Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans
Abstract
The fundamental ability to form attachment is indispensable for human social relationships. Impairments in social behaviour are associated with decreased quality of life and psychopathological states. In non-human mammals, the neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) are key mediators of complex social behaviours, including attachment, social recognition and aggression. In particular, OXT reduces behavioural and neuroendocrine responses to social stress and seems both to enable animals to overcome their natural avoidance of proximity and to inhibit defensive behaviour, thereby facilitating approach behaviour. AVP has primarily been implicated in male-typical social behaviours, including aggression and pair-bond formation, and mediates anxiogenic effects. Initial studies in humans suggest behavioural, neural, and endocrine effects of both neuropeptides, similar to those found in animal studies. This review focuses on advances made to date in the effort to understand the role of OXT and AVP in human social behaviour. First, the literature on OXT and AVP and their involvement in social stress and anxiety, social cognition, social approach, and aggression is reviewed. Second, we discuss clinical implications for mental disorders that are associated with social deficits (e.g. autism spectrum disorder, borderline personality disorder). Finally, a model of the interactions of anxiety and stress, social approach behaviour, and the oxytocinergic system is presented, which integrates the novel approach of a psychobiological therapy in psychopathological states.
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Vasopressin is primarily implicated in male-typical social behaviors including aggression and pair-bond formation, and mediates anxiogenic effects.
“Vasopressin has primarily been implicated in male-typical social behaviors, including aggression and pair-bond formation, and mediates anxiogenic effects (Heinrichs & Domes, 2008).”
From A developmental, mentalization-based approach to the understanding and treatment of borderline personality disorder (2009) · cites this paper as Heinrichs & Domes, 2008
High-dose OT might saturate OT receptors and subsequently bind to vasopressin receptors, to which OT also has binding affinity and which can cause differing and sometimes opposite behavioral effects.
“In other words, high dose OT might saturate OT receptors and subsequently bind to vasopressin receptors, to which OT also has binding affinity and which can cause differing and sometimes opposite behavioral effects (18,38,76,77).”
From Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles (2013) · cites this paper as [77]
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“Since neuropeptides cross the blood–brain barrier after intranasal administration (Born et al., 2002),OXT can also be used in humans to investigate its effects on the central nervous system (Heinrichs and Domes, 2008).”
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- Authors
- HEINRICHS, M., & DOMES, G.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- HEINRICHS, M
- ORCID
- Venue
- Progress in brain research
- Publisher
- Elsevier
- Published
- 2008
- Volume
- 170
- Pages
- 337-350
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1524178766
- Cited by
- 479
- References
- 106
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 14 · 2023: 13 · 2022: 15 · 2021: 26 · 2020: 27 · 2019: 14 · 2018: 39 · 2017: 39 · 2016: 29 · 2015: 36 · 2014: 40 · 2013: 31 · 2012: 37
- FWCI
- 76.80
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Keywords
- oxytocin, vasopressin, neuropeptides, social behavior, attachment, social stress, anxiety, aggression, social cognition, autism spectrum disorder, borderline personality disorder, pair bonding
- MeSH terms
- Aggression, Animals, Anxiety, Autistic Disorder, Borderline Personality Disorder, Cognition, Humans, Interpersonal Relations, Neuropeptides, Oxytocin, Social Behavior, Stress, Psychological, Vasopressins, Recognition, Psychology, Models, Animal
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