Oxytocin Receptor Gene Polymorphism (rs2254298) Interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls
Open accessAbstract
The nonapeptide oxytocin and its receptor have been implicated in the regulation of mammalian social behavior and stress physiology. Evidence is accumulating that the quality of the parental environment is associated with oxytocin biology in children. The present study was designed to examine the interaction of the single nucleotide polymorphism (SNP) rs2254298 within the oxytocin receptor (OXTR) gene and quality of parental environment in predicting children's psychosocial functioning. More specifically, in a sample of 92 Caucasian adolescent girls (9-14 years old), we examined whether adverse parental environment, operationalized as mothers' history of recurrent major depressive disorder, interacts with the rs2254298 SNP on the OXTR gene to predict daughters' symptoms of depression and anxiety. Caucasian girls who both were heterozygous for the OXTR rs2254298 polymorphism and had high early adversity reported the highest levels of symptoms of depression, physical anxiety, and social anxiety. These findings highlight the potential importance of this OXTR gene polymorphism in the etiology of depression and anxiety disorders.
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Allelic variation in the oxytocin receptor gene has been associated with increased symptoms of depression.
“Allelic variation in the oxytocin receptor gene has been associated with increased symptoms of depression (Thompson et al., 2011).”
From Social functioning in major depressive disorder (2016) · cites this paper as Thompson et al., 2011
Early life stress in humans can interact with OXTR variation to influence adult social behavior and emotional regulation.
“Early life stress in humans can interact with OXTR variation to influence adult social behavior and emotional regulation (28–31).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [31]
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- Authors
- Thompson, R. J., Parker, K. J., Hallmayer, J. F., Waugh, C. E., & Gotlib, I. H.
- Affiliations
- Stanford University (US)
- Corresponding author
- Thompson, Renee J.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 36
- Issue
- 1
- Pages
- 144-147
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC2997902
- OpenAlex
- W2046504195
- Cited by
- 211
- References
- 17
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 2 · 2023: 9 · 2022: 12 · 2021: 22 · 2020: 16 · 2019: 8 · 2018: 12 · 2017: 15 · 2016: 21 · 2015: 16 · 2014: 21 · 2013: 14 · 2012: 18
- FWCI
- 19.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH74849, R01MH074849)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin receptor gene, oxytocin receptor, rs2254298, single nucleotide polymorphisms, gene-environment interaction, parental environment, maternal depression history, childhood adversity, depressive symptoms, anxiety symptoms, social anxiety, adolescent girls, psychopathology
- MeSH terms
- Adolescent, Psychology, Adolescent, Anxiety, Mental Disorders, Child, Depression, Family, Female, Humans, Prognosis, Psychopathology, Receptors, Oxytocin, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide
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