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Cited by 50Suicide and Self-Harm StudiesNeural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The neurobiology of self-knowledge in depressed and self-injurious youth

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Quevedo, Karina, Martin, Jodi, Scott, Hannah, Smyda, Garry, Pfeifer, Jennifer H.·2016·Psychiatry Research Neuroimaging
DOI 10.1016/j.pscychresns.2016.06.015PMC PMC5737906
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Abstract

There is limited information regarding the neurobiology underlying non-suicidal self-injury (NSSI) in clinically-referred youth. However, the salience of disturbed interpersonal relationships and disrupted self-processing associated with NSSI suggests the neural basis of social processes as a key area for additional study. Adolescent participants (N=123; M=14.75 years, SD=1.64) were divided into three groups: NSSI plus depression diagnosis (NSSI), depression only (DEP), healthy controls (HC). In the scanner, participants completed an Interpersonal Self-Processing task by taking direct (own) and indirect (mothers', best friends', or classmates') perspectives regarding self-characteristics. Across all perspectives, NSSI showed higher BOLD activation in limbic areas, and anterior and posterior cortical midline structures versus DEP and HC, while HC showed greater activity in rostrolateral, frontal pole and occipital cortex than NSSI and DEP youth. Moreover, NSSI youth showed heightened responses in amygdala, hippocampus, parahippocampus, and fusiform when taking their mothers' perspective, which were negatively correlated with self-reports of the mother's support of adolescents' emotional distress in the NSSI group. NSSI youth also yielded greater precuneus and posterior cingulate cortex activity during indirect self-processing from their classmates' perspective. Findings suggest a role for disruptions in self- and emotion-processing, and conflicted social relationships in the neurobiology of NSSI among depressed adolescents.

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  • In the mother perspective condition compared to baseline, self-injurers show similar activation in amygdala, hippocampus, parahippocampus, and fusiform.

    “The mother perspective condition (compared to baseline) yields similar findings among self-injurers in the amygdala, hippocampus, parahippocampus, and fusiform.”

    From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [87]

  • Depressed self-injurers show greater activation across all perspectives in dorsal PFC, precuneus, PCC, superior parietal lobule, left/right temporal limbic structures, fusiform, and middle temporal gyrus relative to a combined sample of depressed and healthy adolescents.

    “Relative to a combined sample of depressed and healthy adolescents, depressed self-injurers exhibit greater activation across all perspectives in the dorsal PFC, precuneus, PCC, superior parietal lobule, left/right temporal limbic structures (amygdala, parahippocampus, hippocampus), fusiform, and middle temporal gyrus.”

    From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [87]

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Research works printed but not linked: 4

  1. Claes L Houben A Vandereycken W Bijttebier P Muehlenkamp J 2010b Brief report: the association between non-suicidal self-injury, self-concept and acquaintance with self-injurious peers in a sample of adolescents J Adolesc 33 775 778 19910041
  2. Martin J Bureau J-F Lafontaine M-F Cloutier PF Hsiao C Pallanca D Meinz P 2015 Associations between Non-suicidal Self-injury, Attachment Representations, and Maltreatment Development & Psychopathology 28401828
  3. Phillips ML Drevets WC Rauch SL Lane R 2003b Neurobiology of emotion perception I: The neural basis of normal emotion perception Biol Psychiatry 54 504 514 12946879
  4. Whitlock J Muehlenkamp JJ Eckenrode J Purington A Baral Abrams G Barreira P Kress V 2013b Nonsuicidal self-injury as a gateway to suicide Journal of Adolescent Health 52 486 492 23298982

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Authors
Quevedo, K., Martin, J., Scott, H., Smyda, G., & Pfeifer, J. H.
Affiliations
  • University of Minnesota (US)
  • University of Pittsburgh (US)
  • University of Oregon (US)
Corresponding author
Quevedo, Karina
ORCID
Venue
Psychiatry Research Neuroimaging
Publisher
Elsevier BV
Published
2016-08
Volume
254
Pages
145-155
ISSN
0925-4927 (ISSN-L)
DOI
10.1016/j.pscychresns.2016.06.015
PMC
PMC5737906
OpenAlex
W2468038580
Cited by
50
References
98
Citations by year
2026: 10 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 2
FWCI
3.12
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIMH (K01MH092601)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
non-suicidal self-injury, adolescent depression, self-processing, interpersonal relationships, limbic system activation, amygdala, hippocampus, precuneus, posterior cingulate cortex, maternal support, emotional processing, social conflict
MeSH terms
Adolescent, Depression, Depressive Disorder, Emotions, Female, Frontal Lobe, Gyrus Cinguli, Humans, Interpersonal Relations, Male, Occipital Lobe, Self Concept, Case-Control Studies, Self-Injurious Behavior, Friends, Functional Neuroimaging

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