Cited by 137Sirtuins and Resveratrol in MedicineBiochemical and Molecular ResearchCalcium signaling and nucleotide metabolism

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Location, Location, Location: Compartmentalization of NAD+ Synthesis and Functions in Mammalian Cells

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Cambronne, Xiaolu A., Kraus, W. Lee·2020·Trends in Biochemical Sciences

DOI 10.1016/j.tibs.2020.05.010PMC PMC7502477

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Abstract

The numerous biological roles of NAD+ are organized and coordinated via its compartmentalization within cells. The spatial and temporal partitioning of this intermediary metabolite is intrinsic to understanding the impact of NAD+ on cellular signaling and metabolism. We review evidence supporting the compartmentalization of steady-state NAD+ levels in cells, as well as how the modulation of NAD+ synthesis dynamically regulates signaling by controlling subcellular NAD+ concentrations. We further discuss potential benefits to the cell of compartmentalizing NAD+, and methods for measuring subcellular NAD+ levels.

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Nikiforov, 2011, Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation, J. Biol. Chem., 286, 21767, 10.1074/jbc.M110.213298 · DOI · Paper page

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Authors: Cambronne, X. A., & Kraus, W. L.
Affiliations: The University of Texas at Austin (US)
The University of Texas Southwestern Medical Center (US)
Corresponding author: Cambronne, Xiaolu A.
Kraus, W. Lee
ORCID: Cambronne, Xiaolu A.
Kraus, W. Lee
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 2020-10
Volume: 45
Issue: 10
Pages: 858-873
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/j.tibs.2020.05.010
PMC: PMC7502477
OpenAlex: W3037844642
Cited by: 137
References: 130
Citations by year: 2026: 25 · 2025: 23 · 2024: 26 · 2023: 25 · 2022: 21 · 2021: 15 · 2020: 2
FWCI: 1.95
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: NAD+, compartmentalization, NAD+ synthesis, cellular metabolism, signal transduction, subcellular compartmentalization
MeSH terms: Animals, Cell Compartmentation, NAD, Subcellular Fractions, Signal Transduction

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Location, Location, Location: Compartmentalization of NAD+ Synthesis and Functions in Mammalian Cells

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