Cited by 279Stress Responses and CortisolChild Abuse and TraumaPersonality Disorders and Psychopathology

The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.

Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse

Rinne, Thomas, de Kloet, E.Ronald, Wouters, Luuk, Goekoop, Jaap G, DeRijk, Roel H, van den Brink, Wim·2002·Biological Psychiatry

DOI 10.1016/s0006-3223(02)01395-1

Open this paper in CoChat — free account

Abstract

Background High coincidence of childhood abuse, major depressive disorder (MDD), and posttraumatic stress disorder (PTSD) has been reported in patients with borderline personality disorder (BPD). Animals exposed to early trauma show increased stress-induced hypothalamic-pituitary-adrenal (HPA) axis activity due to an enhanced corticotropin-releasing hormone (CRH) drive and glucocorticoid feedback resistance. In humans, PTSD and MDD are associated with decreased and increased resistance to glucocorticoid feedback, respectively, which might reflect persistent changes in neuroendocrine sequelae following childhood abuse. Methods We investigated the relationship between childhood abuse and HPA axis function using a combined dexamethasone/CRH (DEX/CRH) test in 39 BPD patients with (n = 24) and without (n = 15) sustained childhood abuse and comorbid PTSD (n = 12) or MDD (n = 11) and 11 healthy control subjects. Results Chronically abused BPD patients had a significantly enhanced corticotropin (ACTH) and cortisol response to the DEX/CRH challenge compared with nonabused subjects. Comorbid PTSD significantly attenuated the ACTH response. Conclusions Hyperresponsiveness of the HPA axis in chronically abused BPD subjects might be due to the enhanced central drive to pituitary ACTH release. Sustained childhood abuse rather than BPD, MDD, or PTSD pathology accounts for this effect. Possibly due to an enhanced efficacy of HPA suppression by dexamethasone, PTSD attenuates the ACTH response…

Integrity signals

Registry

Crossref · 10.1016/s0006-3223(02)01395-1

Cites

74 of 74 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

An analysis of variance test for normality (complete samples)
SHAPIRO, S. S., & WILK, M. B. (1965) · Biometrika · doi:10.1093/biomet/52.3-4.591 · Cited by 23,480
Practical Nonparametric Statistics
Groggel, D. J., & Conover, W. J. (2000) · Technometrics · doi:10.2307/1271101 · Cited by 11,076
Untitled work
(1992) · Cited by 5,228
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
A Specific Laboratory Test for the Diagnosis of Melancholia: Standardization, Validation, and Clinical Utility
Carroll, B. J. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780260017001 · Cited by 2,243
Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood
Heim, C. (2000) · JAMA · doi:10.1001/jama.284.5.592 · Cited by 1,968
Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638
Childhood trauma in borderline personality disorder.
Herman, J., Perry, J., & van der Kolk, B. A. (1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.4.490 · Cited by 1,277
Axis I Comorbidity of Borderline Personality Disorder
Zanarini, M. C., Frankenburg, F. R., Dubo, E., Sickel, A. E., Trikha, A., Levin, A., & Reynolds, V. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.12.1733 · Cited by 978
Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation
HOLSBOER, F., & Barden, N. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-187 · Cited by 860

Show all 74 references

Research works printed but not linked: 6

Carroll, 1982, Use of dexamethasone test in depression, J Clin Psychiatry, 43, 44
Lahmeyer, 1989, Biologic markers in borderline personality disorder, J Clin Psychiatry, 50, 217
Lim AT (2000): Corticotropine releasing factor (CRF). In: Fink G, editor. Encyclopedia of Stress, 1st ed. London: Academic Press, pp 578–581
Royston, 1982, The W-test for normality, Appl Statistics, 31, 176, 10.2307/2347986 · DOI
Royston JP (1995): Shapiro-Wilk normality test and p value. Appl Statistics 44:98–103 · DOI
Steiner, 1984, Distinguishing subtypes within the borderline domain, Biol Psychiatry, 19, 907

