The DOI matches its Crossref record; 184 of the 184 references it cites were found in a registry or an index.
Intratumor and Intertumor Heterogeneity in Melanoma
Open accessAbstract
Melanoma is a cancer that exhibits one of the most aggressive and heterogeneous features. The incidence rate escalates. A high number of clones harboring various mutations contribute to an exceptional level of intratumor heterogeneity of melanoma. It also refers to metastases which may originate from different subclones of primary lesion. Such component of the neoplasm biology is termed intertumor and intratumor heterogeneity. These levels of tumor heterogeneity hinder accurate diagnosis and effective treatment. The increasing number of research on the topic reflects the need for understanding limitation or failure of contemporary therapies. Majority of analyses concentrate on mutations in cancer-related genes. Novel high-throughput techniques reveal even higher degree of variations within a lesion. Consolidation of theories and researches indicates new routes for treatment options such as targets for immunotherapy. The demand for personalized approach in melanoma treatment requires extensive knowledge on intratumor and intertumor heterogeneity on the level of genome, transcriptome/proteome, and epigenome. Thus, achievements in exploration of melanoma variety are described in details. Particularly, the issue of tumor heterogeneity or homogeneity given BRAF mutations is discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Siegel, R. L., Miller, K. D., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21332 · Cited by 16,003
Siegel, R. L., Miller, K. D., & Jemal, A. (2017) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21387 · Cited by 14,712
Nowell, P. C. (1976) · Science · doi:10.1126/science.959840 · Cited by 6,471
Cancer treatment and survivorship statistics, 2016
Miller, K. D., Siegel, R. L., Lin, C. C., Mariotto, A. B., Kramer, J. L., Rowland, J. H., Stein, K. D., Alteri, R., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21349 · Cited by 6,066
Mutational heterogeneity in cancer and the search for new cancer-associated genes
Lawrence, M. S., Stojanov, P., Polak, P., Kryukov, G. V., Cibulskis, K., Sivachenko, A., Carter, S. L., Stewart, C., Mermel, C. H., Roberts, S. A., et al. (2013) · Nature · doi:10.1038/nature12213 · Cited by 5,461
Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012
Ferlay, J., Steliarova-Foucher, E., Lortet-Tieulent, J., Rosso, S., Coebergh, J. W. W., Comber, H., Forman, D., & Bray, F. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2012.12.027 · Cited by 5,263
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
Tirosh, I., Izar, B., Prakadan, S. M., Wadsworth, M. H., Treacy, D., Trombetta, J. J., Rotem, A., Rodman, C., Lian, C., Murphy, G., et al. (2016) · Science · doi:10.1126/science.aad0501 · Cited by 4,944
Genomic classification of cutaneous melanoma
Akbani, R., Akdemir, K. C., Aksoy, B. A., Albert, M., Ally, A., Amin, S. B., Arachchi, H., Arora, A., Auman, J. T., Ayala, B., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.044 · Cited by 3,151
Clarke, M. F., Dick, J. E., Dirks, P. B., Eaves, C. J., Jamieson, C. H. M., Jones, D. L., Visvader, J., Weissman, I. L., & Wahl, G. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-3126 · Cited by 3,051
Tumour evolution inferred by single-cell sequencing
Navin, N., Kendall, J., Troge, J., Andrews, P., Rodgers, L., McIndoo, J., Cook, K., Stepansky, A., Levy, D., Esposito, D., et al. (2011) · Nature · doi:10.1038/nature09807 · Cited by 2,598
The causes and consequences of genetic heterogeneity in cancer evolution
Burrell, R. A., McGranahan, N., Bartek, J., & Swanton, C. (2013) · Nature · doi:10.1038/nature12625 · Cited by 2,262
Efficient tumour formation by single human melanoma cells
Quintana, E., Shackleton, M., Sabel, M. S., Fullen, D. R., Johnson, T. M., & Morrison, S. J. (2008) · Nature · doi:10.1038/nature07567 · Cited by 1,796
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
Sottoriva, A., Spiteri, I., Piccirillo, S. G. M., Touloumis, A., Collins, V. P., Marioni, J. C., Curtis, C., Watts, C., & Tavaré, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219747110 · Cited by 1,737
Tumor heterogeneity: Causes and consequences
Marusyk, A., & Polyak, K. (2010) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.11.002 · Cited by 1,602
Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas
Harbour, J. W., Onken, M. D., Roberson, E. D. O., Duan, S., Cao, L., Worley, L. A., Council, M. L., Matatall, K. A., Helms, C., & Bowcock, A. M. (2010) · Science · doi:10.1126/science.1194472 · Cited by 1,462
Identification of cells initiating human melanomas
Schatton, T., Murphy, G. F., Frank, N. Y., Yamaura, K., Waaga-Gasser, A. M., Gasser, M., Zhan, Q., Jordan, S., Duncan, L. M., Weishaupt, C., et al. (2008) · Nature · doi:10.1038/nature06489 · Cited by 1,415
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
Landau, D. A., Carter, S. L., Stojanov, P., McKenna, A., Stevenson, K., Lawrence, M. S., Sougnez, C., Stewart, C., Sivachenko, A., Wang, L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.019 · Cited by 1,379
A tumorigenic subpopulation with stem cell properties in melanomas
Fang, D., Nguyen, T. K., Leishear, K., Finko, R., Kulp, A. N., Hotz, S., Van Belle, P. A., Xu, X., Elder, D. E., & Herlyn, M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1343 · Cited by 1,280
