Cocaine addiction: diffusion tensor imaging study of the inferior frontal and anterior cingulate white matter
Abstract
Inferior frontal and anterior cingulate white matter integrity in 32 cocaine-dependent subjects was compared with that in 33 age-matched healthy control subjects. Diffusion tensor imaging data were acquired with a 1.5-T magnetic resonance imaging system. Cocaine-dependent subjects presented significantly lower fractional anisotropy values in inferior frontal white matter at the anterior-posterior commissure plane and higher anterior cingulate white matter values than control subjects. White matter integrity was also associated with impulsivity and motivation to change (Readiness to Change Questionnaire). These findings support the hypothesis that cocaine dependence involves a disruption of orbitofrontal connectivity and suggest that the anterior cingulate brain area might play a role in the motivation to change.
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Cocaine users were reported to have lower white matter fractional anisotropy than controls in several DTI studies.
“Several recent DTI studies have found that cocaine users had lower white matter FA relative to controls (Azadeh et al., 2016; Romero, Asensio, Palau, Sanchez, & Romero, 2010).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Romero, Asensio, Palau, Sanchez, & Romero, 2010
Cocaine abuse is associated with higher FA in some brain regions and lower FA in others.
“cocaine abuse is associated with higher FA in certain regions of the brain, and lower FA in other areas (Morie et al., 2017; Romero et al., 2010).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Romero et al., 2010
Cocaine users have lower white matter FA than controls.
“Several recent DTI studies have found that cocaine users had lower white matter FA relative to controls (Azadeh et al., 2016; Romero, Asensio, Palau, Sanchez, & Romero, 2010).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Romero, Asensio, Palau, Sanchez, & Romero, 2010
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- Authors
- Romero, M. J., Asensio, S., Palau, C., Sanchez, A., & Romero, F. J.
- Affiliations
- Universidad Cardenal Herrera CEU (ES)
- Generalitat Valenciana (ES)
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 181
- Issue
- 1
- Pages
- 57-63
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2141233050
- Cited by
- 103
- References
- 76
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 3 · 2017: 12 · 2016: 11 · 2015: 8 · 2014: 9 · 2013: 4 · 2012: 9
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- CEU Repositorio Institucional (Fundación Universitaria San Pablo CEU) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- cocaine dependence, white matter integrity, fractional anisotropy, impulsivity, motivation for change, readiness to change, addiction
- MeSH terms
- Adult, Analysis of Variance, Brain, Frontal Lobe, Gyrus Cinguli, Humans, Impulsive Behavior, Functional Laterality, Male, Nerve Fibers, Myelinated, Organ Size, Psychiatric Status Rating Scales, Surveys and Questionnaires, Anisotropy, Cocaine-Related Disorders, Diffusion Tensor Imaging
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