Glutathione-activated near-infrared II fluorescent probe for lung metastatic diagnosis and intraoperative imaging of tumor
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Structural rearrangement of LJ-GSH significantly enhanced intramolecular charge transfer, restoring strong fluorescence emission at 815 nm/910 nm.
“The structural rearrangement significantly enhanced intramolecular charge transfer (ICT), thereby restoring strong fluorescence emission at 815 nm/910 nm.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [106]
Within tumor cells and tissues, overexpressed GSH reacted specifically with LJ-GSH via an aromatic nucleophilic substitution reaction, leading to formation of a thiol skeleton.
“Within tumor cells and tissues, overexpressed GSH reacted specifically with LJ-GSH via an aromatic nucleophilic substitution reaction, leading to the formation of a thiol skeleton.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [106]
Yu et al. reported a glutathione-activatable NIR-II probe, LJ-GSH, which initially exhibited quenched fluorescence due to the weak electron-donating nature of its thiophenol group.
“Yu et al. reported a glutathione (GSH)-activatable NIR-II probe, LJ-GSH, which initially exhibited quenched fluorescence due to the weak electron-donating nature of its thiophenol group106.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [106]
The GSH-responsive activation mechanism of LJ-GSH substantially improved the probe's tumor-targeting specificity.
“This GSH-responsive activation mechanism substantially improved the probe’s tumor-targeting specificity.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [106]
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- Authors
- Wang, Y., Zhao, G., Liu, Y., Wang, R., Xing, Y., Dou, K., & Yu, F.
- Affiliations
- Hainan Medical University (CN)
- Corresponding author
- Dou, Kun
- Yu, Fabiao
- Venue
- Sensors and Actuators B: Chemical
- Publisher
- Elsevier BV
- Published
- 2025-03
- Volume
- 426
- Pages
- 137005
- ISSN
- 0925-4005 (ISSN-L)
- OpenAlex
- W4404726544
- Cited by
- 16
- References
- 41
- Citations by year
- 2026: 4 · 2025: 12
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Sensors and Actuators B Chemical (publishedVersion)
- Funders
- Key Research and Development Project of Hainan Province (ZDYF2022SHFZ288)
- National Natural Science Foundation of China (22204037)
- Hainan Medical University (XRC2022003)
- Natural Science Foundation of Hainan Province (823QN245)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- NIR-II fluorescence imaging, lung metastasis, tumor margin delineation, fluorescent probe design
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