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
Tirosh, I., Venteicher, A. S., Hebert, C., Escalante, L. E., Patel, A. P., Yizhak, K., Fisher, J. M., Rodman, C., Mount, C., Filbin, M. G., et al. (2016) · Nature · doi:10.1038/nature20123 · Cited by 1,234
The Genetic Evolution of Melanoma from Precursor Lesions
Shain, A. H., Yeh, I., Kovalyshyn, I., Sriharan, A., Talevich, E., Gagnon, A., Dummer, R., North, J., Pincus, L., Ruben, B., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1502583 · Cited by 1,065
Stem cell concepts renew cancer research
Dick, J. E. (2008) · Blood · doi:10.1182/blood-2008-08-077941 · Cited by 1,010
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing
Zhang, J., Fujimoto, J., Zhang, J., Wedge, D. C., Song, X., Zhang, J., Seth, S., Chow, C.-W., Cao, Y., Gumbs, C., et al. (2014) · Science · doi:10.1126/science.1256930 · Cited by 965
The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma
Van Allen, E. M., Wagle, N., Sucker, A., Treacy, D. J., Johannessen, C. M., Goetz, E. M., Place, C. S., Taylor-Weiner, A., Whittaker, S., Kryukov, G. V., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0617 · Cited by 912
Genetic variegation of clonal architecture and propagating cells in leukaemia
Anderson, K., Lutz, C., van Delft, F. W., Bateman, C. M., Guo, Y., Colman, S. M., Kempski, H., Moorman, A. V., Titley, I., Swansbury, J., et al. (2011) · Nature · doi:10.1038/nature09650 · Cited by 806
Pan-cancer analysis of the extent and consequences of intratumor heterogeneity
Andor, N., Graham, T. A., Jansen, M., Xia, L. C., Aktipis, C. A., Petritsch, C., Ji, H. P., & Maley, C. C. (2016) · Nature Medicine · doi:10.1038/nm.3984 · Cited by 768
In vivo Switching of Human Melanoma Cells between Proliferative and Invasive States
Hoek, K. S., Eichhoff, O. M., Schlegel, N. C., Döbbeling, U., Kobert, N., Schaerer, L., Hemmi, S., & Dummer, R. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2491 · Cited by 743
Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271
Boiko, A. D., Razorenova, O. V., van de Rijn, M., Swetter, S. M., Johnson, D. L., Ly, D. P., Butler, P. D., Yang, G. P., Joshua, B., Kaplan, M. J., et al. (2010) · Nature · doi:10.1038/nature09161 · Cited by 720
Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma
Snuderl, M., Fazlollahi, L., Le, L. P., Nitta, M., Zhelyazkova, B. H., Davidson, C. J., Akhavanfard, S., Cahill, D. P., Aldape, K. D., Betensky, R. A., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.11.005 · Cited by 707
Evolutionary dynamics of carcinogenesis and why targeted therapy does not work
Gillies, R. J., Verduzco, D., & Gatenby, R. A. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3298 · Cited by 684
Melanoma epidemiology and trends
Garbe, C., & Leiter, U. (2009) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2008.09.001 · Cited by 657
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma
Müller, J., Krijgsman, O., Tsoi, J., Robert, L., Hugo, W., Song, C., Kong, X., Possik, P. A., Cornelissen-Steijger, P. D. M., Foppen, M. H. G., et al. (2014) · Nature Communications · doi:10.1038/ncomms6712 · Cited by 639
Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation
Landsberg, J., Kohlmeyer, J., Renn, M., Bald, T., Rogava, M., Cron, M., Fatho, M., Lennerz, V., Wölfel, T., Hölzel, M., et al. (2012) · Nature · doi:10.1038/nature11538 · Cited by 632
Mitf regulation of Dia1 controls melanoma proliferation and invasiveness
Carreira, S., Goodall, J., Denat, L., Rodriguez, M., Nuciforo, P., Hoek, K. S., Testori, A., Larue, L., & Goding, C. R. (2006) · Genes & Development · doi:10.1101/gad.406406 · Cited by 608
Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance
Hugo, W., Shi, H., Sun, L., Piva, M., Song, C., Kong, X., Moriceau, G., Hong, A., Dahlman, K. B., Johnson, D. B., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.061 · Cited by 600
Quintana, E., Shackleton, M., Foster, H. R., Fullen, D. R., Sabel, M. S., Johnson, T. M., & Morrison, S. J. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.10.012 · Cited by 599
The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma
Mahoney, K. M., Freeman, G. J., & McDermott, D. F. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.02.018 · Cited by 571
Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential
Monzani, E., Facchetti, F., Galmozzi, E., Corsini, E., Benetti, A., Cavazzin, C., Gritti, A., Piccinini, A., Porro, D., Santinami, M., et al. (2007) · European Journal of Cancer · doi:10.1016/j.ejca.2007.01.017 · Cited by 556
Hoek, K. S., Schlegel, N. C., Brafford, P., Sucker, A., Ugurel, S., Kumar, R., Weber, B. L., Nathanson, K. L., Phillips, D. J., Herlyn, M., et al. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00322.x · Cited by 555
Szerlip, N. J., Pedraza, A., Chakravarty, D., Azim, M., McGuire, J., Fang, Y., Ozawa, T., Holland, E. C., Huse, J. T., Jhanwar, S., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114033109 · Cited by 538
A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors
Konieczkowski, D. J., Johannessen, C. M., Abudayyeh, O., Kim, J. W., Cooper, Z. A., Piris, A., Frederick, D. T., Barzily-Rokni, M., Straussman, R., Haq, R., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0424 · Cited by 535
Inferring tumor progression from genomic heterogeneity
