Cited by 131Lipoproteins and Cardiovascular HealthNuts composition and effectsNutritional Studies and Diet

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The effect of combining plant sterols, soy protein, viscous fibers, and almonds in treating hypercholesterolemia

Jenkins, David J.A, Kendall, Cyril W.C, Marchie, Augustine, Faulkner, Dorothea, Vidgen, Edward, Lapsley, Karen G, Trautwein, Elke A, Parker, Tina L, Josse, Robert G, Leiter, Lawrence A, Connelly, Philip W·2003·Metabolism

DOI 10.1016/s0026-0495(03)00260-9

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Abstract

Reductions in low-density lipoprotein-cholesterol (LDL-C) result from diets containing almonds, or diets that are either low in saturated fat or high in viscous fibers, soy proteins, or plant sterols. We have therefore combined all of these interventions in a single diet (portfolio diet) to determine whether cholesterol reductions could be achieved of similar magnitude to those reported in recent statin trials which reduced cardiovascular events. Twenty-five hyperlipidemic subjects consumed either a portfolio diet (n=13), very low in saturated fat and high in plant sterols (1.2 g/1,000 kcal), soy protein (16.2 g/1,000 kcal), viscous fibers (8.3 g/1,000 kcal), and almonds (16.6 g/1,000 kcal), or a low-saturated fat diet (n=12) based on whole-wheat cereals and low-fat dairy foods. Fasting blood, blood pressure, and body weight were obtained at weeks 0, 2, and 4 of each phase. LDL-C was reduced by 12.1% +/- 2.4% (P<.001) on the low-fat diet and by 35.0% +/- 3.1% (P<.001) on the portfolio diet, which also reduced the ratio of LDL-C to high-density lipoprotein-cholesterol (HDL-C) significantly (30.0% +/- 3.5%; P<.001). The reductions in LDL-C and the LDL:HDL-C ratio were both significantly lower on the portfolio diet than on the control diet (P<.001 and P<.001, respectively). Mean weight loss was similar on test and control diets (1.0 kg and 0.9 kg, respectively). No difference was seen in blood pressure, HDL-C, serum triglycerides, lipoprotein(a) [Lp(a)], or homocysteine concentr…

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Authors: Jenkins, D. J. A., Kendall, C. W. C., Marchie, A., Faulkner, D., Vidgen, E., Lapsley, K. G., Trautwein, E. A., Parker, T. L., Josse, R. G., Leiter, L. A., & Connelly, P. W.
Affiliations: St. Michael's Hospital (CA)
Almond Board of California (US)
Unilever Research and Development Vlaardingen (NL)
Corresponding author: Jenkins, David J.A
ORCID: Jenkins, David J.A
Kendall, Cyril W.C
Josse, Robert G
Leiter, Lawrence A
Connelly, Philip W
Venue: Metabolism
Publisher: Elsevier BV
Published: 2003-11
Volume: 52
Issue: 11
Pages: 1478-1483
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/s0026-0495(03)00260-9
OpenAlex: W2146648965
Cited by: 131
References: 49
Citations by year: 2025: 6 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 7
FWCI: 8.01
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: hypercholesterolemia, Portfolio diet, phytosterols, soy protein, almond, LDL cholesterol lowering, low saturated fat diet, dietary therapy, statin alternatives, weight loss, blood pressure, lipoprotein(a), homocysteine
MeSH terms: Adult, Aged, Aged, 80 and over, Cholesterol, Cholesterol, Dietary, Dietary Carbohydrates, Dietary Fats, Dietary Fiber, Erythrocyte Deformability, Female, Food Preferences, Homocysteine, Humans, Hypercholesterolemia, Hyperlipidemias, Male, Middle Aged, Phytosterols, Risk Factors, Satiety Response, Prunus, Soybean Proteins

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The effect of combining plant sterols, soy protein, viscous fibers, and almonds in treating hypercholesterolemia

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