The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Nanoparticle vaccines
Open accessAbstract
Nanotechnology increasingly plays a significant role in vaccine development. As vaccine development orientates toward less immunogenic "minimalist" compositions, formulations that boost antigen effectiveness are increasingly needed. The use of nanoparticles in vaccine formulations allows not only improved antigen stability and immunogenicity, but also targeted delivery and slow release. A number of nanoparticle vaccines varying in composition, size, shape, and surface properties have been approved for human use and the number of candidates is increasing. However, challenges remain due to a lack of fundamental understanding regarding the in vivo behavior of nanoparticles, which can operate as either a delivery system to enhance antigen processing and/or as an immunostimulant adjuvant to activate or enhance immunity. This review provides a broad overview of recent advances in prophylactic nanovaccinology. Types of nanoparticles used are outlined and their interaction with immune cells and the biosystem are discussed. Increased knowledge and fundamental understanding of nanoparticle mechanism of action in both immunostimulatory and delivery modes, and better understanding of in vivo biodistribution and fate, are urgently required, and will accelerate the rational design of nanoparticle-containing vaccines.
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1 retracted
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“Therapeutic nanovaccinology is mostly applied for cancer treatment [14–16], and is increasingly explored to treat other diseases or conditions, such as Alzheimer’s [17], hypertension [9], and nicotine addiction [11].”
Background
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Overcoming the challenges in administering biopharmaceuticals: Formulation and delivery strategies
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Németh, Z., Csóka, I., Semnani Jazani, R., Sipos, B., Haspel, H., Kozma, G., Kónya, Z., & Dobó, D. G. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091798 · Cited by 452
Cancer therapy with iron oxide nanoparticles: Agents of thermal and immune therapies
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Metadata
- Authors
- Zhao, L., Seth, A., Wibowo, N., Zhao, C.-X., Mitter, N., Yu, C., & Middelberg, A. P. J.
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 32
- Issue
- 3
- Pages
- 327-337
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W4211241999
- Cited by
- 919
- References
- 9
- FWCI
- 26.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zhao, L., Seth, A., Wibowo, N., Zhao, C.-X., Mitter, N., Yu, C., & Middelberg, A. P. J. (2014). Nanoparticle vaccines. Vaccine. https://doi.org/10.1016/j.vaccine.2013.11.069
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
