Cited by 132Alzheimer's disease research and treatmentsAnimal testing and alternativesDementia and Cognitive Impairment Research

Animal models of Alzheimer disease: historical pitfalls and a path forward

Open access
Cavanaugh, Sarah E.·2014·ALTEX

Abstract

Alzheimer disease (AD) is a medically and financially overwhelming condition, and incidence rates are expected to triple by 2050.Despite decades of research in animal models of AD, the disease remains incompletely understood, with few treatment options. This review summarizes historical and current AD research efforts, with emphasis on the disparity between preclinical animal studies and the reality of human disease and how this has impacted clinical trials. Ultimately, we provide a mechanism for shifting the focus of AD research away from animal models to focus primarily on human biology as a means to improve the applicability of research findings to human disease. Implementation of these alternatives may hasten development of improved strategies to prevent, detect, ameliorate, and possibly cure this devastating disease.

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  • A better understanding of human cellular and circuit organization may help counteract the current lack of success in translating promising rodent results to effective treatment against human neuropsychiatric disorders.

    “A better understanding of human cellular and circuit organization may help counteract the current lack of success in translating promising rodent results to effective treatment against human neuropsychiatric disorders49,50.”

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  1. M701078200 · DOI
  2. Irvine · DOI
  3. 1Q238 · DOI

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Authors
Cavanaugh, S. E.
Affiliations
Physicians Committee for Responsible Medicine (US)
Corresponding author
Cavanaugh, Sarah E.
Venue
ALTEX
Publisher
ALTEX Edition
Published
2014
Volume
31
Issue
3
Pages
279-302
ISSN
  • 0946-7785 (ISSN-L)
  • 1868-596X
OpenAlex
W2333890525
Cited by
132
References
358
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 16 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 16 · 2018: 17 · 2017: 20 · 2016: 14 · 2015: 13 · 2014: 2
FWCI
1.92
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • ALTEX (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, animal models, translational research, preclinical animal studies, clinical trials, human biology, translational gap
MeSH terms
Alzheimer Disease, Animals, Cholinesterase Inhibitors, Computer Simulation, Disease Models, Animal, Humans, Risk Factors, Biomedical Research, History, 20th Century, History, 21st Century, Mice, Rats

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