Altered neural response of the appetitive emotional system in cocaine addiction: an fMRI Study
Open accessAbstract
Research on addiction suggests that emotional alterations play an essential role in the development, maintenance, relapse and treatment outcome of substance abuse disorders. Although many neuroimaging studies focussed on the neural response to conditioned stimuli, much less is known about the neural response to natural affective stimuli in this pathological population. Previous research has demonstrated an altered emotional experience and autonomic response to emotional stimuli using the International Affective Picture System (IAPS) in drug abusers. Here we aimed, using functional magnetic resonance imaging (fMRI), to study the alterations in the neural responsitivity to pleasant (erotic), unpleasant and neutral IAPS stimuli in cocaine addiction. Thirty‐two cocaine‐dependent subjects and 26 matched controls completed an fMRI session during the presentation of a set of IAPS pictures as background, while performing a letter discrimination task. Consistent with previous studies, emotional pictures activated an emotional network including amygdala, medial prefrontal cortex, orbitofrontal cortex and occipito‐temporal areas in both groups. However, compared with controls, the cocaine group showed a significant hypoactivation of the dorsal and ventral striatum (including the nucleus accumbens), thalamus, parietal cortex and dorso‐medial prefrontal cortex (dmPFC) when processing pleasant pictures. The analysis of pleasant versus unpleasant stimuli suggested that between‐group differences in the dmPFC and striatal activation may be attributed to arousal processing rather than valence. These results could reflect the neural basis for the reduced ability of cocaine‐dependent subjects to experience pleasure by daily natural reinforcers, suggesting that these alterations in the emotion processing may play an important role in drug dependence, treatment and relapse.
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Cocaine addicts show hypoactivation of the dorsal and ventral striatum and the dorsomedial prefrontal cortex when viewing pleasant images not linked to substance cues.
“For example, Asensio and collegues [152] reported hypoactivation of the dorsal and ventral striatum and the dorsomedial pre-frontal cortex when cocaine addicts viewed pleasant images not linked to substance cues.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [152]
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Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
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- Authors
- Asensio, S., Romero, M. J., Palau, C., Sanchez, A., Senabre, I., Morales, J. L., Carcelen, R., & Romero, F. J.
- Affiliations
- Universidad Cardenal Herrera CEU (ES)
- Generalitat Valenciana (ES)
- Corresponding author
- Romero, Francisco J.
- Venue
- Addiction Biology
- Publisher
- Wiley
- Published
- 2010-06-23
- Volume
- 15
- Issue
- 4
- Pages
- 504-516
- ISSN
- 1355-6215 (ISSN-L)
- 1369-1600
- OpenAlex
- W1545863601
- Cited by
- 95
- References
- 94
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 10 · 2017: 9 · 2016: 9 · 2015: 9 · 2014: 9 · 2013: 9 · 2012: 10
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Addiction Biology (publishedVersion)
- PubMed (publishedVersion)
- CEU Repositorio Institucional (Fundación Universitaria San Pablo CEU) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- cocaine dependence, emotional processing, International Affective Picture System, dorsal striatum, nucleus accumbens, medial prefrontal cortex, amygdala, arousal, emotional valence, relapse, drug addiction
- MeSH terms
- Adult, Appetitive Behavior, Arousal, Basal Ganglia, Brain, Brain Mapping, Cocaine, Conditioning, Operant, Discrimination, Psychological, Emotions, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net, Nucleus Accumbens, Oxygen Consumption, Parietal Lobe, Pattern Recognition, Visual, Reference Values, Thalamus, Prefrontal Cortex, Cocaine-Related Disorders, Young Adult, Pleasure
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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