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Cytoprotective-Selective Activated Protein C Attenuates Pseudomonas aeruginosa –Induced Lung Injury in Mice

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Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact

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Middle Cerebral Artery Occlusion in the Rabbit Using Selective Angiography

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Activated protein C prevents glutamate- and thrombin-induced activation of nuclear factor-κB in cultured hippocampal neurons

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Endothelial protein C receptor is expressed in rat cortical and hippocampal neurons and is necessary for protective effect of activated protein C at glutamate excitotoxicity

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Neuroprotective Effects of Activated Protein C Through Induction of Insulin-Like Growth Factor-1 (IGF-1), IGF-1 Receptor, and Its Downstream Signal Phosphorylated Serine-Threonine Kinase After Spinal Cord Ischemia in Rabbits

Yamauchi, T., Sakurai, M., Abe, K., Takano, H., & Sawa, Y. (2006) · Stroke · doi:10.1161/01.str.0000206280.30972.21 · Cited by 28 · see citing works

Effects of activated protein C on neonatal hypoxic ischemic brain injury

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The cytoprotective effects of addition of activated protein C into preservation solution on small-for-size grafts in rats

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The APCs of neuroprotection

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From bench to bedside: a review of the clinical trial development plan of drotrecogin alfa (activated)

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Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders

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Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works

Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

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Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

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Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

Montagne, A., Zhao, Z., & Zlokovic, B. V. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20171406 · Cited by 672 · see citing works

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

Nelson, A. R., Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.016 · Cited by 559 · see citing works

Activated protein C: biased for translation

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Blood–spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

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Anti-Inflammatory Targets for the Treatment of Reperfusion Injury in Stroke

Mizuma, A., & Yenari, M. A. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00467 · Cited by 226 · see citing works

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

Mosnier, L. O., Sinha, R. K., Burnier, L., Bouwens, E. A. M., & Griffin, J. H. (2012) · Blood · doi:10.1182/blood-2012-08-452169 · Cited by 217 · see citing works

Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children

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Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway

Bouwens, E. A. M., Stavenuiter, F., & Mosnier, L. O. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12247 · Cited by 175 · see citing works

Blood-Brain Barrier Integrity and Glial Support: Mechanisms that can be Targeted for Novel Therapeutic Approaches in Stroke

Ronaldson, P. T., & Davis, T. P. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802002625 · Cited by 157 · see citing works

Final Results of the RHAPSODY Trial: A Multi‐Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A‐APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke

Lyden, P. D., Pryor, K. E., Coffey, C. S., Cudkowicz, M., CONWIT, R. A., Jadhav, A. P., Sawyer, R. N., Claassen, J., Adeoye, O. M., Song, S. S., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25383 · Cited by 146 · see citing works

Neurovascular Defects and Faulty Amyloid-β Vascular Clearance in Alzheimer's Disease

Sagare, A. P., Bell, R. D., & Zloković, B. V. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-129037 · Cited by 146 · see citing works

Protein C anticoagulant and cytoprotective pathways

Griffin, J. H., Zloković, B. V., & Mosnier, L. O. (2012) · International Journal of Hematology · doi:10.1007/s12185-012-1059-0 · Cited by 143 · see citing works

Activated protein C inhibits high mobility group box 1 signaling in endothelial cells

Bae, J., & Rezaie, A. R. (2011) · Blood · doi:10.1182/blood-2011-06-360701 · Cited by 140 · see citing works

The neurovascular unit and combination treatment strategies for stroke

Zhang, L., Zhang, Z. G., & Chopp, M. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.04.006 · Cited by 133 · see citing works

Activated protein C, protease activated receptor 1, and neuroprotection

Griffin, J. H., Zloković, B. V., & Mosnier, L. O. (2018) · Blood · doi:10.1182/blood-2018-02-769026 · Cited by 129 · see citing works

Purpura Fulminans: Mechanism and Management of Dysregulated Hemostasis

Colling, M. E., & Bendapudi, P. K. (2017) · Transfusion Medicine Reviews · doi:10.1016/j.tmrv.2017.10.001 · Cited by 120 · see citing works

Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective

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Protease-activated receptors in health and disease

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PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke

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Neuroprotective approach in acute ischemic stroke

Eren, F., & Yilmaz, S. E. (2022) · Brain Circulation · doi:10.4103/bc.bc_52_22 · Cited by 100 · see citing works

