Changes in Oxytocin Receptor mRNA in Rat Brain During Pregnancy and the Effects of Estrogen and Interleukin‐6
Abstract
Changes in brain oxytocin receptor (OTR) binding sites during the course of pregnancy may influence the sudden onset of maternal behavior in female rats at parturition. In situ hybridization was used to identify changes in OTR messenger ribonucleic acid (mRNA) expression during pregnancy and parturition. Two patterns of mRNA regulation were observed. Relative to diestrus virgin control females, OTR mRNA was elevated in the lateral septum and medial preoptic area at days 13–15 of pregnancy but not on the morning of parturition. In the central nucleus of the amygdala and ventromedial nucleus of the hypothalamus (VMH), OTR mRNA was most abundant on the morning of parturition. Strong signals for OTR mRNA were detected in the bed nucleus of the stria terminalis, hypothalamic paraventricular nucleus, supraoptic nucleus and suprachiasmatic nucleus. However no group differences were detected in these areas. As estrogen and interleukin‐6 have been suggested to modulate OTR gene expression and both are elevated at the time of parturition, their effects on OTR mRNA in the brain were examined. Estrogen and interleukin‐6, given simultaneously, significantly elevated the concentration of OTR mRNA in the VMH, but not in the amygdala. The increase in the VMH was significantly greater than that produced by estrogen alone, and interleukin‐6 alone had no effects. These results demonstrate that transcriptional regulation of OTR gene expression mediates changes in receptor density in the brain in a region specific manner during pregnancy and suggests a potential mechanism for some of these changes.
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Coordinated release has been suggested for other neuropeptides to aid in body temperature regulation.
“Coordinated release has been suggested for other neuropeptides to aid in body temperature regulation [143].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [143]
The distribution of OXTR mRNA across the brain provides a proxy for the distribution of oxytocin binding.
“The distribution of oxytocin receptor (OXTR) mRNA across the brain provides a proxy for the distribution of oxytocin binding6”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [6]
Cites
Oxytocin Receptors and Human Parturition: A Dual Role for Oxytocin in the Initiation of Labor
Fuchs, A., Fuchs, F., Husslein, P. W., Soloff, M. S., & Fernström, M. J. (1982) · Science · doi:10.1126/science.6278592 · Cited by 494 · see citing works
Shaikh, A. A. (1971) · Biology of Reproduction · doi:10.1093/biolreprod/5.3.297 · Cited by 385 · see citing works
Role of interleukin 6 in fever in rats
LeMay, L. G., Vander, A. J., & Kluger, M. J. (1990) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1990.258.3.r798 · Cited by 226 · see citing works
Neural basis of maternal behavior in the rat
Numan, M. J. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90006-6 · Cited by 104 · see citing works
Oxytocin receptor mRNA expression in the ventromedial hypothalamus during the estrous cycle
Bale, T., Dorsa, D. M., & Johnston, C. I. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-05058.1995 · Cited by 98 · see citing works
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Cited by
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Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708 · see citing works
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856 · see citing works
“Furthermore, infusion of interleukin-6 increases OTR expression in the brain of female rats [97].”
BackgroundSelf-citationNeuropeptidergic regulation of affiliative behavior and social bonding in animals
Lim, M. M., & Young, L. J. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.028 · Cited by 624 · see citing works
Self-citationFrancis, D. D., Champagne, F. C., & Meaney, M. J. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00599.x · Cited by 496 · see citing works
Champagne, F., & Meaney, M. J. (2001) · Progress in Brain Research · doi:10.1016/s0079-6123(01)33022-4 · Cited by 455 · see citing works
Neumann, Wigger, Torner, Holsboer, & Landgraf (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00442.x · Cited by 452 · see citing works
Brain Oxytocin Correlates with Maternal Aggression: link to Anxiety
Bosch, O. J., Meddle, S. L., Beiderbeck, D. I., Douglas, A. J., & Neumann, I. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1342-05.2005 · Cited by 439 · see citing works
The expectant brain: adapting for motherhood
