Depression and oxidative damage to lipids
Abstract
Depression is associated with increased morbidity and mortality from cardiovascular and cerebrovascular diseases. Oxidative damage to lipids is one of the key early events in the etiology of atherosclerosis, the pathologic condition that underlies these diseases. The current study examines the pathophysiological consequences of depression by comparing serum levels of F(2α)-isoprostanes (8-iso-PGF(2α)), a biomarker of oxidative damage to lipids, in a group of depressed individuals (n=73) and a matched comparison group (n=72). The depressed group had significantly higher levels of serum 8-iso-PGF(2α), while controlling for age, gender, race, years of education, daily smoking, number of alcoholic drinks per week, average amount of physical activity per week, and body mass index. Analyses using interviewer ratings on the Hamilton Scale revealed that, within the depressed cohort, there was no significant association between the severity of symptoms and levels of 8-iso-PGF(2α), suggesting this is a threshold rather than a dose-response relationship. Results extend on our knowledge of depression and oxidative damage to lipids. In conclusion, oxidative damage to lipid molecules may represent a common pathophysiological mechanism by which depressed individuals become more vulnerable to atherosclerosis and its clinical sequelae.
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Bipolar disorder is characterized by mutations to mtDNA and mitochondrial dysfunction caused predominantly by excess ROS.
“Bipolar disorder is also characterized by mutations to mtDNA and mitochondrial dysfunction caused predominantly by excess ROS (Andreazza et al. 2018; Yager et al. 2010).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Yager et al. 2010
Plasma protein carbonyls increased during manic and depressive phases in patients with bipolar disorder.
“Plasma protein carbonyls is another oxidative stress marker that has been found to be increased during manic and depressive phases in patients with bipolar disorder (Andreazza et al. 2010; Yager et al. 2010).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Yager et al. 2010
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“On the other hand, correlation analysis done in the patients with depression between levels of 8-iso-PGF 2 a – a marker of oxidative damage to lipids – and 8-oxoG showed that those disparities were independent of each other [18,38].”
MethodCecerska-Heryć, E., Polikowska, A., Serwin, N., Roszak, M., Grygorcewicz, B., Heryć, R., Michalczyk, A., & Dołęgowska, B. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2021.105269 · Cited by 68 · see citing works
- Authors
- Yager, S., Forlenza, M. J., & Miller, G. E.
- Affiliations
- University of British Columbia (CA)
- Duquesne University (US)
- Corresponding author
- Yager, Sarah
- ORCID
- Miller, Gregory E.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 35
- Issue
- 9
- Pages
- 1356-1362
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2100145356
- Cited by
- 120
- References
- 40
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 12 · 2022: 7 · 2021: 7 · 2020: 16 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 7 · 2015: 13 · 2014: 13 · 2013: 10 · 2012: 6
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- depression, lipid peroxidation, 8-isoprostane, atherosclerosis, cardiovascular disease, cerebrovascular disease, biomarkers, depression severity, psychosocial risk factors
- MeSH terms
- Adult, Depressive Disorder, Female, Humans, Lipids, Male, Oxidation-Reduction, Socioeconomic Factors, Stress, Physiological, Lipid Peroxidation, Dinoprost, Case-Control Studies, Oxidative Stress, F2-Isoprostanes, Lipid Metabolism, Young Adult
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