Sorted by citations

Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans.
Miller, G. E., Chen, E., & Zhou, E. S. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.1.25 · Cited by 2,467
Adverse childhood experiences, allostasis, allostatic load and age-related disease
Danese, A., & McEwen, B. S. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.08.019 · Cited by 2,140
The neurobiology of stress and development.
Gunnar, M., & Quevedo, K. (2007) · Annual Review of Psychology · doi:10.1146/annurev.psych.58.110405.085605 · Cited by 2,011
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704
Borderline personality disorder
Lieb, K., Zanarini, M. C., Schmahl, C., Linehan, M. M., & Bohus, M. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16770-6 · Cited by 1,369
Effects of the social environment and stress on glucocorticoid receptor gene methylation: A systematic review
Turecki, G., & Meaney, M. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.022 · Cited by 796
Child maltreatment and the developing HPA axis
Tarullo, A. R., & Gunnar, M. R. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.010 · Cited by 737
Importance of studying the contributions of early adverse experience to neurobiological findings in depression
Heim, C., Plotsky, P. M., & Nemeroff, C. B. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300397 · Cited by 514
Assessment of HPA axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review
de Kloet, C. S., Vermetten, E., Geuze, E., Kavelaars, A., Heijnen, C. J., & Westenberg, H. G. M. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.08.002 · Cited by 503
Theory of mind and emotion regulation difficulties in adolescents with borderline traits
Sharp, C., Pane, H., Ha, C., Venta, A., Patel, A. B., Sturek, J., & Fonagy, P. (2011) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2011.01.017 · Cited by 492
Guideline Watch: Practice Guideline for the Treatment of Patients With Borderline Personality Disorder
Oldham, J. M. (2005) · Focus · doi:10.1176/foc.3.3.396 · Cited by 429
Status of Glucocorticoid Alterations in Post‐traumatic Stress Disorder
Yehuda, R. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04979.x · Cited by 409
Stress, genes and the mechanism of programming the brain for later life
de Kloet, E. R., Sibug, R. M., Helmerhorst, F. M., & Schmidt, M. V. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.008 · Cited by 370
The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma
Heim, C., Mletzko, T., Purselle, D., Musselman, D. L., & Nemeroff, C. B. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.07.002 · Cited by 353
Advances in Understanding Neuroendocrine Alterations in PTSD and Their Therapeutic Implications
YEHUDA, R. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.012 · Cited by 335
Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children
Gunnar, M. R., Fisher, P. A., & THE EARLY EXPERIENCE, S. (2006) · Development and Psychopathology · doi:10.1017/s0954579406060330 · Cited by 347
Comorbidity of borderline personality disorder and posttraumatic stress disorder in the U.S. population
Pagura, J., Stein, M. B., Bolton, J. M., Cox, B. J., Grant, B., & Sareen, J. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.04.016 · Cited by 330
Reliability and Validity of the Borderline Personality Disorder Severity Index
Arntz, A., van den Hoorn, M., Cornelis, J., Verheul, R., van den Bosch, W. M. C., & de Bie, A. J. H. T. (2003) · Journal of Personality Disorders · doi:10.1521/pedi.17.1.45.24053 · Cited by 305
Stress Neurobiology and Developmental Psychopathology
Gunnar, M. R., & Vázquez, D. M. (2015) · Wiley eBooks · doi:10.1002/9780470939390.ch13 · Cited by 291
Childhood trauma and emotional reactivity to daily life stress in adult frequent attenders of general practitioners
Glaser, J.-P., van Os, J., Portegijs, P. J. M., & Myin-Germeys, I. (2006) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2006.04.014 · Cited by 280