Brunton, P. J., & Russell, J. A. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2280 · Cited by 407 · see citing works
Neumann, I. D., Torner, L., & Wigger, A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00433-9 · Cited by 402 · see citing works
Oxytocin pathway gene networks in the human brain
Quintana, D. S., Rokicki, J., van der Meer, D., Alnæs, D., Kaufmann, T., Córdova-Palomera, A., Dieset, I., Andreassen, O. A., & Westlye, L. T. (2019) · Nature Communications · doi:10.1038/s41467-019-08503-8 · Cited by 354 · see citing works
Cameron, N. M., Champagne, F. A., Parent, C., Fish, E. W., Ozaki-Kuroda, K., & Meaney, M. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.022 · Cited by 320 · see citing works
The magnocellular oxytocin system, the fount of maternity: Adaptations in pregnancy
Russell, J. A., Leng, G., & Douglas, A. J. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(02)00104-8 · Cited by 295 · see citing works
Maternal Care, Gene Expression, and the Development of Individual Differences in Stress Reactivity
Francis, D. D., Champagne, F. A., Liu, D., & Meaney, M. J. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08106.x · Cited by 291 · see citing works
Neumann, I. D., Krömer, S. A., Toschi, N., & Ebner, K. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00197-x · Cited by 285 · see citing works
Mother–infant bonding and the evolution of mammalian social relationships
Broad, K. D., Curley, J. P., & Keverne, E. B. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1940 · Cited by 283 · see citing works
Regulation of anxiety during the postpartum period
Lonstein, J. S. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.05.002 · Cited by 229 · see citing works
Dumais, K. M., Bredewold, R., Mayer, T. E., & Veenema, A. H. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.08.012 · Cited by 201 · see citing works
Dynamic changes in oxytocin receptor expression and activation at parturition in the rat brain
Meddle, S. L., Bishop, V. R., Gkoumassi, E., van Leeuwen, F. W., & Douglas, A. J. (2007) · Endocrinology · doi:10.1210/en.2007-0615 · Cited by 195 · see citing works
Hormonal influences in migraine — interactions of oestrogen, oxytocin and CGRP
Krause, D. N., Warfvinge, K., Haanes, K. A., & Edvinsson, L. I. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00544-2 · Cited by 207 · see citing works
Neural circuits of social behaviors: Innate yet flexible
Wei, D., Talwar, V., & Lin, D. (2021) · Neuron · doi:10.1016/j.neuron.2021.02.012 · Cited by 186 · see citing works
Russell, J. A., Douglas, A. J., & Ingram, C. D. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33002-9 · Cited by 187 · see citing works
Chapter 8 Peripartum plasticity within the hypothalamo-pituitary-adrenal axis
Lightman, S. L., Windle, R. J., Wood, S. A., Kershaw, Y. M., Shanks, N. M., & Ingram, C. D. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33009-1 · Cited by 171 · see citing works
Cameron, N. M., Shahrokh, D. K., Corpo, A. D., Dhir, S. K., Moshe Szyf, A., Champagne, F. A., & Meaney, M. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01725.x · Cited by 167 · see citing works
Cytokine production in chorioamnionitis
Saji, F., Samejima, Y., Kamiura, S., Sawai, K., Shimoya, K., & Kimura, T. (2000) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(00)00064-4 · Cited by 162 · see citing works
Blaustein, J. D., & Erskine, M. S. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50004-4 · Cited by 147 · see citing works
Buisman‐Pijlman, F. T. A., Sumracki, N. M., Gordon, J. J., Hull, P. R., Carter, C. S., & Mattie Tops, A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.09.005 · Cited by 143 · see citing works
Ventromedial Hypothalamus and the Generation of Aggression
Hashikawa, Y., Hashikawa, K., Falkner, A. L., & Lin, D. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00094 · Cited by 141 · see citing works
McCormack, S. E., Blevins, J. E., & Lawson, E. A. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz012 · Cited by 140 · see citing works
Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity
Ochedalski, T., Subburaju, S., Wynn, P. C., & Aguilera, G. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01525.x · Cited by 133 · see citing works
Bosch, O. J., Krömer, S. A., Brunton, P. J., & Neumann, I. D. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.11.028 · Cited by 129 · see citing works
Oxytocin-messages via the cerebrospinal fluid: Behavioral effects; a review
Veening, J. G., A, T. R. D. J., & Barendregt, H. P. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.05.004 · Cited by 126 · see citing works
