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Cited by 10Schizophrenia research and treatmentMental Health and PsychiatryNeural and Behavioral Psychology Studies

Emotional context restores cortical prediction error responses in schizophrenia

Vogel, Bob O., Stasch, Joanna, Walter, Henrik, Neuhaus, Andres H.·2018·Schizophrenia Research
DOI 10.1016/j.schres.2018.02.030
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Abstract

The mismatch negativity (MMN) deficit in schizophrenia is a consistently replicated finding and is considered a potential biomarker. From the cognitive neuroscience perspective, MMN represents a cortical correlate of the prediction error, a fundamental computational operator that may be at the core of various cognitive and clinical deficits observed in schizophrenia. The impact of emotion on cognitive processes in schizophrenia is insufficiently understood, and its impact on basic operators of cortical computation is largely unknown. In the visual domain, the facial expression mismatch negativity (EMMN) offers an opportunity to investigate basic computational operators in purely cognitive and in emotional contexts. In this study, we asked whether emotional context enhances cortical prediction error responses in patients with schizophrenia, as is the case in normal subjects. Therefore, seventeen patients with schizophrenia and eighteen controls completed a visual sequence oddball task, which allows for directly comparing MMN components evoked by deviants with high, intermediate and low emotional engagement. Interestingly, patients with schizophrenia showed pronounced deficits in response to neutral stimuli, but almost normal responses to emotional stimuli. The dissociation between impaired MMN and normal EMMN suggests that emotional context not only enhances, but restores cortical prediction error responses in patients with schizophrenia to near-normal levels. Our results show that emotional processing in schizophrenia is not necessarily defect; more likely, emotional processing heterogeneously impacts on cognition in schizophrenia. In fact, this study suggests that emotional context may even compensate for cognitive deficits in schizophrenia that are, in a different sensory domain, discussed as biomarkers.

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  • Age at onset of psychosis is positively correlated with MMN impairment; greater MMN amplitude impairment is associated with younger age at psychosis onset.

    “Age at onset of psychosis was positively correlated with MMN impairment; specifically, individuals with greater MMN amplitude impairment tended to expe­ rience psychosis at a younger age (Vogel et al., 2018).”

    From Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review. (2025) · cites this paper as Vogel et al., 2018

  • Reduced MMN in SCZ was restored to near typical levels when an emotional stimulus context was added.

    “Reduced MMN in SCZ was restored to near typical levels when an emotional stimulus context was added (Vogel et al., 2018).”

    From Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review. (2025) · cites this paper as Vogel et al., 2018

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Authors
Vogel, B. O., Stasch, J., Walter, H., & Neuhaus, A. H.
Affiliations
  • Stiftung Charité (DE)
  • Medizinische Hochschule Brandenburg Theodor Fontane (DE)
Corresponding author
Vogel, Bob O.
ORCID
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2018-07
Volume
197
Pages
434-440
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/j.schres.2018.02.030
OpenAlex
W2790561184
Cited by
10
References
76
Citations by year
2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2018: 1
FWCI
0.59
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
schizophrenia, mismatch negativity
MeSH terms
Facial Recognition, Adult, Cerebral Cortex, Electroencephalography, Emotions, Evoked Potentials, Facial Expression, Female, Humans, Male, Middle Aged, Schizophrenia, Young Adult, Anticipation, Psychological

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