Is Wolbachia participating in the bronchial reactivity of cats with heartworm associated respiratory disease?
Abstract
Heartworm associated respiratory disease is a pulmonary syndrome in cats that results from the vascular and parenchymal inflammatory response associated with the arrival and death of Dirofilaria immitis worms into the distal pulmonary arteries. This parasite harbors intracellular Wolbachia, an endosymbiont bacteria. The association between the parasite and the bacteria is obligatory. Some studies suggest the involvement of Wolbachia in the development of the inflammatory reaction and in the polarization of the host immune response against the parasite. Barometric whole-body plethysmography is a non-invasive pulmonary function test that allows a dynamic study of breathing patterns and is useful to study airway disease and the response to different treatments. The aim of this prospective non-blinded study was to compare the influence of Wolbachia upon the respiratory function variables in a population of cats seropositive to D. immitis by use of Barometric whole-body plethysmography. Fourteen seropositive cats to Wolbachia and eight seronegative cats were put into the plethysmograph chamber and different respiratory variables were measured. The results were analyzed and compared between the two groups of animals. Significant differences were found for bronchoconstriction index variables PAU (pause) (P-value<0.05) and Penh (enhanced pause) (P-value<0.05). The results obtained in our study suggest that Wolbachia seems to produce a greater acute inflammatory response at bronchial, vascular and parenchymal level worsening the state of broncho-reactivity associated with the presence of seropositivity to D. immitis in cats.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The presence of circulating Wolbachia species antigens and anti-Wolbachia antibodies has been associated in experimentally infected cats with an inflammatory reaction in the host tissues that affects respiratory function.
“the presence of circulating Wolbachia species antigens and anti-Wolbachia antibodies has been associated in experimentally infected cats with an inflammatory reaction in the host tissues that affects respiratory function.”
From Dirofilarioses in cats: European guidelines from the ABCD on prevention and management (2020) · cites this paper as [27]
Early or end-stage parasite death can be associated with acute severe lesions (severe pulmonary thromboembolism and eosinophilic inflammatory response in the lungs) causing HARD.
“Early or end-stage parasite death can be associated with acute severe lesions (severe pulmonary thromboembolism and eosino-philic inflammatory response in the lungs) causing the so-called heartworm-associated respiratory disease (HARD)”
From Dirofilarioses in cats: European guidelines from the ABCD on prevention and management (2020) · cites this paper as [27]
Cites
Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography
Hamelmann, E. H., Schwarze, J., Takeda, K., Oshiba, A., Larsen, G. L., Irvin, C. G., & Gelfand, E. W. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.3.9606031 · Cited by 1,286 · see citing works
Human and animal dirofilariasis: The emergence of a zoonotic mosaic
Simón, F., Siles-Lucas, M., Morchón, R., González-Miguel, J., Mellado, I., Carretón, E., & Montoya-Alonso, J. A. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00012-12 · Cited by 834 · see citing works
Self-citationChapter 4 Heartworm Disease in Animals and Humans
McCall, J. W., Genchi, C., Kramer, L. H., Guerrero, J., & Venco, L. (2008) · Advances in Parasitology · doi:10.1016/s0065-308x(08)00204-2 · Cited by 609 · see citing works
Self-citationMolecular evidence for a close relative of the arthropod endosymbiont Wolbachia in a filarial worm
Sironi, M., Bandi, C., Sacchi, L., di Sacco, B., Damiani, G., & Genchi, C. (1995) · Molecular and Biochemical Parasitology · doi:10.1016/0166-6851(95)02494-8 · Cited by 251 · see citing works
Textbook of Respiratory Disease in Dogs and Cats
(2004) · doi:10.1016/b978-0-7216-8706-3.x5001-4 · Cited by 211 · see citing works
<i>Wolbachia</i> bacteria in filarial immunity and disease
Taylor, M. J., Cross, H. F., Ford, L., Makunde, W. H., Prasad, G. B. K. S., & Bilo, K. (2001) · Parasite Immunology · doi:10.1046/j.1365-3024.2001.00400.x · Cited by 106 · see citing works
Association of expiratory airway dysfunction with marked obesity in healthy adult dogs
Bach, J. F., Rozanski, E. A., Bedenice, D., Chan, D. L., Freeman, L. M., Lofgren, J. L. S., Oura, T. J., & Hoffman, A. M. (2007) · American Journal of Veterinary Research · doi:10.2460/ajvr.68.6.670 · Cited by 101 · see citing works
Wolbachia and its influence on the pathology and immunology of Dirofilaria immitis infection
Kramer, L., Grandi, G., Leoni, M., Passeri, B., McCall, J., Genchi, C., Mortarino, M., & Bazzocchi, C. (2008) · Veterinary Parasitology · doi:10.1016/j.vetpar.2008.09.014 · Cited by 94 · see citing works
Self-citationUnderstanding Feline Heartworm Infection: Disease, Diagnosis, and Treatment
Lee, A. C. Y., & Atkins, C. E. (2010) · Topics in Companion Animal Medicine · doi:10.1053/j.tcam.2010.09.003 · Cited by 93 · see citing works
Bazzocchi, C., Ceciliani, F., McCall, J. W., Ricci, I., Genchi, C., & Bandi, C. (2000) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2000.1313 · Cited by 93 · see citing works
Feline heartworm disease: A clinical review
Litster, A. L., & Atwell, R. B. (2008) · Journal of Feline Medicine and Surgery · doi:10.1016/j.jfms.2007.09.007 · Cited by 90 · see citing works
Proceedings of the Heartworm Symposium '80
Eberhard, M. L. (1982) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1982.31.1069 · Cited by 81 · see citing works
Kramer, L., Passeri, B., Corona, S., Simoncini, L., & Casiraghi, M. (2003) · Parasitology Research · doi:10.1007/s00436-002-0765-6 · Cited by 79 · see citing works
Self-citationWhat is new in the Wolbachia/Dirofilaria interaction?
Kozek, W. J. (2005) · Veterinary Parasitology · doi:10.1016/j.vetpar.2005.02.005 · Cited by 71 · see citing works
Airway reactivity measured by barometric whole-body plethysmography in healthy cats
Hoffman, A. M., Dhupa, N., & Cimetti, L. (1999) · American Journal of Veterinary Research · doi:10.2460/ajvr.1999.60.12.1487 · Cited by 69 · see citing works
Montoya-Alonso, J. A., Carretón, E., Corbera, J. A., Juste, M. C., Mellado, I., Morchón, R., & Simón, F. (2011) · Veterinary Parasitology · doi:10.1016/j.vetpar.2011.01.011 · Cited by 67 · see citing works
Self-citationMorchón, R., Ferreira, A. C., Martín-Pacho, J. R., Montoya, A., Mortarino, M., Genchi, C., & Simón, F. (2004) · Veterinary Parasitology · doi:10.1016/j.vetpar.2004.08.003 · Cited by 62 · see citing works
Self-citationBronchodilators in Bronchoscopy-Induced Airflow Limitation in Allergen-Sensitized Cats
Kirschvink, N. A., Leemans, J., Delvaux, F. H., et al. (2005) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2005.tb02677.x · Cited by 53 · see citing works
Dillon, A. R., Warner, A. E., Brawner, W., Hudson, J., & Tillson, M. (2008) · Veterinary Parasitology · doi:10.1016/j.vetpar.2008.09.004 · Cited by 46 · see citing works
Bronchodilators in Bronchoscopy-Induced Airflow Limitation in Allergen-Sensitized Cats
Kirschvink, N. A., Leemans, J., Delvaux, F. H., et al. (2005) · Journal of Veterinary Internal Medicine · doi:10.1892/0891-6640(2005)19 · Cited by 46 · see citing works
Kirschvink, N. A., Leemans, J., Delvaux, F. H., et al. (2007) · The Veterinary Journal · doi:10.1016/j.tvjl.2006.11.004 · Cited by 45 · see citing works
Simón, F., Prieto, G., Morchón, R., Bazzocchi, C., Bandi, C., & Genchi, C. (2003) · Clinical and Vaccine Immunology · doi:10.1128/cdli.10.1.180-181.2003 · Cited by 45 · see citing works
Self-citationIs Wolbachia complicating the pathological effects of Dirofilaria immitis infections?
Kramer, L., Simón, F., Tamarozzi, F., Genchi, M., & Bazzocchi, C. (2005) · Veterinary Parasitology · doi:10.1016/j.vetpar.2005.04.011 · Cited by 44 · see citing works
Self-citationTidal Breathing Flow-Volume Loops in Healthy and Bronchitic Cats
McKieman, B. C., Dye, J. A., & Rozanski, E. A. (1993) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.1993.tb01036.x · Cited by 42 · see citing works
Leemans, J., Kirschvink, N. A., Bernaerts, F., et al. (2008) · The Veterinary Journal · doi:10.1016/j.tvjl.2007.11.008 · Cited by 36 · see citing works
Marcos-Atxutegi, C., Kramer, L. H., Fernandez, I., Simoncini, L., Genchi, M., Prieto, G., & Simón, F. (2003) · Veterinary Parasitology · doi:10.1016/s0304-4017(02)00419-3 · Cited by 31 · see citing works
Self-citationAssociation of Wolbachia with heartworm disease in cats and dogs
Dingman, P. A., Levy, J. K., Kramer, L. H., Johnson, C. M., Lappin, M. R., Greiner, E. C., Courtney, C. H., Tucker, S. J., & Morchón, R. (2010) · Veterinary Parasitology · doi:10.1016/j.vetpar.2010.01.037 · Cited by 30 · see citing works
Self-citationMorchón, R., Bazzocchi, C., López-Belmonte, J., Martín-Pacho, J. R., Kramer, L. H., Grandi, G., & Simón, F. (2007) · Parasitology International · doi:10.1016/j.parint.2006.10.003 · Cited by 30 · see citing works
Self-citationHirt, R., Galler, A. I., Shibly, S., et al. (2009) · The Veterinary Journal · doi:10.1016/j.tvjl.2009.10.007 · Cited by 25 · see citing works
García-Guasch, L., Caro‐Vadillo, A., Manubens-Grau, J., Carretón, E., Morchón, R., Simón, F., & Montoya-Alonso, J. A. (2011) · Veterinary Parasitology · doi:10.1016/j.vetpar.2011.12.013 · Cited by 21 · see citing works
Self-citationDillon, A. R., Warner, A. E., Molina, R. M., Soll, M. D., & KNIGHT, D. H. (1995) · Cited by 20 · see citing works
Wooldridge, A. A., Dillon, A. R., Tillson, D. M., Zhong, Q., & Barney, S. (2012) · American Journal of Veterinary Research · doi:10.2460/ajvr.73.3.439 · Cited by 16 · see citing works
Morchón, R., Roca, F., López-Belmonte, J., Genchi, M., Venco, L., Rodríguez-Barbero, A., & Simón, F. (2007) · Veterinary Parasitology · doi:10.1016/j.vetpar.2007.04.010 · Cited by 12 · see citing works
Self-citationHigh Levels of Serum Thromboxane B2 Are Generated during Human Pulmonary Dirofilariosis
Morchón, R., López-Belmonte, J., Rodríguez‐Barbero, A., & Simón, F. (2006) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00197-06 · Cited by 12 · see citing works
Self-citationComparison of bronchodilators in feline airways: In vitro and in vivo investigations
Leemans, J., Kirschvink, N. A., Delvaux, F. H., et al. (2005) · Open Repository and Bibliography (University of Liège) · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dirofilarioses in cats: European guidelines from the ABCD on prevention and management
Pennisi, M. G., Tasker, S., Hartmann, K., Belák, S., Addie, D., Boucraut-Baralon, C., Egberink, H., Frymus, T., Hofmann-Lehmann, R., Hosie, M., et al. (2020) · Journal of Feline Medicine and Surgery · doi:10.1177/1098612x20917601 · Cited by 53 · see citing works
Feline asthma and heartworm disease: Clinical features, diagnostics and therapeutics
Garrity, S., Lee-Fowler, T., & Reinero, C. (2019) · Journal of Feline Medicine and Surgery · doi:10.1177/1098612x18823348 · Cited by 33 · see citing works
Montoya-Alonso, J. A., Carretón, E., García-Guasch, L., Expósito, J., Armario, B., Morchón, R., & Simón, F. (2014) · Parasites & Vectors · doi:10.1186/s13071-014-0506-6 · Cited by 24 · see citing works
Self-citationVillanueva-saz, S., Giner, J., Verde, M., Yzuel, A., González, A., Lacasta, D., Marteles, D., & Fernández, A. (2021) · Veterinary Parasitology Regional Studies and Reports · doi:10.1016/j.vprsr.2021.100541 · Cited by 11 · see citing works
Dirofilaria immitis could be a risk factor for the development of allergic diseases in humans.
Montoya-Alonso, J. A., Morchón, R., Matos, J. I., Falcón-Cordón, Y., Costa-Rodriguez, N., & Carretón, E. (2020) · Animals · doi:10.3390/ani10101847 · Cited by 7 · see citing works
Self-citationAlho, A. M., Giannelli, A., Colella, V., Otranto, D., de Carvalho, L. M., & Correia, J. J. (2016) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.249.7.751 · Cited by 3 · see citing works
- Authors
- García-Guasch, L., Caro-Vadillo, A., Manubens-Grau, J., Carretón, E., Morchón, R., Simón, F., Kramer, L. H., & Montoya-Alonso, J. A.
- Affiliations
- Universidad de Las Palmas de Gran Canaria (ES)
- Universidad de Salamanca (ES)
- University of Parma (IT)
- Corresponding author
- Montoya-Alonso, J.A.
- Venue
- Veterinary Parasitology
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 196
- Issue
- 1-2
- Pages
- 130-135
- ISSN
- 0304-4017 (ISSN-L)
- OpenAlex
- W1973426160
- Cited by
- 24
- References
- 35
- Citations by year
- 2024: 2 · 2023: 2 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 5 · 2013: 1
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Veterinary Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Acceda (Universidad de Las Palmas de Gran Canaria) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Keywords
- Wolbachia, Dirofilaria immitis, cats, airway hyperresponsiveness, bronchoconstriction, lung function, seropositivity, airway inflammation
- MeSH terms
- Animals, Antibodies, Bacterial, Cat Diseases, Cats, Dirofilariasis, Female, Immunoglobulin G, Male, Plethysmography, Respiratory Tract Diseases, Serologic Tests, Bronchoconstriction, Wolbachia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
