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Cited by 131Lipoproteins and Cardiovascular HealthNuts composition and effectsNutritional Studies and Diet

The DOI matches its Crossref record; 47 of the 49 references it cites were found in a registry or an index.

The effect of combining plant sterols, soy protein, viscous fibers, and almonds in treating hypercholesterolemia

Jenkins, David J.A, Kendall, Cyril W.C, Marchie, Augustine, Faulkner, Dorothea, Vidgen, Edward, Lapsley, Karen G, Trautwein, Elke A, Parker, Tina L, Josse, Robert G, Leiter, Lawrence A, Connelly, Philip W·2003·Metabolism
DOI 10.1016/s0026-0495(03)00260-9
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Abstract

Reductions in low-density lipoprotein-cholesterol (LDL-C) result from diets containing almonds, or diets that are either low in saturated fat or high in viscous fibers, soy proteins, or plant sterols. We have therefore combined all of these interventions in a single diet (portfolio diet) to determine whether cholesterol reductions could be achieved of similar magnitude to those reported in recent statin trials which reduced cardiovascular events. Twenty-five hyperlipidemic subjects consumed either a portfolio diet (n=13), very low in saturated fat and high in plant sterols (1.2 g/1,000 kcal), soy protein (16.2 g/1,000 kcal), viscous fibers (8.3 g/1,000 kcal), and almonds (16.6 g/1,000 kcal), or a low-saturated fat diet (n=12) based on whole-wheat cereals and low-fat dairy foods. Fasting blood, blood pressure, and body weight were obtained at weeks 0, 2, and 4 of each phase. LDL-C was reduced by 12.1% +/- 2.4% (P<.001) on the low-fat diet and by 35.0% +/- 3.1% (P<.001) on the portfolio diet, which also reduced the ratio of LDL-C to high-density lipoprotein-cholesterol (HDL-C) significantly (30.0% +/- 3.5%; P<.001). The reductions in LDL-C and the LDL:HDL-C ratio were both significantly lower on the portfolio diet than on the control diet (P<.001 and P<.001, respectively). Mean weight loss was similar on test and control diets (1.0 kg and 0.9 kg, respectively). No difference was seen in blood pressure, HDL-C, serum triglycerides, lipoprotein(a) [Lp(a)], or homocysteine concentr…

Overview

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Crossref · 10.1016/s0026-0495(03)00260-9

Cites

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Citations

Cites

Research works printed but not linked: 2

  1. 1999, FDA Final Rule for Food Labelling: Health Claims: Soy Protein and Coronary Heart Disease, Federal Register, 64, 57699
  2. 1994, Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease, Lancet, 344, 1383

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Metadata

Authors
Jenkins, D. J. A., Kendall, C. W. C., Marchie, A., Faulkner, D., Vidgen, E., Lapsley, K. G., Trautwein, E. A., Parker, T. L., Josse, R. G., Leiter, L. A., & Connelly, P. W.
Affiliations
  • St. Michael's Hospital (CA)
  • Almond Board of California (US)
  • Unilever Research and Development Vlaardingen (NL)
Corresponding author
Jenkins, David J.A
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
2003-11
Volume
52
Issue
11
Pages
1478-1483
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/s0026-0495(03)00260-9
OpenAlex
W2146648965
Cited by
131
References
49
Citations by year
2025: 6 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 7
FWCI
8.01
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
hypercholesterolemia, Portfolio diet, phytosterols, soy protein, almond, LDL cholesterol lowering, low saturated fat diet, dietary therapy, statin alternatives, weight loss, blood pressure, lipoprotein(a), homocysteine
MeSH terms
Adult, Aged, Aged, 80 and over, Cholesterol, Cholesterol, Dietary, Dietary Carbohydrates, Dietary Fats, Dietary Fiber, Erythrocyte Deformability, Female, Food Preferences, Homocysteine, Humans, Hypercholesterolemia, Hyperlipidemias, Male, Middle Aged, Phytosterols, Risk Factors, Satiety Response, Prunus, Soybean Proteins

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