoff, F. (2007) · Journal of Anatomy · doi:10.1111/j.1469-7580.2007.00734.x · Cited by 156 · see citing works
Induction of the Phase II Detoxification Pathway Suppresses Neuron Loss in Drosophila Models of Parkinson's Disease
Trinh, K., Moore, K., Wes, P. D., Muchowski, P. J., Dey, J., Andrews, L. A., & Pallanck, L. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4778-07.2008 · Cited by 151 · see citing works
Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy
Aronica, E., Zurolo, E., Iyer, A. M., et al. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2011.03115.x · Cited by 151 · see citing works
Polyglutamine Diseases and Transport Problems
Gunawardena, S., & Goldstein, L. S. B. (2005) · Archives of Neurology · doi:10.1001/archneur.62.1.46 · Cited by 145 · see citing works
Lysosomes Are the Major Vesicular Compartment Undergoing Ca2+-Regulated Exocytosis from Cortical Astrocytes
Li, D., Ropert, N., Koulakoff, A., Giaume, C., & Oheim, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0744-08.2008 · Cited by 143 · see citing works
Innate and adaptive immunity in amyotrophic lateral sclerosis: Evidence of complement activation
Sta, M., Sylva-Steenland, R. M. R., Casula, M., de Jong, J. M. B. V., Troost, D., Aronica, E., & Baas, F. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.002 · Cited by 143 · see citing works
Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis
Hughes, E. G., Elmariah, S. B., & Balice‐Gordon, R. J. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.10.004 · Cited by 143 · see citing works
Visualization of localized store‐operated calcium entry in mouse astrocytes. Close proximity to the endoplasmic reticulum
Golovina, V. A. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.085035 · Cited by 140 · see citing works
Emerging restorative treatments for Parkinson's disease
Deierborg, T., Soulet, D., Roybon, L., Hall, V. J., & Brundin, P. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.05.001 · Cited by 139 · see citing works
Interactions between Purkinje neurones and Bergmann glia
Bellamy, T. C. (2006) · The Cerebellum · doi:10.1080/14734220600724569 · Cited by 135 · see citing works
Expression of mRNAs of multidrug resistance proteins (Mrps) in cultured rat astrocytes, oligodendrocytes, microglial cells and neurones
Hirrlinger, J., König, J., & Dringen, R. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01082.x · Cited by 132 · see citing works
Synaptobrevin2‐expressing vesicles in rat astrocytes: insights into molecular characterization, dynamics and exocytosis
Crippa, D., Schenk, U., Francolini, M., Rosa, P., Verderio, C., Zonta, M., Pozzan, T., Matteoli, M., & Carmignoto, G. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.094052 · Cited by 131 · see citing works
Effects of brain‐derived neurotrophic factor (BDNF) on glial cells and serotonergic neurones during development
Djalali, S., Höltje, M., Große, G., Rothe, T., Stroh, T., Große, J., Deng, D. R., Hellweg, R., Grantyn, R., Hörtnagl, H., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02911.x · Cited by 130 · see citing works
Chemokine Fractalkine/CX3CL1 Negatively Modulates Active Glutamatergic Synapses in Rat Hippocampal Neurons
Ragozzino, D., Angelantonio, S. D., Trettel, F., Bertollini, C., Maggi, L., Gross, C. T., Charo, I. F., Limatola, C., & Eusebi, F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3192-06.2006 · Cited by 129 · see citing works
Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes
Palygin, O., Lalo, U., & Pankratov, Y. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01374.x · Cited by 121 · see citing works
Gap junction wiring: a `new' principle in cell-to-cell communication in the nervous system?1Published on the World Wide Web on 4 November 1997.1
Dermietzel, R. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00031-3 · Cited by 117 · see citing works
A New Nerve Growth Factor-Mimetic Peptide Active on Neuropathic Pain in Rats
Colangelo, A. M., Bianco, M. R., Vitagliano, L., Cavaliere, C., Cirillo, G., GIOIA, L. D., Diana, D., Colombo, D., Redaelli, C., Zaccaro, L., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5201-07.2008 · Cited by 116 · see citing works
Self-citation
Signaling by death receptors in the nervous system
Haase, G., Pettmann, B., Raoul, C., & Henderson, C. E. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.07.013 · Cited by 115 · see citing works
Ca 2+ ‐dependent glutamate release involves two classes of endoplasmic reticulum Ca 2+ stores in astrocytes
Hua, X. J., Malarkey, E. B., Sunjara, V., Rosenwald, S. E., Li, W., & Parpura, V. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20061 · Cited by 115 · see citing works
Fast Subplasma Membrane Ca2+Transients Control Exo-Endocytosis of Synaptic-Like Microvesicles in Astrocytes
Marchaland, J., Calì, C., Voglmaier, S. M., Li, H., Regazzi, R., Edwards, R. H., & Bezzi, P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0040-08.2008 · Cited by 113 · see citing works
A cell‐biological model of p75 NTR signaling
Blöchl, A., & Blöchl, R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04496.x · Cited by 112 · see citing works
Functional neuroanatomy of the endocannabinoid system
Pazos, M. R., NUNEZ, E., Benito, C., Tolón, R. M., & Romero, J. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.01.030 · Cited by 111 · see citing works
Eph receptors and ephrins in neuron–astrocyte communication at synapses