Regulation of thrombosis and vascular function by protein methionine oxidation

Gu, S. X., Stevens, J. W., & Lentz, S. R. (2015) · Blood · doi:10.1182/blood-2015-01-544676 · Cited by 79 · see citing works

Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease

Jeon, M.-T., Kim, K.-S., Kim, E. S., Lee, S., Kim, J., Hoe, H.-S., & Kim, D.-G. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101333 · Cited by 76 · see citing works

Activated Mesenchymal Stem Cells Induce Recovery Following Stroke Via Regulation of Inflammation and Oligodendrogenesis

Tobin, M. K., Stephen, T. K. L., Lopez, K. L., Pergande, M. R., Bartholomew, A. M., Cologna, S. M., & Lazarov, O. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.013583 · Cited by 75 · see citing works

Neuroprotection in Acute Ischemic Stroke: A Battle Against the Biology of Nature

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Ablation of matrix metalloproteinase-9 gene decreases cerebrovascular permeability and fibrinogen deposition post traumatic brain injury in mice

Muradashvili, N., Benton, R. L., Saatman, K. E., Tyagi, S. C., & Lominadze, D. G. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9550-3 · Cited by 66 · see citing works

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice

Lazić, D., Sagare, A. P., Nikolakopoulou, A. M., Griffin, J. H., Vassar, R. J., & Zloković, B. V. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181035 · Cited by 64 · see citing works

An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tPA for ischemic stroke in rodents

Wang, Y.-M., Zhang, Z.-G., Chow, N., Davis, T., Griffin, J., Chopp, M., & Zlokovic, B. (2012) · Stroke · doi:10.1161/strokeaha.112.658997 · Cited by 70 · see citing works

Phase 1 Safety, Tolerability and Pharmacokinetics of 3K3A-APC in Healthy Adult Volunteers

Lyden, P. D., Levy, H. A., Weymer, S., Pryor, K. E., Kramer, W. G., Griffin, J. H., Davis, T. P., & Zloković, B. V. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612819666131230131454 · Cited by 64 · see citing works

An Activated Protein C Analog Stimulates Neuronal Production by Human Neural Progenitor Cells via a PAR1-PAR3-S1PR 1 -Akt Pathway

Guo, H., Zhao, Z., Yang, Q., Wang, M., Bell, R. D., Wang, S., Chow, N., Davis, T. P., Griffin, J. H., Goldman, S. A., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4491-12.2013 · Cited by 61 · see citing works

Thrombin regulation of synaptic plasticity: Implications for physiology and pathology

Maggio, N., Itsekson, Z., Dominissini, D., Blatt, I., Amariglio, N., Rechavi, G., Tanné, D., & Chapman, J. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.02.011 · Cited by 60 · see citing works

Intravenous infusion of mesenchymal stem cells improves impaired cognitive function in a cerebral small vessel disease model

Nakazaki, M., Sasaki, M., Kataoka-Sasaki, Y., Oka, S., Suzuki, J., Sasaki, Y., Nagahama, H., Hashi, K., Kocsis, J. D., & Honmou, O. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.04.018 · Cited by 58 · see citing works

Activated Protein C Analog Protects From Ischemic Stroke and Extends the Therapeutic Window of Tissue-Type Plasminogen Activator in Aged Female Mice and Hypertensive Rats

Wang, Y., Zhao, Z., Chow, N., Rajput, P. S., Griffin, J. H., Lyden, P. D., & Zloković, B. V. (2013) · Stroke · doi:10.1161/strokeaha.113.003350 · Cited by 57 · see citing works

Rivaroxaban Does Not Increase Hemorrhage after Thrombolysis in Experimental Ischemic Stroke

Ploen, R., Sun, L., Zhou, W., Heitmeier, S., Zorn, M., Jenetzky, E., & Veltkamp, R. C. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.226 · Cited by 56 · see citing works

The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling

Gleeson, E. M., O’Donnell, J. S., & Preston, R. J. S. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0825-0 · Cited by 56 · see citing works

Role of fibrinogen in cerebrovascular dysfunction after traumatic brain injury

Muradashvili, N., & Lominadze, D. G. (2013) · Brain Injury · doi:10.3109/02699052.2013.823562 · Cited by 54 · see citing works

Aptamer Technology: Adjunct Therapy for Malaria

Kamarudin, N. A. A. N., Mohammed, N., & Mustaffa, K. M. F. (2017) · Biomedicines · doi:10.3390/biomedicines5010001 · Cited by 54 · see citing works

Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity

Stavenuiter, F., & Mosnier, L. O. (2014) · Blood · doi:10.1182/blood-2014-06-582775 · Cited by 53 · see citing works

Cytoprotective-selective activated protein C therapy for ischaemic stroke

Zloković, B. V., Griffin, J. H., & Mosnier, L. O. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-05-0448 · Cited by 53 · see citing works

SUR1-TRPM4 channel activation and phasic secretion of MMP-9 induced by tPA in brain endothelial cells

Gerzanich, V., Kwon, M. S., Woo, S. K., Ivanov, A., & Simard, J. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195526 · Cited by 52 · see citing works

Lipoxygenase: An Emerging Target for Stroke Therapy

van Leyen, K. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273112119990053 · Cited by 50 · see citing works

Protein C system defects inflicted by the malaria parasite protein PfEMP1 can be overcome by a soluble EPCR variant

Bouwens, E. A. M., Tamayo, I., Turner, L., Wang, C. W., Stins, M. F., Theander, T. G., Petersen, J. E. V., Hermida, J., Mosnier, L. O., & Lavstsen, T. (2015) · Thrombosis and Haemostasis · doi:10.1160/th15-01-0018 · Cited by 48 · see citing works

Endothelial and Astrocytic Support by Human Bone Marrow Stem Cell Grafts into Symptomatic ALS Mice towards Blood-Spinal Cord Barrier Repair

Garbuzova-Davis, S. N., Kurien, C., Thomson, A., Falco, D., Ahmad, S., Staffetti, J. F., Steiner, G. A., Abraham, S., James, G. V., Mahendrasah, A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00993-0 · Cited by 49 · see citing works

Metal–Organic Frameworks‐Based Nanoplatforms for the Theranostic Applications of Neurological Diseases

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Activated protein C promotes neuroprotection: mechanisms and translation to the clinic

Griffin, J. H., Fernández, J. A., Lyden, P. D., & Zloković, B. V. (2016) · Thrombosis Research · doi:10.1016/s0049-3848(16)30368-1 · Cited by 43 · see citing works

Homeostatic effects of coagulation protease‐dependent signaling and protease activated receptors

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Differential Signaling by Protease-Activated Receptors: Implications for Therapeutic Targeting

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Human Bone Marrow Endothelial Progenitor Cell Transplantation into Symptomatic ALS Mice Delays Disease Progression and Increases Motor Neuron Survival by Repairing Blood-Spinal Cord Barrier

Garbuzova-Davis, S. N., Kurien, C., Haller, E. M., Eve, D. J., Navarro, S., Steiner, G. A., Mahendrasah, A., Hailu, S., Khatib, M., Boccio, K. J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41747-4 · Cited by 40 · see citing works

Organ-Specific Protection Against Lipopolysaccharide-Induced Vascular Leak Is Dependent on the Endothelial Protein C Receptor

von Drygalski, A., Furlan-Freguia, C., Ruf, W., Griffin, J. H., & Mosnier, L. O. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.301082 · Cited by 37 · see citing works

Apolipoprotein E Receptor 2 Mediates Activated Protein C–Induced Endothelial Akt Activation and Endothelial Barrier Stabilization

Sinha, R. K., Yang, X. V., Fernández, J. A., Xu, X., Mosnier, L. O., & Griffin, J. H. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.306795 · Cited by 37 · see citing works

2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis

Griffin, J. H., Mosnier, L. O., Fernández, J. A., & Zloković, B. V. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308038 · Cited by 36 · see citing works

Therapeutic management of ischemic stroke

Bindal, P., Kumar, V., Kapil, L., Singh, C., & Singh, A. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02804-y · Cited by 38 · see citing works

Selective induction of P-glycoprotein at the CNS barriers during symptomatic stage of an ALS animal model

Chan, G. N. Y., Evans, R. A., Banks, D. B., Mesev, E. V., Miller, D. S., & Cannon, R. E. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.12.049 · Cited by 34 · see citing works

The Imbalance of Vascular Molecules in Alzheimer's Disease

Bell, R. D. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121060 · Cited by 35 · see citing works

Expression of MHC class I-related molecules MICA, HLA-E and EPCR shape endothelial cells with unique functions in innate and adaptive immunity

Gavlovsky, P.-J., Tonnerre, P., Guitton, C., & Charreau, B. L. (2016) · Human Immunology · doi:10.1016/j.humimm.2016.02.007 · Cited by 32 · see citing works