Opacka‐Juffry, J., & Mohiyeddini, C. (2011) · Stress · doi:10.3109/10253890.2011.560309 · Cited by 122 · see citing works
The Associations Between Oxytocin and Trauma in Humans: A Systematic Review
Donadon, M. F., Martín‐Santos, R., & Osório, F. D. L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00154 · Cited by 119 · see citing works
Neural, cognitive, and evolutionary foundations of human altruism
Marsh, A. A. (2015) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1377 · Cited by 119 · see citing works
Oxytocin and vasopressin: genetics and behavioral implications
Caldwell, H. K., & Young, W. S. (2006) · Handbook of Neurochemistry and Molecular Neurobiology · doi:10.1007/978-0-387-30381-9_25 · Cited by 113 · see citing works
Oxytocin pathways in the intergenerational transmission of maternal early life stress
Töpfer, P., Heim, C. C., Entringer, S., Binder, E. B., Wadhwa, P. D., & Buß, C. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.026 · Cited by 114 · see citing works
Oxytocin and Vasopressin: Genetics and Behavioral Implications
Caldwell, H. K., & Young, W. S. (2006) · Springer eBooks · doi:10.1007/0-387-30395-2_25 · Cited by 113 · see citing works
OxytocinSynthesis, Secretion, and Reproductive Functions
BURBACH, J., YOUNG, L., & RUSSELL, J. (2006) · Knobil and Neill's Physiology of Reproduction · doi:10.1016/b978-012515400-0/50063-4 · Cited by 113 · see citing works
Self-citationDouglas, A. J., Johnstone, L. E., & Leng, G. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.012 · Cited by 108 · see citing works
Bisphenol-A exposure during pregnancy and lactation affects maternal behavior in rats
Seta, D. D., Minder, I., Dessì-Fulgheri, F., & Farabollini, F. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.11.017 · Cited by 107 · see citing works
Impairments in the Initiation of Maternal Behavior in Oxytocin Receptor Knockout Mice
Rich, M. E., deCárdenas, E. J., Lee, H.-J., & Caldwell, H. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098839 · Cited by 105 · see citing works
Broad, K. D., Lévy, F., Evans, G., Kimura, T., Keverne, E. B., & Kendrick, K. M. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00782.x · Cited by 100 · see citing works
Gammie, S. C. (2005) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582305281086 · Cited by 100 · see citing works
Suppression of Leptin During Lactation: Contribution of the Suckling StimulusVersusMilk Production1
Brogan, R. S., Mitchell, S. E., Trayhurn, P., & Smith, M. S. (1999) · Endocrinology · doi:10.1210/endo.140.6.6802 · Cited by 99 · see citing works
CD38 and its role in oxytocin secretion and social behavior
Higashida, H., Yokoyama, S., Kikuchi, M., & Munesue, T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.011 · Cited by 98 · see citing works
Oxytocin-induced excitation of neurones in the rat central and medial amygdaloid nuclei
Terenzi, M. G., & Ingram, C. D. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.04.004 · Cited by 91 · see citing works
Curley, J. P., Jensen, C. L., Franks, B., & Champagne, F. A. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.013 · Cited by 90 · see citing works
Windle, R. J., Gamble, L. E., Kershaw, Y. M., Wood, S. A., Lightman, S. L., & Ingram, C. D. (2006) · Endocrinology · doi:10.1210/en.2005-1079 · Cited by 90 · see citing works
Lonstein, J. S., Maguire, J. L., Meinlschmidt, G., & Neumann, I. D. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12188 · Cited by 83 · see citing works
Oxytocin receptor dynamics in the brain across development and species
Vaidyanathan, R., & Hammock, E. A. D. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22403 · Cited by 82 · see citing works
Beery, A. K., McEwen, L. M., MacIsaac, J. L., Francis, D. D., & Kobor, M. S. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.022 · Cited by 81 · see citing works
Modified in situ Hybridization Chain Reaction Using Short Hairpin DNAs
Tsuneoka, Y., & Funato, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00075 · Cited by 80 · see citing works
Oxytocin receptor expression patterns in the human brain across development
Rokicki, J., Kaufmann, T., de Lange, A. G., van der Meer, D., Bahrami, S., Sartorius, A. M., Haukvik, U. K., Steen, N. E., Schwarz, E., Stein, D. J., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01305-5 · Cited by 74 · see citing works
Bealer, S. L., Armstrong, W. E., & Crowley, W. R. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00217.2010 · Cited by 76 · see citing works
Nyuyki, K. D., Waldherr, M., Baeuml, S., & Neumann, I. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023599 · Cited by 74 · see citing works