Murai, K. K., & Pasquale, E. B. (2011) · Glia · doi:10.1002/glia.21226 · Cited by 109 · see citing works
Human amyloid β‐induced neuroinflammation is an early event in neurodegeneration
Craft, J. M., Watterson, D. M., & Eldik, L. J. V. (2005) · Glia · doi:10.1002/glia.20306 · Cited by 108 · see citing works
S100β Increases Levels of β‐Amyloid Precursor Protein and Its Encoding mRNA in Rat Neuronal Cultures
Li, Y., Wang, J., Sheng, J. G., Liu, L., Barger, S. W., Jones, R. A., Eldik, L. J. V., Mrak, R. E., & Griffin, W. S. T. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71041421.x · Cited by 106 · see citing works
Mutation of a NCKX Eliminates Glial Microdomain Calcium Oscillations and Enhances Seizure Susceptibility
Melom, J. E., & Littleton, J. T. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3920-12.2013 · Cited by 106 · see citing works
Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype
Roberts, K., Zeineddine, R., Corcoran, L., Li, W., Campbell, I. L., & Yerbury, J. J. (2012) · Glia · doi:10.1002/glia.22444 · Cited by 102 · see citing works
Neurochemical and morphological changes associated with human epilepsy
Glass, M., & Dragunow, M. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(95)00005-n · Cited by 98 · see citing works
The international society for developmental psychobiology annual meeting symposium: Impact of early life experiences on brain and behavioral development
Sullivan, R. M., Wilson, D. A., Feldon, J., Yee, B. K., Meyer, U., Richter‐Levin, G., Avital, A., Tsoory, M., Gruß, M., Bock, J., et al. (2006) · Developmental Psychobiology · doi:10.1002/dev.20170 · Cited by 98 · see citing works
The function of p75NTR in glia
Cragnolini, A. B., & Friedman, W. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2007.11.005 · Cited by 97 · see citing works
Synchronization of Ca2+ oscillations: involvement of ATP release in astrocytes
Koizumi, S. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07438.x · Cited by 95 · see citing works
Astrocytes protect neurons from neurotoxic injury by serum glutamate
Ye, Z., & Sontheimer, H. W. (1998) · Glia · doi:10.1002/(sici)1098-1136(199803)22:3 · Cited by 94 · see citing works
Localization of SNARE proteins and secretory organelle proteins in astrocytes in vitro and in situ
Wilhelm, A., Volknandt, W., Langer, D. J., Nolte, C., Kettenmann, H., & Zimmermann, H. (2003) · Neuroscience Research · doi:10.1016/j.neures.2003.11.002 · Cited by 94 · see citing works
Role of glia in developmental synapse formation
Allen, N. J. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.06.004 · Cited by 91 · see citing works
Mitochondria Modulate Ca2+-Dependent Glutamate Release from Rat Cortical Astrocytes
Reyes, R. C., & Parpura, V. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3484-08.2008 · Cited by 87 · see citing works
Opposing Control of Cannabinoid Receptor Stimulation on Amyloid-β-Induced Reactive Gliosis: In Vitro and in Vivo Evidence
Esposito, G., Iuvone, T., Savani, C., Scuderi, C., Filippis, D. D., Papa, M., Marzo, V. D., & Steardo, L. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.121566 · Cited by 83 · see citing works
Self-citation
Immunological Aetiology of Major Psychiatric Disorders
Sperner‐Unterweger, B. (2005) · Drugs · doi:10.2165/00003495-200565110-00004 · Cited by 82 · see citing works
Activation of the Wnt/β-catenin signaling pathway is associated with glial proliferation in the adult spinal cord of ALS transgenic mice
Chen, Y., Guan, Y., Liu, H., Wu, X., Yu, L., Wang, S., Zhao, C., Du, H., & Wang, X. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.03.006 · Cited by 79 · see citing works
Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate
Rea, K., Roche, M., & Finn, D. P. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707440 · Cited by 79 · see citing works
Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure‐susceptible DBA/2 mice
Inyushin, M. Y., Kucheryavykh, L. Y., Kucheryavykh, Y. V., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02592.x · Cited by 78 · see citing works
GABA and glutamate signaling: homeostatic control of adult forebrain neurogenesis
Platel, J., Lacar, B., & Bordey, A. (2007) · Journal of Molecular Histology · doi:10.1007/s10735-007-9103-8 · Cited by 78 · see citing works
Intrathecal NGF Administration Reduces Reactive Astrocytosis and Changes Neurotrophin Receptors Expression Pattern in a Rat Model of Neuropathic Pain
Cirillo, G., Cavaliere, C., Bianco, M. R., Simone, A. D., Colangelo, A. M., Sellitti, S., Alberghina, L., & Papa, M. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9430-2 · Cited by 75 · see citing works
Self-citation
Microglia and Central Nervous System Immunity
Kaur, G., Han, S. J., Yang, I., & Crane, C. A. (2009) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2009.08.009 · Cited by 74 · see citing works
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Imbe, H., Kimura, A., Donishi, T., & Kaneoke, Y. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.007 · Cited by 71 · see citing works
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Song, W., Zukor, H., Lin, S.-H., Hascalovici, J., Liberman, A., Tavitian, A., Mui, J., Vali, H., Tong, X., Bhardwaj, S. K., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6469-11.2012 · Cited by 69 · see citing works
