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Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques
Open accessAbstract
Intranasal (IN) administration is a widely used method for examining the effect of oxytocin (OT) on social behavior and cognition in healthy subjects and psychiatric populations. IN-OT in humans enhances trust, emotional perception, and empathetic behavior and is under investigation as a potential pharmacotherapy to enhance social functioning in a variety of neuropsychiatric disorders, including autism spectrum disorders (ASD). Nonhuman primates (NHP) are an important model for understanding the effect of OT on social cognition, its neural mechanisms, and the development of IN-OT as a pharmacotherapy for treating social deficits in humans. However, NHP and even some human populations, such as very young infants and children, cannot easily follow the detailed self-administration protocol used in the majority of human IN-OT studies. Therefore, we evaluated the efficacy of several OT-administration routes for elevating central OT concentrations in rhesus macaques. First, we examined the effect of IN and intravenous (IV) routes of OT administration on concentrations of OT and vasopressin (AVP) in plasma and lumbar CSF. Second, we examined these same measures in monkeys after an aerosolized (AE) OT delivery route. All three administration routes significantly increased plasma OT concentrations, but only the AE-OT route significantly increased concentrations of CSF OT. No route affected concentrations of AVP in plasma or CSF. This study confirms that the AE route is the most effective method for increasing central OT concentrations in monkeys, and may also be an effective route, alternative to IN, for administering OT to some human populations.
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In the citing paper
“In a larger study, Modi et al. gave 24IU oxytocin (~5µg/kg body weight) to macaques by spray or aerosol; only the aerosol produced a significant increase in CSF (from ~20 to ~60pg/ml) (25).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [25]
Experimental — accuracy not yet measuredIn the citing paper
“The intranasal dose administered in the present study has been associated with changes in central function in humans 58, and similar or smaller doses of oxytocin or vasopressin (24–48 IU for oxytocin; 40–80 IU for vasopressin) have been associated with elevations in peptide levels in the cerebrospinnal fluid in humans or macaques of no more than approximately 55 pg/ml in actual levels 70, 71, 72,”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [72]
In the citing paper
“In addition, several studies have found that IN-OT leads to a significant increase in OT concentrations in cerebrospinal fluid, which may also be indicative of IN-OT reaching the brain [30, 31].”
From Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study (2015) · cites this paper as [31]
In the citing paper
“Also, in monkeys, IN-OT or OT intake via a nebulizer (25 or 48 IU) increased OT CSF concentration compared to placebo (Chang et al. 2012; Dal Monte et al. 2014; Modi et al. 2014).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Modi et al. 2014
In the citing paper
“While there is conflicting evidence on whether peripheral OT can cross the BBB (Modi et al., 2014), our study suggests that even if OT does travel across this barrier in small amounts, this quantity is not large enough to dampen amygdala activity compared to placebo.”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Modi et al., 2014
In the citing paper
“The here-observed immediate influence of intranasal oxytocin on psychopathology and hence on brain function is supported by primate studies showing that intranasal oxytocin, such as other intranasally administered anxiolytic neuropeptides like NPS [45], are able to reach the cerebrospinal fluid [46, 47] and thus, assumingly, also the brain.”
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Citations
Cites
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356
Intranasal delivery of biologics to the central nervous system
Lochhead, J. J., & Thorne, R. G. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.002 · Cited by 1,214
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059
Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.
Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954
Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941
Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856 · cited 2×
“For example, in animals OTenhances social information processing, social recognition, maternal care, and social attachment through actions on central OTreceptors (Ross and Young, 2009).”
Oxytocin increases gaze to the eye region of human faces
Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.026 · Cited by 798
Research works printed but not linked: 2
- Frank, 2011, 146, 313
- Lochhead, 2011, 64, 614
Cited by
Sorted by citations
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Intranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 616
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520
“Indeed, intranasal OT administration also leads to increases in OT in plasma and saliva in humans (Gossen et al., 2012; van Ijzendoorn et al., 2012) and rhesus macaques (Modi et al., 2014).”