The combined dexamethasone/CRH test as a potential surrogate marker in depression
Ising, M., Kunzel, H. E., Binder, E. B., Nickel, T., Modell, S., & Holsboer, F. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.03.014 · Cited by 275
Early life stress, the development of aggression and neuroendocrine and neurobiological correlates: What can we learn from animal models?
Veenema, A. H. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.03.003 · Cited by 275
Childhood parental loss and adult hypothalamic-pituitary-adrenal function
Tyrka, A. R., Wier, L., Price, L. H., Ross, N., Anderson, G. M., Wilkinson, C. W., & Carpenter, L. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.011 · Cited by 250
Impulsivity as a common process across borderline personality and substance use disorders
Bornovalova, M. A., Lejuez, C. W., Daughters, S. B., Rosenthal, M. Z., & Lynch, T. R. (2005) · Clinical Psychology Review · doi:10.1016/j.cpr.2005.05.005 · Cited by 266
The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions
Dunlop, B. W., & Wong, A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.10.010 · Cited by 271
Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function
Anacker, C., O'Donnell, K. J., & Meaney, M. J. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/canacker · Cited by 237
Interface between hypothalamic‐pituitary‐adrenal axis and brain‐derived neurotrophic factor in depression
Kunugi, H., Hori, H., Adachi, N., & Numakawa, T. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02135.x · Cited by 200
Childhood Trauma Is Associated With Hypothalamic-Pituitary-Adrenal Axis Responsiveness in Irritable Bowel Syndrome
Videlock, E. J., Adeyemo, M. A., Licudine, A., Hirano, M., Ohning, G., Mayer, M., Mayer, E. A., & Chang, L. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.058 · Cited by 198
Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder
Yehuda, R., Golier, J. A., Yang, R.-K., & Tischler, L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.010 · Cited by 196
Neuroimaging in borderline personality disorder
Schmahl, C. G., & Bremner, J. D. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.08.011 · Cited by 203
Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression?
de Kloet, E. R., DeRijk, R. H., & Meijer, O. C. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0403 · Cited by 193
Self-citation
Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed
Alt, S. R., Turner, J. D., Klok, M. D., Meijer, O. C., Lakke, E. A. J. F., DeRijk, R. H., & Muller, C. P. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.001 · Cited by 184
Self-citation
Borderline personality disorder and emotion regulation: Insights from the Polyvagal Theory
Austin, M. A., Riniolo, T. C., & Porges, S. W. (2007) · Brain and Cognition · doi:10.1016/j.bandc.2006.05.007 · Cited by 199
Adulthood trauma and HPA-axis functioning in healthy subjects and PTSD patients: A meta-analysis
Klaassens, E. R., Giltay, E. J., Cuijpers, P. J., van Veen, T., & Zitman, F. G. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.003 · Cited by 195
Interpersonal Stress Regulation and the Development of Anxiety Disorders: An Attachment-Based Developmental Framework
Nolte, T., Guiney, J., Fonagy, P., Mayes, L. C., & Luyten, P. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00055 · Cited by 210
Enhanced cortisol suppression in response to dexamethasone administration in traumatized veterans with and without posttraumatic stress disorder
de Kloet, C. S., Vermetten, E. H. G. J. M., Heijnen, C. J., Geuze, E., Lentjes, E. G. W. M., & Westenberg, H. G. M. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.12.009 · Cited by 177
Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms
Cattane, N., Rossi, R., Lanfredi, M., & Cattaneo, A. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1383-2 · Cited by 205
Type D personality: the heart, stress, and cortisol
Sher, L. (2005) · QJM · doi:10.1093/qjmed/hci064 · Cited by 175
