Cited by 79Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

Developmental effects of oxytocin on stress response: Single versus repeated exposure

KRAMER, K, CUSHING, B, CARTER, C·2003·Physiology & Behavior

Abstract

Both exogenous and endogenous oxytocin (OT) are associated with an attenuated stress response. Increased levels of OT in the early postnatal period have been shown to affect behavior and physiology in rodents, and these effects last into adulthood, suggesting an organizational role for OT during development. We investigated the effects of neonatal exposure to OT on the development of the stress response in male and female prairie voles (Microtus ochrogaster). OT or an OT antagonist (OTA) was administered either on postnatal day 1 (single, D1) or days 1-7 (repeated, D1-7) and then on day 8 the response to social isolation was assessed by quantifying ultrasonic vocalizations (USVs) and measuring plasma corticosterone (CORT). Treatment effects were observed only in females. A single treatment with OTA was associated with a decrease in vocalizations, while repeated treatment produced an increase in vocalizations. A single treatment with either saline or OTA increased basal CORT. The results suggest that endogenous OT may be involved in the development of the stress response in females.

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Crossref · 10.1016/s0031-9384(03)00175-6

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72 of 72 references verified0 citation errors · 0 not checkable

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Authors
KRAMER, K., CUSHING, B., & CARTER, C.
Affiliations
University of Illinois Chicago (US)
Corresponding author
KRAMER, K
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2003-09
Volume
79
Issue
4-5
Pages
775-782
ISSN
0031-9384 (ISSN-L)
OpenAlex
W1964681334
Cited by
79
References
72
Citations by year
2025: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 9 · 2012: 5
FWCI
6.49
Type
journal article
Language
en
Open access
closed
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (MH 01992, K01MH001992)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 41293, P01HD038490, HD38490, F32HD041293)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
oxytocin, stress response, oxytocin antagonist, Microtus ochrogaster, social isolation, ultrasonic vocalizations, corticosterone, sex differences, developmental programming, postnatal development
MeSH terms
Animals, Animals, Newborn, Corticosterone, Arvicolinae, Drug Administration Schedule, Female, Male, Oxytocin, Sex Factors, Social Isolation, Stress, Psychological, Vocalization, Animal

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