Cited by 218Tryptophan and brain disordersSuicide and Self-Harm StudiesStress Responses and Cortisol

The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.

The role of cytokines in the pathophysiology of suicidal behavior

Open access

Ganança, Licínia, Oquendo, Maria A., Tyrka, Audrey R., Cisneros-Trujillo, Sebastian, Mann, J. John, Sublette, M. Elizabeth·2016·Psychoneuroendocrinology

DOI 10.1016/j.psyneuen.2015.10.008PMC PMC4910882

Open this paper in CoChat — free account

Abstract

Objective Immune dysregulation has been implicated in depression and other psychiatric disorders. What is less clear is how immune dysregulation can affect risk of suicidal behavior. We reviewed the scientific literature concerning cytokines related to suicidal ideation, suicidal behavior and suicide, and surveyed clinical and neurobiological factors associated with cytokine levels that may modulate effects of inflammation on suicide risk.Methods We searched PubMed, Embase, Scopus and PsycINFO for relevant studies published from 1980 through February, 2015. Papers were included if they were written in English and focused on cytokine measurements in patients with suicidal behaviors.Results The literature search yielded 22 studies concerning cytokines and suicidal ideation, suicide attempts or suicide completion. The most consistent finding was elevated interleukin (IL)-6, found in 8 out of 14 studies, in CSF, blood, and postmortem brain. In one study, IL-6 in CSF was also found to be higher in violent than nonviolent attempters and to correlate with future suicide completion. Low plasma IL-2 was observed in 2 studies of suicide attempters, while divergent results were seen for tumor necrosis factor (TNF)-α, interferon (IFN)-γ, transforming growth factor (TGF)-β, IL-4, and soluble Il-2 receptors.Conclusions Given the complexity suggested by the heterogenous cytokine findings, putative mediators and moderators of inflammation on suicidal behavior merit further study. Elevated IL-6 was the most robust cytokine finding, associated with suicidal ideation and both nonfatal suicide attempts and suicides. Future studies should evaluate the predictive value of high IL-6, consider how this may alter brain function to impact suicidal behavior, and explore the potential beneficial effects of reducing IL-6 on suicide risk.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.psyneuen.2015.10.008