BackgroundThe biology of mammalian parenting and its effect on offspring social development
Rilling, J. K., & Young, L. J. (2014) · Science · doi:10.1126/science.1252723 · Cited by 452
Self-citationDoes Oxytocin Increase Trust in Humans? A Critical Review of Research
Nave, G., Camerer, C., & McCullough, M. (2015) · Perspectives on Psychological Science · doi:10.1177/1745691615600138 · Cited by 316
Quintana, D. S., Lischke, A., Grace, S., Scheele, D., Ma, Y., & Becker, B. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00864-7 · Cited by 263
Lee, M. R., Scheidweiler, K. B., Diao, X. X., Akhlaghi, F., Cummins, A., Huestis, M. A., Leggio, L., & Averbeck, B. B. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.27 · Cited by 235
Kinetics and dose dependency of intranasal oxytocin effects on amygdala reactivity
Spengler, F. B., Schultz, J., Scheele, D., Essel, M., Maier, W., Heinrichs, M., & Hurlemann, R. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.04.015 · Cited by 229
Freeman, S. M., Inoue, K., Smith, A. L., Goodman, M. M., & Young, L. J. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.03.023 · Cited by 185
“More recently, IN-OT administration in rhesus macaques has been shown to increase central OT concentrations (Chang et al., 2012) (Modi et al., 2014) and to affect a variety of social behaviors including increasing gaze to the eye region of monkey faces (Ebitz et al., 2013), increasing both selfish…”
BackgroundPaloyelis, Y., Doyle, O. M., Zelaya, F. O., Maltezos, S., Williams, S. C., Fotopoulou, A., & Howard, M. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.005 · Cited by 187
CSF and blood oxytocin concentration changes following intranasal delivery in macaque
Dal Monte, O., Noble, P. L., Turchi, J., Cummins, A., & Averbeck, B. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103677 · Cited by 177
Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics
Kazdoba, T. M., Leach, P. T., Yang, M., Silverman, J. L., Solomon, M., & Crawley, J. N. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_5003 · Cited by 185
McCormack, S. E., Blevins, J. E., & Lawson, E. A. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz012 · Cited by 148
Effects of oxytocin administration on spirituality and emotional responses to meditation
Cappellen, P. V., Way, B. M., Isgett, S. F., & Fredrickson, B. L. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw078 · Cited by 143
Blevins, J. E., & Baskin, D. G. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.023 · Cited by 135
Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques
Lee, M. R., Shnitko, T. A., Blue, S. W., Kaucher, A. V., Winchell, A. J., Erikson, D. W., Grant, K. A., & Leggio, L. (2020) · Nature Communications · doi:10.1038/s41467-020-15942-1 · Cited by 132
Plasma and CSF oxytocin levels after intranasal and intravenous oxytocin in awake macaques
Freeman, S. M., Samineni, S., Allen, P. C., Stockinger, D., Bales, K. L., Hwa, G. G. C., & Roberts, J. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.014 · Cited by 128
Overview of human oxytocin research
Kendrick, K. M., Guastella, A. J., & Becker, B. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_19 · Cited by 121
Smith, A. S., Korgan, A. C., & Young, W. S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104324 · Cited by 110
Quintana, D. S., Guastella, A. J., Westlye, L. T., & Andreassen, O. A. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.166 · Cited by 107
Oxytocin for the treatment of drug and alcohol use disorders
Lee, M. R., & Weerts, E. M. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000258 · Cited by 105
Social Decision-Making and the Brain: A Comparative Perspective
Tremblay, S., Sharika, K. M., & Platt, M. L. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.01.007 · Cited by 116
Quintana, D. S., Westlye, L. T., Alnæs, D., Rustan, Ø. G., Kaufmann, T., Smerud, K. T., Mahmoud, R. A., Djupesland, P. G., & Andreassen, O. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.010 · Cited by 102
Oxytocin and stress-related disorders: neurobiological mechanisms and treatment opportunities
Sippel, L. M., Allington, C. E., Pietrzak, R. H., Harpaz-Rotem, I., Mayes, L. C., & Olff, M. (2017) · Chronic Stress · doi:10.1177/2470547016687996 · Cited by 99
The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis
Lawson, E. A., Olszewski, P. K., Weller, A., & Blevins, J. E. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12805 · Cited by 100
Evidence for Intranasal Oxytocin Delivery to the brain: Recent Advances and Future Perspectives
Quintana, D. S., Smerud, K. T., Andreassen, O. A., & Djupesland, P. G. (2018) · Therapeutic Delivery · doi:10.4155/tde-2018-0002 · Cited by 98
Daughters, K., Manstead, A. S. R., Hubble, K., Rees, A., Thapar, A., & van Goozen, S. H. M. (2015) · PLOS ONE · doi:10.1371/journal.pone.0145104 · Cited by 92
“In addition, several studies have found that IN-OT leads to a significant increase in OT concentrations in cerebrospinal fluid, which may also be indicative of IN-OT reaching the brain [30, 31].”