Navin, N., Krasnitz, A., Rodgers, L., Cook, K., Meth, J., Kendall, J., Riggs, M., Eberling, Y., Troge, J., Grubor, V., et al. (2010) · Genome Research · doi:10.1101/gr.099622.109 · Cited by 524
Cancer stem cells versus phenotype‐switching in melanoma
Hoek, K. S., & Goding, C. R. (2010) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2010.00757.x · Cited by 506
Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state
Verfaillie, A., Imrichova, H., Atak, Z. K., Dewaele, M., Rambow, F., Hulselmans, G., Christiaens, V., Svetlichnyy, D., Luciani, F., Van den Mooter, L., et al. (2015) · Nature Communications · doi:10.1038/ncomms7683 · Cited by 489
Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer
Klein, C. A., Blankenstein, T. J., Schmidt-Kittler, O., Petronio, M., Polzer, B., Stoecklein, N. H., & Riethmüller, G. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09838-0 · Cited by 479
BRAF/NRAS Mutation Frequencies Among Primary Tumors and Metastases in Patients With Melanoma
Colombino, M., Capone, M., Lissia, A., Cossu, A., Rubino, C., De Giorgi, V., Massi, D., Fonsatti, E., Staibano, S., Nappi, O., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.41.2452 · Cited by 471
Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells
Notta, F., Mullighan, C. G., Wang, J. C. Y., Poeppl, A., Doulatov, S., Phillips, L. A., Ma, J., Minden, M. D., Downing, J. R., & Dick, J. E. (2011) · Nature · doi:10.1038/nature09733 · Cited by 463
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation
Gupta, P. B., Kuperwasser, C., Brunet, J.-P., Ramaswamy, S., Kuo, W.-L., Gray, J. W., Naber, S. P., & Weinberg, R. A. (2005) · Nature Genetics · doi:10.1038/ng1634 · Cited by 439
The gene expression signatures of melanoma progression
Haqq, C., Nosrati, M., Sudilovsky, D., Crothers, J., Khodabakhsh, D., Pulliam, B. L., Federman, S., Miller, J. R., Allen, R. E., Singer, M. I., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501564102 · Cited by 433
How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine
Gerlinger, M., & Swanton, C. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605912 · Cited by 421
Lee, J.-H., Choi, J.-W., & Kim, Y.-S. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10185.x · Cited by 419
Madore, J., Vilain, R. E., Menzies, A. M., Kakavand, H., Wilmott, J. S., Hyman, J., Yearley, J. H., Kefford, R. F., Thompson, J. F., Long, G. V., et al. (2015) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12340 · Cited by 398
Omholt, K., Platz, A., Kanter, L., Ringborg, U. K., & Hansson, J. (2003) · PubMed · Cited by 394
Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia
Li, S., Garrett-Bakelman, F. E., Chung, S. S., Sanders, M. A., Hricik, T., Rapaport, F., Patel, J., Dillon, R., Vijay, P., Brown, A. L., et al. (2016) · Nature Medicine · doi:10.1038/nm.4125 · Cited by 387
Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing
Campbell, P. J., Pleasance, E. D., Stephens, P. J., Dicks, E., Rance, R., Goodhead, I., Follows, G. A., Green, A. R., Futreal, P. A., & Stratton, M. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801523105 · Cited by 365
Gray, E. S., Rizos, H., Reid, A. L., Boyd, S. C., Pereira, M. R., Lo, J., Tembe, V., Freeman, J., Lee, J. H. J., Scolyer, R. A., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5788 · Cited by 336
Civenni, G., Walter, A., Kobert, N., Mihic-Probst, D., Zipser, M., Belloni, B., Seifert, B., Moch, H., Dummer, R., van den Broek, M., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3997 · Cited by 326
Park, S. Y., Gönen, M., Kim, H. J., Michor, F., & Polyak, K. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40724 · Cited by 324
Edlundh-Rose, E., Egyha??zi, S., Omholt, K., Mansson-Brahme, E., Platz, A., Hansson, J., & Lundeberg, J. (2006) · Melanoma Research · doi:10.1097/01.cmr.0000232300.22032.86 · Cited by 318
The evolution of tumour phylogenetics: principles and practice
Schwartz, R., & Schäffer, A. A. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2016.170 · Cited by 318
BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma.
Dong, J., Phelps, R. G., Qiao, R., Yao, S., Benard, O., Ronai, Z. A., & Aaronson, S. A. (2003) · PubMed · Cited by 310
Intratumor Heterogeneity in Hepatocellular Carcinoma
Friemel, J., Rechsteiner, M., Frick, L., Böhm, F., Struckmann, K., Egger, M., Moch, H., Heikenwalder, M., & Weber, A. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0122 · Cited by 296
Houben, R., Becker, J. C., Kappel, A., Terheyden, P. A. M., Bröcker, E., Goetz, R., & Rapp, U. R. (2004) · Journal of Carcinogenesis · doi:10.1186/1477-3163-3-6 · Cited by 294
Intra- and Inter-Tumor Heterogeneity of BRAFV600EMutations in Primary and Metastatic Melanoma
Yancovitz, M., Litterman, A., Yoon, J., Ng, E., Shapiro, R. L., Berman, R. S., Pavlick, A. C., Darvishian, F., Christos, P., Mazumdar, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029336 · Cited by 283
Falletta, P., Sanchez-del-Campo, L., Chauhan, J., Effern, M., Kenyon, A., Kershaw, C. J., Siddaway, R., Lisle, R., Freter, R., Daniels, M. J., et al. (2017) · Genes & Development · doi:10.1101/gad.290940.116 · Cited by 239
Fallahi‐Sichani, M., Becker, V., Izar, B., Baker, G. J., Lin, J., Boswell, S. A., Shah, P., Rotem, A., Garraway, L. A., & Sorger, P. K. (2017) · Molecular Systems Biology · doi:10.15252/msb.20166796 · Cited by 235
