Cited by 131Tryptophan and brain disordersSchizophrenia research and treatmentNeuroinflammation and Neurodegeneration Mechanisms

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Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and psychotic symptoms in schizophrenia and bipolar disorder

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Hope, Sigrun, Ueland, Thor, Steen, Nils Eiel, Dieset, Ingrid, Lorentzen, Steinar, Berg, Akiah O., Agartz, Ingrid, Aukrust, Pål, Andreassen, Ole A.·2013·Schizophrenia Research

DOI 10.1016/j.schres.2012.12.023

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Abstract

BACKGROUND: Previous studies suggest elevated inflammation in schizophrenia and bipolar disorder, with increased activity of the Interleukin 1 (IL-1), interleukin 6 (IL-6), tumor necrosis factor (TNF)-alpha, von Willebrand factor (vWf) and osteoprotegerin (OPG). It is unclear how immune activation is involved in the psychopathology. We investigated if elevated inflammation was associated with disease severity (trait) or current symptom level (state), comparing psychotic with general characteristics. METHODS: Plasma levels of sTNF receptor 1 (sTNF-R1), IL-1 receptor antagonist (IL-1Ra), IL-6, vWf and OPG were measured with ELISA techniques in 322 patients with schizophrenia spectrum and bipolar disorder. Current symptom level (state) was measured with Global Assessment of Functioning (GAF) and Positive and Negative Syndrome Scale (PANSS). Disease severity (trait) was measured with premorbid adjustment scale (PAS), age at onset, number of psychotic episodes and number and length of hospitalizations. RESULTS: After controlling for confounders, IL-1Ra and TNF-R1 were independently associated with GAF, and significantly correlated with PANSS negative and positive, respectively. In addition, Il-1Ra was associated with PAS, and sTNF-R1 with number of hospitalizations and psychotic episodes. VWf was significantly correlated with psychotic episodes, OPG with hospitalizations and IL-6 with history of psychosis. Linear regression analysis showed that GAF remained associated with sTNF-R1 and IL-1Ra with PANSS, after controlling for the other clinical measures. CONCLUSIONS: This supports that inflammatory markers, particularly IL-1Ra and sTNF-R1 are associated with both general disease severity and psychotic features. This supports a role of immune activation in the core pathological mechanisms of severe mental disorders.

