Developmental effects of oxytocin on stress response: Single versus repeated exposure
Abstract
Both exogenous and endogenous oxytocin (OT) are associated with an attenuated stress response. Increased levels of OT in the early postnatal period have been shown to affect behavior and physiology in rodents, and these effects last into adulthood, suggesting an organizational role for OT during development. We investigated the effects of neonatal exposure to OT on the development of the stress response in male and female prairie voles (Microtus ochrogaster). OT or an OT antagonist (OTA) was administered either on postnatal day 1 (single, D1) or days 1-7 (repeated, D1-7) and then on day 8 the response to social isolation was assessed by quantifying ultrasonic vocalizations (USVs) and measuring plasma corticosterone (CORT). Treatment effects were observed only in females. A single treatment with OTA was associated with a decrease in vocalizations, while repeated treatment produced an increase in vocalizations. A single treatment with either saline or OTA increased basal CORT. The results suggest that endogenous OT may be involved in the development of the stress response in females.
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Oxytocin can produce opposing effects at different dosages.
“OT (like other peptides) can produce opposing effects at different dosages (19–22).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [21]
Female prairie voles administered oxytocin on postnatal day 1 have reductions in baseline plasma corticosterone by postnatal day 8 compared to animals treated with saline or an oxytocin receptor antagonist.
“Female prairie voles administered Oxt on PND1 have reductions in baseline plasma corticosterone by PND8 compared to animals treated with saline or an OTA (23).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [23]
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- Authors
- KRAMER, K., CUSHING, B., & CARTER, C.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- KRAMER, K
- ORCID
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 79
- Issue
- 4-5
- Pages
- 775-782
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W1964681334
- Cited by
- 79
- References
- 72
- Citations by year
- 2025: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 9 · 2012: 5
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 01992, K01MH001992)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 41293, P01HD038490, HD38490, F32HD041293)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, stress response, oxytocin antagonist, Microtus ochrogaster, social isolation, ultrasonic vocalizations, corticosterone, sex differences, developmental programming, postnatal development
- MeSH terms
- Animals, Animals, Newborn, Corticosterone, Arvicolinae, Drug Administration Schedule, Female, Male, Oxytocin, Sex Factors, Social Isolation, Stress, Psychological, Vocalization, Animal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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