Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans
Abstract
The effect of short-term aerobic exercise and a following ramp incremental cycle ergometry to exhaustion on the acute response of the serum concentrations of brain derived neurotrophic factor (BDNF) and cortisol (COR) was examined in 8 healthy male athletes. Venous and capillary blood samples were drawn at rest, immediately after a 10 min warm-up period with aerobic exercise and after a ramp test to exhaustion, as well as 3, 6, 10 and 15 min post exercise. Capillary blood lactate (LA) concentration and blood gases as well as serum BDNF and COR concentrations did not change during the warm-up period. LA was increased (p<0.05) at the end of the ramp test and during recovery period while bicarbonate concentration, carbon dioxide pressure, pH and base excess were decreased (p<0.05) during this period. Serum BDNF was increased at the point of exhaustion (p<0.05) while no significant differences were found between values at rest and those during recovery period. At 10 and 15 min post incremental exercise, COR concentrations were increased (p<0.05) compared to rest. The present study is the first to demonstrate in humans that in contrast to short duration aerobic exercise immediately after a following short duration high-intensity exercise to exhaustion, there is a transient augmentation of serum BDNF concentration. Short-term response of serum BDNF and COR concentrations differs as BDNF returns to baseline level faster than COR.
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Peripheral BDNF concentration returns to baseline within about minutes to one hour after exercise cessation.
“In a period of about minutes to one hour after cessation of exercise, the level of peripheral BDNF concentration returns to the baseline [174,176,177,178].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [177]
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High-Intensity Aerobic Exercise Acutely Increases Brain-derived Neurotrophic Factor
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- Authors
- Rojas Vega, S., Strüder, H. K., Vera Wahrmann, B., Schmidt, A., Bloch, W., & Hollmann, W.
- Affiliations
- German Sport University Cologne (DE)
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 1121
- Issue
- 1
- Pages
- 59-65
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2021515441
- Cited by
- 357
- References
- 49
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 13 · 2023: 11 · 2022: 26 · 2021: 19 · 2020: 26 · 2019: 32 · 2018: 26 · 2017: 26 · 2016: 26 · 2015: 22 · 2014: 25 · 2013: 19 · 2012: 11
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- brain-derived neurotrophic factor, cortisol, acute exercise response, low-intensity aerobic exercise, high-intensity exercise, post-exercise recovery, blood lactate, blood gases, capillary blood, serum biomarkers
- MeSH terms
- Adult, Exercise Test, Heat Exhaustion, Humans, Hydrocortisone, Male, Sports, Exercise, Brain-Derived Neurotrophic Factor, Lactic Acid
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