An oxytocin antagonist infused into the central nucleus of the amygdala increases maternal aggressive behavior

Lubin, Deborah A.; Elliot, Jay C.; Black, Mitchell C.; Johns, Josephine M.

doi:10.1037/0735-7044.117.2.195

Cited by 146Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

An oxytocin antagonist infused into the central nucleus of the amygdala increases maternal aggressive behavior

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Lubin, Deborah A., Elliot, Jay C., Black, Mitchell C., Johns, Josephine M.·2003·Behavioral Neuroscience

DOI 10.1037/0735-7044.117.2.195PMC PMC3109068

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Abstract

Decreased oxytocin levels in the amygdalas of rat dams following chronic gestational cocaine exposure have been correlated with heightened maternal aggressive behavior. In this experiment, drug-naive dams were implanted with bilateral cannulas into the central nucleus of the amygdala (CNA) or control area and infused with 1,000 or 500 ng of an oxytocin antagonist (OTA) or buffer, 4 hr before testing. Behavior was compared among dams infused with OTA into target areas just outside the CNA and cocaine-treated dams (infused with buffer). Dams infused with 1,000 ng OTA attacked intruders significantly more often than buffer-infused dams. OTA did not affect other behaviors, suggesting that disruption of oxytocin activity in the CNA may be sufficient to selectively alter maternal aggressive behavior.

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Chronic ICV administration of oxytocin receptor antagonists can reduce maternal aggression in strains of rats exhibiting high anxiety and higher levels of defensive aggression.
“Chronic ICV administration of oxytocin receptor antagonists can reduce maternal aggression in strains of rats exhibiting high anxiety and higher levels of defensive aggression (Bosch et al., 2005 but see Lubin et al., 2003).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Lubin et al., 2003

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Authors: Lubin, D. A., Elliot, J. C., Black, M. C., & Johns, J. M.
Affiliations: University of North Carolina at Chapel Hill (US)
Venue: Behavioral Neuroscience
Publisher: American Psychological Association (APA)
Published: 2003
Volume: 117
Issue: 2
Pages: 195-201
ISSN: 0735-7044 (ISSN-L)
1939-0084
DOI: 10.1037/0735-7044.117.2.195
PMC: PMC3109068
OpenAlex: W2040553957
Cited by: 145
References: 43
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 9 · 2014: 5 · 2013: 7 · 2012: 10
FWCI: 14.83
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: National Institutes of Health
National Institute on Drug Abuse (DA13283-01A1, R01DA013362, DA13362-01, R29DA008456, R01DA013283)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin antagonist, central amygdala, maternal aggression, maternal behavior, intruder, oxytocin, rats
MeSH terms: Aggression, Amygdala, Anesthetics, Local, Animals, Behavior, Animal, Cocaine, Dose-Response Relationship, Drug, Female, Hormone Antagonists, Maternal Behavior, Oxytocin, Pregnancy, Time Factors, Rats, Sprague-Dawley, Ventral Tegmental Area, Rats

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An oxytocin antagonist infused into the central nucleus of the amygdala increases maternal aggressive behavior

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