Geyer, F. C., Weigelt, B., Natrajan, R., Lambros, M. B., de Biase, D., Vatcheva, R., Savage, K., Mackay, A., Ashworth, A., & Reis‐Filho, J. S. (2010) · The Journal of Pathology · doi:10.1002/path.2675 · Cited by 233
Riesenberg, S., Groetchen, A., Siddaway, R., Bald, T., Reinhardt, J., Smorra, D., Kohlmeyer, J., Renn, M., Phung, B., Aymans, P., et al. (2015) · Nature Communications · doi:10.1038/ncomms9755 · Cited by 227
Sigalotti, L., Fratta, E., Coral, S., Tanzarella, S., Danielli, R., Colizzi, F., Fonsatti, E., Traversari, C., Altomonte, M., & Maio, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1442 · Cited by 217
The NF1 gene in tumor syndromes and melanoma
Kiuru, M., & Busam, K. J. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2016.142 · Cited by 217
Phenotype Switching: Tumor Cell Plasticity as a Resistance Mechanism and Target for Therapy
Kemper, K., de Goeje, P. L., Peeper, D. S., & van Amerongen, R. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1174 · Cited by 216
Incidence of BRAF Oncogene Mutation and Clinical Relevance for Primary Cutaneous Melanomas
Shinozaki, M., Fujimoto, A., Morton, D. L., & Hoon, D. S. B. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-1169-3 · Cited by 212
Cancer stem cells and human malignant melanoma
Schatton, T., & Frank, M. H. (2008) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2007.00427.x · Cited by 210
Stoecklein, N. H., Hosch, S. B., Bezler, M., Stern, F., Hartmann, C. H., Vay, C., Siegmund, A., Scheunemann, P., Schurr, P., Knoefel, W. T., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.04.005 · Cited by 209
Heterogeneous Tumor Subpopulations Cooperate to Drive Invasion
Chapman, A., Fernandez del Ama, L., Ferguson, J., Kamarashev, J., Wellbrock, C., & Hurlstone, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.045 · Cited by 203
Metapopulation dynamics and spatial heterogeneity in cancer
González-García, I., Solé, R. V., & Costa, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202139299 · Cited by 201
Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination
Sanborn, J. Z., Chung, J., Purdom, E., Wang, N. J., Kakavand, H., Wilmott, J. S., Butler, T., Thompson, J. F., Mann, G. J., Haydu, L. E., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508074112 · Cited by 192
Sensi, M., Nicolini, G., Petti, C., Bersani, I., Lozupone, F., Molla, A., Vegetti, C., Nonaka, D., Mortarini, R., Parmiani, G., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209379 · Cited by 183
Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma
Reuben, A., Spencer, C. N., Prieto, P. A., Gopalakrishnan, V., Reddy, S. M., Miller, J. P., Mao, X., De Macedo, M. P., Chen, J., Song, X., et al. (2017) · npj Genomic Medicine · doi:10.1038/s41525-017-0013-8 · Cited by 166 · cited 4×
“[201] established that heterogeneous response to targeted therapy and immune checkpoint blockade is observed in the majority of patients.”
BackgroundInfluentialIntegrating next-generation sequencing into clinical oncology: strategies, promises and pitfalls
Horak, P., Fröhling, S., & Glimm, H. (2016) · ESMO Open · doi:10.1136/esmoopen-2016-000094 · Cited by 165
Phenotype Switching in Melanoma: Implications for Progression and Therapy
Li, F. Z., Dhillon, A. S., Anderson, R. L., McArthur, G., & Ferrao, P. T. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00031 · Cited by 163
Genetic divergence in the clonal evolution of breast cancer.
Fujii, H., Marsh, C., Cairns, P., Sidransky, D., & Gabrielson, E. (1996) · PubMed · Cited by 163
Whole genome sequencing of matched primary and metastatic acral melanomas
Turajlic, S., Furney, S. J., Lambros, M. B., Mitsopoulos, C., Kozarewa, I., Geyer, F. C., MacKay, A., Hakas, J., Zvelebil, M., Lord, C. J., et al. (2012) · Genome Research · doi:10.1101/gr.125591.111 · Cited by 163
Precise microdissection of human prostate cancers reveals genotypic heterogeneity.
Macintosh, C. A., Stower, M. J., Reid, N., et al. (1998) · PubMed · Cited by 162
Detection of BRAF p.V600E Mutations in Melanomas
Colomba, E., Hélias-Rodzewicz, Z., Von Deimling, A., Marin, C., Terrones, N., Pechaud, D., Surel, S., Côté, J.-F., Peschaud, F., Capper, D., et al. (2013) · The Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2012.09.001 · Cited by 160
PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison
Sunshine, J. C., Nguyen, P. L., Kaunitz, G. J., Cottrell, T. R., Berry, S., Esandrio, J., Xu, H., Ogurtsova, A., Bleich, K. B., Cornish, T. C., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-1821 · Cited by 158
Complex patterns of ETS gene alteration arise during cancer development in the human prostate
Clark, J., Attard, G., Jhavar, S. G., Flohr, P., Reid, A. H. M., Bono, J. S. D., Eeles, R. A., Scardino, P. T., Cuzick, J. M., Fisher, G., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210843 · Cited by 156
Merlo, L. M. F., Shah, N. A., Li, X., Blount, P. L., Vaughan, T. L., Reid, B. J., & Maley, C. C. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0108 · Cited by 155
Fujii, H., Yoshida, M., Gong, Z. X., Matsumoto, T., Hamano, Y., Fukunaga, M., Hruban, R. H., Gabrielson, E., & Shirai, T. (2000) · PubMed · Cited by 153
Hypoxia Contributes to Melanoma Heterogeneity by Triggering HIF1α-Dependent Phenotype Switching
Widmer, D. S., Hoek, K. S., Cheng, P. F., Eichhoff, O. M., Biedermann, T., Raaijmakers, M. I. G., Hemmi, S., Dummer, R., & Levesque, M. P. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.115 · Cited by 148