Corticotropin‐releasing hormone (CRH) in psychiatry: from stress to psychopathology
Claes, S. J. (2004) · Annals of Medicine · doi:10.1080/07853890310017044 · Cited by 152
The neurobiological correlates of childhood adversity and implications for treatment
Tyrka, A. R., Burgers, D. E., Philip, N. S., Price, L. H., & Carpenter, L. L. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12143 · Cited by 142
“Early-life stress is linked to altered neuroendocrine function in adults with psychiatric disorders such as MDD, post-traumatic stress disorder (PTSD), and borderline personality disorder (9, 10).”
Background
An Increased Capacity for Adrenal DHEA Release is Associated with Decreased Avoidance and Negative Mood Symptoms in Women with PTSD
Rasmusson, A. M., Vasek, J., Lipschitz, D. S., Vojvoda, D., Mustone, M. E., Shi, Q., Gudmundsen, G. R., Morgan, C. A., Wolfe, J., & Charney, D. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300432 · Cited by 141
Stress, Memory, and the Hippocampus
Wingenfeld, K., & Wolf, O. T. (2014) · Frontiers of Neurology and Neuroscience · doi:10.1159/000356423 · Cited by 139
Trauma, Genes, and the Neurobiology of Personality Disorders
Goodman, M. S., New, A. S., & Siever, L. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.008 · Cited by 134
Executive neurocognition, memory systems, and borderline personality disorder
Fertuck, E. A., Lenzenweger, M. F., Clarkin, J. F., Hoermann, S., & Stanley, B. (2005) · Clinical Psychology Review · doi:10.1016/j.cpr.2005.05.008 · Cited by 141
Mind, brain, and personality disorders.
Gabbard, G. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.4.648 · Cited by 120
Dysfunctional stress responses in chronic pain
Woda, A., Picard, P., & Dutheil, F. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.05.017 · Cited by 128
Borderline personality disorder: Hypothalamus pituitary adrenal axis and findings from neuroimaging studies
Wingenfeld, K., Spitzer, C., Rullkötter, N., & Löwe, B. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.014 · Cited by 135
Neural correlates of the individual emotional Stroop in borderline personality disorder
Wingenfeld, K., Rullkoetter, N., Mensebach, C., Beblo, T., Mertens, M., Kreisel, S., Toepper, M., Driessen, M., & Woermann, F. G. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.024 · Cited by 124
Fermented foods: Harnessing their potential to modulate the microbiota-gut-brain axis for mental health
Balasubramanian, R., Schneider, E., Gunnigle, E., Cotter, P. D., & Cryan, J. F. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105562 · Cited by 143
Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome
Eede, F. V. D., Moorkens, G. H., Houdenhove, B. V., Cosyns, P. R., & Claes, S. J. (2007) · Neuropsychobiology · doi:10.1159/000104468 · Cited by 125
Psychosocial animal model of PTSD produces a long-lasting traumatic memory, an increase in general anxiety and PTSD-like glucocorticoid abnormalities
Zoladz, P. R., Fleshner, M., & Diamond, D. M. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.02.007 · Cited by 124
Depressive Symptoms in Adults Separated from Their Parents as Children: A Natural Experiment during World War II
Pesonen, A., Räikkönen, K., Heinonen, K., Kajantie, E., Forsén, T., & Eriksson, J. G. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm254 · Cited by 118
Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences
Claessens, S. E. F., Daskalakis, N. P., van der Veen, R., Oitzl, M. S., de Kloet, E. R., & Champagne, D. L. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2118-y · Cited by 123
Maternal separation alters nerve growth factor and corticosterone levels but not the DNA methylation status of the exon 17 glucocorticoid receptor promoter region
Daniels, W. M. U., Fairbairn, L., van Tilburg, G., McEvoy, C. R. E., Zigmond, M. J., Russell, V. A., & Stein, D. J. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-009-9163-4 · Cited by 118
Neuroendocrine Aspects of PTSD