Unravelling the glial response in the pathogenesis of Alzheimer's disease

Alibhai, J. D., Diack, A. B., & Manson, J. C. (2018) · The FASEB Journal · doi:10.1096/fj.201801360r · Cited by 31 · see citing works

A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease

Stringer, M. S., Lee, H., Huuskonen, M. T., MacIntosh, B. J., Brown, R., Montagne, A., Atwi, S., Ramirez, J., Jansen, M. A., Marshall, I., et al. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00843-8 · Cited by 31 · see citing works

Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1

Wang, Y., Zhao, Z., Chow, N., Ali, T., Griffin, J. H., & Zloković, B. V. (2013) · Brain Research · doi:10.1016/j.brainres.2013.02.023 · Cited by 30 · see citing works

The role of EPCR in the pathogenesis of severe malaria

Mosnier, L. O., & Lavstsen, T. (2016) · Thrombosis Research · doi:10.1016/s0049-3848(16)30364-4 · Cited by 30 · see citing works

Activated protein C based therapeutic strategies in chronic diseases

Bock, F. M., Shahzad, K., Vergnolle, N., & Isermann, B. (2014) · Thrombosis and Haemostasis · doi:10.1160/th13-11-0967 · Cited by 30 · see citing works

Thrombomodulin‐dependent protein C activation is required for mitochondrial function and myelination in the central nervous system

Wolter, J., Schild, L., Bock, F. M., Hellwig, A., Gadi, I., Al‐Dabet, M. M., Ranjan, S., Rönicke, R., Nawroth, P. P., Petersen, K., et al. (2016) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13494 · Cited by 28 · see citing works

NMDA-receptor inhibition restores Protease-Activated Receptor 1 (PAR1) mediated alterations in homeostatic synaptic plasticity of denervated mouse dentate granule cells

Becker, D., Ikenberg, B. D., Schiener, S., Maggio, N., & Vlachos, A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.07.013 · Cited by 24 · see citing works

Neuroprotective delivery platforms as an adjunct to mechanical thrombectomy

Babadjouni, R., Walcott, B. P., Liu, Q., Tenser, M. S., Amar, A. P., & Mack, W. J. (2017) · Neurosurgical FOCUS · doi:10.3171/2017.1.focus16514 · Cited by 24 · see citing works

Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke

Amar, A. P., Griffin, J. H., & Zloković, B. V. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00344 · Cited by 23 · see citing works

Targeting Fatigue in Stroke Patients

Barritt, A. W., & Smithard, D. G. (2011) · ISRN Neurology · doi:10.5402/2011/805646 · Cited by 23 · see citing works

The effectiveness of Robot-Assisted Gait Training versus conventional therapy on mobility in severely disabled progressIve MultiplE sclerosis patients (RAGTIME): study protocol for a randomized controlled trial

Straudi, S., Manfredini, F., Lamberti, N., Zamboni, P., Bernardi, F., Marchetti, G., Pinton, P., Bonora, M., Secchiero, P., Tisato, V., et al. (2017) · Trials · doi:10.1186/s13063-017-1838-2 · Cited by 22 · see citing works

Salmon-derived thrombin inhibits development of chronic pain through an endothelial barrier protective mechanism dependent on APC

Smith, J. R., Galie, P. A., Slochower, D. R., Weisshaar, C. L., Janmey, P. A., & Winkelstein, B. A. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.11.062 · Cited by 21 · see citing works

Cerebral Microbleeds in Murine Amyloid Angiopathy

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Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside

Zhao, R., Lin, H., Bereza-Malcolm, L., Clarke, E., Jackson, C., & Xue, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040903 · Cited by 21 · see citing works

Rationale for the Role of Heparin and Related GAG Antithrombotics in COVID-19 Infection

Magnani, H. N. (2021) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029620977702 · Cited by 19 · see citing works

Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C

Amar, A. P., Sagare, A. P., Zhao, Z., Wang, Y., Nelson, A. R., Griffin, J. H., & Zloković, B. V. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.09.021 · Cited by 19 · see citing works

Inflammatory Diseases - A Modern Perspective

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Neuroprotective effects of activated protein C on intrauterine inflammation-induced neonatal white matter injury are associated with the downregulation of fibrinogen-like protein 2/fibroleukin prothrombinase and the inhibition of pro-inflammatory cytokine expression