Halait, H., DeMartin, K., Shah, S., Soviero, S., Langland, R., Cheng, S., Hillman, G. R., Wu, L., & Lawrence, H. J. (2012) · Diagnostic Molecular Pathology · doi:10.1097/pdm.0b013e31823b216f · Cited by 145
Kemper, K., Krijgsman, O., Cornelissen‐Steijger, P., Shahrabi, A., Weeber, F., Song, J., Kuilman, T., Vis, D. J., Wessels, L. F. A., Voest, E. E., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404914 · Cited by 141
Anderson, S., Bloom, K. J., Vallera, D. U., Rueschoff, J., Meldrum, C. J., Schilling, R., Kovach, B., Lee, J. R.-J., Ochoa, P., Langland, R., et al. (2012) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2011-0505-oa · Cited by 139
Govindarajan, B., Bai, X., Cohen, C., Zhong, H., Kilroy, S. M., Louis, G. W., Moses, M. A., & Arbiser, J. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212929200 · Cited by 130
Advances in Immunotherapy for Melanoma: A Comprehensive Review
Rodríguez‐Cerdeira, C., Carnero-Gregorio, M., López-Bárcenas, A., Sánchez-Blanco, E., Sánchez-Blanco, B., Fabbrocini, G., Bardhi, B., Sinani, A., & Arenas, R. (2017) · Mediators of Inflammation · doi:10.1155/2017/3264217 · Cited by 130
Eradication of melanomas by targeted elimination of a minor subset of tumor cells
Schmidt, P., Kopecky, C., Hombach, A. A., Zigrino, P., Mauch, C., & Abken, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009069108 · Cited by 129
Lin, J., Goto, Y., Murata, H., Sakaizawa, K., Uchiyama, A., Saida, T., & Takata, M. (2011) · British Journal of Cancer · doi:10.1038/sj.bjc.6606072 · Cited by 122
Aubele, M. M., Mattis, A. E., Zitzelsberger, H. F., Walch, A. K., Kremer, M., Hutzler, P., Höfler, H., & Werner, M. (1999) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(98)00205-2 · Cited by 122
Okada, Y., Hurwitz, E. E., Esposito, J. M., et al. (2003) · PubMed · Cited by 118
Harbst, K., Lauss, M., Cirenajwis, H., Isaksson, K., Rosengren, F., Törngren, T., Kvist, A., Johansson, M. C., Vallon‐Christersson, J., Baldetorp, B., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3476 · Cited by 110
Characterization of Melanoma Cells Capable of Propagating Tumors from a Single Cell
Held, M. A., Curley, D. P., Dankort, D. L., McMahon, M., Muthusamy, V., & Bosenberg, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2153 · Cited by 109
Boursault, L., Haddad, V., Vergier, B., Cappellen, D., Verdon, S., Bellocq, J., Jouary, T., & Merlio, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070826 · Cited by 108
Lai, C.-Y., Schwartz, B. E., & Hsu, M. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0624 · Cited by 107
Konishi, N., Hiasa, Y., Matsuda, H., Tao, M., Tsuzuki, T., Hayashi, I., Kitahori, Y., Shiraishi, T., Yatani, R., & Shimazaki, J. (1995) · Europe PMC (PubMed Central) · Cited by 105
COX-2 expression positively correlates with PD-L1 expression in human melanoma cells
Botti, G., Fratangelo, F., Cerrone, M., Liguori, G., Cantile, M., Anniciello, A. M., Scala, S., D’Alterio, C., Trimarco, C., Ianaro, A., et al. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1150-7 · Cited by 104
BUSAM, K. J., Hedvat, C. V., Pulitzer, M. P., von Deimling, A., & Jungbluth, A. A. (2012) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e318271249e · Cited by 104
Mutation analysis of BRAF and KIT in circulating melanoma cells at the single cell level
Sakaizawa, K., Goto, Y., Kiniwa, Y., Uchiyama, A., Harada, K., Shimada, S., Saida, T., Ferrone, S., Takata, M., Uhara, H., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.12 · Cited by 103
Intratumoral Heterogeneity of Immunohistochemical Marker Expression in Breast Carcinoma
Nassar, A., Radhakrishnan, A., Cabrero, I. A., Cotsonis, G., & Cohen, C. (2010) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0b013e3181dddb20 · Cited by 100
Single-cell gene expression signatures reveal melanoma cell heterogeneity
Ennen, M., Keime, C., Kobi, D., Mengus, G., Lipsker, D. M., Thibault-Carpentier, C., & Davidson, I. (2014) · Oncogene · doi:10.1038/onc.2014.262 · Cited by 97
Intra‐tumour heterogeneity – going beyond genetics
Caiado, F., Silva‐Santos, B., & Norell, H. (2016) · FEBS Journal · doi:10.1111/febs.13705 · Cited by 96
Zhang, X. C., Xu, C., Mitchell, R. M., Zhang, B., Zhao, D., Li, Y., Huang, X. H., Fan, W., Wang, H., Lerma, L. A., et al. (2013) · Neoplasia · doi:10.1593/neo.131400 · Cited by 92
Side Population Cells from Human Melanoma Tumors Reveal Diverse Mechanisms for Chemoresistance
Luo, Y., Ellis, L. Z., Dallaglio, K., Takeda, M. R., Robinson, W. A., Robinson, S. E., Liu, W., Lewis, K. D., McCarter, M. D., Gonzalez, R. C., et al. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.161 · Cited by 88
Gray, E. S., Reid, A. L., Bowyer, S. E., Calapre, L., Siew, K. S. W., Pearce, R. L., Cowell, L., Frank, M. H., Millward, M., & Ziman, M. R. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.127 · Cited by 86
Clonal Architectures and Driver Mutations in Metastatic Melanomas
Ding, L., Kim, M., Kanchi, K., Dees, N. D., Lu, C., Griffith, M., Fenstermacher, D., Sung, H., Miller, C. A., Goetz, B. D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111153 · Cited by 85
The Wnts of change: How Wnts regulate phenotype switching in melanoma
Webster, M. R., Kugel, C. H., & Weeraratna, A. T. (2015) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2015.10.002 · Cited by 83