Cites

126 of 126 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department
Larkin, G. L., & Beautrais, A. L. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000629 · Cited by 259
Retracted
The world report on violence and health
Krug, E. G., Mercy, J. A., Dahlberg, L. L., & Zwi, A. B. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11133-0 · Cited by 9,110
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Overview of the immune response
Chaplin, D. D. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.12.980 · Cited by 2,235
Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators
McEwen, B. S. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.071 · Cited by 1,864
The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights
Coutinho, A. E., & Chapman, K. E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.04.005 · Cited by 1,815
Toward a clinical model of suicidal behavior in psychiatric patients
Mann, J. J., Waternaux, C., Haas, G. L., & Malone, K. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.181 · Cited by 1,791 · cited 6×
“These factors appear to contribute as much as 30-50% to the broad suicidality phenotype (Mann et al., 2009).”
BackgroundMethodInfluential
Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms.
Miller, G. E., Chen, E., & Parker, K. J. (2011) · Psychological Bulletin · doi:10.1037/a0024768 · Cited by 1,785
Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance
Calder, P. C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.010 · Cited by 1,717
Risk factors for suicide in individuals with depression: a systematic review
Hawton, K., Casañas i Comabella, C., Haw, C., & Saunders, K. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.01.004 · Cited by 1,469
Chronic stress and age-related increases in the proinflammatory cytokine IL-6.
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531903100 · Cited by 1,267
Neurobiology of suicidal behaviour
Mann, J. J. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1220 · Cited by 1,260
BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
Bramham, C. R., & Messaoudi, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.003 · Cited by 1,193
World Report on Violence and Health
Daher, M. (2002) · New South Wales Public Health Bulletin · doi:10.1071/nb02075 · Cited by 1,028
Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior
Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000
Interleukin (IL)-6, Tumour Necrosis Factor Alpha (TNF-α) and Soluble Interleukin-2 Receptors (SIL-2R) Are Elevated in Patients with Major Depressive Disorder: A Meta-Analysis and Meta-Regression
Liu, Y., Ho, R. C.-M., & Mak, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.003 · Cited by 948
CYTOKINE TARGETS IN THE BRAIN: IMPACT ON NEUROTRANSMITTERS AND NEUROCIRCUITS: Review: Cytokine Targets in the Brain
Miller, A. H., Haroon, E., Raison, C. L., & Felger, J. C. (2013) · Depression and Anxiety · doi:10.1002/da.22084 · Cited by 892
Altered Gene Expression of Brain-Derived Neurotrophic Factor and Receptor Tyrosine Kinase B in Postmortem Brain of Suicide Subjects
Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875
Neurobehavioral Effects of Interferon-α in Cancer Patients Phenomenology and Paroxetine Responsiveness of Symptom Dimensions
Capuron, L. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00407-9 · Cited by 797
The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine
Müller, N., Schwarz, M. J., Dehning, S., Douhe, A., Cerovecki, A., Goldstein-Müller, B., Spellmann, I., Hetzel, G., Maino, K., Kleindienst, N., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001805 · Cited by 794
Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide
Steiner, J., Bielau, H., Brisch, R., Danos, P., Ullrich, O., Mawrin, C., Bernstein, H.-G., & Bogerts, B. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.10.013 · Cited by 791
Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression
Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762
Cytokine Production and Treatment Response in Major Depressive Disorder
Lanquillon, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00134-7 · Cited by 735
Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers.
Ferrucci, L., Cherubini, A., Bandinelli, S., Bartali, B., Corsi, A., Lauretani, F., Martin, A., Andres-Lacueva, C., Senin, U., & Guralnik, J. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1303 · Cited by 696
Prevalence and comorbidity of mental disorders in persons making serious suicide attempts: a case-control study
Beautrais, A. L., Joyce, P. R., Mulder, R. T., Fergusson, D. M., Deavoll, B. J., & Nightingale, S. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.8.1009 · Cited by 654
The Neural Correlates of Anhedonia in Major Depressive Disorder
Keedwell, P. A., Andrew, C., Williams, S. C. R., Brammer, M. J., & Phillips, M. L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.019 · Cited by 650
CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression
Raison, C. L., Dantzer, R., Kelley, K. W., Lawson, M. A., Woolwine, B. J., Vogt, G., Spivey, J. R., Saito, K., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.116 · Cited by 630
Prospective study of clinical predictors of suicidal acts after a major depressive episode in patients with major depressive disorder or bipolar disorder
Oquendo, M. A., Galfalvy, H., Russo, S., Ellis, S. P., Grunebaum, M. F., Burke, A., & Mann, J. J. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.8.1433 · Cited by 605
Risk Factors for Suicide Completion in Major Depression: A Case-Control Study of Impulsive and Aggressive Behaviors in Men
Dumais, A., Lesage, A. D., Alda, M., Rouleau, G., Dumont, M., Chawky, N., Roy, M., Mann, J. J., Benkelfat, C., & Turecki, G. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.11.2116 · Cited by 583
Self-citation
Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses
Frank, M. G., Baratta, M. V., Sprunger, D. B., Watkins, L. R., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.03.005 · Cited by 578
Rapid Resolution of Suicidal Ideation After a Single Infusion of an N -Methyl- D -Aspartate Antagonist in Patients With Treatment-Resistant Major Depressive Disorder
DiazGranados, N., Ibrahim, L. A., Brutsche, N. E., Ameli, R., Henter, I. D., Luckenbaugh, D. A., Machado-Vieira, R., & Zarate, C. A. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05327blu · Cited by 564
Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides
Torres-Platas, S. G., Cruceanu, C., Chen, G. G., Turecki, G., & Mechawar, N. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.05.007 · Cited by 545
Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions
Tynan, R. J., Naicker, S., Hinwood, M., Nalivaiko, E., Buller, K. M., Pow, D. V., Day, T. A., & Walker, F. R. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.02.001 · Cited by 531
Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity
Lindqvist, D., Janelidze, S., Hagell, P., Erhardt, S., Samuelsson, M., Minthon, L., Hansson, O., Björkqvist, M., Träskman-Bendz, L., & Brundin, L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.030 · Cited by 524
Immunologic messenger molecules: Cytokines, interferons, and chemokines
Commins, S. P., Borish, L., & Steinke, J. W. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.07.008 · Cited by 500
To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers
O’Connor, M.-F., Bower, J. E., Cho, H. J., Creswell, J. D., Dimitrov, S., Hamby, M. E., Hoyt, M. A., Martin, J. L., Robles, T. F., Sloan, E. K., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.04.005 · Cited by 500 · cited 2×
“Many of the cytokines studied in relation to suicide (Janelidze et al., 2011; Kim et al., 2008; Lindqvist et al., 2009; Tonelli et al., 2008) are known stimulators of IDO, and knockout mice for the IDO gene fail to express depressive-like symptoms despite immune activation (O'Connor et al., 2009a).”
Background
Neuropsychiatric Adverse Effects of Interferon-??: Recognition and Management
Raison, C. L., Demetrashvili, M., Capuron, L., & Miller, A. H. (2005) · CNS Drugs · doi:10.2165/00023210-200519020-00002 · Cited by 483
Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity
Calabrese, F., Rossetti, A. C., Racagni, G., Gass, P., Riva, M. A., & Molteni, R. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00430 · Cited by 482
The Relationship of Childhood Abuse to Impulsivity and Suicidal Behavior in Adults With Major Depression
Brodsky, B. S., Oquendo, M., Ellis, S. P., Haas, G. L., Malone, K. M., & Mann, J. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1871 · Cited by 438
Aggression, Impulsivity, and Suicide Behavior: A Review of the Literature
Gvion, Y., & Apter, A. (2011) · Archives of Suicide Research · doi:10.1080/13811118.2011.565265 · Cited by 426
Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex
Hinwood, M., Morandini, J., Day, T. A., & Walker, F. R. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr229 · Cited by 420
The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: integration of resting EEG, fMRI, and volumetric techniques
Wacker, J., Dillon, D. G., & Pizzagalli, D. A. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.058 · Cited by 405
Candidate endophenotypes for genetic studies of suicidal behavior
Mann, J. J., Arango, V. A., Avenevoli, S., Brent, D. A., Champagne, F. A., Clayton, P., Currier, D., Dougherty, D. M., Haghighi, F., Hodge, S. E., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.021 · Cited by 398
Increased BDNF Promoter Methylation in the Wernicke Area of Suicide Subjects
Keller, S., Sarchiapone, M., Zarrilli, F., Videtič, A., Ferraro, A., Carli, V., Sacchetti, S., Lembo, F., Angiolillo, A., Jovanovic, N., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.9 · Cited by 379
Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims
Pandey, G. N., Rizavi, H. S., Ren, X., Fareed, J., Hoppensteadt, D. A., Roberts, R. C., Conley, R. R., & Dwivedi, Y. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.08.006 · Cited by 378
Stressful early life experiences and immune dysregulation across the lifespan
Fagundes, C. P., Glaser, R., & Kiecolt-Glaser, J. K. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.06.014 · Cited by 371
Meta-analysis of cytokines and chemokines in suicidality: Distinguishing suicidal versus nonsuicidal patients
Black, C., & Miller, B. J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.014 · Cited by 366
Omega-3 supplementation lowers inflammation and anxiety in medical students: A randomized controlled trial
Kiecolt-Glaser, J. K., Belury, M. A., Andridge, R., Malarkey, W. B., & Glaser, R. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.07.229 · Cited by 340
IL-6 and its circadian secretion in humans
Vgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Trakada, G., & Chrousos, G. P. (2005) · Neuroimmunomodulation · doi:10.1159/000084844 · Cited by 338
Positron Emission Tomography of Regional Brain Metabolic Responses to a Serotonergic Challenge and Lethality of Suicide Attempts in Major Depression
Oquendo, M. A., Placidi, G. P. A., Malone, K. M., Campbell, C., Keilp, J., Brodsky, B., Kegeles, L. S., Cooper, T. B., Parsey, R. V., Van Heertum, R. L., et al. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.1.14 · Cited by 313
Induction of IDO by Bacille Calmette-Guérin Is Responsible for Development of Murine Depressive-Like Behavior
O’Connor, J. C., Lawson, M. A., André, C., Briley, E. M., Szegedi, S. S., Lestage, J., Castanon, N., Herkenham, M. A., Dantzer, R., & Kelley, K. W. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802722 · Cited by 305
Toward a Biosignature for Suicide
Oquendo, M. A., Sullivan, G. M., Sudol, K., Baca-Garcia, E., Stanley, B. H., Sublette, M. E., & Mann, J. J. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14020194 · Cited by 299
Cytokine levels in the blood may distinguish suicide attempters from depressed patients
Janelidze, S., Mattei, D., Westrin, Å., Träskman-Bendz, L., & Brundin, L. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.10.010 · Cited by 298
Inflammation, Glutamate, and Glia in Depression:A Literature Review
McNally, L., Bhagwagar, Z., & Hannestad, J. (2008) · CNS Spectrums · doi:10.1017/s1092852900016734 · Cited by 289
Eating ourselves to death (and despair): The contribution of adiposity and inflammation to depression
Shelton, R. C., & Miller, A. H. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.004 · Cited by 264
Elevated Cytokine Expression in the Orbitofrontal Cortex of Victims of Suicide
Tonelli, L. H., Stiller, J., Rujescu, D., Giegling, I., Schneider, B., Maurer, K., Schnabel, A., Möller, H. ‐., Chen, H. H., & Postolache, T. T. (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.01128.x · Cited by 252
Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder
Sublette, M. E., Galfalvy, H. C., Fuchs, D., Lapidus, M., Grunebaum, M. F., Oquendo, M. A., John Mann, J., & Postolache, T. T. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.05.002 · Cited by 250
Self-citation
Adverse Childhood Experiences and Suicidal Behavior
Brodsky, B. S., & Stanley, B. (2008) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2008.02.002 · Cited by 238
Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicide risk
Sublette, M. E., Hibbeln, J. R., Galfalvy, H., Oquendo, M. A., & Mann, J. J. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.6.1100 · Cited by 230
Basal Ganglia Hypermetabolism and Symptoms of Fatigue during Interferon-α Therapy
Capuron, L., Pagnoni, G., Demetrashvili, M. F., Lawson, D. H., Fornwalt, F. B., Woolwine, B., Berns, G. S., Nemeroff, C. B., & Miller, A. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301362 · Cited by 229
Anterior Cingulate Activation and Error Processing During Interferon-Alpha Treatment
Capuron, L., Pagnoni, G., Demetrashvili, M., Woolwine, B. J., Nemeroff, C. B., Berns, G. S., & Miller, A. H. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.033 · Cited by 222
Astrocytic Hypertrophy in Anterior Cingulate White Matter of Depressed Suicides
Torres-Platas, S. G., Hercher, C., Davoli, M. A., Maussion, G., Labonté, B., Turecki, G., & Mechawar, N. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.154 · Cited by 221
SUICIDAL IDEATION IS ASSOCIATED WITH ELEVATED INFLAMMATION IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER: Research Article: Suicidal Ideation and Inflammation
O'Donovan, A., Rush, G., Hoatam, G., Hughes, B. M., McCrohan, A., Kelleher, C., O'Farrelly, C., & Malone, K. M. (2013) · Depression and Anxiety · doi:10.1002/da.22087 · Cited by 210
Omega-3 fatty acid supplementation in patients with recurrent self-harm
Hallahan, B. P., Hibbeln, J. R., Davis, J. M., & Garland, M. R. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.022707 · Cited by 193
Suicide attempt and n-3 fatty acid levels in red blood cells: A case control study in china
Huan, M., Hamazaki, K., Sun, Y., Itomura, M., Liu, H., Kang, W., Watanabe, S., TERASAWA, K., & Hamazaki, T. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.028 · Cited by 185
Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women
Suarez, E. C., Lewis, J. G., Krishnan, R. R., & Young, K. H. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.01.002 · Cited by 185
Anhedonia predicts suicidal ideation in a large psychiatric inpatient sample
Winer, E. S., Nadorff, M. R., Ellis, T. E., Allen, J. G., Herrera, S., & Salem, T. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.04.016 · Cited by 179
Serum concentrations of CRP, IL-6, TNF-α and cortisol in major depressive disorder with melancholic or atypical features
Karlović, D., Serretti, A., Vrkić, N., Martinac, M., & Marčinko, D. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.12.007 · Cited by 175
Toll-like receptors in the depressed and suicide brain
Pandey, G. N., Rizavi, H. S., Ren, X., Bhaumik, R., & Dwivedi, Y. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.01.021 · Cited by 164
Predicting future suicide attempts among depressed suicide ideators: A 10-year longitudinal study
May, A. M., Klonsky, E. D., & Klein, D. N. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.04.009 · Cited by 161
Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger
Frank, M. G., Watkins, L. R., & Maier, S. F. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.02.004 · Cited by 160
Effects of interferon-α, interferon-γ and cAMP on the transcriptional regulation of the serotonin transporter
Morikawa, O., Sakai, N., Obara, H., & Saito, N. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00187-3 · Cited by 160
Psychological stress activates interleukin-1β gene expression in human mononuclear cells
Brydon, L., Edwards, S., Jia, H., Mohamed-Ali, V., Zachary, I., Martin, J. F., & Steptoe, A. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2004.12.003 · Cited by 159
Relationships between lower plasma L-tryptophan levels and immune-inflammatory variables in depression
Maes, M. H. J., Meltzer, H. Y., Scharpé, S., Bosmans, E., Suy, E., Meester, I. D., Calabrese, J. R., & Cosyns, P. R. (1993) · Psychiatry Research · doi:10.1016/0165-1781(93)90102-m · Cited by 158
The role of inflammatory cytokines in suicidal behavior: A systematic review
Serafini, G., Pompili, M., Elena Seretti, M., Stefani, H., Palermo, M., Coryell, W., & Girardi, P. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.06.002 · Cited by 151
The relation of aggression, hostility, and anger to lipopolysaccharide-stimulated tumor necrosis factor (TNF)-α by blood monocytes from normal men
Suarez, E. C., Lewis, J. G., & Kuhn, C. M. (2002) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00019-3 · Cited by 145
Is there a neuroanatomical basis of the vulnerability to suicidal behavior? A coordinate-based meta-analysis of structural and functional MRI studies
van Heeringen, K., Bijttebier, S., Desmyter, S., Vervaet, M., & Baeken, C. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00824 · Cited by 141
Differences in cytokines between non-suicidal patients and suicidal patients in major depression
Kim, Y.-K., Lee, S.-W., Kim, S.-H., Shim, S.-H., Han, S.-W., Choi, S.-H., & Lee, B.-H. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.041 · Cited by 140
Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA
Oliver, E., McGillicuddy, F. C., Harford, K. A., Reynolds, C. M., Phillips, C. M., Ferguson, J. F., & Roche, H. M. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.06.014 · Cited by 139
Interleukin-6 levels in relation to psychosocial factors: studies on serum, saliva, and in vitro production by blood mononuclear cells.
Sjögren, E., Leanderson, P., Kristenson, M., & Ernerudh, J. (2006) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2005.08.001 · Cited by 137
A Preliminary Study of Cytokines in Suicidal and Nonsuicidal Adolescents with Major Depression
Gabbay, V., Klein, R. G., Guttman, L. E., Babb, J. S., Alonso, C. M., Nishawala, M., Katz, Y., Gaite, M. R., & Gonzalez, C. J. (2009) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2008.0140 · Cited by 136 · cited 14×
“, 2013), there was no difference in blood levels between depressed attempters and nonattempters, but cytokine levels did distinguish depressed patients from healthy controls (Gabbay et al., 2009; Kim et al., 2008; Lee and Kim, 2010), indicating more of a role as biomarkers for depression than suicide.”
BackgroundResultInfluential
Risk for Depression During Interferon-Alpha Treatment Is Affected by the Serotonin Transporter Polymorphism
Lotrich, F. E., Ferrell, R. E., Rabinovitz, M., & Pollock, B. G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.009 · Cited by 135
Increased soluble interleukin‐2 receptor concentrations in suicide attempters
Nässberger, L., & Träskman‐Bendz, L. (1993) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1993.tb03412.x · Cited by 135
PROINFLAMMATORY AND “RESILIENCY” PROTEINS IN THE CSF OF PATIENTS WITH MAJOR DEPRESSION: Cytokines, Resiliency Proteins and Major Depression
Martinez, J. M., Garakani, A., Yehuda, R., & Gorman, J. M. (2012) · Depression and Anxiety · doi:10.1002/da.20876 · Cited by 131
Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts
Vargas, H. O., Nunes, S. O. V., de Castro, M. P., Bortolasci, C. C., Barbosa, D. S., Morimoto, H. K., Venugopal, K., Dodd, S., Maes, M. H. J., & Berk, M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.05.016 · Cited by 126
Prefrontal cortex markers of suicidal vulnerability in mood disorders: a model-based structural neuroimaging study with a translational perspective
Ding, Y., Lawrence, N., Olié, E., Cyprien, F., le Bars, E., Bonafé, A., Phillips, M. L., Courtet, P., & Jollant, F. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.1 · Cited by 124
Joint Effect of Hostility and Severity of Depressive Symptoms on Plasma Interleukin-6 Concentration
Suarez, E. C. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000062530.94551.ea · Cited by 120
A meta-analysis of cytokines in suicidal behavior
Ducasse, D., Olié, E., Guillaume, S., Artéro, S., & Courtet, P. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.02.004 · Cited by 119
Suicide Deaths of Active-Duty US Military and Omega-3 Fatty-Acid Status
Lewis, M. D., Hibbeln, J. R., Johnson, J. E., Lin, Y. H., Hyun, D. Y., & Loewke, J. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.11m06879 · Cited by 119
Suicidal patients are deficient in vitamin D, associated with a pro-inflammatory status in the blood
Grudet, C., Malm, J., Westrin, Å., & Brundin, L. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.08.016 · Cited by 112
Obesity and suicide risk in adults—A systematic review
Klinitzke, G., Steinig, J., Blüher, M., Kersting, A., & Wagner, B. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.07.010 · Cited by 112
Suicidal ideation during interferon-α2b and ribavirin treatment of patients with chronic hepatitis C
Dieperink, E., Ho, S. B., Tetrick, L., Thuras, P., Dua, K., & Willenbring, M. L. (2004) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2004.01.003 · Cited by 106
Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters
Isung, J., Aeinehband, S., Mobarrez, F., Mårtensson, B., Nordström, P., Åsberg, M., Piehl, F., & Jokinen, J. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.123 · Cited by 100
T‐helper 1/T‐helper 2 cytokine imbalance and clinical phenotypes of acute‐phase major depression
HUANG, T., & Lee, C. (2007) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2007.01686.x · Cited by 97
Exploratory associations with Tumor Necrosis Factor-α, disinhibition and suicidal endorsement after traumatic brain injury
Juengst, S. B., Kumar, R. G., Arenth, P. M., & Wagner, A. K. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.05.020 · Cited by 95
Low plasma vascular endothelial growth factor (VEGF) associated with completed suicide
Isung, J., Mobarrez, F., Nordström, P., Åsberg, M., & Jokinen, J. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.624549 · Cited by 94
CSF biomarkers in suicide attempters – a principal component analysis
Lindqvist, D., Janelidze, S., Erhardt, S., Träskman‐Bendz, L., Engström, G., & Brundin, L. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01655.x · Cited by 86
Regional Brain Glucose Uptake Distinguishes Suicide Attempters from Non-Attempters in Major Depression
Sublette, M. E., Milak, M. S., Galfalvy, H., Oquendo, M. A., Malone, K. M., & Mann, J. J. (2013) · Archives of Suicide Research · doi:10.1080/13811118.2013.801813 · Cited by 86
Low IL ‐8 is associated with anxiety in suicidal patients: genetic variation and decreased protein levels
Janelidze, S., Suchankova, P., Ekman, A., Erhardt, S., Sellgren, C., Samuelsson, M., Westrin, A., Minthon, L., Hansson, O., Träskman‐Bendz, L., et al. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12339 · Cited by 86
High interleukin-6 and impulsivity: determining the role of endophenotypes in attempted suicide
Isung, J., Aeinehband, S., Mobarrez, F., Nordström, P., Runeson, B., Åsberg, M., Piehl, F., & Jokinen, J. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.113 · Cited by 85 · cited 4×
“Four articles were excluded due to overlapping samples (Grudet et al., 2014; Isung et al., 2014; Janelidze et al., 2015; Lee and Kim, 2010).”
BackgroundInfluential
Allergy: A risk factor for suicide?
Postolache, T. T., Komarow, H. D., & Tonelli, L. H. (2008) · Current Treatment Options in Neurology · doi:10.1007/s11940-008-0039-4 · Cited by 81
A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department
Larkin, G. L., Beautrais, A. L., Turelli, R., Sanacora, G., Powsner, S. M., Lippmann, M. J., & Krystal, J. H. (2011) · European Psychiatry · doi:10.1016/s0924-9338(11)73311-9 · Cited by 80
Suicidal ideation in family carers of people with dementia: a pilot study
O’Dwyer, S., Moyle, W., Zimmer‐Gembeck, M. J., & Leo, D. D. (2013) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3941 · Cited by 69
Immune activation in non-treated suicidal major depression
Mendlovic, S., Mozes, E., Eilat, E., Doron, A., Lereya, J., Zakuth, V., & Spirer, Z. (1999) · Immunology Letters · doi:10.1016/s0165-2478(98)00145-x · Cited by 69
Mortality and Suicide Risk in Treatment-Resistant Depression: An Observational Study of the Long-Term Impact of Intervention
Olin, B., Jayewardene, A. K., Bunker, M. T., & Moreno, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048002 · Cited by 65
Venlafaxine inhibits the upregulation of plasma tumor necrosis factor-alpha (TNF-α) in the Chinese patients with major depressive disorder: A prospective longitudinal study
Li, Z., Qi, D., Chen, J., Zhang, C., Yi, Z., Yuan, C., Wang, Z., Hong, W., Yu, S., Cui, D., et al. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.05.005 · Cited by 63
Low-Level Stress Induces Production of Neuroprotective Factors in Wild-Type but Not BDNF+/-Mice: Interleukin-10 and Kynurenic Acid
Dugan, A. M., Parrott, J. M., Redus, L., Hensler, J. G., & O’Connor, J. C. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv089 · Cited by 61
Allergy is associated with suicide completion with a possible mediating role of mood disorder - a population-based study
Qin, P., Mortensen, P. B., Waltoft, B. L., & Postolache, T. T. (2010) · Allergy · doi:10.1111/j.1398-9995.2010.02523.x · Cited by 60
Immune dysfunction in bipolar disorder and suicide risk: is there an association between peripheral corticotropin‐releasing hormone and interleukin‐1β?
Monfrim, X., Gazal, M., De Leon, P. B., Quevedo, L., Souza, L. D., Jansen, K., Oses, J. P., Pinheiro, R. T., Silva, R. A., Lara, D. R., et al. (2014) · Bipolar Disorders · doi:10.1111/bdi.12214 · Cited by 52
Do cytokines really sing the blues?
Raison, C. L., & Miller, A. H. (2013) · Europe PMC (PubMed Central) · Cited by 52
Concomitant interferon alpha stimulation and TLR3 activation induces neuronal expression of depression-related genes that are elevated in the brain of suicidal persons
Hoyo-Becerra, C., Huebener, A., Trippler, M., Lutterbeck, M., Liu, Z. J., Truebner, K., Bajanowski, T., Gerken, G., Hermann, D. M., & Schlaak, J. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083149 · Cited by 49
What can post-mortem studies tell us about the pathoetiology of suicide?
Pandey, G. N., & Dwivedi, Y. (2010) · Future Neurology · doi:10.2217/fnl.10.49 · Cited by 49
TNF-alpha −308G>A polymorphism is associated with suicide attempts in major depressive disorder
Kim, Y., Hong, J.-P., Hwang, J.-A., Lee, H., Yoon, H., Lee, B.-H., Jung, H., Hahn, S., & Na, K. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.03.019 · Cited by 47
Is seasonality of suicides stronger in victims with hospital-treated atopic disorders?
Timonen, M., Viilo, K. M., Hakko, H. H., Särkioja, T., Meyer‐Rochow, V. B., Väisänen, E., & Räsänen, P. K. (2004) · Psychiatry Research · doi:10.1016/j.psychres.2004.02.005 · Cited by 47
Prepartum Depressive Symptoms Correlate Positively with C-Reactive Protein Levels and Negatively with Tryptophan Levels: A Preliminary Report.
Scrandis, D. A., LANGENBERG, P. W., Tonelli, L. H., Sheikh, T. M., Manogura, A. C., Alberico, L. A., Hermanstyne, T. O., Fuchs, D., Mighty, H. E., Hasday, J. D., et al. (2008) · PubMed · Cited by 42
Role of IL-10 −1082, IFN-γ +874, and TNF-α −308 Genes Polymorphisms in Suicidal Behavior
Omrani, M. D., Boushehri, B., Bagheri, M., Salarilak, S., Alipour, A., Anoshae, M., & Massomi, R. (2009) · Archives of Suicide Research · doi:10.1080/13811110903266418 · Cited by 36
Transforming growth factor-β1 and major depressive disorder with and without attempted suicide: Preliminary study
Lee, H.-Y., & Kim, Y. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.03.023 · Cited by 31
A Functional Serotonin Transporter Gene Polymorphism and Depressive Effects Associated With Interferon- Treatment
Pierucci‐Lagha, A., Covault, J., Bonkovsky, H. L., Feinn, R., Abreu, C., Sterling, R. K., Fontana, R. J., & Kranzler, H. R. (2010) · Psychosomatics · doi:10.1176/appi.psy.51.2.137 · Cited by 31
Suicide and Prescription Rates of Intranasal Corticosteroids and Nonsedating Antihistamines for Allergic Rhinitis
Woo, J., Gibbons, R. D., Qin, P., Komarow, H. D., Kim, J. B., Rogers, C. A., Mann, J. J., & Postolache, T. T. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06765 · Cited by 30
Pro-inflammatory cytokines and soluble receptors in response to acute psychosocial stress: Differential reactivity in bipolar disorder
Wieck, A., Grassi‐Oliveira, R., do Prado, C. H., Rizzo, L. B., de Oliveira, A. S., Kommers-Molina, J., Viola, T. W., Vieira, É. L. M., Teixeira, A. L., & Bauer, M. E. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.07.040 · Cited by 26
A multiplex immunoassay gives different results than singleplex immunoassays which may bias epidemiologic associations
de Koning, L., Liptak, C., Shkreta, A., Bradwin, G., Hu, F. B., Pradhan, A. D., Rifai, N., & Kellogg, M. D. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.04.006 · Cited by 23
Soluble Interleukin 2 Receptor Levels, Temperament and Character in Formerly Depressed Suicide Attempters Compared with Normal Controls
Rothenhäusler, H., Stepan, A., & Kapfhammer, H. (2006) · Suicide and Life-Threatening Behavior · doi:10.1521/suli.2006.36.4.455 · Cited by 22
Putative role of TNF-α, interleukin-8 and ICAM-1 as indicators of an early inflammatory reaction after burn: a morphological and immunohistochemical study of lung tissue of fire victims
Boehm, J., Fischer, K. R., & Bohnert, M. (2010) · Journal of Clinical Pathology · doi:10.1136/jcp.2010.079863 · Cited by 21
The association of TGF‐β1 codon 10 polymorphism with suicide behavior
Omrani, M. D., Bagheri, M., Boushehri, B., Azizi, F., & Anoshae, M. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32082 · Cited by 17
Depression Symptomatology and Neurobiology
Gelenberg, A. J. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.8001tx16c · Cited by 17
Association study of the interleukin-1 gene complex and tumor necrosis factor alpha gene with suicide attempts
Sáiz, P. A., García‐Portilla, M. P., Paredes, B., Arango, C., Morales, B., Álvarez, V., Coto, E., Bobes-Bascarán, T., Bousoño, M., & Bobes, J. (2008) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3282fb002a · Cited by 14