Yehuda, R. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-28082-0_13 · Cited by 117
Biochemical markers subtyping major depressive disorder
Kunugi, H., Hori, H., & Ogawa, S. (2015) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12299 · Cited by 120
HPA Axis Alterations in Mental Disorders: Impact on Memory and its Relevance for Therapeutic Interventions
Wingenfeld, K., & Wolf, O. T. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00207.x · Cited by 118
The Role of Trauma in Early Onset Borderline Personality Disorder: A Biopsychosocial Perspective
Bozzatello, P., Rocca, P., Baldassarri, L., Bosia, M., & Bellino, S. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.721361 · Cited by 111
Signaling Pathways in Brain Involved in Predisposition and Pathogenesis of Stress‐Related Disease: Genetic and Kinetic Factors Affecting the MR/GR Balance
de Kloet, E. R., & DeRijk, R. H. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.003 · Cited by 115
Self-citation
A Neurobiological Model of Borderline Personality Disorder: Systematic and Integrative Review
Ruocco, A. C., & Carcone, D. (2016) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000123 · Cited by 111
Increased anterior cingulate cortex and hippocampus activation in Complex PTSD during encoding of negative words
Thomaes, K., Dorrepaal, E., Draijer, N., de Ruiter, M. B., Elzinga, B. M., Sjoerds, Z., van Balkom, A. J., Smit, J. H., & Veltman, D. J. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr084 · Cited by 103
Drug treatment for personality disorders
Tyrer, P. J., & BATEMAN, A. W. (2004) · Advances in Psychiatric Treatment · doi:10.1192/apt.10.5.389 · Cited by 102
Effects of childhood trauma on HPA-axis reactivity in women free of lifetime psychopathology
Klaassens, E. R., van Noorden, M. S., Giltay, E. J., van Pelt, J., van Veen, T., & Zitman, F. G. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.04.011 · Cited by 101
Psychiatric Comorbidity in Treatment‐Seeking Alcoholics: The Role of Childhood Trauma and Perceived Parental Dysfunction
Langeland, W., Draijer, N., & van den Brink, W. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000117831.17383.72 · Cited by 100
A preliminary study of cortisol and norepinephrine reactivity to psychosocial stress in borderline personality disorder with high and low dissociation
Simeon, D., Knutelska, M., Smith, L. M., Baker, B. R., & Hollander, E. (2006) · Psychiatry Research · doi:10.1016/j.psychres.2005.11.014 · Cited by 100
Potential programming of dopaminergic circuits by early life stress
Rodrigues, A.-J., Leão, P., Carvalho, M., Almeida, O. F. X., & Sousa, N. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2085-3 · Cited by 97
Associations of childhood trauma with hypothalamic-pituitary-adrenal function in borderline personality disorder and major depression.
Fernando, S. C., Beblo, T., Schlosser, N., Terfehr, K., Otte, C., Löwe, B., Wolf, O. T., Spitzer, C., Driessen, M., & Wingenfeld, K. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.02.012 · Cited by 96
Mechanisms differentiating normal from abnormal aggression: Glucocorticoids and serotonin
Haller, J., Mikics, É., Halász, J., & Tóth, M. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.064 · Cited by 94
Hypothalamic-pituitary-adrenal axis functioning in borderline personality disorder: A meta-analysis
Drews, E., Fertuck, E. A., Koenig, J., Kaess, M., & Arntz, A. R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.008 · Cited by 106
Effects of cortisol on cognition in major depressive disorder, posttraumatic stress disorder and borderline personality disorder - 2014 Curt Richter Award Winner
Wingenfeld, K., & Wolf, O. T. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.009 · Cited by 92
Corticotropin-releasing hormone and the hypothalamic–pituitary–adrenal axis in psychiatric disease
Naughton, M., Dinan, T. G., & Scott, L. V. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-59602-4.00005-8 · Cited by 97
Attachment and Personality Disorders: A Short Review
