Cited by 103Advanced Neuroimaging Techniques and ApplicationsSubstance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Cocaine addiction: diffusion tensor imaging study of the inferior frontal and anterior cingulate white matter

Romero, Maria J., Asensio, Samuel, Palau, Carmina, Sanchez, Amparo, Romero, Francisco J.·2010·Psychiatry Research: Neuroimaging

Abstract

Inferior frontal and anterior cingulate white matter integrity in 32 cocaine-dependent subjects was compared with that in 33 age-matched healthy control subjects. Diffusion tensor imaging data were acquired with a 1.5-T magnetic resonance imaging system. Cocaine-dependent subjects presented significantly lower fractional anisotropy values in inferior frontal white matter at the anterior-posterior commissure plane and higher anterior cingulate white matter values than control subjects. White matter integrity was also associated with impulsivity and motivation to change (Readiness to Change Questionnaire). These findings support the hypothesis that cocaine dependence involves a disruption of orbitofrontal connectivity and suggest that the anterior cingulate brain area might play a role in the motivation to change.

Integrity signals

Registry

Crossref · 10.1016/j.pscychresns.2009.07.004

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Authors
Romero, M. J., Asensio, S., Palau, C., Sanchez, A., & Romero, F. J.
Affiliations
  • Universidad Cardenal Herrera CEU (ES)
  • Generalitat Valenciana (ES)
Venue
Psychiatry Research: Neuroimaging
Publisher
Elsevier BV
Published
2010-01
Volume
181
Issue
1
Pages
57-63
ISSN
0925-4927 (ISSN-L)
OpenAlex
W2141233050
Cited by
103
References
76
Citations by year
2024: 2 · 2023: 2 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 3 · 2017: 12 · 2016: 11 · 2015: 8 · 2014: 9 · 2013: 4 · 2012: 9
FWCI
5.27
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
  • CEU Repositorio Institucional (Fundación Universitaria San Pablo CEU) (submittedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
cocaine dependence, white matter integrity, fractional anisotropy, impulsivity, motivation for change, readiness to change, addiction
MeSH terms
Adult, Analysis of Variance, Brain, Frontal Lobe, Gyrus Cinguli, Humans, Impulsive Behavior, Functional Laterality, Male, Nerve Fibers, Myelinated, Organ Size, Psychiatric Status Rating Scales, Surveys and Questionnaires, Anisotropy, Cocaine-Related Disorders, Diffusion Tensor Imaging

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