Exosome-Mediated Metastasis: From Epithelial–Mesenchymal Transition to Escape from Immunosurveillance

Epithelial-Mesenchymal Transitions in Development and Disease

Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931

The distribution of secondary growths in cancer of the breast.

Paget, S. (1889) · The Lancet · doi:10.1016/s0140-6736(00)49915-0 · Cited by 5,277

Tumour exosome integrins determine organotropic metastasis

Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880

Routes and mechanisms of extracellular vesicle uptake

Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24641 · Cited by 2,832

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., Becker, A., Hoshino, A., Mark, M. T., Molina, H., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3169 · Cited by 2,692

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

Baietti, M. F., Zhang, Z., Mortier, E., Melchior, A., Degeest, G., Geeraerts, A., Ivarsson, Y., Depoortere, F., Coomans, C., Vermeiren, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2502 · Cited by 1,899

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

Ohno, S.-I., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A., Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2012.180 · Cited by 1,666

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

Parolini, I., Federici, C., Raggi, C., Lugini, L., Palleschi, S., De Milito, A., Coscia, C., Iessi, E., Logozzi, M., Molinari, A., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041152 · Cited by 1,555

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

Melo, S. A., Sugimoto, H., O’Connell, J. T., Kato, N., Villanueva, A., Vidal, A., Qiu, L., Vitkin, E., Perelman, L. T., Melo, C. A., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.005 · Cited by 1,531

Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis

Zhou, W., Fong, M. Y., Min, Y., Somlo, G., Liu, L., Palomares, M. R., Yu, Y., Chow, A., O’Connor, S. T. F., Chin, A. R., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.007 · Cited by 1,476

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

Fabbri, M., Paone, A., Calore, F., Galli, R., Gaudio, E., Santhanam, R., Lovat, F., Fadda, P., Mao, C., Nuovo, G. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209414109 · Cited by 1,434

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

Luga, V., Zhang, L., Viloria-Petit, A. M., Ogunjimi, A. A., Inanlou, M. R., Chiu, E., Buchanan, M., Hosein, A. N., Basik, M., & Wrana, J. L. (2012) · Cell · doi:10.1016/j.cell.2012.11.024 · Cited by 1,311

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

Zhang, L., Zhang, S., Yao, J., Lowery, F. J., Zhang, Q., Huang, W.-C., Li, P., Li, M., Wang, X., Zhang, C., et al. (2015) · Nature · doi:10.1038/nature15376 · Cited by 1,175

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

Murphy, D. A., & Courtneidge, S. A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3141 · Cited by 1,055

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

Hood, J. L., San, R. S., & Wickline, S. A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4455 · Cited by 1,036

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

Kucharzewska, P., Christianson, H. C., Welch, J. E., Svensson, K. J., Fredlund, E., Ringnér, M., Mörgelin, M., Bourseau-Guilmain, E., Bengzon, J., & Belting, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220998110 · Cited by 939

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

Christianson, H. C., Svensson, K. J., van Kuppevelt, T. H., Li, J.-P., & Belting, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304266110 · Cited by 903

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

Zomer, A., Maynard, C., Verweij, F. J., Kamermans, A., Schäfer, R., Beerling, E., Schiffelers, R. M., de Wit, E., Berenguer, J., Ellenbroek, S. I. J., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.042 · Cited by 869

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

Webber, J., Steadman, R., Mason, M. D., Tabi, Z., & Clayton, A. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1722 · Cited by 852

Biodistribution and delivery efficiency of unmodified tumor-derived exosomes

Smyth, T., Kullberg, M., Malik, N., Smith-Jones, P., Graner, M. W., & Anchordoquy, T. J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.013 · Cited by 722

Interaction and uptake of exosomes by ovarian cancer cells

Escrevente, C., Keller, S., Altevogt, P., & Costa, J. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-108 · Cited by 666

Tetraspanins: push and pull in suppressing and promoting metastasis

Zöller, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2543 · Cited by 663

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

Bobrie, A., Krumeich, S., Reyal, F., Recchi, C., Moita, L. F., Seabra, M. C., Ostrowski, M., & Théry, C. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0925 · Cited by 645

Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior

Hoshino, D., Kirkbride, K. C., Costello, K., Clark, E. S., Sinha, S., Grega-Larson, N., Tyska, M. J., & Weaver, A. M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.050 · Cited by 561

Human tumor virus utilizes exosomes for intercellular communication

Meckes, D. G., Shair, K. H. Y., Marquitz, A. R., Kung, C.-P., Edwards, R. H., & Raab-Traub, N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014194107 · Cited by 541

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

Clayton, A., Al-Taei, S., Webber, J., Mason, M. D., & Tabi, Z. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003884 · Cited by 540

Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts

Paggetti, J., Haderk, F., Seiffert, M., Janji, B., Distler, U., Ammerlaan, W., Kim, Y. J., Adam, J., Lichter, P., Solary, E., et al. (2015) · Blood · doi:10.1182/blood-2014-12-618025 · Cited by 471

Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes

Webber, J. P., Spary, L. K., Sanders, A. J., Chowdhury, R., Jiang, W. G., Steadman, R., Wymant, J., Jones, A. T., Kynaston, H., Mason, M. D., et al. (2015) · Oncogene · doi:10.1038/onc.2013.560 · Cited by 438

Anticancer Drugs Cause Release of Exosomes with Heat Shock Proteins from Human Hepatocellular Carcinoma Cells That Elicit Effective Natural Killer Cell Antitumor Responses in Vitro

Lv, L.-H., Wan, Y.-L., Lin, Y., Zhang, W., Yang, M., Li, G.-L., Lin, H.-M., Shang, C.-Z., Chen, Y.-J., & Min, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.340588 · Cited by 420

Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)

Whiteside, T. L. (2013) · Biochemical Society Transactions · doi:10.1042/bst20120265 · Cited by 388

Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules: HYPOXIC-EXOSOMES ROLE IN PCA AGGRESSIVENESS

Ramteke, A., Ting, H., Agarwal, C., Mateen, S., Somasagara, R., Hussain, A., Graner, M., Frederick, B., Agarwal, R., & Deep, G. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22124 · Cited by 385

Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3

Aung, T., Chapuy, B., Vogel, D., Wenzel, D., Oppermann, M., Lahmann, M., Weinhage, T., Menck, K., Hupfeld, T., Koch, R., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102855108 · Cited by 374

KRAS-dependent sorting of miRNA to exosomes

Cha, D. J., Franklin, J. L., Dou, Y., Liu, Q., Higginbotham, J. N., Demory Beckler, M., Weaver, A. M., Vickers, K., Prasad, N., Levy, S., et al. (2015) · eLife · doi:10.7554/elife.07197 · Cited by 367

Amphiregulin exosomes increase cancer cell invasion

Higginbotham, J. N., Demory Beckler, M., Gephart, J. D., Franklin, J. L., Bogatcheva, G., Kremers, G.-J., Piston, D. W., Ayers, G. D., McConnell, R. E., Tyska, M. J., et al. (2011) · Current Biology · doi:10.1016/j.cub.2011.03.043 · Cited by 360

Exosomes Derived from Epstein-Barr Virus-Infected Cells Are Internalized via Caveola-Dependent Endocytosis and Promote Phenotypic Modulation in Target Cells

Nanbo, A., Kawanishi, E., Yoshida, R., & Yoshiyama, H. (2013) · Journal of Virology · doi:10.1128/jvi.01310-13 · Cited by 355

Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin

Federici, C., Petrucci, F., Caimi, S., Cesolini, A., Logozzi, M., Borghi, M., D'Ilio, S., Lugini, L., Violante, N., Azzarito, T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088193 · Cited by 354

Exosomal Tumor MicroRNA Modulates Premetastatic Organ Cells

Rana, S., Malinowska, K., & Zöller, M. (2013) · Neoplasia · doi:10.1593/neo.122010 · Cited by 346

Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma

Ye, S.-B., Li, Z.-L., Luo, D.-H., Huang, B.-J., Chen, Y.-S., Zhang, X.-S., Cui, J., Zeng, Y.-X., & Li, J. (2014) · Oncotarget · doi:10.18632/oncotarget.2118 · Cited by 346

Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB

Chow, A., Zhou, W., Liu, L., Fong, M. Y., Champer, J., Van Haute, D., Chin, A. R., Ren, X., Gugiu, B. G., Meng, Z., et al. (2014) · Scientific Reports · doi:10.1038/srep05750 · Cited by 345

Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes

Aga, M., Bentz, G. L., Raffa, S., Torrisi, M. R., Kondo, S., Wakisaka, N., Yoshizaki, T., Pagano, J. S., & Shackelford, J. (2014) · Oncogene · doi:10.1038/onc.2014.66 · Cited by 337

Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes

Thompson, C. A., Purushothaman, A., Ramani, V. C., Vlodavsky, I., & Sanderson, R. D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.c112.444562 · Cited by 322

Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models

Suetsugu, A., Honma, K., Saji, S., Moriwaki, H., Ochiya, T., & Hoffman, R. M. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.007 · Cited by 317

Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets

Muller, L., Mitsuhashi, M., Simms, P., Gooding, W. E., & Whiteside, T. L. (2016) · Scientific Reports · doi:10.1038/srep20254 · Cited by 309

Neoplastic Reprogramming of Patient-Derived Adipose Stem Cells by Prostate Cancer Cell-Associated Exosomes