Lorenzini, N., & Fonagy, P. (2013) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.11.2.155 · Cited by 107
Dynamic output and control of the hypothalamic-pituitary-adrenal axis in critical illness and major surgery
Gibbison, B., Angelini, G. D., & Lightman, S. L. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet077 · Cited by 87
Multidimensional anatomy of ‘modern type depression’ in Japan: A proposal for a different diagnostic approach to depression beyond the DSM‐5
Kato, T. A., Hashimoto, R., Hayakawa, K., Kubo, H., Watabe, M., Teo, A. R., & Kanba, S. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12360 · Cited by 86
Childhood adversity and allostatic overload of the hypothalamic–pituitary–adrenal axis: A vulnerability model for depressive disorders
Wilkinson, P. O., & Goodyer, I. M. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000472 · Cited by 95
Dissociation and borderline personality disorder: An update for clinicians
Korzekwa, M. I., Dell, P. F., & Pain, C. (2009) · Current Psychiatry Reports · doi:10.1007/s11920-009-0013-1 · Cited by 85
Trauma and Stressor-Related Disorders
Walsh, K., Wells, J. B., Lurie, B., & Koenen, K. C. (2015) · Springer eBooks · doi:10.1007/978-3-319-13060-6_6 · Cited by 85
Mechanisms underlying sexual violence exposure and psychosocial sequelae: A theoretical and empirical review.
Walsh, K., Galea, S., & Koenen, K. C. (2012) · Clinical Psychology Science and Practice · doi:10.1111/cpsp.12004 · Cited by 96
Borderline personality disorder: A comparison between children and adults
Sharp, C., & Romero, C. (2007) · Bulletin of the Menninger Clinic · doi:10.1521/bumc.2007.71.2.85 · Cited by 83
Environmental Stressors and Epigenetic Control of the Hypothalamic-Pituitary-Adrenal Axis
Lee, R. S., & Sawa, A. (2014) · Neuroendocrinology · doi:10.1159/000369585 · Cited by 84
Epigenetics and memory: causes, consequences and treatments for post‐traumatic stress disorder and addiction
Pizzimenti, C. L., & Lattal, K. M. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12187 · Cited by 79
Is Abuse Causally Related to Urologic Symptoms? Results from the Boston Area Community Health (BACH) Survey
Link, C. L., Lutfey, K., Steers, W. D., & McKinlay, J. B. (2007) · European Urology · doi:10.1016/j.eururo.2007.03.024 · Cited by 76
Differences in the response to the combined DEX-CRH test between PTSD patients with and without co-morbid depressive disorder
de Kloet, C. S., Vermetten, E. H. G. J. M., Lentjes, E. G. W. M., Geuze, E., PELT, J. V., Manuel, R., Heijnen, C. J., & Westenberg, H. G. M. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.11.016 · Cited by 71
The Hypothalamic-Pituitary-Adrenal Axis in Borderline Personality Disorder
Zimmerman, D. J., & Choi-Kain, L. W. (2009) · Harvard Review of Psychiatry · doi:10.1080/10673220902996734 · Cited by 74
How to measure glucocorticoid receptor’s sensitivity in patients with stress-related psychiatric disorders
Leistner, C., & Menke, A. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.01.023 · Cited by 69
Increased corticosterone in peripubertal rats leads to long-lasting alterations in social exploration and aggression
Veenit, V., Cordero, M. I., Tzanoulinou, S., & Sandi, C. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00026 · Cited by 68
Fluvoxamine Reduces Responsiveness of HPA Axis in Adult Female BPD Patients with a History of Sustained Childhood Abuse
Rinne, T., de Kloet, E. R., Wouters, L. F., Goekoop, J. G., Rijk, R. H. D., & van den Brink, W. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300003 · Cited by 67
Self-citation
Cortisol Response To Interpersonal Stress in Young Adults With Borderline Personality Disorder: A Pilot Study
Walter, M., Bureau, J.-F., Holmes, B. M., Bertha, E. A., Hollander, M., Wheelis, J., Brooks, N. H., & Lyons-Ruth, K. (2008) · European Psychiatry · doi:10.1016/j.eurpsy.2007.12.003 · Cited by 66
Sleep problems in childhood and borderline personality disorder symptoms in early adolescence