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The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Bipolar Disorder
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515
MANIC DEPRESSIVE ILLNESS
Davenport, Y. B., Adland, M. L., Gold, P. W., & Goodwin, F. K. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92810-1 · Cited by 2,925
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020
Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects
Miller, B. J., Buckley, P., Seabolt, W., Mellor, A., & Kirkpatrick, B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.04.013 · Cited by 1,742
Manic-depressive illness
Papageorgis, D. (1991) · Behaviour Research and Therapy · doi:10.1016/0005-7967(91)90087-j · Cited by 1,537
Immune modulation of learning, memory, neural plasticity and neurogenesis
Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483
Evidence for a cytokine model of cognitive function
McAfoose, J., & Baune, B. T. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.005 · Cited by 760
Psychiatric genetics: progress amid controversy
Burmeister, M., McInnis, M. G., & Zöllner, S. K. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2381 · Cited by 541
Inflammation and the Phenomenology, Pathophysiology, Comorbidity, and Treatment of Bipolar Disorder
Goldstein, B. I., Kemp, D. E., Soczynska, J. K., & McIntyre, R. S. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08r04505 · Cited by 522
Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease
Koprich, J. B., Reske-Nielsen, C., Mithal, P., & Isacson, O. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-8 · Cited by 355
Global Assessment of Functioning (GAF): properties and frontier of current knowledge
Aas, I. M. (2010) · Annals of General Psychiatry · doi:10.1186/1744-859x-9-20 · Cited by 341
Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein.
Gabay, C., Smith, M. F., Eidlen, D. M., & Arend, W. P. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119488 · Cited by 325
Soluble receptors for tumour necrosis factor in clinical laboratory diagnosis
Diez‐Ruiz, A., Tilz, G. P., Zangerle, R., Baier‐Bitterlich, G., WACHTER, H., & Fuchs, D. (1995) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1995.tb01618.x · Cited by 306
TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation
Bélarbi, K., Jopson, T. D., Tweedie, D., Arellano, C., Luo, W., Greig, N. H., & Rosi, S. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-23 · Cited by 289
Minocycline benefits negative symptoms in early schizophrenia: a randomised double-blind placebo-controlled clinical trial in patients on standard treatment
Chaudhry, I. B., Hallak, J. E. C., Husain, N., Minhas, F., Stirling, J., Richardson, P., Dursun, S. M., Dunn, G., & Deakin, J. F. W. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112444941 · Cited by 284
The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder.
Drexhage, R. C., Knijff, E. M., Padmos, R. C., Heul-Nieuwenhuijzen, L. V. D., Beumer, W., Versnel, M. A., & Drexhage, H. A. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.144 · Cited by 263
Autoimmune diseases, bipolar disorder, and non-affective psychosis
Eaton, W. W., Pedersen, M. G., Nielsen, P. R., & Mortensen, P. B. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00853.x · Cited by 262
Cytokines in schizophrenia and the effects of antipsychotic drugs
Drzyzga, Ł. R., Obuchowicz, E., Marcinowska, A., & Herman, Z. S. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.02.002 · Cited by 242
Cytokine hypothesis of schizophrenia pathogenesis: Evidence from human studies and animal models
Watanabe, Y., Someya, T., & Nawa, H. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02094.x · Cited by 204
Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries
Williams, H. J., Craddock, N. J., Russo, G., Hamshere, M. L., Moskvina, V., Dwyer, S., Smith, R., Green, E., Grozeva, D., Holmans, P., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq471 · Cited by 195
C-Reactive Protein Increases BBB Permeability: Implications for Obesity and Neuroinflammation
Hsuchou, H., Kastin, A. J., Mishra, P. K., & Pan, W. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000343302 · Cited by 192
Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance
Kunz, M., Ceresér, K. M. M., Goi, P. D., Fries, G. R., Teixeira, A. L., Fernandes, B. S., Belmonte-de-Abreu, P. S., Kauer‐Sant’Anna, M., Kapczinski, F. P., & Gama, C. S. (2011) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462011000300010 · Cited by 189
The Level of Cardiovascular Risk Factors in Bipolar Disorder Equals That of Schizophrenia: A Comparative Study
Birkenaes, A. B., Opjordsmoen, S., Brunborg, C., Engh, J. A., Jonsdottir, H., Ringen, P. A., Simonsen, C., Vaskinn, A., Birkeland, K. I., Friis, S., et al. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0614 · Cited by 185
Self-citation
Localization of TNFα and IL-1a immunoreactivities in striatal neurons after surgical injury to the hippocampus
Tchélingérian, J., Quinonero, J., Booss, J., & Jacque, C. (1993) · Neuron · doi:10.1016/0896-6273(93)90312-f · Cited by 185
Nonsteroidal Anti-Inflammatory Drugs in Schizophrenia
Sommer, I. E., de Witte, L. D., Begemann, M., & Kahn, R. S. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10r06823 · Cited by 182
