The DOI matches its Crossref record; 68 of the 70 references it cites were found in a registry or an index.
Prostaglandin D2 and sleep/wake regulation
Abstract
Prostaglandin (PG) D2 is the most potent endogenous sleep-promoting substance. PGD2 is produced by lipocalin-type PGD synthase localized in the leptomeninges, choroid plexus, and oligodendrocytes in the brain, and is secreted into the cerebrospinal fluid as a sleep hormone. PGD2 stimulates DP1 receptors localized in the leptomeninges under the basal forebrain and the hypothalamus. As a consequence, adenosine is released as a paracrine sleep-promoting molecule to activate adenosine A2A receptor-expressing sleep-promoting neurons and to inhibit adenosine A1 receptor-possessing arousal neurons. PGD2 activates a center of non-rapid eye movement (NREM) sleep regulation in the ventrolateral preoptic area, probably mediated by adenosine signaling, which activation inhibits the histaminergic arousal center in the tuberomammillary nucleus via descending GABAergic and galaninergic projections. The administration of a lipocalin-type PGD synthase inhibitor (SeCl4), DP1 antagonist (ONO-4127Na) or adenosine A2A receptor antagonist (caffeine) suppresses both NREM and rapid eye movement (REM) sleep, indicating that the PGD2-adenosine system is crucial for the maintenance of physiological sleep.
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“In a recent study, half of the IBD patients reported sleep disturbances as assessed by the PSQI (550), with strongest associations in patients with active disease (10, 209).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [550]
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Metadata
- Authors
- Urade, Y., & Hayaishi, O.
- Corresponding author
- Urade, Yoshihiro
- Venue
- Sleep Medicine Reviews
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 15
- Issue
- 6
- Pages
- 411-418
- ISSN
- 1087-0792 (ISSN-L)
- OpenAlex
- W2086043410
- Cited by
- 200
- References
- 70
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 13 · 2023: 16 · 2022: 14 · 2021: 18 · 2020: 12 · 2019: 12 · 2018: 8 · 2017: 20 · 2016: 10 · 2015: 11 · 2014: 16 · 2013: 24 · 2012: 8
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ono Pharmaceutical
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- prostaglandin D2, sleep regulation, sleep-wake regulation, DP1 receptor, adenosine A2A receptor, adenosine signaling, NREM sleep, REM sleep, ventrolateral preoptic area, tuberomammillary nucleus, galanin, caffeine, sleep-promoting neurons, cerebrospinal fluid
- MeSH terms
- Adenosine, Animals, Brain, Humans, Sleep, Sleep Stages, Wakefulness, Prostaglandin D2, Mice
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