Cottu, P. H., Asselah, J., Lae, M. E., Pierga, J., Dieras, V. C., Mignot, L., Sigal‐Zafrani, B., & Vincent‐Salomon, A. (2008) · Annals of Oncology · doi:10.1093/annonc/mdn021 · Cited by 82
Therapeutic implications of cellular and molecular biology of cancer stem cells in melanoma
Kumar, D., Gorain, M., Kundu, G., & Kundu, G. C. (2017) · Molecular Cancer · doi:10.1186/s12943-016-0578-3 · Cited by 80
Bustos, B. D. U., Estal, R. M., Pérez-Simó, G., Jiménez, I. D. J., Muñoz, B. E., Serna, M. R., de Miquel, V. A., Ros, M. L., Sánchez, R. B., Nagore, E., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00606-w · Cited by 78
Kim, J. E., Leung, E. Y., Baguley, B. C., & Finlay, G. J. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00097 · Cited by 76
Wilmott, J. S., Tembe, V., Howle, J. R., Sharma, R. N., Thompson, J. F., Rizos, H., Lo, R. S., Kefford, R. F., Scolyer, R. A., & Long, G. V. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0530 · Cited by 76
Mapping heterogeneity in patient-derived melanoma cultures by single-cell RNA-seq
Gerber, T., Willscher, E., Loeffler‐Wirth, H., Hopp, L., Schadendorf, D., Schartl, M., Anderegg, U., Camp, J. G., Treutlein, B., Binder, H., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13666 · Cited by 76
Goswami, R. S., Patel, K. P., Singh, R. R., Meric‐Bernstam, F., Kopetz, S., Subbiah, V., Álvarez, R. H., Davies, M. A., Jabbar, K. J., Roy‐Chowdhuri, S., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2391 · Cited by 75
Chatterjee, A., Stockwell, P. A., Ahn, A., Rodger, E. J., Leichter, A. L., & Eccles, M. R. (2016) · Oncotarget · doi:10.18632/oncotarget.14042 · Cited by 73
Molecular and genetic diversity in the metastatic process of melanoma
Harbst, K., Lauss, M., Cirenajwis, H., Winter, C., Howlin, J., Törngren, T., Kvist, A., Nodin, B., Olsson, E., Häkkinen, J., et al. (2014) · The Journal of Pathology · doi:10.1002/path.4318 · Cited by 72
Varley, K. E., Mutch, D. G., Edmonston, T. B., Goodfellow, P. J., & Mitra, R. D. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp457 · Cited by 72
Giaretti, W., Monaco, R., Pujič, N., Rapallo, A., Nigro, S., & Geido, E. (1996) · PubMed · Cited by 71
Investigating the utility of human melanoma cell lines as tumour models
Vincent, K. M., & Postovit, L.-M. M. (2017) · Oncotarget · doi:10.18632/oncotarget.14443 · Cited by 70
Manning, C. S., Hooper, S., & Sahai, E. A. (2014) · Oncogene · doi:10.1038/onc.2014.362 · Cited by 69
Katona, T. M., Jones, T. D., Wang, M., Eble, J. N., Billings, S. D., & Cheng, L. (2007) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e31802b3488 · Cited by 67
Distinct subclonal tumour responses to therapy revealed by circulating cell-free DNA
Gremel, G., Lee, R. J., Girotti, M. R., Mandal, A. K., Valpione, S., Garner, G., Ayub, M., Wood, S. L., Rothwell, D. G., Fusi, A., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw278 · Cited by 59
Testing the cancer stem cell hypothesis in melanoma: The clinics will tell
Shakhova, O., & Sommer, L. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.10.009 · Cited by 57
Frequent intra-tumoural heterogeneity of promoter hypermethylation in malignant melanoma.
Rastetter, M., Schagdarsurengin, U., Lahtz, C., Fiedler, E., Marsch, W. C., Dammann, R., & Helmbold, P. (2007) · PubMed · doi:10.14670/hh-22.1005 · Cited by 55
Alvarado, C., Beitel, L. K., Sircar, K., Aprikian, A. G., Trifiro, M. A., & Gottlieb, B. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0399 · Cited by 55
Anwar, M. A. F., Murad, F. G., Dawson, E., Elmageed, Z. Y. A., Tsumagari, K., & Kandil, E. H. (2016) · Journal of Surgical Research · doi:10.1016/j.jss.2016.04.029 · Cited by 54
BRAF and NRAS Mutations are Heterogeneous and Not Mutually Exclusive in Nodular Melanoma
Chiappetta, C., Proietti, I., Soccodato, V., Puggioni, C., Zaralli, R., Pacini, L., Porta, N., Skroza, N., Petrozza, V., Potenza, C., et al. (2014) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000000071 · Cited by 53
Wouters, J., Stas, M., Gremeaux, L., Govaere, O., den broeck, A. V., Maes, H., Agostinis, P., Roskams, T., van den Oord, J. J., & Vankelecom, H. E. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076550 · Cited by 52
Cao, W., Wu, W., Yan, M., Tian, F., Ma, C., Zhang, Q., Li, X., Han, P., Liu, Z., Gu, J., et al. (2015) · Oncogenesis · doi:10.1038/oncsis.2015.34 · Cited by 52
Variations of BRAF mutant allele percentage in melanomas
Hélias‐Rodzewicz, Z., Funck‐Brentano, E., Baudoux, L., Jung, C. K., Zimmermann, U. S., Marin, C., Clérici, T., Gall, C. L., Peschaud, F., Taly, V., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1515-3 · Cited by 51
Discrepancy in BRAF status among patients with metastatic malignant melanoma: A meta-analysis
Valachis, A., & Ullenhag, G. J. (2017) · European Journal of Cancer · doi:10.1016/j.ejca.2017.05.015 · Cited by 51
Intra- and Inter-Tumoral Homogeneity of BRAFV600E Mutations in Melanoma Tumors
Riveiro‐Falkenbach, E., Villanueva, C. A., Garrido, M. C., Ruano, Y., García-Martín, R., Godoy, E., Ortiz-Romero, P. L., Ríos-Martín, J. J., Santos-Briz, A. J., & Rodríguez‐Peralto, J. L. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.229 · Cited by 47
Circulating tumor cells: Exploring intratumor heterogeneity of colorectal cancer
Raimondi, C., Nicolazzo, C., Gradilone, A., Giannini, G., FALCO, E. D., Chimenti, I., Varriale, E., Hauch, S., Plappert, L., Cortesi, E., et al. (2014) · Cancer Biology & Therapy · doi:10.4161/cbt.28020 · Cited by 47
