Cited by 373Memory and Neural MechanismsMemory Processes and InfluencesNeural dynamics and brain function

Hippocampal Representation of Related and Opposing Memories Develop within Distinct, Hierarchically Organized Neural Schemas

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McKenzie, Sam, Frank, Andrea J., Kinsky, Nathaniel R., Porter, Blake, Rivière, Pamela D., Eichenbaum, Howard·2014·Neuron

Abstract

Recent evidence suggests that the hippocampus may integrate overlapping memories into relational representations, or schemas, that link indirectly related events and support flexible memory expression. Here we explored the nature of hippocampal neural population representations for multiple features of events and the locations and contexts in which they occurred. Hippocampal networks developed hierarchical organizations of associated elements of related but separately acquired memories within a context, and distinct organizations for memories where the contexts differentiated object-reward associations. These findings reveal neural mechanisms for the development and organization of relational representations.

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Crossref · 10.1016/j.neuron.2014.05.019

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  • A spatial schema is separate from an event schema, reflecting learned recurring patterns of spatial relations among key elements of an environment, and facilitated through navigation in that environment.

    “Here we consider the possibility of a spatial schema as separate from an event schema [G], instead reflecting learned recurring patterns of spatial relations among key elements of an environment 14,18,28 , and facilitated through the act of navigating in that environment [29][30][31][32] .”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [18]

  • Generalized representations formed by rodents in the reviewed studies seem to rely on gist-like representations rather than schemas.

    “For example, the generalized representations formed by rodents in the studies reviewed above seem to rely on gist-like representations rather than schemas 18,53,54 .”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [18]

  • The connectivity of a space in view is reflected in the activity of the occipital place area.

    “Recent work has shown that the connectivity of a space in view is reflected in the activity of the occipital place area 18 , but how this connectivity extends to active navigation is not known.”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [18]

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Authors
McKenzie, S., Frank, A. J., Kinsky, N. R., Porter, B., Rivière, P. D., & Eichenbaum, H.
Affiliations
Boston University (US)
Corresponding author
Eichenbaum, Howard
Venue
Neuron
Publisher
Elsevier BV
Published
2014-07
Volume
83
Issue
1
Pages
202-215
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2001711642
Cited by
373
References
80
Citations by year
2026: 19 · 2025: 37 · 2024: 20 · 2023: 29 · 2022: 36 · 2021: 37 · 2020: 32 · 2019: 24 · 2018: 34 · 2017: 37 · 2016: 38 · 2015: 23 · 2014: 7
FWCI
19.53
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH051570, MH 094263, MH 52090, P50MH094263, R01MH052090)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
hippocampus, relational memory, memory schemas, contextual memory, memory integration
MeSH terms
Animals, Hippocampus, Male, Memory, Nerve Net, Neurons, Psychomotor Performance, Random Allocation, Reward, Rats, Long-Evans

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