Wigger, A., & Neumann, I. D. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00068-4 · Cited by 74 · see citing works
Higashida, H., Yokoyama, S., Huang, J., Liu, L., Ma, W., Akther, S., Higashida, C., Kikuchi, M., Minabe, Y., & Munesue, T. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.01.030 · Cited by 74 · see citing works
Señarís, R. M., Trujillo‐Güiza, M. L., Navia, B., Comes, G., Ferrer, B., Giralt, M., & Hidalgo, J. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02158.x · Cited by 70 · see citing works
Oxytocin promotes intuitive rather than deliberated cooperation with the in-group
Ten Velden, F. S., Daughters, K., & De Dreu, C. K. W. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.06.005 · Cited by 66 · see citing works
Tsuneoka, Y., Yoshida, S., Takase, K., Oda, S., Kuroda, M., & Funato, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-10213-4 · Cited by 64 · see citing works
Numan, M. J., FLEMING, A., & Lévy, F. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50040-3 · Cited by 63 · see citing works
Harony, H., & Wagner, S. (2010) · Neurosignals · doi:10.1159/000321035 · Cited by 62 · see citing works
Harony-Nicolas, H., Mamrut, S., Brodsky, L., Shahar-Gold, H., Barki-Harrington, L., & Wagner, S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.10.004 · Cited by 61 · see citing works
Jiang, J., Zou, Y., Xie, C., Yang, M., Tong, Q., Yuan, M.-M., Pei, X., Deng, S., Tian, M., Xiao, L., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.08.023 · Cited by 59 · see citing works
Neurotransmitter/Neuropeptide Interactions in the Regulation of Neurohypophyseal Hormone Release
Sladek, C. D., & Kapoor, J. R. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7779 · Cited by 58 · see citing works
Bisagno, V., & Cadet, J. L. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000049 · Cited by 60 · see citing works
McHenry, J. A., Rubinow, D. R., & Stuber, G. D. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.001 · Cited by 56 · see citing works
Oxytocin receptor binding in the hypothalamus during gestation in rats
Bealer, S. L., Lipschitz, D. L., Ramoz, G., & Crowley, W. R. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00766.2005 · Cited by 54 · see citing works
Stamatakis, A., Kalpachidou, T., Raftogianni, A., Zografou, E., Τζάνου, Α., Pondiki, S., & Stylianopoulou, F. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.11.016 · Cited by 57 · see citing works
Genetic, epigenetic and environmental impact on sex differences in social behavior
Shepard, K. N., Michopoulos, V., Toufexis, D. J., & Wilson, M. E. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.016 · Cited by 57 · see citing works
Xu, C., Liu, W., You, X., Leimert, K. B., Popowycz, K., Fang, X., Wood, S. L., Slater, D. M., Sun, Q., Gu, H., et al. (2015) · Molecular Human Reproduction · doi:10.1093/molehr/gav018 · Cited by 53 · see citing works
The interplay of oxytocin and sex hormones
Quintana, D. S., Glaser, B. D., Kang, H., Kildal, E. S.-M., Audunsdottir, K., Sartorius, A. M., & Barth, C. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105765 · Cited by 54 · see citing works
Day length and estradiol affect same-sex affiliative behavior in the female meadow vole
Beery, A. K., Loo, T. J., & Zucker, I. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.02.007 · Cited by 50 · see citing works
Higashida, H. (2015) · The Journal of Physiological Sciences · doi:10.1007/s12576-015-0425-0 · Cited by 49 · see citing works
Hypothalamic Neuropeptide Brain Protection: Focus on Oxytocin
Panaro, M. A., Benameur, T., & Porro, C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051534 · Cited by 48 · see citing works
Douglas, A. J. (2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80014-8 · Cited by 48 · see citing works
The role of oxytocin in mothers’ theory of mind and interactive behavior during the perinatal period
MacKinnon, A. L., Gold, I., Feeley, N., Hayton, B., Carter, C. S., & Zelkowitz, P. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.06.003 · Cited by 47 · see citing works
Baracz, S. J., Everett, N. A., Robinson, K. J., Campbell, G. R., & Cornish, J. L. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12861 · Cited by 46 · see citing works
Inoue, K., Ford, C. L., Horie, K., & Young, L. J. (2022) · Journal of Comparative Neurology · doi:10.1002/cne.25382 · Cited by 45 · see citing works
Self-citationLopatina, O. L., Liu, H.-X., Amina, S., Hashii, M., & Higashida, H. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.012 · Cited by 45 · see citing works
The Brain Oxytocin Receptor(s?)
