Sex differences and developmental effects of oxytocin on aggression and social behavior in prairie voles (Microtus ochrogaster)
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Various hormones, including sex steroids and neuropeptides, have been implicated in aggression. In this study we examined (1) sex differences in intrasexual aggression in naïve prairie voles; (2) the effects of developmental manipulations of oxytocin on intrasexual aggression; and (3) changes in patterns of intrasexual aggression after brief exposure to an animal of the opposite sex. Within 24 h of birth, infants were randomly assigned to receive either an injection of oxytocin (OT) or oxytocin antagonist (OTA) or to one of two control (CTL) groups receiving either isotonic saline or handling without injection. As adults, animals were tested twice in a neutral arena; before (Test 1) and 24 h after (Test 2) a 4-h exposure to an animal of the opposite sex. In Test 1, CTL males were more likely to show aggressive and less likely to show social behavior than CTL females. No significant treatment differences were observed within either sex in Test 1. In Test 2, after brief exposure to a male, females treated with OT became more aggressive and less social than OTA or CTL females. Male aggressive behavior did not change after exposure to a female. An increase in aggression and decline in social behavior toward other females, seen here in OT-treated females, is typically observed only following several days of female-male cohabitation. These findings demonstrate a sex difference in intrasexual aggression and suggest that neonatal exposure to OT may facilitate the onset of the mate-guarding component of pair bonding in female prairie voles.
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Sex differences in responses to OT are pervasive in both adult voles and in single-dose developmental studies.
“While sex differences in responses to OT are pervasive in both adult voles (3,72) and in single-dose developmental studies (37,38,73)”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [73]
Studies in numerous species provide converging evidence that oxytocin during development can have permanent effects on the brain and behavior.
“Yet, in the last 12 years, there has been a resurgence of research in this area, with studies in numerous species providing converging evidence that Oxt during development can have permanent effects on the brain and behavior (3, 13–29) (see Table 1).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [18]
In female prairie voles, a single injection of oxytocin on postnatal day 1 results in increases in intrasexual aggression in adults, suggesting strengthened pair bond formation.
“In female prairie voles, a single injection of Oxt on PND1 results in increases in intrasexual aggression in adults, suggesting strengthened pair bond formation (18)”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [18]
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“Furthermore, although OT promotes pair bonding in female prairie voles, female voles treated with OT early in development show aggression andmate-guarding behaviors aswell as reduced social behaviors (Bales & Carter, 2003).”
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Hostetler, C. M., Harkey, S. L., Krzywosinski, T. B., Aragona, B. J., & Bales, K. L. (2011) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32834affd2 · Cited by 19 · see citing works
Self-citationFeng, T., An, S., Kinden, R., Zhang, X., Jia, R., & Tai, F. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.038 · Cited by 18 · see citing works
Early experience and the developmental programming of oxytocin and vasopressin
Sue carter, C., Boone, E. M., & Bales, K. L. (2008) · Neurobiology of the Parental Brain · doi:10.1016/b978-012374285-8.00027-5 · Cited by 14 · see citing works
The organizational effects of oxytocin and vasopressin: Behavioral implications
Cushing, B. S. (2013) · Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior · doi:10.1017/cbo9781139017855.006 · Cited by 9 · see citing works
- Authors
- Bales, K. L., & Carter, C. S.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Bales, Karen L
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 44
- Issue
- 3
- Pages
- 178-184
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2062734425
- Cited by
- 195
- References
- 49
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2023: 9 · 2022: 12 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 15 · 2017: 16 · 2016: 13 · 2015: 19 · 2014: 9 · 2013: 12 · 2012: 9
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01 HD 38490, P01HD038490, F32 HD08702, F32HD008702)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- oxytocin, oxytocin antagonist, Microtus ochrogaster, intrasexual aggression, sex differences, social behavior, pair bonding, mate guarding, neonatal hormone exposure, neuropeptides
- MeSH terms
- Aggression, Aging, Animals, Arvicolinae, Female, Male, Oxytocin, Sex Characteristics, Social Behavior
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