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Anticoagulation increases alveolar hemorrhage in mice infected with influenza A

Tatsumi, K., Antoniak, S., Subramaniam, S., Gondouin, B., Neidich, S. D., Beck, M. A., Mickelson, J., Monroe, D. M., Bastarache, J. A., & Mackman, N. (2016) · Physiological Reports · doi:10.14814/phy2.13071 · Cited by 18 · see citing works

Properties of extracellular proteinase—an activator of protein C in blood plasma formed by Aspergillus ochraceus

Osmolovskiy, A. A., Kreyer, V. G., Baranova, N. A., Кураков, А. В., & Егоров, Н. С. (2014) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683815010123 · Cited by 17 · see citing works

Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity

Castillo-González, J., Ruiz, J. L., Serrano-Martínez, I., Forte‐Lago, I., Ubago-Rodríguez, A., Caro, M., Pérez‐Gómez, J. M., Benítez-Troncoso, A., Andrés‐León, E., Sánchez‐Navarro, M., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02908-5 · Cited by 16 · see citing works

Xueshuantong injection combined with Salvianolate lyophilized injection improves the synaptic plasticity against focal cerebral ischemia/reperfusion injury in rats through PI3K/AKT/mTOR and RhoA/ROCK pathways

Yuan, Q., Wang, F., Jia, Z., Zhang, T., Sun, J., Du, X., Wang, S., Chai, L., & Hu, L. (2022) · Brain Research · doi:10.1016/j.brainres.2022.147923 · Cited by 16 · see citing works

Activated protein C inhibits amyloid β production via promoting expression of ADAM-10

Li, B., Yu, D., & Xu, Z. (2013) · Brain Research · doi:10.1016/j.brainres.2013.12.005 · Cited by 15 · see citing works

Elevated Inflammatory Markers and Arterial Stiffening Exacerbate Tau but Not Amyloid Pathology in Older Adults with Mild Cognitive Impairment

Clark, A. L., Initiative, A. D. N., Weigand, A. J., Thomas, K. R., Solders, S. K., Delano‐Wood, L., Bondi, M. W., Bernier, R. A., Sundermann, E. E., Banks, S. J., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201382 · Cited by 15 · see citing works

Activation of PAR1 contributes to ferroptosis of Schwann cells and inhibits regeneration of myelin sheath after sciatic nerve crush injury in rats via Hippo-YAP/ACSL4 pathway

Wu, Z., Sun, J. F., Liao, Z., Sun, T., Huang, L., Qiao, J., Ling, C., Chen, C., Zhang, B., & Wang, H. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115053 · Cited by 14 · see citing works

Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation

Lyden, P. D., Pryor, K. E., Minigh, J. L., Davis, T. P., Griffin, J. H., Levy, H. A., & Zloković, B. V. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.593582 · Cited by 14 · see citing works

NF-κB-dependent and -independent pathways in the protective effects of activated protein C in hippocampal and cortical neurons at excitotoxicity

Gorbacheva, L. R., Strukova, S. M., Pinelis, V. G., Ishiwata, S., Stricker, R., & Reiser, G. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.05.008 · Cited by 14 · see citing works

Neonatal brain injury and systemic inflammation: modulation by activated protein C ex vivo

Eliwan, H. O., Watson, R. W. G., Aslam, S., Regan, I. E., Philbin, B., O'Hare, F. M., O’Neill, A., Preston, R. J. S., Blanco, A., Grant, T., et al. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12453 · Cited by 14 · see citing works

Protease-Activated Receptor-1 Supports Locomotor Recovery by Biased Agonist Activated Protein C after Contusive Spinal Cord Injury

Whetstone, W. D., Walker, B. A., Trivedi, A. A., Lee, S., Noble‐Haeusslein, L. J., & Hsu, J.-Y. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170512 · Cited by 15 · see citing works

A Rich-Club Organization in Brain Ischemia Protein Interaction Network

Alawieh, A. M., Sabra, Z., Sabra, M., Tomlinson, S., & Zaraket, F. A. (2015) · Scientific Reports · doi:10.1038/srep13513 · Cited by 13 · see citing works

Fibrinogen-cellular prion protein complex formation on astrocytes

Charkviani, M., Muradashvili, N., Sulimai, N., & Lominadze, D. G. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00224.2020 · Cited by 13 · see citing works

Properties of Extracellular Proteinase—an Activator of Protein C in Blood Plasma Formed byAspergillus ochraceus

Osmolovskiy, A. A., Kreyer, V. G., Baranova, N. A., Кураков, А. В., & Егоров, Н. С. (2015) · Прикладная биохимия и микробиология · doi:10.7868/s0555109915010122 · Cited by 12 · see citing works

Down-regulation of the clotting cascade by the protein C pathway.

Stavenuiter, F., Bouwens, E. A. M., & Mosnier, L. O. (2013) · PubMed · Cited by 11 · see citing works

A new concept of action of hemostatic proteases on inflammation, neurotoxicity, and tissue regeneration

Горбачева, Л. Р., Kiseleva, E. V., Savinkova, I. G., & Strukova, S. M. (2017) · Biochemistry (Moscow) · doi:10.1134/s0006297917070033 · Cited by 11 · see citing works

Impaired tissue barriers as potential therapeutic targets for Parkinson’s disease and amyotrophic lateral sclerosis

Fang, X. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0239-x · Cited by 11 · see citing works

Activated Protein C (APC) and 3K3A-APC-Induced Regression of Choroidal Neovascularization (CNV) Is Accompanied by Vascular Endothelial Growth Factor (VEGF) Reduction

Livnat, T., Weinberger, Y., Fernández, J. A., Alaa, B., Ben-David, G., Palevski, D., Levy‐Mendelovich, S., Kenet, G., Budnik, I., Nisgav, Y., et al. (2021) · Biomolecules · doi:10.3390/biom11030358 · Cited by 10 · see citing works

Cell painting with an engineered EPCR to augment the protein C system

Bouwens, E. A. M., Stavenuiter, F., & Mosnier, L. O. (2015) · Thrombosis and Haemostasis · doi:10.1160/th15-01-0079 · Cited by 10 · see citing works

Activated protein C and thrombin participate in the regulation of astrocyte functions

Иванова, А. Е., Горбачева, Л. Р., Strukova, S. M., Pinelis, V. G., & Reiser, G. (2014) · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · doi:10.1134/s1990747813050048 · Cited by 10 · see citing works

Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders

Bicker, J., Alves, G., Fonseca, C., Falcão, A. C., & Fortuna, A. C. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105226 · Cited by 9 · see citing works

Insights into the structural biology of G-protein coupled receptors impacts drug design for central nervous system neurodegenerative processes.

Dalet, F.-G. E., Guadalupe, T.-F. J., del Carmen, C.-H. M., Humberto, G.-A. C., & Soriano-Ursua, M. A. (2013) · PubMed Central · doi:10.3969/j.issn.1673-5374.2013.24.009 · Cited by 9 · see citing works

Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice

Wang, Y., Sinha, R. K., Mosnier, L. O., Griffin, J. H., & Zloković, B. V. (2013) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2013.02.009 · Cited by 9 · see citing works

Physiological cerebrovascular remodeling in response to chronic mild hypoxia: A role for activated protein C

Burnier, L., Boroujerdi, A., Fernández, J. A., Welser-Alves, J. V., Griffin, J. H., & Milner, R. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.07.004 · Cited by 9 · see citing works

Activated protein C promotes neuroprotection: mechanisms and translation to the clinic

Griffin, J. H., Fernández, J. A., Lyden, P. D., & Zloković, B. V. (2016) · Thrombosis Research · doi:10.1016/s0049-3848(16)30368-1 · Cited by 43 · see citing works

Anti-Inflammatory, Antithrombotic, and Neuroprotective Effects of Activated Protein C in a Murine Model of Focal Ischemic Stroke

Shibata, M., Kumar, S. R., Amar, A. P., Fernández, J. A., Hofman, F. M., Griffin, J. H., & Zloković, B. V. (2001) · Circulation · doi:10.1161/01.cir.103.13.1799 · Cited by 199 · see citing works

Activated protein C, protease activated receptor 1, and neuroprotection

Griffin, J. H., Zloković, B. V., & Mosnier, L. O. (2018) · Blood · doi:10.1182/blood-2018-02-769026 · Cited by 129 · see citing works

Activated protein C in neuroprotection and malaria

Mosnier, L. O. (2019) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000528 · Cited by 10 · see citing works

Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3

Guo, H., Liu, D., Gelbard, H. A., Cheng, T., Insalaco, R., Fernández, J. A., Griffin, J. H., & Zloković, B. V. (2004) · Neuron · doi:10.1016/s0896-6273(04)00019-4 · Cited by 247 · see citing works