BackgroundCalcagnoli, F., Kreutzmann, J. C., de Boer, S. F., Althaus, M., & Koolhaas, J. M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.019 · Cited by 96
Alvares, G. A., Quintana, D. S., & Whitehouse, A. J. O. (2017) · Autism Research · doi:10.1002/aur.1692 · Cited by 91
Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward
Bradley, E., & Woolley, J. D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.007 · Cited by 92
Oxytocin promotes coordinated out-group attack during intergroup conflict in humans
Zhang, H., Gross, J., De Dreu, C., & Ma, Y. (2019) · eLife · doi:10.7554/elife.40698 · Cited by 87
Modi, M. E., Inoue, K., Barrett, C. E., Kittelberger, K. A., Smith, D. G., Landgraf, R., & Young, L. J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.35 · Cited by 82
Inhaled oxytocin increases positive social behaviors in newborn macaques
Simpson, E. A., Sclafani, V., Paukner, A., Hamel, A. F., Novak, M. A., Meyer, J. S., Suomi, S. J., & Ferrari, P. F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402471111 · Cited by 82
A, T. R. D. J., & Neumann, I. D. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_13 · Cited by 76
Chang, S. W. C., & Platt, M. L. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.006 · Cited by 71
Oxytocin promotes intuitive rather than deliberated cooperation with the in-group
Ten Velden, F. S., Daughters, K., & De Dreu, C. K. W. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.06.005 · Cited by 66
Oxytocin modulates fMRI responses to facial expression in macaques
Liu, N., Hadj-Bouziane, F., Jones, K. B., Turchi, J. N., Averbeck, B. B., & Ungerleider, L. G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508097112 · Cited by 65
Oxytocin: Parallel Processing in the Social Brain?