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Lee, M., McGeer, E. G., Kodela, R., Kashfi, K., & McGeer, P. L. (2013) · Glia · doi:10.1002/glia.22553 · Cited by 69 · see citing works
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Leo, D., Adriani, W., Cavaliere, C., Cirillo, G., Marco, E. M., Romano, E., di Porzio, U., Papa, M., Perrone‐Capano, C., & Giovanni Laviola, A. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00486.x · Cited by 66 · see citing works
Self-citation
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Stewart, V. C., Heslegrave, A., Brown, G. C., Clark, J. B., & Heales, S. (2002) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01878.x · Cited by 65 · see citing works
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Cavaliere, C., Cirillo, G., Bianco, M. R., Rossi, F., de Novellis, V., Maione, S., & Papa, M. (2007) · Neuron Glia Biology · doi:10.1017/s1740925x07000695 · Cited by 61 · see citing works
Self-citation
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Matrone, C., Barbagallo, A., Rosa, L. R. L., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1960-11.2011 · Cited by 61 · see citing works
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Saavedra, A., Baltazar, G., Rodrigues‐Santos, P., Carvalho, C. M., & Duarte, E. P. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.04.008 · Cited by 61 · see citing works
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Occhipinti, R., Somersalo, E., & Daniela Calvetti, A. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90377.2008 · Cited by 57 · see citing works
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Xia, M., & Zhu, Y. (2011) · Glia · doi:10.1002/glia.21138 · Cited by 53 · see citing works
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McCullough, S., Xu, X.-J., Dent, S., Bekiranov, S., Roeder, R., & Grant, P. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1218331110 · Cited by 48 · see citing works
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Jacobsen, K. X., MacDonald, H. R., Lemonde, S., Daigle, M., Grimes, D. A., Bulman, D. E., & Albert, P. R. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.08.003 · Cited by 46 · see citing works
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Vig, P. J., Shao, Q., Subramony, S., Lopez, M. E., & Safaya, E. (2009) · Cerebellum · doi:10.1007/s12311-009-0125-5 · Cited by 44 · see citing works
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Turner, J. R., Ecke, L. E., Briand, L. A., Haydon, P. G., & Blendy, J. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2897-4 · Cited by 44 · see citing works
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Quincozes‐Santos, A., Bobermin, L. D., Tonial, R. P. L., Bambini-Júnior, V., Riesgo, R. D. S., & Gottfried, C. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-009-0095-0 · Cited by 42 · see citing works
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Schiffer, D., & Fiano, V. (2004) · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders · doi:10.1080/14660820310016822 · Cited by 41 · see citing works
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Kanner, B. I., & Borre, L. (2002) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(02)00260-8 · Cited by 40 · see citing works
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Caudle, R. M. (2006) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-3-2 · Cited by 37 · see citing works
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Verleysdonk, S., & Hamprecht, B. (2000) · Glia · doi:10.1002/(sici)1098-1136(200003)30:1 · Cited by 37 · see citing works
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Hatton, G. I., & Yang, Q. Z. (1994) · Brain Research · doi:10.1016/0006-8993(94)90207-0 · Cited by 37 · see citing works
Atrial Natriuretic Peptide-like Immunoreactivity in Neurons and Astrocytes of Human Cerebellum and Inferior Olivary Complex
McKenzie, J. C., Juan, Y.-W., Thomas, C. R., Berman, N. E. J., & Klein, R. M. (2001) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540104901113 · Cited by 37 · see citing works
Altered astrocytic response to activation in SOD1G93A mice and its implications on amyotrophic lateral sclerosis pathogenesis
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Authors: Papa, M., De Luca, C., Petta, F., Alberghina, L., & Cirillo, G.
Affiliations: University of Campania "Luigi Vanvitelli" (IT)
University of Milano-Bicocca (IT)
ORCID: Alberghina, Lilia
Cirillo, Giovanni
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2014-05
Volume: 42
Pages: 35-54
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2014.01.010
OpenAlex: W2089397496
Cited by: 104
References: 215
Citations by year: 2026: 2 · 2025: 7 · 2024: 3 · 2023: 5 · 2022: 11 · 2021: 7 · 2020: 12 · 2019: 21 · 2018: 6 · 2017: 4 · 2016: 8 · 2015: 13 · 2014: 5
FWCI: 0.81
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Funders: Regione Campania
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Keywords: astrocytes, glial cells, gliotransmitters, astrocyte-neuron interaction, maladaptive plasticity, neurodegenerative diseases, traumatic brain injury, neuroinflammation, neuronal cell death, therapeutic target
MeSH terms: Animals, Astrocytes, Gliosis, Humans, Nervous System Diseases, Neuronal Plasticity, Neurons

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Astrocyte–neuron interplay in maladaptive plasticity.

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