Oxytocin selectively increases ERα mRNA in the neonatal hypothalamus and hippocampus of female prairie voles
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During neonatal development exogenous oxytocin increases ERalpha immunoreactivity in the hypothalamus of female prairie voles. The purpose of this study was to determine if the increase in ERalpha is associated with an increase in ERalpha mRNA expression and to determine if the effect is specific to ER subtype or if oxytocin also influences ERbeta mRNA expression. On the day of birth female prairie vole pups were treated with oxytocin, an oxytocin antagonist, or saline. Brains were collected and RT-PCR was used to determine the effect of treatment on ER mRNA production in the hypothalamus, hippocampus, and cortex. Within 2h of treatment oxytocin significantly increased ERalpha mRNA expression in the hypothalamus and hippocampus, but not the cortex, while inhibiting the effects of endogenous oxytocin reduced the expression of ERalpha mRNA in the hippocampus. Neonatal treatment did not affect the expression of ERbetamRNA. The results demonstrate that the effects of oxytocin treatment are region and ER subtype specific and that during the neonatal period oxytocin can affect the expression of ERalpha by altering message production. The regional specific changes in ERalpha mRNA expression in females are consistent with studies examining the behavioral and physiological effects of neonatal manipulation of oxytocin in females.
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Neonatal oxytocin manipulation increases the expression of estrogen receptor alpha in the hippocampus, ventral lateral septum, and central nucleus of the amygdala.
“and neonatal Oxt manipulation increases the expression of ERα in the hippocampus (79), ventral lateral septum (LS), and central nucleus of the amygdala (24).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [79]
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- Authors
- Pournajafi-Nazarloo, H., Carr, M. S., Papademeteriou, E., Schmidt, J. V., & Cushing, B. S.
- Affiliations
- University of Illinois Chicago (US)
- University of Akron (US)
- Corresponding author
- Cushing, Bruce S.
- Venue
- Neuropeptides
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 41
- Issue
- 1
- Pages
- 39-44
- ISSN
- 0143-4179 (ISSN-L)
- PMC
- PMC2692963
- OpenAlex
- W2019037243
- Cited by
- 23
- References
- 23
- Citations by year
- 2025: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropeptides (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH 01992, K01MH001992)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 48390)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- oxytocin, estrogen receptor alpha, estrogen receptor beta, neonatal development, hypothalamus, hippocampus, Microtus ochrogaster, oxytocin antagonist, sex differences
- MeSH terms
- Animals, Animals, Newborn, Cerebral Cortex, Arvicolinae, Female, Hippocampus, Hypothalamus, Oxytocin, RNA, Messenger, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, Estrogen Receptor alpha
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