Abd Elmageed, Z. Y., Yang, Y., Thomas, R., Ranjan, M., Mondal, D., Moroz, K., Fang, Z., Rezk, B. M., Moparty, K., Sikka, S. C., et al. (2014) · Stem Cells · doi:10.1002/stem.1619 · Cited by 295

The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans

Liégeois, S., Benedetto, A., Garnier, J.-M., Schwab, Y., & Labouesse, M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200511072 · Cited by 293

Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts

Chowdhury, R., Webber, J. P., Gurney, M., Mason, M. D., Tabi, Z., & Clayton, A. (2015) · Oncotarget · doi:10.18632/oncotarget.2711 · Cited by 272

Targeting Vacuolar H+-ATPases as a New Strategy against Cancer

Fais, S., De Milito, A., You, H., & Qin, W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1805 · Cited by 264

RNA Trafficking by Acute Myelogenous Leukemia Exosomes

Huan, J., Hornick, N. I., Shurtleff, M. J., Skinner, A. M., Goloviznina, N. A., Roberts, C. T., & Kurre, P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2184 · Cited by 259

Modulation of B-cell exosome proteins by gamma herpesvirus infection

Meckes, D. G., Gunawardena, H. P., Dekroon, R. M., Heaton, P. R., Edwards, R. H., Ozgur, S., Griffith, J. D., Damania, B., & Raab-Traub, N. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303906110 · Cited by 243

Detachment of Breast Tumor Cells Induces Rapid Secretion of Exosomes Which Subsequently Mediate Cellular Adhesion and Spreading

Koumangoye, R. B., Sakwe, A. M., Goodwin, J. S., Patel, T., & Ochieng, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024234 · Cited by 227

Gastric Cancer Exosomes Trigger Differentiation of Umbilical Cord Derived Mesenchymal Stem Cells to Carcinoma-Associated Fibroblasts through TGF-β/Smad Pathway

Gu, J., Qian, H., Shen, L., Zhang, X., Zhu, W., Huang, L., Yan, Y., Mao, F., Zhao, C., Shi, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052465 · Cited by 220

Effect of Nasopharyngeal Carcinoma-Derived Exosomes on Human Regulatory T Cells

Mrizak, D., Martin, N., Barjon, C., Jimenez-Pailhes, A.-S., Mustapha, R., Niki, T., Guigay, J., Pancré, V., de Launoit, Y., Busson, P., et al. (2015) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/dju363 · Cited by 211

Exosomes from bulk and stem cells from human prostate cancer have a differential microRNA content that contributes cooperatively over local and pre-metastatic niche

Sánchez, C. A., Andahur, E. I., Valenzuela, R., Castellón, E. A., Fullá, J. A., Ramos, C. G., & Triviño, J. C. (2016) · Oncotarget · doi:10.18632/oncotarget.6540 · Cited by 205

Examination of the specificity of tumor cell derived exosomes with tumor cells in vitro

Smyth, T. J., Redzic, J. S., Graner, M. W., & Anchordoquy, T. J. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.07.026 · Cited by 195

The heparanase/syndecan‐1 axis in cancer: mechanisms and therapies

Ramani, V. C., Purushothaman, A., Stewart, M. D., Thompson, C. A., Vlodavsky, I., Au, J. L., & Sanderson, R. D. (2013) · The FEBS Journal · doi:10.1111/febs.12168 · Cited by 189

Urothelial cells undergo epithelial-to-mesenchymal transition after exposure to muscle invasive bladder cancer exosomes

Franzen, C. A., Blackwell, R. H., Todorovic, V, Greco, K. A., Foreman, K. E., Flanigan, R. C., Kuo, P. C., & Gupta, G. N. (2015) · Oncogenesis · doi:10.1038/oncsis.2015.21 · Cited by 182

The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding

Yue, S., Mu, W., Erb, U., & Zöller, M. (2015) · Oncotarget · doi:10.18632/oncotarget.2958 · Cited by 181

Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors

Jeppesen, D. K., Nawrocki, A., Jensen, S. G., Thorsen, K., Whitehead, B., Howard, K. A., Dyrskjøt, L., Ørntoft, T. F., Larsen, M. R., & Ostenfeld, M. S. (2014) · PROTEOMICS · doi:10.1002/pmic.201300452 · Cited by 177

Matrix metalloproteinase 13‐containing exosomes promote nasopharyngeal carcinoma metastasis

You, Y., Shan, Y., Chen, J., Yue, H., You, B., Shi, S., Li, X., & Cao, X. (2015) · Cancer Science · doi:10.1111/cas.12818 · Cited by 176

Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion

Atay, S., Banskota, S., Crow, J., Sethi, G., Rink, L., & Godwin, A. K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310501111 · Cited by 168

Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity

Zhang, H.-G., Kim, H., Liu, C., Yu, S., Wang, J., Grizzle, W. E., Kimberly, R. P., & Barnes, S. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.04.015 · Cited by 165

Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre–metastatic Niche

Giles, A. J., Reid, C. M., Evans, J. D., Murgai, M., Vicioso, Y. M., Highfill, S. L., Kasai, M., Vahdat, L. T., Mackall, C. L., Lyden, D. C., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-0204 · Cited by 162

Molecular characterization of exosome-like vesicles from breast cancer cells

Kruger, S., Elmageed, Z. Y. A., Hawke, D. H., Wörner, P. M., Jansen, D. A., Abdel-Mageed, A. B., Alt, E. U., & Izadpanah, R. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-44 · Cited by 160

Tumor lymphangiogenesis and melanoma metastasis

Rinderknecht, M., & Detmar, M. J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21494 · Cited by 159

Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC

Battke, C., Ruiss, R., WELSCH, U. N., Wimberger, P., Lang, S., Jochum, S., & Zeidler, R. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-0979-5 · Cited by 155

Pathogenic role of Epstein–Barr virus latent membrane protein-1 in the development of nasopharyngeal carcinoma

Yoshizaki, T., Kondo, S., Wakisaka, N., Murono, S., Endo, K., Sugimoto, H., Nakanishi, S., Tsuji, A., & Ito, M. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.05.018 · Cited by 143

Curcumin inhibitsin vitroandin vivochronic myelogenous leukemia cells growth: a possible role for exosomal disposal of miR-21

Taverna, S., Giallombardo, M., Pucci, M., Flugy, A. M., Manno, M., Raccosta, S., Rolfo, C. D., Leo, G. D., & Alessandro, R. (2015) · Oncotarget · doi:10.18632/oncotarget.4204 · Cited by 143

Exosome proteomics reveals transcriptional regulator proteins with potential to mediate downstream pathways

Ung, T. H., Madsen, H. J., Hellwinkel, J. E., Lencioni, A., & Graner, M. W. (2014) · Cancer Science · doi:10.1111/cas.12534 · Cited by 135

Curcumin Modulates Pancreatic Adenocarcinoma Cell-Derived Exosomal Function

Osterman, C. J. D., Lynch, J. C., Leaf, P., Gonda, A., Bennit, H. R. F., Griffiths, D., & Wall, N. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132845 · Cited by 127

Glioma-derived extracellular vesicles selectively suppress immune responses

Hellwinkel, J. E., Redzic, J. S., Harland, T., Gunaydin, D., Anchordoquy, T. J., & Graner, M. W. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov170 · Cited by 115

Tumor-derived exosomes are enriched in ΔNp73, which promotes oncogenic potential in acceptor cells and correlates with patient survival

Soldevilla, B., Rodríguez, M., Millán, C. S., García‐Barberán, V., Fernández-Periañez, R., Gil-Calderón, B., Martín, P., García‐Grande, A., Silva, J., Bonilla, F., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt437 · Cited by 105

Application of a Persistent Heparin Treatment Inhibits the Malignant Potential of Oral Squamous Carcinoma Cells Induced by Tumor Cell-Derived Exosomes

Sento, S., Sasabe, E., & Yamamoto, T. (2016) · PLOS ONE · doi:10.1371/journal.pone.0148454 · Cited by 91

Exosomes enriched in stemness/metastatic-related mRNAS promote oncogenic potential in breast cancer

Rodríguez, M., Silva, J., Herrera, A., Herrera, M., Peña, C., Martín, P., Gil-Calderón, B., Larriba, M. J., Coronado, M. J., Soldevilla, B., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5818 · Cited by 86

The histone deacetylase inhibitor SAHA induces HSP60 nitration and its extracellular release by exosomal vesicles in human lung-derived carcinoma cells

Campanella, C., D’Anneo, A., Marino, A., Bavisotto, C. C., Barone, R., Emanuele, S., Cascio, F. L., Mocciaro, E., Fais, S., de Macario, E. C., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6680 · Cited by 74

Molecular principles of metastasis: a hallmark of cancer revisited

Fares, J., Fares, M. Y., Khachfe, H. H., Salhab, H. A., & Fares, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0134-x · Cited by 2,379

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

Mashouri, L., Yousefi, H., Aref, A. R., Ahadi, A. M., Molaei, F., & Alahari, S. K. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0991-5 · Cited by 1,363

Exosomes: key players in cancer and potential therapeutic strategy

Dai, J., Su, Y., Zhong, S., Cong, L., Liu, B., Yang, J., Tao, Y., He, Z., Chen, C., & Jiang, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00261-0 · Cited by 1,186

Tumor-Associated Macrophages: Recent Insights and Therapies

Zhou, J., Tang, Z., Gao, S., Li, C., Feng, Y., & Zhou, X. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00188 · Cited by 619

Exosome-based immunotherapy: a promising approach for cancer treatment

Xu, Z., Zeng, S., Gong, Z., & Yan, Y. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01278-3 · Cited by 482