Prevalence of autoimmune diseases in in-patients with schizophrenia: nationwide population-based study
Chen, S.-J., Chao, Y.-L., Chen, C., Chang, C., Wu, E. C., Wu, C., Yeh, H.-H. H., Chen, C., & Tsai, H. (2012) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.111.092098 · Cited by 182
Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia.
Hope, S., Dieset, I., Agartz, I., Steen, N. E., Ueland, T., Melle, I., Aukrust, P., & Andreassen, O. A. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.08.003 · Cited by 164 · cited 1×
“There was no significant elevation of IL-6 or IL-1Ra, but these markers were associated with affective state and severity of depression in bipolar disorder (Hope et al., 2011).”
Self-citation
Synergistic effects of psychological and immune stressors on inflammatory cytokine and sickness responses in humans
Brydon, L., Walker, C., Wawrzyniak, A., Whitehead, D., Okamura, H., Yajima, J., Tsuda, A., & Steptoe, A. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.09.007 · Cited by 164
Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor
Hope, S., Melle, I. S., Aukrust, P., Steen, N. E., Birkenaes, A. B., Lorentzen, S., Agartz, I., Ueland, T., & Andreassen, O. A. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00757.x · Cited by 155
Self-citation
Effects of Acute Mental Stress and Exercise on Inflammatory Markers in Patients With Coronary Artery Disease and Healthy Controls
Kop, W. J., Weissman, N. J., Zhu, J., Bonsall, R. W., Doyle, M. F., Stretch, M. R., Glaes, S. B., Krantz, D. S., Gottdiener, J. S., & Tracy, R. P. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.11.006 · Cited by 117
Serum IL‐1β, sIL‐2R, IL‐6, IL‐8 and TNF‐α in schizophrenic patients, relation with symptomatology and responsiveness to risperidone treatment
Erbağcı, A. B., Herken, H., Köylüoğlu, O., Yılmaz, N., & Tarakçıoğlu, M. (2001) · Mediators of Inflammation · doi:10.1080/09629350123895 · Cited by 113
Item response analysis of the Positive and Negative Syndrome Scale
Santor, D. A., Ascher‐Svanum, H., Lindenmayer, J., & Obenchain, R. L. (2007) · BMC Psychiatry · doi:10.1186/1471-244x-7-66 · Cited by 107
Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
Jiang, H., Hampel, H., Prvulovic, D., Wallin, A., Blennow, K., Li, R., & Shen, Y. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-69 · Cited by 99
Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels
Rafiq, S., Stevens, K., Hurst, A. J., Murray, A., Henley, W., Weedon, M. N., Bandinelli, S., Corsi, A. M., Guralnik, J. M., Ferruci, L., et al. (2007) · Genes & Immunity · doi:10.1038/sj.gene.6364393 · Cited by 92
Social interaction prevents the development of depressive-like behavior post nerve injury in mice: a potential role for oxytocin
Norman, G. J., Karelina, K., Morris, J. S., Zhang, N., Cochran, M., & Courtney DeVries, A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181de8678 · Cited by 88
Cytokine Polymorphisms in the Pathophysiology of Mood Disorders
Clerici, M., Arosio, B., Mundo, E., Cattaneo, E., Pozzoli, S. M., Dell’Osso, B. M., Vergani, C., Trabattoni, D., & Altamura, A. C. (2009) · CNS Spectrums · doi:10.1017/s1092852900020393 · Cited by 86
Levels of circulating interleukin-1 receptor antagonist and C-reactive protein in long-term survivors of testicular cancer with chronic cancer-related fatigue
Orre, I. J., Murison, R. C. C., Dahl, A. A., Ueland, T., Aukrust, P., & Fosså, S. D. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.04.003 · Cited by 86
Self-citation
Targeting TNF-α receptors for neurotherapeutics
Chadwick, W., Magnus, T., Martin, B., Keselman, A. M., Mattson, M. P., & Maudsley, S. R. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.07.005 · Cited by 82
Positive effects of a physiological dose of GH on markers of atherogenesis: a placebo-controlled study in patients with adult-onset GH deficiency
Bollerslev, J., Ueland, T., Jørgensen, A. P., Fougner, K. J., Wergeland, R., Schreiner, T., & Burman, P. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02125 · Cited by 77
Self-citation
Central infusion of interleukin-1 receptor antagonist blocks the reduction in social behavior produced by prior stressor exposure
Arakawa, H., Blandino, P., & Deak, T. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.04.024 · Cited by 76
Central mediation of the effects of interleukin-1 on social exploration and body weight in mice
Bluthé, R.-M., Dantzer, R., & Kelley, K. W. (1997) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(96)00042-x · Cited by 75
Effects of lithium on lipopolysaccharide-induced inflammation in rat primary glia cells
Nahman, S., Belmaker, R., & Azab, A. N. (2011) · Innate Immunity · doi:10.1177/1753425911421512 · Cited by 73
Reproducibility of serum cytokines and growth factors
Gu, Y., Zeleniuch‐Jacquotte, A., Linkov, F. Y., Koenig, K. L., Liu, M., Velikokhatnaya, L., Shore, R. E., Marrangoni, A., Toniolo, P. G., Lokshin, A. E., et al. (2008) · Cytokine · doi:10.1016/j.cyto.2008.10.014 · Cited by 72
Illicit drug use in patients with psychotic disorders compared with that in the general population: a cross‐sectional study
Ringen, P. A., Melle, I. S., Birkenaes, A. B., Engh, J. A., Færden, A., Jónsdóttir, H., Nesvåg, R., Vaskinn, A., Friis, S., Larsen, F., et al. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.01135.x · Cited by 71
Self-citation
Immune and Neuroimmune Alterations in Mood Disorders and Schizophrenia
Drexhage, R. C., Weigelt, K., van Beveren, N., Cohen, D., Versnel, M. A., Nolen, W. A., & Drexhage, H. A. (2011) · International Review of Neurobiology · doi:10.1016/b978-0-12-387718-5.00007-9 · Cited by 71
Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain
Spulber, S. D., Mateos, L., Oprica, M., Cedazo-Mı́nguez, Á., Bartfai, T., Winblad, B. G., & Schultzberg, M. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.01.010 · Cited by 70
Opposite Effects of Catechol-O-Methyltransferase Val158Met on Cortical Function in Healthy Subjects and Patients with Schizophrenia
Prata, D. P., Mechelli, A., Fu, C. H. Y., Picchioni, M., Kane, F., Kalidindi, S., McDonald, C., Howes, O. D., Kravariti, E., Demjaha, A., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.027 · Cited by 66
Validity of the Premorbid Adjustment Scale
Brill, N., Reichenberg, A., Weiser, M., & Rabinowitz, J. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm128 · Cited by 66
Increased serum interleukin-I? and interleukin-6 in elderly, chronic schizophrenic patients on stable antipsychotic medication
Schmitt, A., Bertsch, T., Tost, H., Bergmann, A., Henning, U., Klimke, A., & Falkai, P. (2005) · Neuropsychiatric Disease and Treatment · doi:10.2147/nedt.1.2.171.61048 · Cited by 65
Antiherpes Virus–Specific Treatment and Cognition in Schizophrenia: A Test-of-Concept Randomized Double-Blind Placebo-Controlled Trial
Prasad, K. M. R., Eack, S. M., Keshavan, M. S., Yolken, R. H., Iyengar, S., & Nimgaonkar, V. L. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs040 · Cited by 59
Special Section on the GAF: Using the GAF as a National Mental Health Outcome Measure in the Department of Veterans Affairs
Greenberg, G. A., & Rosenheck, R. A. (2005) · Psychiatric Services · doi:10.1176/appi.ps.56.4.420 · Cited by 56
Effect of neuroleptic administration on serum levels of soluble IL-2 receptor-alpha and IL-1 receptor antagonist in schizophrenic patients
Sirota, P., Meiman, M. E., Hershko, R., & Bessler, H. (2005) · Psychiatry Research · doi:10.1016/j.psychres.2004.04.012 · Cited by 51
Investigating the association between neurocognition and psychosis in bipolar disorder: further evidence for the overlap with schizophrenia
Jabben, N., Arts, B. M. G., Krabbendam, L., & van Os, J. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00663.x · Cited by 47
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Chen, S., Lee, S.-Y., Chang, Y.-H., Chen, S., Chu, C.-H., Tzeng, N., Lee, I., Chen, P. S., Yeh, T. L., Huang, S., et al. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9382-z · Cited by 46
Analysis of peripheral immune activation in schizophrenia using quantitative reverse-transcription polymerase chain reaction (RT-PCR)
Freudenreich, O., Brockman, M. A., Henderson, D. C., Evins, A. E., Fan, X., Walsh, J. P., & GOFF, D. C. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2008.11.007 · Cited by 45
Catechol O-methyltransferase variants and cognitive performance in schizophrenia and bipolar disorder versus controls
Wirgenes, K. V., Djurovic, S., Sundet, K. S., Agartz, I., Mattingsdal, M., Athanasiu, L., Melle, I. S., & Andreassen, O. A. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.05.007 · Cited by 42
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Zhang, X. Y., Cao, L. Y., Song, C., Wu, G. Y., Chen, D. C., Qi, L. Y., Wang, F., Xiu, M. H., Chen, S., Zhang, Y., et al. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1295-4 · Cited by 42
Remission in schizophrenia: analysis in a naturalistic setting
Eberhard, J., Levander, S. E., & Lindström, E. (2008) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2008.08.010 · Cited by 39
No response of plasma substance P, but delayed increase of interleukin-1 receptor antagonist to acute psychosocial stress
Rohleder, N., Wolf, J. M., Herpfer, I., Fiebich, B. L., Kirschbaum, C., & Lieb, K. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.12.016 · Cited by 39
Osteoprotegerin levels in patients with severe mental disorders
Hope, S., Melle, I. S., Aukrust, P., Agartz, I., Lorentzen, S., Steen, N. E., Djurovic, S., Ueland, T., & Andreassen, O. A. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.090088 · Cited by 24
Self-citation
Association between the interleukin‐1 receptor antagonist gene and negative symptom improvement during antipsychotic treatment†
Mata, I. F., Crespo‐Facorro, B., Pérez‐Iglesias, R., Carrasco-Marı́n, E., Arranz, M. J., Pelayo‐Terán, J. M., Leyva‐Cobián, F., & Vázquez‐Barquero, J. L. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30405 · Cited by 22
Dopamine induces TNFα and TNF-R1 expression in SH-SY5Y human neuroblastoma cells
Gómez-Santos, C., Francisco, R., Giménez‐Xavier, P., & Ambrosio, S. (2007) · Neuroreport · doi:10.1097/wnr.0b013e3282f0d3db · Cited by 17
Genetic determinants of circulating levels of tumor necrosis factor receptor II and their association with TNF-RII gene polymorphisms
Vistoropsky, Y., Ermakov, S. V., Toliat, M. R., Trofimov, S., Altmüller, J., Malkin, I., Nürnberg, P., & Livshits, G. (2010) · Cytokine · doi:10.1016/j.cyto.2010.04.013 · Cited by 6

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Authors: Hope, S., Ueland, T., Steen, N. E., Dieset, I., Lorentzen, S., Berg, A. O., Agartz, I., Aukrust, P., & Andreassen, O. A.
Affiliations: Oslo University Hospital (NO)
University of Oslo (NO)
Corresponding author: Hope, Sigrun
ORCID: Hope, Sigrun
Ueland, Thor
Steen, Nils Eiel
Dieset, Ingrid
Lorentzen, Steinar
Berg, Akiah O.
Agartz, Ingrid
Aukrust, Pål
Andreassen, Ole A.
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2013-04
Volume: 145
Issue: 1-3
Pages: 36-42
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2012.12.023
OpenAlex: W2079187454
Cited by: 131
References: 66
Citations by year: 2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 7 · 2020: 12 · 2019: 15 · 2018: 16 · 2017: 13 · 2016: 16 · 2015: 11 · 2014: 11 · 2013: 3
FWCI: 4.61
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/3.0/ (vor, 106 d)
Locations: Schizophrenia Research (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor 1
MeSH terms: Adolescent, Adult, Aged, Bipolar Disorder, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Psychotic Disorders, Regression Analysis, Schizophrenia, Severity of Illness Index, von Willebrand Factor, Interleukin-6, Receptors, Tumor Necrosis Factor, Osteoprotegerin, Interleukin 1 Receptor Antagonist Protein, Young Adult

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Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and psychotic symptoms in schizophrenia and bipolar disorder

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