Lereya, S. T., Winsper, C., Tang, N. K. Y., & Wolke, D. (2017) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-016-0158-4 · Cited by 65
Personality Disorders and Traits as Predictors of Incident Cardiovascular Disease: Findings From the 23-Year Follow-Up of The Baltimore ECA Study
Lee, H. B., Bienvenu, O. J., Cho, S.-H., Ramsey, C. M., Bandeen‐Roche, K., Eaton, W. W., & Nestadt, G. (2010) · Psychosomatics · doi:10.1176/appi.psy.51.4.289 · Cited by 64
Developmental psychopathology and neurobiology of aggression
Gollan, J. K., Lee, R., & Coccaro, E. F. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050546 · Cited by 68
New developments in the neurobiology of borderline personality disorder
Bohus, M., Schmahl, C. G., & Lieb, K. (2004) · Current Psychiatry Reports · doi:10.1007/s11920-004-0038-4 · Cited by 62
Childhood trauma and cortisol awakening response in symptomatic patients with anorexia nervosa and bulimia nervosa
Monteleone, A. M., Monteleone, P., Serino, I., Scognamiglio, P., Genio, M. D., & Maj, M. (2015) · International Journal of Eating Disorders · doi:10.1002/eat.22375 · Cited by 63
Blunted ACTH response to dexamethasone suppression-CRH stimulation in posttraumatic stress disorder
Ströhle, A., Scheel, M., Modell, S., & Holsboer, F. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.01.015 · Cited by 57
Efficacy and Tolerability of Pharmacotherapies for Borderline Personality Disorder
Bellino, S., Paradiso, E., & Bogetto, F. (2008) · CNS Drugs · doi:10.2165/00023210-200822080-00005 · Cited by 60
Maus-tratos na infância e psicopatologia no adulto: caminhos para a disfunção do eixo hipotálamo-pituitária-adrenal
Mello, M. F., Faria, A. A., Mello, A. F., Carpenter, L. L., Tyrka, A. R., & Price, L. H. (2009) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462009000600002 · Cited by 65
NMDA neurotransmission as a critical mediator of borderline personality disorder
Grosjean, B., & Tsai, G. E. (2007) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0710 · Cited by 57
Daytime Cortisol Secretion in 6-Month-Old Twins: Genetic and Environmental Contributions as a Function of Early Familial Adversity
Ouellet‐Morin, I., Dionne, G., Pérusse, D., LUPIEN, S. J., Arseneault, L., Barr, R. G., Tremblay, R. E., & Boivin, M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.003 · Cited by 57
Basal cortisol and DHEA levels in women with borderline personality disorder
Jogems-Kosterman, B. J. M., de Knijff, D. W. W., Kusters, R., & van Hoof, J. J. M. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.07.019 · Cited by 55

Authors: Rinne, T., de Kloet, E. R., Wouters, L., Goekoop, J. G., DeRijk, R. H., & van den Brink, W.
Affiliations: Vrije Universiteit Amsterdam (NL)
Leiden University Medical Center (NL)
Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author: Rinne, Thomas
ORCID: de Kloet, E.Ronald
Wouters, Luuk
van den Brink, Wim
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2002-12
Volume: 52
Issue: 11
Pages: 1102-1112
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/s0006-3223(02)01395-1
OpenAlex: W2068221498
Cited by: 279
References: 74
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 9 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 14 · 2014: 20 · 2013: 19 · 2012: 10
FWCI: 5.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Nationaal Fonds Geestelijke Volksgezondheid (4820)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords: borderline personality disorder, childhood abuse, hypothalamic-pituitary-adrenal axis, ACTH response, cortisol, post-traumatic stress disorder, major depressive disorder, trauma exposure
MeSH terms: Adolescent, Adrenocorticotropic Hormone, Adult, Borderline Personality Disorder, Child Abuse, Corticotropin-Releasing Hormone, Dexamethasone, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Middle Aged, Pituitary-Adrenal System, Stress Disorders, Post-Traumatic, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks