Cited by 374Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

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Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins

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Beasley, Clare L, Zhang, Zhi J, Patten, Iain, Reynolds, Gavin P·2002·Biological Psychiatry

DOI 10.1016/s0006-3223(02)01360-4

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Abstract

Background Postmortem studies have provided evidence for abnormalities of the gamma-aminobutyric acid (GABA)-ergic system in schizophrenia, including deficits of GABA-containing interneurons. The calcium-binding proteins parvalbumin, calbindin, and calretinin can be used as markers for specific subpopulations of cortical GABAergic interneurons.Methods Following our previous observation of a reduction in the density of parvalbumin- but not calretinin-immunoreactive cells in the prefrontal cortex (Brodmann area 10) in schizophrenia, we have quantified the laminar density of neurons immunoreactive for the calcium-binding proteins parvalbumin, calbindin, and calretinin in a further prefrontal cortical region (Brodmann area 9) in patients with schizophrenia, bipolar disorder, major depression, and in matched control subjects (each group n = 15).Results Initial statistical analysis revealed reductions in the total cortical density of parvalbumin- and calbindin- but not calretinin-immunoreactive neurons in schizophrenia relative to control subjects. Further analysis comparing individual laminar densities between groups indicated that, following correction for multiple comparisons, only a reduction in calbindin-immunoreactive neurons in cortical layer II in the schizophrenic group attained statistical significance.Conclusions These findings suggest that deficits of specific GABAergic neurons, defined by the presence of calcium-binding proteins, are present in schizophrenia. Trends toward similar reductions are observed in bipolar disorder.

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Authors: Beasley, C. L., Zhang, Z. J., Patten, I., & Reynolds, G. P.
Affiliations: University of Sheffield (GB)
Corresponding author: Beasley, Clare L
ORCID: Beasley, Clare L
Reynolds, Gavin P
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2002-10
Volume: 52
Issue: 7
Pages: 708-715
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/s0006-3223(02)01360-4
OpenAlex: W1969171865
Cited by: 374
References: 38
Citations by year: 2026: 3 · 2025: 5 · 2024: 16 · 2023: 11 · 2022: 12 · 2021: 11 · 2020: 14 · 2019: 20 · 2018: 14 · 2017: 14 · 2016: 21 · 2015: 23 · 2014: 22 · 2013: 20 · 2012: 19
FWCI: 6.40
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Research Portal (Queen's University Belfast) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: schizophrenia, GABAergic interneurons, prefrontal cortex, calcium-binding proteins, parvalbumin, calbindin, calretinin, bipolar disorder, major depressive disorder, Brodmann area 9, Brodmann area 10
MeSH terms: Adult, Calcium-Binding Proteins, Cell Count, Female, gamma-Aminobutyric Acid, Humans, Immunohistochemistry, Interneurons, Male, Middle Aged, Parvalbumins, Schizophrenia, Prefrontal Cortex, Calbindins, S100 Calcium Binding Protein G, Calbindin 2

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Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins

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