Dölen, G. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12284 · Cited by 65
Jiang, Y., & Platt, M. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-25607-1 · Cited by 69
Oxytocin, social cognition and psychiatry
Young, L. J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.186 · Cited by 64
Self-citationTargeting the Oxytocin System: New Pharmacotherapeutic Approaches
Gulliver, D. W., Werry, E. L., Reekie, T. A., Katte, T. A., Jorgensen, W. T., & Kassiou, M. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.11.001 · Cited by 67
Horta, M., Kaylor, K., Feifel, D., & Ebner, N. C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.012 · Cited by 63
Rault, J. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.03.015 · Cited by 64
Paloyelis, Y., Krahé, C., Maltezos, S., Williams, S. C., Howard, M. A., & Fotopoulou, A. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12347 · Cited by 61
Oxytocin as Treatment for Social Cognition, Not There Yet
Erdozain, A. M., & Peñagarikano, O. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00930 · Cited by 62
Ferris, C. F., Yee, J. R., Kenkel, W. M., Dumais, K. M., Moore, K., Veenema, A. H., Kulkarni, P. P., Perkybile, A. M., & Carter, C. S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00245 · Cited by 60
Current findings on the role of oxytocin in the regulation of food intake
Spetter, M. S., & Hallschmid, M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.007 · Cited by 61
Sack, M., Spieler, D., Wizelman, L., Epple, G., Stich, J., Zaba, M., & Schmidt, U. (2017) · BMC Medicine · doi:10.1186/s12916-017-0801-0 · Cited by 57
Oxytocin and vasopressin inhibit hyper-aggressive behaviour in socially isolated mice
Tan, O., Musullulu, H., Raymond, J. S., Wilson, B. B., Langguth, M., & Bowen, M. T. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.016 · Cited by 59
Putnam, P. T., Roman, J. M., Zimmerman, P. E., & Gothard, K. M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.05.016 · Cited by 53
“Although IN-OT does increase the CSF levels of OT (Dal Monte et al., 2014b; Modi et al., 2014) we also cannot rule out the possibility that the observed results are due, at least in part, to the peripheral effects of OT (Leng and Ludwig, 2015).”
Yao, S., & Kendrick, K. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020323 · Cited by 55
Oppong‐Damoah, A., Zaman, R. U., D’Souza, M. J., & Murnane, K. S. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.12.011 · Cited by 51
The two fold role of oxytocin in social developmental disorders: A cause and a remedy?
Lefèvre, A., & Sirigu, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.01.011 · Cited by 48
Oxytocin regulates reunion affiliation with a pairmate following social separation in marmosets
Cavanaugh, J., Mustoe, A. C., & French, J. A. (2018) · American Journal of Primatology · doi:10.1002/ajp.22750 · Cited by 42
Oxytocin Receptor Signaling in Vascular Function and Stroke
McKay, E. C., & Counts, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.574499 · Cited by 45
A precision medicine approach to oxytocin trials
Andari, E., Hurlemann, R., & Young, L. J. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_29 · Cited by 40
Self-citationIntranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates
Galbusera, A., Felice, A. D., Girardi, S., Bassetto, G., Maschietto, M., Nishimori, K., Chini, B., Papaleo, F., Vassanelli, S., & Gozzi, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.283 · Cited by 38
Alaerts, K., Bernaerts, S., Vanaudenaerde, B. M., Daniëls, N., & Wenderoth, N. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.01.008 · Cited by 42
Marmosets treated with oxytocin are more socially attractive to their long-term mate
Cavanaugh, J., Huffman, M. C., Harnisch, A. M., & French, J. A. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00251 · Cited by 36
McCormack, S. E., Wang, Z., Wade, K., Dedio, A., Cilenti, N., Crowley, J., Plessow, F., Bamba, V., Roizen, J. D., Jiang, Y., et al. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad037 · Cited by 37
Oxytocin and potential benefits for obesity treatment
Olszewski, P. K., Klockars, A., & Levine, A. S. (2017) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000351 · Cited by 35
Kou, J., Lan, C., Zhang, Y., Wang, Q., Zhou, F., Zhao, Z., Montag, C., Yao, S., Becker, B., & Kendrick, K. M. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01241-w · Cited by 39
Simpson, E. A., Paukner, A., Sclafani, V., Kaburu, S., Suomi, S. J., & Ferrari, P. F. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4480-x · Cited by 38
The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders
Okamoto, Y., Ishitobi, M., Wada, Y., & Kosaka, H. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160413120845 · Cited by 33
Xu, X., Yao, S., Xu, L., Geng, Y., Zhao, W., Ma, X., Kou, J., Luo, R., & Kendrick, K. M. (2017) · Scientific Reports · doi:10.1038/srep40589 · Cited by 33
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Ellenbogen, M. A. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_20 · Cited by 34
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Patin, A., Scheele, D., & Hurlemann, R. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_22 · Cited by 32
The Neuropeptide Oxytocin Enhances Information Sharing and Group Decision Making Quality
de Wilde, T. R. W., Velden, F. S. T., & Dreu, C. K. W. D. (2017) · Scientific Reports · doi:10.1038/srep40622 · Cited by 32
Oxytocin Fails to Recruit Serotonergic Neurotransmission in the Autistic Brain
Lefèvre, A., Mottolese, R., Redouté, J., Costes, N., Bars, D. L., Geoffray, M., Leboyer, M., & Sirigu, A. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx272 · Cited by 31
Bridging the gap between rodents and humans: The role of non‐human primates in oxytocin research
Putnam, P. T., Young, L. J., & Gothard, K. M. (2018) · American Journal of Primatology · doi:10.1002/ajp.22756 · Cited by 28
Modi, M. E., Majchrzak, M. J., Fonseca, K. R., Doran, A., Osgood, S., Vanase-Frawley, M., Feyfant, E., McInnes, H., Darvari, R., Buhl, D. L., et al. (2016) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.232702 · Cited by 29
Oxytocin as an Anti-obesity Treatment
Niu, J., Tong, J., & Blevins, J. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.743546 · Cited by 30
Wiśniewski, K. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9504-2_11 · Cited by 30
Kelly, A. M., & Ophir, A. G. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.10.010 · Cited by 28
Divergent effects of oxytocin on eye contact in bonobos and chimpanzees
Brooks, J., Kano, F., Sato, Y., Yeow, H., Morimura, N., Nagasawa, M., Kikusui, T., & Yamamoto, S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105119 · Cited by 27
Althaus, M., Groen, Y., Wijers, A. A., Noltes, H., Tucha, O. M., Sweep, F. C. G. J., Calcagnoli, F., & Hoekstra, P. J. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4339-1 · Cited by 28
Fifty Years of Advances in Neuroendocrinology
Russell, J. A. (2018) · Brain and Neuroscience Advances · doi:10.1177/2398212818812014 · Cited by 26
Moy, S. S., Teng, B. L., Nikolova, V. D., Riddick, N. V., Simpson, C. D., Deusen, A. L. V., Janzen, W. P., Sassano, M. F., Pedersen, C. A., & Jarstfer, M. B. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.10.036 · Cited by 26
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Bauman, M. D., Murai, T., Hogrefe, C. E., & Platt, M. L. (2018) · American Journal of Primatology · doi:10.1002/ajp.22913 · Cited by 25
Río, R. T.-D., van den Burg, E. H., Stoop, R., & Hegoburu, C. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5030-5 · Cited by 26
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Effects of chronic oxytocin on attention to dynamic facial expressions in infant macaques
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Metadata
- Authors
- Modi, M. E., Connor-Stroud, F., Landgraf, R., Young, L. J., & Parr, L. A.
- Affiliations
- Emory University (US)
- Max Planck Institute of Psychiatry (DE)
- Corresponding author
- Modi, Meera E.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 45
- Pages
- 49-57
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC4120060
- OpenAlex
- W2043628043
- Cited by
- 129
- References
- 53
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 16 · 2018: 23 · 2017: 18 · 2016: 24 · 2015: 15 · 2014: 9
- FWCI
- 32.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Science Foundation
- Emory University
- National Institutes of Health (P51OD011132)
- Yerkes National Primate Research Center, Emory University
- National Institute of Mental Health (K02MH064692, MH064692, MH068791, R21MH090776, R01MH068791, P50MH100023)
- National Center for Research Resources (P51RR165, P51RR000165)
- Office of Research Infrastructure Programs, National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, rhesus monkeys, intranasal administration, intravenous administration, vasopressin, route of administration, social cognition, autism spectrum disorder, pharmacotherapy
- MeSH terms
- Administration, Intranasal, Aerosols, Animals, Biological Availability, Macaca mulatta, Male, Oxytocin, Time Factors, Up-Regulation, Nasal Sprays, Administration, Intravenous
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