Cited by 196Nutritional Studies and DietLipoproteins and Cardiovascular HealthAgriculture Sustainability and Environmental Impact

Effects of plant-based diets on plasma lipids

Ferdowsian, Hope R., Barnard, Neal D.·2009·The American Journal of Cardiology

Abstract

Dyslipidemia is a primary risk factor for cardiovascular disease, peripheral vascular disease, and stroke. Current guidelines recommend diet as first-line therapy for patients with elevated plasma cholesterol concentrations. However, what constitutes an optimal dietary regimen remains a matter of controversy. Large prospective trials have demonstrated that populations following plant-based diets, particularly vegetarian and vegan diets, are at lower risk for ischemic heart disease mortality. The investigators therefore reviewed the published scientific research to determine the effectiveness of plant-based diets in modifying plasma lipid concentrations. Twenty-seven randomized controlled and observational trials were included. Of the 4 types of plant-based diets considered, interventions testing a combination diet (a vegetarian or vegan diet combined with nuts, soy, and/or fiber) demonstrated the greatest effects (up to 35% plasma low-density lipoprotein cholesterol reduction), followed by vegan and ovolactovegetarian diets. Interventions allowing small amounts of lean meat demonstrated less dramatic reductions in total cholesterol and low-density lipoprotein levels. In conclusion, plant-based dietary interventions are effective in lowering plasma cholesterol concentrations.

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Crossref · 10.1016/j.amjcard.2009.05.032

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  • Randomized controlled trial evidence shows a protective effect of plant-based diets on intermediate outcomes, including weight change, lipid profile, glycemic control, and blood pressure.

    “Additionally, randomized controlled trial evidence showing the protective effect of plant-based diets on intermediate outcomes, including weight change, lipid profile, glycemic control, and blood pressure lends further support to our findings.(35–38)”

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Authors
Ferdowsian, H. R., & Barnard, N. D.
Affiliations
George Washington University (US)
Corresponding author
Ferdowsian, Hope R.
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
2009-10
Volume
104
Issue
7
Pages
947-956
ISSN
0002-9149 (ISSN-L)
OpenAlex
W1976331330
Cited by
196
References
73
Citations by year
2025: 9 · 2024: 8 · 2023: 10 · 2022: 6 · 2021: 20 · 2020: 20 · 2019: 11 · 2018: 8 · 2017: 17 · 2016: 9 · 2015: 13 · 2014: 15 · 2013: 12 · 2012: 14
FWCI
1.67
Type
journal article
Language
en
Open access
closed
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Physical Sciences › Environmental Science › Ecology › Agriculture Sustainability and Environmental Impact
Keywords
plant-based diet, plasma lipids, dyslipidemia, LDL cholesterol, total cholesterol, vegetarian diet, vegan diet, dietary intervention, cardiovascular risk, nuts, soybean, dietary fiber
MeSH terms
Cardiovascular Diseases, Coronary Artery Disease, Female, Humans, Hyperlipidemias, Cholesterol, LDL, Male, Phytotherapy, Plants, Prognosis, Diet, Vegetarian, Randomized Controlled Trials as Topic, Treatment Outcome, Risk Assessment, Dietary Supplements

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