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Involvement of the kynurenine pathway in the pathogenesis of Parkinson's disease
Abstract
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of dopaminergic neurons and localized neuroinflammation occurring in the midbrain several years before the actual onset of symptoms. Neuroinflammation leads to microglia activation and release of a large number of proinflammatory mediators. The kynurenine pathway (KP) of tryptophan catabolism is one of the major regulators of the immune response and is also likely to be implicated in the inflammatory and neurotoxic events in Parkinsonism. Several neuroactive compounds are produced through the KP that can be either a neurotoxic, neuroprotective or immunomodulator. Among these metabolites kynurenic acid (KYNA), produced by astrocytes, is considered as neuroprotective whereas quinolinic acid (QUIN), released by activated microglia, can activate the N-methyl-d-aspartate (NMDA) receptor-signalling pathway, leading to excitotoxicity and amplify the inflammatory response. Previous studies have shown that NMDA antagonists can ease symptoms and exert a neuroprotective effect in PD both in vivo and in vitro. There are to date several lines of evidence linking some of the KP intermediates and the neuropathogenesis of PD. Moreover, it is likely that some of the KP metabolites could be used as prognostic biomarkers and that pharmacological modulators of the KP enzymes could represent a new therapeutic strategy for PD.
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In the citing paper
“previous studies showing that quinolinic acid (QA), a QUIN precursor, contributes to neuroinflammation and is implicated in various neurodegenerative diseases [55,56,57].”
In the citing paper
“By contrast, quinolinic acid, released by microglia, can activate the NMDA receptor-signaling pathway, leading to excitotoxicity and increasing the inflammatory response.”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Lim C. K. et al., 2017
In the citing paper
“Recently, the kinurenic pathway (KP) has been implicated in the inflammatory and neurotoxic processes in PD.”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Lim C. K. et al., 2017
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Background
Metadata
- Authors
- Lim, C. K., Fernández-Gomez, F. J., Braidy, N., Estrada, C., Costa, C., Costa, S., Bessede, A., Fernandez-Villalba, E., Zinger, A., Herrero, M. T., & Guillemin, G. J.
- Affiliations
- Macquarie University (AU)
- UNSW Sydney (AU)
- Instituto Murciano de Investigación Biosanitaria (ES)
- Universidade Federal da Bahia (BR)
- The University of Sydney (AU)
- St Vincent's Hospital Sydney (AU)
- Corresponding author
- Guillemin, Gilles J.
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 155
- Pages
- 76-95
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W2322232345
- Cited by
- 159
- References
- 270
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 19 · 2023: 14 · 2022: 17 · 2021: 22 · 2020: 19 · 2019: 22 · 2018: 6 · 2017: 10
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Spanish Ministry of Science and Innovation (01293)
- European Community’s Seventh Framework Programme (115009)
- Australian Research Council
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Parkinson's disease, kynurenine pathway, tryptophan catabolism, neuroinflammation, microglial activation, kynurenic acid, quinolinic acid, NMDA receptor, excitotoxicity, dopaminergic neuron loss, neuroprotection, NMDA receptor antagonists, biomarkers, therapeutic target
- MeSH terms
- Animals, Humans, Kynurenine, Parkinson Disease
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