Bruno, W., (IMI), O. B. O. T. I. M. I., Martinuzzi, C., Andreotti, V., Pastorino, L., Spagnolo, F., Dalmasso, B., Cabiddu, F., Gualco, M., Ballestrero, A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.14094 · Cited by 46
Seftor, E. A., Seftor, R. E. B., Weldon, D. S., Kirsammer, G. T., Margaryan, N. V., Gilgur, A., & Hendrix, M. J. C. (2014) · Seminars in Oncology · doi:10.1053/j.seminoncol.2014.02.001 · Cited by 42
Bradish, J. R., Richey, J. D., Post, K. M., Meehan, K. L., Sen, J. D., Malek, A. J., Katona, T. M., Warren, S. J. P., Logan, T. F., Fecher, L. A., et al. (2014) · Modern Pathology · doi:10.1038/modpathol.2014.136 · Cited by 42
Microgenomics profile the endogenous angiogenic phenotype in subpopulations of aggressive Melanoma
Demou, Z. N., & Hendrix, M. J. C. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21855 · Cited by 40
Therapeutic implications of melanoma heterogeneity
Hachey, S. J., & Boiko, A. D. (2016) · Experimental Dermatology · doi:10.1111/exd.13002 · Cited by 40
NGFR-Positive Desmoplastic Melanomas with Focal or Absent S-100 Staining
Radfar, A., Stefanato, C. M., Ghosn, S. H., & Bhawan, J. (2006) · American Journal of Dermatopathology · doi:10.1097/01.dad.0000183696.46573.ee · Cited by 39
Genetic heterogeneity and clonal evolution in neuroblastoma
Mora, J., Cheung, N.-K. V., & Gerald, W. L. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1849 · Cited by 38
Clonal heterogeneity in sporadic melanomas as revealed by loss-of-heterozygosity analysis
Takata, M., Morita, R., & Takehara, K. (2000) · International Journal of Cancer · Cited by 38
Lamy, P., Castan, F., Lozano, N., Montélion, C., Audran, P., Bibeau, F., Roques, S., Montels, F., & Laberenne, A.-C. (2015) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2015.02.004 · Cited by 37
Marino, F. Z., Liguori, G., Aquino, G., Mantia, E. L., Bòsari, S., Ferrero, S., Rosso, L., Gaudioso, G., Rosa, N. D., Scrima, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139264 · Cited by 37
Manfredi, L., Meyer, N., Tournier, É., Grand, D., Uro‐Coste, E., Rochaix, P., Brousset, P., & Lamant, L. (2015) · Acta Dermato Venereologica · doi:10.2340/00015555-2326 · Cited by 36
Anaka, M., Hudson, C., Lo, P., Do, H., Caballero, O. L., Davis, I. D., Dobrovic, A., Cebon, J. S., & Behren, A. (2013) · BMC Medical Genomics · doi:10.1186/1755-8794-6-40 · Cited by 35
Pennec, S. L., Konopka, T., Gacquer, D., Fimereli, D., Tarabichi, M., Tomás, G., Savagner, F., Decaussin‐Petrucci, M., Trésallet, C., Andry, G., et al. (2015) · Endocrine Related Cancer · doi:10.1530/erc-14-0351 · Cited by 35
BRAF-V600 Mutation Heterogeneity in Primary and Metastatic Melanoma
Yaman, B., Kandiloğlu, G., & Akalın, T. (2015) · American Journal of Dermatopathology · doi:10.1097/dad.0000000000000404 · Cited by 34
Benetkiewicz, M., Piotrowski, A., de Ståhl, T. D., Jankowski, M., Bała, D., Hoffman, J., Śrutek, E., Laskowski, R., Zegarski, W., & Dumanski, J. (2006) · International Journal of Oncology · doi:10.3892/ijo.29.4.935 · Cited by 33
Phenotypic diversity of patient-derived melanoma populations in stem cell medium
Sztiller-Sikorska, M., Hartman, M. L., Talar, B., Jakubowska, J., Zaleśna, I., & Czyż, M. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2015.48 · Cited by 33
BRAFV600EProtein Expression in Primary Cutaneous Malignant Melanomas and Paired Metastases
Eriksson, H., Zebary, A., Vassilaki, I., Omholt, K., Ghaderi, M., & Hansson, J. (2015) · JAMA Dermatology · doi:10.1001/jamadermatol.2014.3689 · Cited by 32
Schirosi, L., Strippoli, S., Gaudio, F. D., et al. (2016) · BMC Cancer · doi:10.1186/s12885-016-2951-4 · Cited by 32
Future of circulating tumor cells in the melanoma clinical and research laboratory settings
Souza, L. M. D., Robertson, B. M., & Robertson, G. P. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.01.023 · Cited by 32
Cancer Stem Cells (CSCs) in melanoma: There's smoke, but is there fire?
Brinckerhoff, C. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25796 · Cited by 31
Analysis of intratumor heterogeneity unravels lung cancer evolution
de Bruin, E. C., McGranahan, N., & Swanton, C. (2015) · Molecular & Cellular Oncology · doi:10.4161/23723556.2014.985549 · Cited by 29
Richmond‐Sinclair, N. M., Lee, E., Cummings, M. C., Williamson, R., Müller, K., Green, A. C., Hayward, N. K., & Whiteman, D. C. (2008) · Melanoma Research · doi:10.1097/cmr.0b013e32830d8329 · Cited by 27
Kaji, T., Yamasaki, O., Takata, M., Otsuka, M., Hamada, T., Morizane, S., Asagoe, K., Yanai, H., Hirai, Y., Umemura, H., et al. (2016) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2016.10.006 · Cited by 27
Update on the clinical use of kinase inhibitors in melanoma
Cosgarea, I., Ritter, C., Becker, J. C., Schadendorf, D., & Ugurel, S. (2017) · Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · doi:10.1111/ddg.13321 · Cited by 27
Saroufim, M., Habib, R., Gerges, R., Saab, J., Loya, A., Amr, S. S., Sheikh, S. S., Satti, M., Oberkanins, C., & Khalifeh, I. M. (2014) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2014.09.008 · Cited by 26
Sharma, B. K., Manglik, V., O’Connell, M. P., Weeraratna, A. T., McCarron, E. C., Broussard, J., DiVito, K. A., Simbulan-Rosenthal, C. M., Rosenthal, D. S., & Zapas, J. L. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1590 · Cited by 25
Epigenetic mechanisms involved in melanoma pathogenesis and chemoresistance.