Verbalis, J. G. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0178 · Cited by 45 · see citing works
The Septal Region and Social Behavior
Sheehan, T. P., & Numan, M. (2000) · Springer eBooks · doi:10.1007/978-1-4612-1302-4_8 · Cited by 44 · see citing works
Brunton, P. J. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02067.x · Cited by 43 · see citing works
Neumann, I. D., Bosch, O. J., Toschi, N., Torner, L., & Douglas, A. J. (2003) · Endocrinology · doi:10.1210/en.2003-0037 · Cited by 43 · see citing works
Jiménez, A., Young, L. J., Río, R. T.-D., LaPrairie, J. L., & González‐Mariscal, G. (2015) · Brain Research · doi:10.1016/j.brainres.2015.10.043 · Cited by 41 · see citing works
Self-citationOxytocin Receptor Signaling in Vascular Function and Stroke
McKay, E. C., & Counts, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.574499 · Cited by 41 · see citing works
Bosch, O. J., Sartori, S. B., Singewald, N., & Neumann, I. D. (2007) · Stress · doi:10.1080/10253890701223197 · Cited by 34 · see citing works
Editorial: The Oxytocin/Oxytocin Receptor System—Expect the Unexpected
Bussolati, G., & Cassoni, P. (2001) · Endocrinology · doi:10.1210/endo.142.4.8147 · Cited by 34 · see citing works
Garcia, A. N., Bezner, K. S., Depena, C., Yin, W., & Gore, A. C. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.11.011 · Cited by 33 · see citing works
Sexual Dimorphism of Parental Care: From Genes to Behavior
Zilkha, N., Scott, N., & Kimchi, T. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031447 · Cited by 32 · see citing works
Chapter 8 Neurobiology of Maternal Behavior in Sheep
Lévy, F., & Keller, M. (2008) · Advances in the study of behavior · doi:10.1016/s0065-3454(08)00008-9 · Cited by 31 · see citing works
Ophir, A. G., Sorochman, G., Evans, B. L., & Prounis, G. S. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12049 · Cited by 31 · see citing works
Amico, J. A., Cai, H.-M., & Vollmer, R. R. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.07.004 · Cited by 30 · see citing works
Muscle-specific interleukin-6 deletion influences body weight and body fat in a sex-dependent manner
Ferrer, B., Navia, B., Giralt, M., Comes, G., Carrasco, J., Molinero, A., Quintana, A., Señarís, R. M., & Hidalgo, J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.03.001 · Cited by 29 · see citing works
Stoesz, B. M., Hare, J. F., & Snow, W. M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.11.007 · Cited by 28 · see citing works
Oxytocin’s dynamic role across the lifespan
Audunsdottir, K., & Quintana, D. S. (2022) · Aging Brain · doi:10.1016/j.nbas.2021.100028 · Cited by 28 · see citing works
Amina, S., Hashii, M., Ma, W. ‐., Yokoyama, S., Lopatina, O. L., Liu, H., Islam, M. S., & Higashida, H. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01978.x · Cited by 27 · see citing works
Driessen, T. M., Zhao, C., Whittlinger, A., Williams, H., & Gammie, S. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083098 · Cited by 25 · see citing works
Maternal behavior: activation of the central oxytocin receptor system in parturient rats?
Lin, S. H., Kiyohara, T., & Sun, B. (2003) · Neuroreport · doi:10.1097/00001756-200308060-00007 · Cited by 25 · see citing works
- Authors
- Young, L. J., Muns, S., Wang, Z., & Insel, T. R.
- Affiliations
- Emory University (US)
- Corresponding author
- Young, Larry J.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 1997-11
- Volume
- 9
- Issue
- 11
- Pages
- 859-865
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2115024338
- Cited by
- 160
- References
- 5
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 9 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 8 · 2014: 11 · 2013: 7 · 2012: 5
- FWCI
- 7.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29mh054554-06)
- National Institute of Mental Health (MH54554, MH 56538, R01MH056538)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin receptor, mRNA expression, pregnancy, childbirth, estrogen, interleukin-6, ventromedial hypothalamus, lateral septum, medial preoptic area, amygdala, transcriptional regulation, maternal behavior, rat brain
- MeSH terms
- Animals, Brain, Diestrus, Estradiol, Female, Hypothalamus, Labor, Obstetric, Ovariectomy, Pregnancy, Pregnancy, Animal, RNA, Messenger, Time Factors, Interleukin-6, Rats, Sprague-Dawley, In Situ Hybridization, Receptors, Oxytocin, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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