Sorted by citations

Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms
Kappelmann, N., Arloth, J., Georgakis, M. K., Czamara, D., Rost, N., Ligthart, S., Khandaker, G. M., & Binder, E. B. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.3436 · Cited by 270
Psychiatric face of COVID-19
Steardo, L., Steardo, L., & Verkhratsky, A. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00949-5 · Cited by 227
The Role of BDNF in the Neuroimmune Axis Regulation of Mood Disorders
Jin, Y., Sun, L., Yang, W., Cui, R., & Xu, S. B. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00515 · Cited by 205
Biomarkers of Suicide Attempt Behavior: Towards a Biological Model of Risk
Sudol, K., & Mann, J. J. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0781-y · Cited by 225
The effects of vitamin B on the immune/cytokine network and their involvement in depression
Mikkelsen, K., Stojanovska, L., Prakash, M. D., & Apostolopoulos, V. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.11.012 · Cited by 157

See all 218

Authors: Ganança, L., Oquendo, M. A., Tyrka, A. R., Cisneros-Trujillo, S., Mann, J. J., & Sublette, M. E.
Affiliations: University of Lisbon (PT)
Brown University (US)
New York State Psychiatric Institute (US)
Columbia University Irving Medical Center (US)
Corresponding author: Sublette, M. Elizabeth
ORCID: Ganança, Licínia
Tyrka, Audrey R.
Mann, J. John
Sublette, M. Elizabeth
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2016-01
Volume: 63
Pages: 296-310
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/j.psyneuen.2015.10.008
PMC: PMC4910882
OpenAlex: W1771262887
Cited by: 217
References: 126
Citations by year: 2026: 9 · 2025: 21 · 2024: 28 · 2023: 16 · 2022: 22 · 2021: 26 · 2020: 19 · 2019: 21 · 2018: 29 · 2017: 18 · 2016: 8
FWCI: 1.03
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (P50MH090964, R01MH083704, MH P50 MH090964, R01MH101107)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: cytokines, suicidal behavior, suicidal ideation, suicide attempts, suicide completion, interleukin-6, immune dysregulation, inflammation, interleukin-2, TNF-α, interferon-gamma, TGF-beta, IL-4, soluble interleukin-2 receptor, cerebrospinal fluid cytokines, postmortem brain, depression
MeSH terms: Depression, Humans, Inflammation, Suicide, Suicide, Attempted, Cytokines, Self-Injurious Behavior, Inflammation Mediators, Suicidal Ideation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of cytokines in the pathophysiology of suicidal behavior

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks