The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Oxytocin has dose-dependent developmental effects on pair-bonding and alloparental care in female prairie voles
Open accessAbstract
The present study examines the developmental consequences of neonatal exposure to oxytocin on adult social behaviors in female prairie voles (Microtus ochrogaster). Female neonates were injected within 24 h of birth with isotonic saline or one of four dosages of oxytocin (OT). As adults, females were tested in an elevated plus-maze paradigm (a measure of anxiety and exploratory behavior), and for alloparental behavior and partner preferences. At 2 mg/kg OT, females took longer to approach pups, but were the only group to form a statistically significant within-group partner preference. At 4 mg/kg OT, females retrieved pups significantly more frequently but no longer displayed a partner preference; while females treated developmentally with 8 mg/kg spent significantly more time in side-to-side contact with a male stranger than any other treatment group. OT may have broad developmental consequences, but these effects are not linear and may both increase and decrease the propensity to display behaviors such as pair-bonding.
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In the citing paper
“OT injected into the cerebral ventricles (ICV) of a virgin rat could produce nurturing behavior towards pups within two hours [7].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [7]
In the citing paper
“In addition, a single shot of oxytocin in pups shortly after birth was associated with increased participation in allo-parental care when they became adults (Bales et al., 2007).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Bales et al., 2007
In the citing paper
“OT (like other peptides) can produce opposing effects at different dosages (19–22).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [19]
In the citing paper
“Females seem more resilient to developmental manipulations, typically responding only at higher dose of OT (19,39).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [19]
In the citing paper
“In voles, we found a single intraperitoneal OT administration postnatal day 1, led to long-term effects on partner preference in both male and female prairie voles, which differed depending on dose (19, 20).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [19]
In the citing paper
“Previous animal14, 15 and human studies on diseases other than ASD16, 17, 18 have shown dose-dependent oxytocin efficacy.”
From Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial (2016) · cites this paper as [14]
In the citing paper
“Yet, in the last 12 years, there has been a resurgence of research in this area, with studies in numerous species providing converging evidence that Oxt during development can have permanent effects on the brain and behavior (3, 13–29) (see Table 1).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [16]
In the citing paper
“Oxt treatment also increases the responsiveness of females to pups, as measured by approach times, although this effect is dose dependent, with the lowest dose of Oxt resulting in longer approach times compared to saline controls (16).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [16]
In the citing paper
“Animal research has shown the potential for long-term adverse effects after large oxytocin doses.67, 68”
Citations
Cites
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Neuroendocrine perspectives on social attachment and love
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Uvnäs-Moberg, K. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00056-0 · Cited by 966
A role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948 · cited 1×
“…in socially monogamous prairie voles has revealed that both OT and AVP play major roles in the expression of social behaviors, including pair-bonding (Winslow et al., 1993, 1994; Cho et al., 1999) and parental behaviors (Wang et al., 1994, 1998; Pedersen and Boccia, 2002; Bales et al., 2004b).”
BackgroundPedersen, C. A., & Prange, A. J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6661 · Cited by 841
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
Oxytocin induces maternal behavior in virgin female rats
Pedersen, C. A., Ascher, J. A., Monroe, Y. L., & Prange, A. J. (1982) · Science · doi:10.1126/science.7071605 · Cited by 770
Liu, Y., & Wang, Z. X. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00555-4 · Cited by 580 · cited 1×
“OT may be particularly related to pair-bond formation and parenting behavior in female voles (Liu and Wang, 2003; Olazabal and Young, 2006) and is also associated with mating (Carter, 1992).”
BackgroundCho, M. M., DeVries, A. C., Williams, J. R., & Carter, C. S. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.5.1071 · Cited by 529
Cited by
Sorted by citations
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037
Beetz, A., Uvnäs-Moberg, K., Julius, H., & Kotrschal, K. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00234 · Cited by 904
“That the OT system plays a major role in social bonds has been documented by several studies (e.g., Carter, 1998; Carter and Keverne, 2002; Bales et al., 2007).”
Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856
“For example, a single treatment with OT 24 hours after birth alters the expression of alloparental behavior in female prairie voles when they reach adulthood [46].”
BackgroundOxytocin pathways and the evolution of human behavior
Carter, C. S. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115110 · Cited by 714
“However, high doses of oxytocin had the opposite consequences, producing animals that preferred an unfamiliar partner (Bales et al. 2007b).”
BackgroundInfluentialSelf-citationDumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520
“…per sex, which might explain the limited brain regions in which sex differences in V1aR binding were found (C57B6 mice: Dubois Dauphin et al., 1996; Siberian hamsters: Dubois-Dauphlin et al., 1991; golden hamsters: Delville & Ferris, 1995; voles: Bales et al., 2007a; Smeltzer et al., 2006).”
BackgroundInfluential
Metadata
- Authors
- Bales, K. L., van Westerhuyzen, J. A., Lewis-Reese, A. D., Grotte, N. D., Lanter, J. A., & Carter, C. S.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Bales, Karen L.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 52
- Issue
- 2
- Pages
- 274-279
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC1978481
- OpenAlex
- W2017104298
- Cited by
- 192
- References
- 55
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 25 · 2019: 9 · 2018: 12 · 2017: 18 · 2016: 17 · 2015: 17 · 2014: 14 · 2013: 18 · 2012: 8
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- U.S. Public Health Service (R01 073022)
- National Institute of Mental Health (R01MH073022)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01 HD 38490, P01HD038490, F32 HD08702, F32HD008702)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Human-Animal Interaction Studies
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- oxytocin, Microtus ochrogaster, pair bonding, mate preferences, alloparental care, pup retrieval, female social behavior, anxiety, exploratory behavior, dose-dependent effects, developmental programming
- MeSH terms
- Animals, Animals, Newborn, Arvicolinae, Dose-Response Relationship, Drug, Female, Nesting Behavior, Oxytocin, Pair Bond, Maze Learning
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