Martínez‐Cardús, A., Vizoso, M., Morán, S., & Manzano, J. L. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.06.20 · Cited by 24
Update on melanoma epigenetics
de Unamuno, B., Palanca, S., & Botella, R. (2015) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000217 · Cited by 22
Varying Mutational Alterations in Multiple Primary Melanomas
Egberts, F., Bohne, A., Krüger, S., Hedderich, J., Rompel, R., Haag, J., Röcken, C., & Hauschild, A. (2015) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2015.07.010 · Cited by 21
Kaisaki, P. J., Cutts, A., Popitsch, N. P., Camps, C., Pentony, M. M., Wilson, G. A., Page, S., Kaur, K., Vavoulis, D. V., Henderson, S. J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162809 · Cited by 21
Liquid Biopsies for Assessing Metastatic Melanoma Progression
Huynh, K. T., & Hoon, D. S. �. (2016) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2016016075 · Cited by 19
Clinical and therapeutic implications of BRAF mutation heterogeneity in metastatic melanoma
Ardakani, N. M., Leslie, C., Grieu‐Iacopetta, F., et al. (2016) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12569 · Cited by 19
Mirkina, I. I., Hadzijusufovic, E., Krepler, C., Mikula, M., Mechtcheriakova, D., Strommer, S., Stella, A., Jensen‐Jarolim, E., Höeller, C., Wacheck, V., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084417 · Cited by 18
An Aggressive Hypoxia Related Subpopulation of Melanoma Cells is TRP-2 Negative
Lenggenhager, D. M., Fontecedro, A. C., Storz, M., Shakhova, O., Sommer, L., Widmer, D. S., Seifert, B., Moch, H., Dummer, R., & Mihic‐Probst, D. (2014) · Translational Oncology · doi:10.1016/j.tranon.2014.02.018 · Cited by 16
Heterogeneity of monosomy 3 in fine needle aspiration biopsy of choroidal melanoma.
Chang, M. Y., Rao, N. P., Burgess, B. L., Johnson, L., & McCannel, T. A. (2013) · Europe PMC (PubMed Central) · Cited by 15
Verlinden, I. V., van den Hurk, K., Clarijs, R., Willig, A. P., Stallinga, C. M., Roemen, G. M. J. M., van den Oord, J. J., Hausen, A. Z., Speel, E. M., & Winnepenninckx, V. J. L. (2014) · Medicine · doi:10.1097/md.0000000000000285 · Cited by 15
Roesch, A. (2015) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.12584 · Cited by 14
The extent of whole‐genome copy number alterations predicts aggressive features in primary melanomas
Gandolfi, G., Longo, C., Moscarella, E., Zalaudek, I., Sancisi, V., Raucci, M., Manzotti, G., Gugnoni, M., Piana, S., Argenziano, G., et al. (2015) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12436 · Cited by 14
Low Levels of Genetic Heterogeneity in Matched Lymph Node Metastases from Patients with Melanoma
Casula, M., Colombino, M., Manca, A., Caracò, C., Botti, G., Ascierto, P. A., Lissia, A., Cossu, A., Palmieri, G., Mozzillo, N., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.05.103 · Cited by 14
Erramuzpe, A., Cortés, J. M., & Lopez, J. I. (2017) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-017-2223-y · Cited by 11
Intratumoral DNA stem-line heterogeneity in superficial spreading melanoma
Helmbold, P., Altrichter, D., Klapperstück, T., & Marsch, W. C. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2004.12.049 · Cited by 9
Cell Dispersal Influences Tumor Heterogeneity and Introduces a Bias in NGS Data Interpretation
Pongor, L. S., Papp, H., Méhes, E., Czirók, A., & Győrffy, B. (2017) · Scientific Reports · doi:10.1038/s41598-017-07487-z · Cited by 9
Identification of genetic disparity between primary and metastatic melanoma in human patients
Swoboda, A., Rasin‐Streden, D., Schanab, O., Okamoto, I., Pehamberger, H., Petzelbauer, P., & Mikula, M. (2011) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20890 · Cited by 7
Cited by
Targeting Tumor Microenvironment for Cancer Therapy
Roma-Rodrigues, C., Mendes, R., Baptista, P. V., & Fernandes, A. R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040840 · Cited by 1,187
Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma
Wouters, J., Kalender-Atak, Z., Minnoye, L., Spanier, K. I., De Waegeneer, M., Bravo González-Blas, C., Mauduit, D., Davie, K., Hulselmans, G., Najem, A., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0547-3 · Cited by 258
de Maar, J. S., Sofias, A. M., Porta Siegel, T., Vreeken, R. J., Moonen, C., Bos, C., & Deckers, R. (2020) · Theranostics · doi:10.7150/thno.38625 · Cited by 71
Unraveling resistance to immunotherapy in MSI-high colorectal cancer
Heregger, R., Huemer, F., Steiner, M., Gonzalez-Martinez, A., Greil, R., & Weiss, L. (2023) · Cancers · doi:10.3390/cancers15205090 · Cited by 52
Identification of Cancer Stem Cell Subpopulations in Head and Neck Metastatic Malignant Melanoma
Yoganandarajah, V., Patel, J., van Schaijik, B., Bockett, N., Brasch, H. D., Paterson, E., Sim, D., Davis, P. F., Roth, I. M., Itinteang, T., et al. (2020) · Cells · doi:10.3390/cells9020324 · Cited by 26
Metadata
- Authors
- Grzywa, T. M., Paskal, W., & Włodarski, P. K.
- Venue
- Translational Oncology
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 10
- Issue
- 6
- Pages
- 956-975
- ISSN
- 1936-5233 (ISSN-L)
- OpenAlex
- W2765099905
- Cited by
- 299
- References
- 184
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.