Hippocampal Representation of Related and Opposing Memories Develop within Distinct, Hierarchically Organized Neural Schemas
Open accessAbstract
Recent evidence suggests that the hippocampus may integrate overlapping memories into relational representations, or schemas, that link indirectly related events and support flexible memory expression. Here we explored the nature of hippocampal neural population representations for multiple features of events and the locations and contexts in which they occurred. Hippocampal networks developed hierarchical organizations of associated elements of related but separately acquired memories within a context, and distinct organizations for memories where the contexts differentiated object-reward associations. These findings reveal neural mechanisms for the development and organization of relational representations.
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A spatial schema is separate from an event schema, reflecting learned recurring patterns of spatial relations among key elements of an environment, and facilitated through navigation in that environment.
“Here we consider the possibility of a spatial schema as separate from an event schema [G], instead reflecting learned recurring patterns of spatial relations among key elements of an environment 14,18,28 , and facilitated through the act of navigating in that environment [29][30][31][32] .”
From From cognitive maps to spatial schemas (2023) · cites this paper as [18]
Generalized representations formed by rodents in the reviewed studies seem to rely on gist-like representations rather than schemas.
“For example, the generalized representations formed by rodents in the studies reviewed above seem to rely on gist-like representations rather than schemas 18,53,54 .”
From From cognitive maps to spatial schemas (2023) · cites this paper as [18]
The connectivity of a space in view is reflected in the activity of the occipital place area.
“Recent work has shown that the connectivity of a space in view is reflected in the activity of the occipital place area 18 , but how this connectivity extends to active navigation is not known.”
From From cognitive maps to spatial schemas (2023) · cites this paper as [18]
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Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis
Huszár, R., Zhang, Y., Blockus, H., & Buzsáki, G. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01138-x · Cited by 104 · see citing works
Toward the neural implementation of structure learning
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Hippocampal Place Fields Maintain a Coherent and Flexible Map across Long Timescales
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Self-citationNeurophysiology of Remembering
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Schematic representations of local environmental space guide goal-directed navigation
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The Hippocampus Generalizes across Memories that Share Item and Context Information
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- Authors
- McKenzie, S., Frank, A. J., Kinsky, N. R., Porter, B., Rivière, P. D., & Eichenbaum, H.
- Affiliations
- Boston University (US)
- Corresponding author
- Eichenbaum, Howard
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 83
- Issue
- 1
- Pages
- 202-215
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4082468
- OpenAlex
- W2001711642
- Cited by
- 373
- References
- 80
- Citations by year
- 2026: 19 · 2025: 37 · 2024: 20 · 2023: 29 · 2022: 36 · 2021: 37 · 2020: 32 · 2019: 24 · 2018: 34 · 2017: 37 · 2016: 38 · 2015: 23 · 2014: 7
- FWCI
- 19.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH051570, MH 094263, MH 52090, P50MH094263, R01MH052090)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- hippocampus, relational memory, memory schemas, contextual memory, memory integration
- MeSH terms
- Animals, Hippocampus, Male, Memory, Nerve Net, Neurons, Psychomotor Performance, Random Allocation, Reward, Rats, Long-Evans
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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