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Cited by 31Neuroendocrine regulation and behaviorAnimal Behavior and ReproductionHypothalamic control of reproductive hormones

Neonatal manipulation of oxytocin influences female reproductive behavior and success

Cushing, Bruce S., Levine, Karyn, Cushing, Nancy L.·2005·Hormones and Behavior
DOI 10.1016/j.yhbeh.2004.08.004
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Abstract

During early neonatal development, oxytocin (OT) may influence the expression of adult behavior and physiology. Here we test the prediction that early postnatal exposure to OT or an oxytocin antagonist (OTA) can affect the subsequent expression of sexual receptivity and reproductive success of females. To test this hypothesis, female prairie voles (Microtus ochrogaster) received one of four treatments within 24 h of birth. Three groups received an intraperitoneal injection of OT, OTA, or isotonic saline. A fourth group was handled, but not injected. Around 75 days of age, females were paired with sexually experienced males for 72 h and sexual activity was recorded. Treatment had no effect on the probability of mating. Injection, regardless of treatment, reduced latency to mate compared with handled controls. OT and OTA treatment decreased mating bout frequency compared to saline and handled controls, while OTA treatment increased reproductive success, probability of successfully producing a litter. The results suggest that neonatally OT, both endogenous and exogenous, can affect the expression of adult female reproductive activity and that blocking the effects of endogenous OT during neonatal development can affect female reproductive success. Finally, the results suggest that a number of aspects of reproduction are regulated by OT during the postnatal period, but that the mechanism of action may differ depending upon the reproductive activity.

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  • Studies in numerous species provide converging evidence that oxytocin during development can have permanent effects on the brain and behavior.

    “Yet, in the last 12 years, there has been a resurgence of research in this area, with studies in numerous species providing converging evidence that Oxt during development can have permanent effects on the brain and behavior (3, 13–29) (see Table 1).”

    From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [20]

  • In prairie voles, injection of both oxytocin and an oxytocin receptor antagonist on postnatal day 1 decreases the frequency of mating bouts in adult males and females.

    “whereas an injection of both Oxt and an Oxt receptor antagonist (OTA), also on PND1, decreases the frequency of mating bouts in both adult males and females (20).”

    From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [20]

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Authors
Cushing, B. S., Levine, K., & Cushing, N. L.
Affiliations
University of Illinois Chicago (US)
Corresponding author
Cushing, Bruce S.
ORCID
Cushing, Bruce S.
Venue
Hormones and Behavior
Publisher
Elsevier BV
Published
2005-01
Volume
47
Issue
1
Pages
22-28
ISSN
0018-506X (ISSN-L)
DOI
10.1016/j.yhbeh.2004.08.004
OpenAlex
W2094179010
Cited by
31
References
56
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 2 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
2.78
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Hormones and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
oxytocin, oxytocin antagonist, Microtus ochrogaster, female reproductive behavior, reproductive success, sexual receptivity, mating behavior, postnatal development, litter size
MeSH terms
Age Factors, Animals, Animals, Newborn, Female, Fertility, Male, Muridae, Oxytocin, Pair Bond, Random Allocation, Sexual Behavior, Animal, Sex Factors

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